Grant Number:	5U01CA265729-04 Interpret this number
Primary Investigator:	Hur, Chin
Organization:	Columbia University Health Sciences
Project Title:	Comparative Modeling of Gastric Cancer Disparities and Prevention in the Us and Globally
Fiscal Year:	2024

Gastric cancer (GC), specifically gastric adenocarcinoma, is the fifth most common cancer and the third leading cause of cancer death globally and has been categorized as a neglected cancer by the World Health Organization. In the U.S., there are stark disparities, with Blacks, Hispanics and Asians having a nearly two- fold greater risk of developing or dying from GC compared to Whites, reflecting differences in risk factors, such as Helicobacter pylori (H. pylori) infection and smoking, as well as access to primary prevention and care. Several factors are changing the landscape of GC prevention, including a better understanding of the disease natural history, new evidence on prevention from prospective studies, and anticipated results from randomized controlled trials. As early GC detection can improve survival by allowing for curative surgical or noninvasive endoscopic resection, new targeted approaches to GC prevention have the potential to markedly improve population health and reduce GC disparities within the U.S. Although H. pylori has been the primary focus of global GC prevention efforts to date, substantial variation by subpopulation in H. pylori prevalence in the U.S. and the world has accentuated the need to optimize H. pylori screen-and-treat interventions for vulnerable groups. One approach is targeted endoscopic screening of high-risk individuals. For instance, persons found to have gastric intestinal metaplasia, a precursor lesion associated with a high progression risk to gastric neoplasia, are recommended to undergo endoscopic surveillance in many countries. A critical need exists to identify effective and cost-effective strategies to address these clinical challenges in the U.S., as well as globally. This proposed work builds upon prior GC work spanning GC and H. pylori simulation modeling studies, GC secondary database analyses, and relevant methodologic and global cancer modeling publications. The research team for this proposal has a vast collective experience in simulation and comparative modeling for cancer control, clinical expertise across the spectrum of GC prevention and care, and a demonstrated track record and commitment to informing cancer care and policy. The proposed three modeling groups are well-positioned to perform and successfully complete the highly relevant project aims. The overarching goal of the proposed research is to produce innovative and paradigm-shifting changes to cancer care through a disparities-focused modeling approach targeting the most vulnerable, high-risk populations that bear the greatest burden of GC in the US, and the world. We will accomplish this goal by performing comparative modeling and completing the following aims: 1) Develop GC simulation models to estimate GC outcomes for subgroups by race and ethnicity in the U.S.; 2) Assess the impact of risk factor trends and primary prevention strategies on GC disparities; 3) Evaluate targeted secondary prevention strategies for reducing early onset-related mortality and GC disparities, and 4) Adapt the models to evaluate GC prevention policies in the global setting.




MODELING EARLY-ONSET CANCER KINETICS TO STUDY CHANGES IN UNDERLYING RISK, DETECTION, AND IMPACT OF POPULATION SCREENING.
Authors: Mirzaei N.M. , Hur C. , Terry M.B. , Dalerba P. , Yang W. .
Source: Medrxiv : The Preprint Server For Health Sciences, 2024-12-08 00:00:00.0; , .
EPub date: 2024-12-08 00:00:00.0.
PMID: 39677417
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Differences in Ancestry and Presence of Gastric Precursor Lesions in Individuals With Young- and Average-Onset Gastric Cancer.
Authors: Magahis P.T. , Cornet N. , Tang L. , Arora K. , Hingorani N. , King S. , Markowitz A.J. , Schattner M. , Shimada S. , Maron S.B. , et al. .
Source: Cancer Medicine, 2024 Dec; 13(23), p. e70451.
PMID: 39629931
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Racial, Ethnic, and Sex Differences in Incidence-Based Mortality of Aggregate Upper Gastrointestinal Cancers.
Authors: Malick A. , Ferris J.S. , Hur C. , Abrams J.A. , Soroush A. .
Source: Clinical And Translational Gastroenterology, 2024-08-01 00:00:00.0; 15(8), p. e00745.
EPub date: 2024-08-01 00:00:00.0.
PMID: 39007497
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CLINICOPATHOLOGICAL CHARACTERISTICS AND RISK FACTORS OF YOUNG-ONSET GASTRIC CARCINOMA: A SYSTEMATIC REVIEW AND META-ANALYSIS.
Authors: Li Y. , Hahn A.I. , Laszkowska M. , Jiang F. , Zauber A.G. , Leung W.K. .
Source: Clinical And Translational Gastroenterology, 2024-05-08 00:00:00.0; , .
EPub date: 2024-05-08 00:00:00.0.
PMID: 38717039
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Global burden of young-onset gastric cancer: a systematic trend analysis of the global burden of disease study 2019.
Authors: Li Y. , Hahn A.I. , Laszkowska M. , Jiang F. , Zauber A.G. , Leung W.K. .
Source: Gastric Cancer : Official Journal Of The International Gastric Cancer Association And The Japanese Gastric Cancer Association, 2024-04-03 00:00:00.0; , .
EPub date: 2024-04-03 00:00:00.0.
PMID: 38570392
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Prevalence of Gastric Precursor Lesions in Countries with Differential Gastric Cancer Burden: A Systematic Review & Meta-Analysis.
Authors: Mülder D.T. , Hahn A.I. , Huang R.J. , Zhou M.J. , Blake B. , Omofuma O. , Murphy J.D. , Gutiérrez-Torres D.S. , Zauber A.G. , O'Mahony J.F. , et al. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2024-03-02 00:00:00.0; , .
EPub date: 2024-03-02 00:00:00.0.
PMID: 38438000
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The Effect of Nationwide Organized Cancer Screening Programs on Gastric Cancer Mortality: A Synthetic Control Study.
Authors: Sun D. , Mülder D.T. , Li Y. , Nieboer D. , Park J.Y. , Suh M. , Hamashima C. , Han W. , O'Mahony J.F. , Lansdorp-Vogelaar I. .
Source: Gastroenterology, 2024 Mar; 166(3), p. 503-514.
EPub date: 2023-11-24 00:00:00.0.
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Endoscopic Surveillance of Intestinal Metaplasia of the Esophagogastric Junction: A Decision Modeling Analysis.
Authors: Yoon J.Y. , Lim F. , Shah S.C. , Rubenstein J.H. , Abrams J.A. , Katzka D. , Inadomi J. , Kim M.K. , Hur C. .
Source: The American Journal Of Gastroenterology, 2024-01-26 00:00:00.0; , .
EPub date: 2024-01-26 00:00:00.0.
PMID: 38275234
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Epidemiology of Gastric Malignancies 2000-2018 According to Histology: A Population-Based Analysis of Incidence and Temporal Trends.
Authors: Rustgi S.D. , McKinley M. , McBay B. , Zylberberg H.M. , Gomez S.L. , Hur C. , Kastrinos F. , Gupta S. , Kim M.K. , Itzkowitz S.H. , et al. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2023 Dec; 21(13), p. 3285-3295.e8.
EPub date: 2023-02-14 00:00:00.0.
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Authors: Rustgi S.D. , McKinley M. , McBay B. , Zylberberg H.M. , Gomez S.L. , Hur C. , Kastrinos F. , Gupta S. , Kim M.K. , Itzkowitz S.H. , et al. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2023 Dec; 21(13), p. 3285-3295.e8.
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Approaches to developing de novo cancer population models to examine questions about cancer and race in bladder, gastric, and endometrial cancer and multiple myeloma: the Cancer Intervention and Surveillance Modeling Network incubator program.
Authors: Sereda Y. , Alarid-Escudero F. , Bickell N.A. , Chang S.H. , Colditz G.A. , Hur C. , Jalal H. , Myers E.R. , Layne T.M. , Wang S.Y. , et al. .
Source: Journal Of The National Cancer Institute. Monographs, 2023-11-08 00:00:00.0; 2023(62), p. 219-230.
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Impact of Helicobacter pylori infection status on outcomes among patients with advanced gastric cancer treated with immune checkpoint inhibitors.
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Source: Journal For Immunotherapy Of Cancer, 2023 Oct; 11(10), .
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Factors associated with detection of hereditary diffuse gastric cancer on endoscopy in individuals with germline CDH1 mutations.
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EPub date: 2023-04-23 00:00:00.0.
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Management of Gastric Intestinal Metaplasia.
Authors: Rustgi S.D. , Zylberberg H.M. , Hur C. , Shah S.C. .
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2023-04-19 00:00:00.0; , .
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Cost-effectiveness of screening with polymerase chain reaction for Helicobacter pylori to prevent gastric cancer and peptic ulcers.
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Databases for Gastrointestinal Clinical and Public Health Research: Have Database, Will Research.
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