Grant Number:	5U01CA253912-05 Interpret this number
Primary Investigator:	Kim, Jane
Organization:	Harvard School Of Public Health
Project Title:	Comparative Modeling to Inform Cervical Cancer Control Policies
Fiscal Year:	2024

Project Summary Despite successful cervical cancer screening in the United States (US), over 13,000 women develop and 4,000 women die from cervical cancer each year. The discovery of human papillomavirus (HPV) as the necessary cause of cervical cancer precipitated a surge of new evidence and development of innovative HPV-based technologies, both screening and prophylactic vaccination, that have allowed for significant changes in our approach to cervical cancer control over the past two decades. These new technologies represent tremendous opportunities for effective, equitable, and efficient cervical cancer programs in the US but also pose significant challenges for decision-making. Given the limited availability of outcomes data for new screening and vaccination approaches from empirical studies, policy-makers have become uniquely reliant on mathematical modeling to provide a synthesized evidence base for decision-making for cervical cancer control strategies. These models can be used to integrate the most up-to-date data, extrapolate short-term findings into long-term outcomes, and evaluate what-if scenarios that would otherwise be impractical or infeasible to conduct in clinical studies. The proposed CISNET project will represent the continued, productive collaboration of five independent modeling groups from the US, Australia, and the Netherlands that will leverage a series of state- of-the-art mathematical models of HPV and cervical carcinogenesis for comparative modeling. We will pursue analyses related to the impact of newly-revised screening and HPV vaccination guidelines, the comparative effectiveness of forthcoming screening and HPV vaccination strategies and approaches, the optimal routes for reducing cervical cancer disparities, the potential for cervical cancer elimination in the US, and optimal screening and vaccination strategies in women living with HIV. Our efforts will also involve wide dissemination of findings to various stakeholders to increase transparency and confidence in model-based analyses.




Historical Bias in Mortgage Lending, Redlining, and Implications for the Uncertain Geographic Context Problem: A Study of Structural Housing Discrimination in Dallas and Boston.
Authors: Beauchamp A.M. , Tiro J.A. , Haas J.S. , Kobrin S.C. , Alegria M. , Hughes A.E. .
Source: Journal Of Urban Health : Bulletin Of The New York Academy Of Medicine, 2024-08-21 00:00:00.0; , .
EPub date: 2024-08-21 00:00:00.0.
PMID: 39168963
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State-level disparities in cervical cancer prevention and impact on outcomes in the U.S.: A modeling study.
Authors: Alarid-Escudero F. , Gracia V. , Wolf M. , Zhao R. , Easterly C.W. , Kim J.J. , Canfell K. , de Kok I.M.C.M. , Barnabas R.V. , Kulasingam S. .
Source: Medrxiv : The Preprint Server For Health Sciences, 2024-06-12 00:00:00.0; , .
EPub date: 2024-06-12 00:00:00.0.
PMID: 38947042
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Cost-effectiveness of single-visit cervical cancer screening in KwaZulu-Natal, South Africa: a model-based analysis accounting for the HIV epidemic.
Authors: Tran J. , Hathaway C.L. , Broshkevitch C.J. , Palanee-Phillips T. , Barnabas R.V. , Rao D.W. , Sharma M. .
Source: Frontiers In Oncology, 2024; 14, p. 1382599.
EPub date: 2024-04-24 00:00:00.0.
PMID: 38720798
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Authors: Broshkevitch C.J. , Barnabas R.V. , Liu G. , Palanee-Phillips T. , Rao D.W. .
Source: Plos One, 2024; 19(5), p. e0301997.
EPub date: 2024-05-23 00:00:00.0.
PMID: 38781268
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Authors: Spencer J.C. , Burger E.A. , Campos N.G. , Regan M.C. , Sy S. , Kim J.J. .
Source: Journal Of The National Cancer Institute. Monographs, 2023-11-08 00:00:00.0; 2023(62), p. 188-195.
PMID: 37947333
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Data gaps and opportunities for modeling cancer health equity.
Authors: Trentham-Dietz A. , Corley D.A. , Del Vecchio N.J. , Greenlee R.T. , Haas J.S. , Hubbard R.A. , Hughes A.E. , Kim J.J. , Kobrin S. , Li C.I. , et al. .
Source: Journal Of The National Cancer Institute. Monographs, 2023-11-08 00:00:00.0; 2023(62), p. 246-254.
PMID: 37947335
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Estimated US Cancer Deaths Prevented With Increased Use of Lung, Colorectal, Breast, and Cervical Cancer Screening.
Authors: Knudsen A.B. , Trentham-Dietz A. , Kim J.J. , Mandelblatt J.S. , Meza R. , Zauber A.G. , Castle P.E. , Feuer E.J. .
Source: Jama Network Open, 2023-11-01 00:00:00.0; 6(11), p. e2344698.
EPub date: 2023-11-01 00:00:00.0.
PMID: 37991759
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Authors: Sahu M. , Bayer C.J. , Roberts D.A. , van Rooyen H. , van Heerden A. , Shahmanesh M. , Asiimwe S. , Sausi K. , Sithole N. , Ying R. , et al. .
Source: Plos Global Public Health, 2023; 3(9), p. e0000610.
EPub date: 2023-09-05 00:00:00.0.
PMID: 37669249
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Authors: Burger E.A. , de Kok I.M.C.M. , O'Mahony J.F. , Rebolj M. , Jansen E.E.L. , de Bondt D.D. , Killen J. , Hanley S.J. , Castanon A. , Regan M.C. , et al. .
Source: Elife, 2022-10-12 00:00:00.0; 11, .
EPub date: 2022-10-12 00:00:00.0.
PMID: 36222673
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Authors: Rao D.W. , Bayer C.J. , Liu G. , Chikandiwa A. , Sharma M. , Hathaway C.L. , Tan N. , Mugo N. , Barnabas R.V. .
Source: Journal Of The International Aids Society, 2022 Oct; 25(10), p. e26021.
PMID: 36225139
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Authors: Liu G. , Mugo N.R. , Bayer C. , Rao D.W. , Onono M. , Mgodi N.M. , Chirenje Z.M. , Njoroge B.W. , Tan N. , Bukusi E.A. , et al. .
Source: Eclinicalmedicine, 2022 Mar; 45, p. 101306.
EPub date: 2022-02-19 00:00:00.0.
PMID: 35243272
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Authors: Smith M.A. , Burger E.A. , Castanon A. , de Kok I.M.C.M. , Hanley S.J.B. , Rebolj M. , Hall M.T. , Jansen E.E.L. , Killen J. , O'Farrell X. , et al. .
Source: Preventive Medicine, 2021 10; 151, p. 106623.
EPub date: 2021-05-23 00:00:00.0.
PMID: 34029578
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Cost-effectiveness analysis of the 2019 American Society for Colposcopy and Cervical Pathology Risk-Based Management Consensus Guidelines for the management of abnormal cervical cancer screening tests and cancer precursors.
Authors: Munshi V.N. , Perkins R.B. , Sy S. , Kim J.J. .
Source: American Journal Of Obstetrics And Gynecology, 2021-09-20 00:00:00.0; , .
EPub date: 2021-09-20 00:00:00.0.
PMID: 34547295
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Cervical screening during the COVID-19 pandemic: optimising recovery strategies.
Authors: Castanon A. , Rebolj M. , Burger E.A. , de Kok I.M.C.M. , Smith M.A. , Hanley S.J.B. , Carozzi F.M. , Peacock S. , O'Mahony J.F. .
Source: The Lancet. Public Health, 2021 07; 6(7), p. e522-e527.
EPub date: 2021-04-30 00:00:00.0.
PMID: 33939965
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Authors: Naslazi E. , Hontelez J.A.C. , Naber S.K. , van Ballegooijen M. , de Kok I.M.C.M. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2021-04-09 00:00:00.0; , .
EPub date: 2021-04-09 00:00:00.0.
PMID: 33837119
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Source: Journal Of Medical Screening, 2021-03-17 00:00:00.0; , p. 9691413211001097.
EPub date: 2021-03-17 00:00:00.0.
PMID: 33730899
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Authors: Kim J.J. , Simms K.T. , Killen J. , Smith M.A. , Burger E.A. , Sy S. , Regan C. , Canfell K. .
Source: Plos Medicine, 2021 03; 18(3), p. e1003534.
EPub date: 2021-03-11 00:00:00.0.
PMID: 33705382
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Source: Frontiers In Public Health, 2021; 9, p. 670032.
EPub date: 2021-07-01 00:00:00.0.
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Source: Gynecologic Oncology, 2020 09; 158(3), p. 710-718.
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