Grant Number:	5R50CA221836-08 Interpret this number
Primary Investigator:	Gulati, Roman
Organization:	Fred Hutchinson Cancer Center
Project Title:	Statistical Modeling to Support Population and Translational Cancer Research
Fiscal Year:	2024

PROJECT SUMMARY/ABSTRACT Developing effective strategies for cancer control requires rigorous analysis of empirical evidence and similarly rigorous analysis to address inevitable gaps in empirical evidence. During the previous project period, the Principal Investigator provided critical statistical support for a broad spectrum of research studies focused on prostate cancer, ranging from basic science experiments through clinical trials and population modeling studies. In this renewal application, he will continue to provide biostatistical analysis services for a multi-project translational prostate cancer research program and computer modeling expertise for a cancer surveillance research program that uses biomathematical models to address evidence gaps and inform population prostate cancer policies. He will also serve as lead modeler in the Data Modeling and Analytics Core of a new multi-project research program that will investigate clinical utility of novel cancer diagnostic technologies and multi-cancer early detection tests. Successfully supporting these research programs requires broad expertise in biostatistical methods, computer programming, and data analysis to identify and implement appropriate methods, interrogate model assumptions, and bracket uncertainty in results. Outstanding scientific collaboration and communication skills are essential to explain strengths and limitations of selected approaches and to bring projects from the scientific inquiry phase through peer review so that their results can impact the delivery of care. During the previous project period, the Principal Investigator consistently demonstrated all these skills and has been instrumental in establishing his research group's leadership in cancer modeling for evidence generation and policy development. Planned studies for the renewal period include modeling of natural history and outcomes for new multi-cancer early detection tests, investigating outcomes of strategies for precision early detection and treatment, and identifying targeted screening and treatment strategies to reduce health disparities. Renewal of the Principal Investigator's Research Specialist award will facilitate his research group's continued stellar level of productivity and foster his continued dissemination of high-impact research characterized by statistical and modeling approaches that are transparent, rigorous, and reliable.




Lifetime Health and Economic Outcomes of Biparametric Magnetic Resonance Imaging as First-Line Screening for Prostate Cancer : A Decision Model Analysis.
Authors: Gulati R. , Jiao B. , Al-Faouri R. , Sharma V. , Kaul S. , Fleishman A. , Wymer K. , Boorjian S.A. , Olumi A.F. , Etzioni R. , et al. .
Source: Annals Of Internal Medicine, 2024-06-04 00:00:00.0; , .
EPub date: 2024-06-04 00:00:00.0.
PMID: 38830219
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Assessment of TROP2, CEACAM5 and DLL3 in metastatic prostate cancer: Expression landscape and molecular correlates.
Authors: Ajkunic A. , Sayar E. , Roudier M.P. , Patel R.A. , Coleman I.M. , De Sarkar N. , Hanratty B. , Adil M. , Zhao J. , Zaidi S. , et al. .
Source: Npj Precision Oncology, 2024-05-17 00:00:00.0; 8(1), p. 104.
EPub date: 2024-05-17 00:00:00.0.
PMID: 38760413
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Genetic risk and likelihood of prostate cancer detection on first biopsy by ancestry.
Authors: Lee K.M. , Nelson T.J. , Bryant A. , Teerlink C.C. , Gulati R. , Pagadala M.S. , Tcheandjieu C. , Pridgen K.M. , DuVall S.L. , Yamoah K. , et al. .
Source: Journal Of The National Cancer Institute, 2024-05-08 00:00:00.0; 116(5), p. 753-757.
PMID: 38212986
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Genomic Correlates of Prostate-Specific Membrane Antigen Expression and Response to ¹⁷⁷Lu-PSMA-617: A Retrospective Multicenter Cohort Study.
Authors: Raychaudhuri R. , Mo G. , Tuchayi A.M. , Graham L. , Gulati R. , Pritchard C.C. , Haffner M.C. , Yezefski T. , Hawley J.E. , Cheng H.H. , et al. .
Source: Jco Precision Oncology, 2024 Apr; 8, p. e2300634.
PMID: 38662984
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Projecting the impact of multi-cancer early detection on late-stage incidence using multi-state disease modeling.
Authors: Lange J.M. , Gogebakan K.C. , Gulati R. , Etzioni R. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2024-03-20 00:00:00.0; , .
EPub date: 2024-03-20 00:00:00.0.
PMID: 38506751
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The Prostate Cancer Active Lifestyle Study (PALS): A randomized controlled trial of diet and exercise in overweight and obese men on active surveillance.
Authors: Wright J.L. , Schenk J.M. , Gulati R. , Beatty S.J. , VanDoren M. , Lin D.W. , Porter M.P. , Morrissey C. , Dash A. , Gore J.L. , et al. .
Source: Cancer, 2024-02-14 00:00:00.0; , .
EPub date: 2024-02-14 00:00:00.0.
PMID: 38353455
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ASSESSMENT OF CELL SURFACE TARGETS IN METASTATIC PROSTATE CANCER: EXPRESSION LANDSCAPE AND MOLECULAR CORRELATES.
Authors: Ajkunic A. , Sayar E. , Roudier M.P. , Patel R.A. , Coleman I.M. , De Sarkar N. , Hanratty B. , Adil M. , Zhao J. , Zaidi S. , et al. .
Source: Research Square, 2023-12-19 00:00:00.0; , .
EPub date: 2023-12-19 00:00:00.0.
PMID: 38196594
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Quantifying the potential benefits of early detection for pancreatic cancer through a counterfactual simulation modeling analysis.
Authors: Park J. , Lim F. , Prest M. , Ferris J.S. , Aziz Z. , Agyekum A. , Wagner S. , Gulati R. , Hur C. .
Source: Scientific Reports, 2023-11-16 00:00:00.0; 13(1), p. 20028.
EPub date: 2023-11-16 00:00:00.0.
PMID: 37973858
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Racial disparities in prostate cancer mortality: a model-based decomposition of contributing factors.
Authors: Gulati R. , Nyame Y.A. , Lange J.M. , Shoag J.E. , Tsodikov A. , Etzioni R. .
Source: Journal Of The National Cancer Institute. Monographs, 2023-11-08 00:00:00.0; 2023(62), p. 212-218.
PMID: 37947332
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Revisiting the Standard Blueprint for Biomarker Development to Address Emerging Cancer Early Detection Technologies.
Authors: Etzioni R. , Gulati R. , Patriotis C. , Rutter C. , Zheng Y. , Srivastava S. , Feng Z. .
Source: Journal Of The National Cancer Institute, 2023-11-06 00:00:00.0; , .
EPub date: 2023-11-06 00:00:00.0.
PMID: 37941446
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Characterization of HOXB13 expression patterns in localized and metastatic castration-resistant prostate cancer.
Authors: Patel R.A. , Sayar E. , Coleman I. , Roudier M.P. , Hanratty B. , Low J.Y. , Jaiswal N. , Ajkunic A. , Dumpit R. , Ercan C. , et al. .
Source: The Journal Of Pathology, 2023-10-18 00:00:00.0; , .
EPub date: 2023-10-18 00:00:00.0.
PMID: 37850574
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Benefits and harms of prostate specific antigen testing according to Australian guidelines.
Authors: Caruana M. , Gulati R. , Etzioni R. , Barratt A. , Armstrong B.K. , Chiam K. , Nair-Shalliker V. , Luo Q. , Bang A. , Grogan P. , et al. .
Source: International Journal Of Cancer, 2023-10-11 00:00:00.0; , .
EPub date: 2023-10-11 00:00:00.0.
PMID: 37819139
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Prostate Cancer Screening in African American Men: A Review of the Evidence.
Authors: Kensler K.H. , Johnson R. , Morley F. , Albrair M. , Dickerman B.A. , Gulati R. , Holt S.K. , Iyer H.S. , Kibel A.S. , Lee J.R. , et al. .
Source: Journal Of The National Cancer Institute, 2023-09-15 00:00:00.0; , .
EPub date: 2023-09-15 00:00:00.0.
PMID: 37713266
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Short-term Endpoints for Cancer Screening Trials: Does Tumor Subtype Matter?
Authors: Owens L. , Gogebakan K.C. , Menon U. , Gulati R. , Weiss N.S. , Etzioni R. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2023-06-01 00:00:00.0; 32(6), p. 741-743.
PMID: 37259797
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Targeting advanced prostate cancer with STEAP1 chimeric antigen receptor T cell and tumor-localized IL-12 immunotherapy.
Authors: Bhatia V. , Kamat N.V. , Pariva T.E. , Wu L.T. , Tsao A. , Sasaki K. , Sun H. , Javier G. , Nutt S. , Coleman I. , et al. .
Source: Nature Communications, 2023-04-11 00:00:00.0; 14(1), p. 2041.
EPub date: 2023-04-11 00:00:00.0.
PMID: 37041154
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Reversible epigenetic alterations mediate PSMA expression heterogeneity in advanced metastatic prostate cancer.
Authors: Sayar E. , Patel R.A. , Coleman I.M. , Roudier M.P. , Zhang A. , Mustafi P. , Low J.Y. , Hanratty B. , Ang L.S. , Bhatia V. , et al. .
Source: Jci Insight, 2023-02-23 00:00:00.0; , .
EPub date: 2023-02-23 00:00:00.0.
PMID: 36821396
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Pathological Effects of Apalutamide in Lower-risk Prostate Cancer: Results From a Phase II Clinical Trial.
Authors: Schweizer M.T. , True L. , Gulati R. , Zhao Y. , Ellis W. , Schade G. , Montgomery B. , Goyal S. , Nega K. , Hakansson A.K. , et al. .
Source: The Journal Of Urology, 2023 Feb; 209(2), p. 354-363.
EPub date: 2023-02-01 00:00:00.0.
PMID: 36621991
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Reply by Authors.
Authors: Schweizer M.T. , True L. , Gulati R. , Zhao Y. , Ellis W. , Schade G. , Montgomery B. , Goyal S. , Nega K. , Hakansson A.K. , et al. .
Source: The Journal Of Urology, 2023 Feb; 209(2), p. 362-363.
EPub date: 2023-02-01 00:00:00.0.
PMID: 36621992
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Internet-Based Germline Genetic Testing for Men With Metastatic Prostate Cancer.
Authors: Cheng H.H. , Sokolova A.O. , Gulati R. , Bowen D. , Knerr S.A. , Klemfuss N. , Grivas P. , Hsieh A. , Lee J.K. , Schweizer M.T. , et al. .
Source: Jco Precision Oncology, 2023 Jan; 7, p. e2200104.
PMID: 36623239
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Bipolar androgen therapy plus olaparib in men with metastatic castration-resistant prostate cancer.
Authors: Schweizer M.T. , Gulati R. , Yezefski T. , Cheng H.H. , Mostaghel E. , Haffner M.C. , Patel R.A. , De Sarkar N. , Ha G. , Dumpit R. , et al. .
Source: Prostate Cancer And Prostatic Diseases, 2022-12-23 00:00:00.0; , .
EPub date: 2022-12-23 00:00:00.0.
PMID: 36564459
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Reducing Prostate Cancer Overdiagnosis.
Authors: Gulati R. .
Source: The New England Journal Of Medicine, 2022-12-08 00:00:00.0; 387(23), p. 2187-2188.
PMID: 36477037
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Clonal Relationships of Adjacent Gleason Pattern 3 and Gleason Pattern 5 Lesions in Gleason Scores 3+5=8 and 5+3=8.
Authors: Bakbak H. , Sayar E. , Kaur H.B. , Salles D.C. , Patel R.A. , Hicks J. , Lotan T.L. , De Marzo A.M. , Gulati R. , Epstein J.I. , et al. .
Source: Human Pathology, 2022-10-26 00:00:00.0; , .
EPub date: 2022-10-26 00:00:00.0.
PMID: 36309296
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Cost-Effectiveness Analysis of Prostate Cancer Screening in the UK: A Decision Model Analysis Based on the CAP Trial.
Authors: Keeney E. , Sanghera S. , Martin R.M. , Gulati R. , Wiklund F. , Walsh E.I. , Donovan J.L. , Hamdy F. , Neal D.E. , Lane J.A. , et al. .
Source: Pharmacoeconomics, 2022-10-06 00:00:00.0; , .
EPub date: 2022-10-06 00:00:00.0.
PMID: 36201131
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Editorial Comment.
Authors: Gulati R. , Nyame Y.A. .
Source: The Journal Of Urology, 2022-09-06 00:00:00.0; , p. 101097JU000000000000283504.
EPub date: 2022-09-06 00:00:00.0.
PMID: 36065679
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Therapeutic Implications for Intrinsic Phenotype Classification of Metastatic Castration-Resistant Prostate Cancer.
Authors: Coleman I.M. , DeSarkar N. , Morrissey C. , Xin L. , Roudier M.P. , Sayar E. , Li D. , Corey E. , Haffner M.C. , Nelson P.S. .
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2022-07-15 00:00:00.0; 28(14), p. 3127-3140.
PMID: 35552660
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Stage Shift as an Endpoint in Cancer Screening Trials: Implications for Evaluating Multicancer Early Detection Tests.
Authors: Owens L. , Gulati R. , Etzioni R. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2022-07-01 00:00:00.0; 31(7), p. 1298-1304.
PMID: 35477176
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Harm-to-Benefit of Three Decades of Prostate Cancer Screening in Black Men.
Authors: Basourakos S.P. , Gulati R. , Vince R.A. , Spratt D.E. , Lewicki P.J. , Hill A. , Nyame Y.A. , Cullen J. , Markt S.C. , Barbieri C.E. , et al. .
Source: Nejm Evidence, 2022 Jun; 1(6), .
EPub date: 2022-05-15 00:00:00.0.
PMID: 35721307
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Evaluation of Prostate Cancer Screening Strategies in a Low-Resource, High-risk Population in the Bahamas.
Authors: Heijnsdijk E.A.M. , Gulati R. , Lange J.M. , Tsodikov A. , Roberts R. , Etzioni R. .
Source: Jama Health Forum, 2022 05; 3(5), p. e221116.
EPub date: 2022-05-20 00:00:00.0.
PMID: 35977253
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Inherited TP53 Variants and Risk of Prostate Cancer.
Authors: Maxwell K.N. , Cheng H.H. , Powers J. , Gulati R. , Ledet E.M. , Morrison C. , Le A. , Hausler R. , Stopfer J. , Hyman S. , et al. .
Source: European Urology, 2022 Mar; 81(3), p. 243-250.
EPub date: 2021-12-01 00:00:00.0.
PMID: 34863587
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Genomic attributes of homology-directed DNA repair deficiency in metastatic prostate cancer.
Authors: De Sarkar N. , Dasgupta S. , Chatterjee P. , Coleman I. , Ha G. , Ang L.S. , Kohlbrenner E.A. , Frank S.B. , Nunez T.A. , Salipante S.J. , et al. .
Source: Jci Insight, 2021-12-08 00:00:00.0; 6(23), .
EPub date: 2021-12-08 00:00:00.0.
PMID: 34877933
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A Clinical Decision Aid to Support Personalized Treatment Selection for Patients with Clinical T1 Renal Masses: Results from a Multi-institutional Competing-risks Analysis.
Authors: Psutka S.P. , Gulati R. , Jewett M.A.S. , Fadaak K. , Finelli A. , Legere L. , Morgan T.M. , Pierorazio P.M. , Allaf M.E. , Herrin J. , et al. .
Source: European Urology, 2021-11-30 00:00:00.0; , .
EPub date: 2021-11-30 00:00:00.0.
PMID: 34862099
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A Quantitative Framework to Study Potential Benefits and Harms of Multi-cancer Early Detection Testing.
Authors: Jiao B. , Gulati R. , Katki H.A. , Castle P.E. , Etzioni R. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2021-09-20 00:00:00.0; , .
EPub date: 2021-09-20 00:00:00.0.
PMID: 34548329
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Efficacy of systemic therapies in men with metastatic castration resistant prostate cancer harboring germline ATM versus BRCA2 mutations.
Authors: Sokolova A.O. , Marshall C.H. , Lozano R. , Gulati R. , Ledet E.M. , De Sarkar N. , Grivas P. , Higano C.S. , Montgomery B. , Nelson P.S. , et al. .
Source: The Prostate, 2021-09-13 00:00:00.0; , .
EPub date: 2021-09-13 00:00:00.0.
PMID: 34516663
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Divining Harm-Benefit Tradeoffs of Magnetic Resonance Imaging-targeted Biopsy.
Authors: Etzioni R. , Haffner M.C. , Gulati R. .
Source: European Urology, 2021-08-31 00:00:00.0; , .
EPub date: 2021-08-31 00:00:00.0.
PMID: 34479754
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Multi-Cancer Early Detection: Learning from the past to Meet the Future.
Authors: Etzioni R. , Gulati R. , Weiss N.S. .
Source: Journal Of The National Cancer Institute, 2021-08-27 00:00:00.0; , .
EPub date: 2021-08-27 00:00:00.0.
PMID: 34450655
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Economic Evaluation of Urine-Based or Magnetic Resonance Imaging Reflex Tests in Men With Intermediate Prostate-Specific Antigen Levels in the United States.
Authors: Jiao B. , Gulati R. , Hendrix N. , Gore J.L. , Rais-Bahrami S. , Morgan T.M. , Etzioni R. .
Source: Value In Health : The Journal Of The International Society For Pharmacoeconomics And Outcomes Research, 2021 Aug; 24(8), p. 1111-1117.
EPub date: 2021-04-22 00:00:00.0.
PMID: 34372976
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Clarifying the Trade-Offs of Risk-Stratified Screening for Prostate Cancer: A Cost-Effectiveness Study.
Authors: Hendrix N. , Gulati R. , Jiao B. , Kader A.K. , Ryan S.T. , Etzioni R. .
Source: American Journal Of Epidemiology, 2021-05-22 00:00:00.0; , .
EPub date: 2021-05-22 00:00:00.0.
PMID: 34023874
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The Impact of Intensifying Prostate Cancer Screening in Black Men: A Model-Based Analysis.
Authors: Nyame Y.A. , Gulati R. , Heijnsdijk E.A.M. , Tsodikov A. , Mariotto A.B. , Gore J.L. , Etzioni R. .
Source: Journal Of The National Cancer Institute, 2021-05-08 00:00:00.0; , .
EPub date: 2021-05-08 00:00:00.0.
PMID: 33963850
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When to Discuss Prostate Cancer Screening With Average-Risk Men.
Authors: Gulati R. , Carlsson S.V. , Etzioni R. .
Source: American Journal Of Preventive Medicine, 2021-05-06 00:00:00.0; , .
EPub date: 2021-05-06 00:00:00.0.
PMID: 33966938
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Targeting backdoor androgen synthesis through AKR1C3 inhibition: A presurgical hormonal ablative neoadjuvant trial in high-risk localized prostate cancer.
Authors: Graham L.S. , True L.D. , Gulati R. , Schade G.R. , Wright J. , Grivas P. , Yezefski T. , Nega K. , Alexander K. , Hou W.M. , et al. .
Source: The Prostate, 2021-03-23 00:00:00.0; , .
EPub date: 2021-03-23 00:00:00.0.
PMID: 33755225
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Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling.
Authors: Brady L. , Kriner M. , Coleman I. , Morrissey C. , Roudier M. , True L.D. , Gulati R. , Plymate S.R. , Zhou Z. , Birditt B. , et al. .
Source: Nature Communications, 2021-03-03 00:00:00.0; 12(1), p. 1426.
EPub date: 2021-03-03 00:00:00.0.
PMID: 33658518
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Impact of cancer screening on metastasis: A prostate cancer case study.
Authors: Lange J. , Remmers S. , Gulati R. , Bill-Axelson A. , Johansson J.E. , Kwiatkowski M. , Auvinen A. , Hugosson J. , Hu J.C. , Roobol M.J. , et al. .
Source: Journal Of Medical Screening, 2021-02-09 00:00:00.0; , p. 969141321989738.
EPub date: 2021-02-09 00:00:00.0.
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Prostate-Specific Antigen Screening and Recent Increases in Advanced Prostate Cancer.
Authors: Nyame Y.A. , Gulati R. , Tsodikov A. , Gore J.L. , Etzioni R. .
Source: Jnci Cancer Spectrum, 2021 Feb; 5(1), p. pkaa098.
EPub date: 2020-10-26 00:00:00.0.
PMID: 33442662
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Reconsidering the Trade-offs of Prostate Cancer Screening.
Authors: Shoag J.E. , Nyame Y.A. , Gulati R. , Etzioni R. , Hu J.C. .
Source: The New England Journal Of Medicine, 2020-06-18 00:00:00.0; 382(25), p. 2465-2468.
PMID: 32558473
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Combined TP53 and RB1 Loss Promotes Prostate Cancer Resistance to a Spectrum of Therapeutics and Confers Vulnerability to Replication Stress.
Authors: Nyquist M.D. , Corella A. , Coleman I. , De Sarkar N. , Kaipainen A. , Ha G. , Gulati R. , Ang L. , Chatterjee P. , Lucas J. , et al. .
Source: Cell Reports, 2020-05-26 00:00:00.0; 31(8), p. 107669.
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Overdiagnosis and Lives Saved by Reflex Testing Men With Intermediate Prostate-Specific Antigen Levels.
Authors: Gulati R. , Morgan T.M. , A'mar T. , Psutka S.P. , Tosoian J.J. , Etzioni R. .
Source: Journal Of The National Cancer Institute, 2020-04-01 00:00:00.0; 112(4), p. 384-390.
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Identification of Therapeutic Vulnerabilities in Small-cell Neuroendocrine Prostate Cancer.
Authors: Corella A.N. , Cabiliza Ordonio M.V.A. , Coleman I. , Lucas J.M. , Kaipainen A. , Nguyen H.M. , Sondheim D. , Brown L.G. , True L.D. , Lee J.K. , et al. .
Source: Clinical Cancer Research : An Official Journal Of The American Association For Cancer Research, 2020-04-01 00:00:00.0; 26(7), p. 1667-1677.
EPub date: 2019-12-05 00:00:00.0.
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Reply by Authors.
Authors: Gulati R. , Psutka S.P. , Etzioni R. .
Source: The Journal Of Urology, 2020 04; 203(4), p. 842.
EPub date: 2019-12-17 00:00:00.0.
PMID: 31845828
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Lifetime benefits and harms of PSA-based risk screening for prostate cancer.
Authors: Heijnsdijk E.A.M. , Gulati R. , Tsodikov A. , Lange J.M. , Mariotto A.B. , Vickers A.J. , Carlsson S.V. , Etzioni R. .
Source: Journal Of The National Cancer Institute, 2020-01-09 00:00:00.0; , .
EPub date: 2020-01-09 00:00:00.0.
PMID: 32067047
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CDK12-Mutated Prostate Cancer: Clinical Outcomes With Standard Therapies and Immune Checkpoint Blockade.
Authors: Schweizer M.T. , Ha G. , Gulati R. , Brown L.C. , McKay R.R. , Dorff T. , Hoge A.C.H. , Reichel J. , Vats P. , Kilari D. , et al. .
Source: Jco Precision Oncology, 2020; 4, p. 382-392.
EPub date: 2020-04-21 00:00:00.0.
PMID: 32671317
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