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Grant Details

Grant Number: 2U01CA215834-05A1 Interpret this number
Primary Investigator: Bailey, Regan
Organization: Texas A&M Agrilife Research
Project Title: Development of a Total Nutrient Index
Fiscal Year: 2024


Abstract

PROJECT SUMMARY Dietary indices and scores provide a comprehensive and robust approach for nutritional exposure assessment, especially in relation to chronic disease risk. While dietary supplement (DS) use is very common among the U.S. population, with over 52% of adults and 33% of children routinely taking one or more (predominantly nutrient containing) products, no existing metrics assessed intakes from DS in addition to those from the diet. For this reason, we developed the Total Nutrient Index (TNI), a measure designed to evaluate total usual micronutrient intakes, inclusive of intakes from foods and DS, relative to the Dietary Reference Intakes for eight micronutrients identified as under consumed among the U.S. population by the 2015-2020 Dietary Guidelines for Americans (DGA) in the first period of this award. We examined the relative validity of the TNI compared to biomarkers of nutritional status among a nationally representative sample of U.S. adults and determined that 1) the TNI is a useful metric for total micronutrient exposure assessment, and 2) that the TNI yielded higher correlations with nutritional biomarkers when compared with those obtained from dietary intake alone. However, with the emergence of the precision nutrition era, understanding how unique combinations of nutrients and specific amounts of these nutrients can optimize the nutritional and health status of different population subgroups is of utmost importance. Accordingly, in the present competing continuation proposal, we intend to update the TNI to accommodate a life stage approach, to utilize machine learning techniques to identify critical nutrients and in what combinations optimally benefit the health and nutrition of individuals across the life course, and relate the TNI to risk factors, health outcomes, and mortality. In Aim 1, we plan to develop and validate the TNI-2, an updated extension of the TNI that is tailored to different life stages and includes nutrients and food components of



Publications

Artificial intelligence in food and nutrition evidence: The challenges and opportunities.
Authors: Bailey R.L. , MacFarlane A.J. , Field M.S. , Tagkopoulos I. , Baranzini S.E. , Edwards K.M. , Rose C.J. , Schork N.J. , Singhal A. , Wallace B.C. , et al. .
Source: Pnas Nexus, 2024 Dec; 3(12), p. pgae461.
EPub date: 2024-10-15 00:00:00.0.
PMID: 39677367
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Eating Egg-Rich Diets and Modeling the Addition of One Daily Egg Reduced Risk of Nutrient Inadequacy among United States Adolescents with and without Food Insecurity.
Authors: Morales-Juárez A. , Cowan-Pyle A.E. , Bailey R.L. , Eicher-Miller H.A. .
Source: The Journal Of Nutrition, 2024 Nov; 154(11), p. 3475-3484.
EPub date: 2024-09-21 00:00:00.0.
PMID: 39307281
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The Use of Ginger Bioactive Compounds in Pregnancy: An Evidence Scan and Umbrella Review of Existing Meta-Analyses.
Authors: Tiani K.A. , Arenaz C.M. , Spill M.K. , Foster M.J. , Davis J.S. , Bailey R.L. , Field M.S. , Stover P.J. , MacFarlane A.J. .
Source: Advances In Nutrition (bethesda, Md.), 2024 Nov; 15(11), p. 100308.
EPub date: 2024-09-28 00:00:00.0.
PMID: 39343171
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Dietary choline and betaine intake minimally impacts rate of annualized cognitive performance throughout the menopause transition: data from the Study of Women's Health Across the Nation.
Authors: Cowan-Pyle A.E. , Wallace T.C. , Klatt K.C. , Slavin M. , Bailey R.L. .
Source: Menopause (new York, N.y.), 2024-10-01 00:00:00.0; 31(10), p. 853-861.
EPub date: 2024-07-30 00:00:00.0.
PMID: 39078663
Related Citations

Dietary Quality and Diet-Related Factors Among Emerging Adults (18-23 y) in the United States Are a Cause for Concern: National Health and Nutrition Examination Survey 2015-2018.
Authors: Cowan-Pyle A.E. , Bailey R.L. , Gao J. , Hess J.M. , Ademu L.O. , Smith J.L. , Mitchell D.C. , Racine E.F. .
Source: The Journal Of Nutrition, 2024 Aug; 154(8), p. 2524-2533.
EPub date: 2024-06-27 00:00:00.0.
PMID: 38944345
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The Evolution of Science and Regulation of Dietary Supplements: Past, Present, and Future.
Authors: Coates P.M. , Bailey R.L. , Blumberg J.B. , El-Sohemy A. , Floyd E. , Goldenberg J.Z. , Gould Shunney A. , Holscher H.D. , Nkrumah-Elie Y. , Rai D. , et al. .
Source: The Journal Of Nutrition, 2024 Aug; 154(8), p. 2335-2345.
EPub date: 2024-07-04 00:00:00.0.
PMID: 38971530
Related Citations

Snack frequency, size, and energy density are associated with diet quality among US adolescents.
Authors: Tripicchio G.L. , Bailey R.L. , Davey A. , Croce C.M. , Fisher J.O. .
Source: Public Health Nutrition, 2023 Nov; 26(11), p. 2374-2382.
EPub date: 2023-08-07 00:00:00.0.
PMID: 37548183
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Reply to E Ciappio et al.
Authors: Sauder K.A. , Couzens G.L. , Bailey R.L. , Hockett C.W. , Switkowski K.M. , Lyall K. , Kerver J.M. , Dabelea D. , Maldonado L.E. , O'Connor T.G. , et al. .
Source: The American Journal Of Clinical Nutrition, 2023 Sep; 118(3), p. 731-732.
PMID: 37661110
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Precision Nutrition: The Hype Is Exceeding the Science and Evidentiary Standards Needed to Inform Public Health Recommendations for Prevention of Chronic Disease.
Authors: Bailey R.L. , Stover P.J. .
Source: Annual Review Of Nutrition, 2023-08-21 00:00:00.0; 43, p. 385-407.
PMID: 37603433
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Usual nutrient intakes and diet quality among United States older adults participating in the Supplemental Nutrition Assistance Program compared with income-eligible nonparticipants.
Authors: Qin Y. , Cowan A.E. , Bailey R.L. , Jun S. , Eicher-Miller H.A. .
Source: The American Journal Of Clinical Nutrition, 2023 Jul; 118(1), p. 85-95.
EPub date: 2023-05-18 00:00:00.0.
PMID: 37407169
Related Citations

Major Gaps in Understanding Dietary Supplement Use in Health and Disease.
Authors: Bailey R.L. , Jun S. , Cowan A.E. , Eicher-Miller H.A. , Gahche J.J. , Dwyer J.T. , Hartman T.J. , Mitchell D.C. , Seguin-Fowler R.A. , Carroll R.J. , et al. .
Source: Annual Review Of Nutrition, 2023-05-17 00:00:00.0; , .
EPub date: 2023-05-17 00:00:00.0.
PMID: 37196365
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Evaluating a Food Pantry-Based Intervention to Improve Food Security, Dietary Intake, and Quality in Midwestern Food Pantries.
Authors: Eicher-Miller H.A. , Wright B.N. , Tooze J.A. , Craig B.A. , Liu Y. , Bailey R.L. , McCormack L.A. , Stluka S. , Franzen-Castle L. , Henne B. , et al. .
Source: Journal Of The Academy Of Nutrition And Dietetics, 2022 11; 122(11), p. 2060-2071.
EPub date: 2022-02-26 00:00:00.0.
PMID: 35231664
Related Citations

Trends in overall and micronutrient-containing dietary supplement use among U.S. adults and children, NHANES 2007-2018.
Authors: Cowan A.E. , Tooze J.A. , Gahche J.J. , Eicher-Miller H.A. , Guenther P.M. , Dwyer J.T. , Potischman N. , Bhadra A. , Carroll R.J. , Bailey R.L. .
Source: The Journal Of Nutrition, 2022-08-02 00:00:00.0; , .
EPub date: 2022-08-02 00:00:00.0.
PMID: 35918260
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A Randomized Intervention of Supplemental Nutrition Assistance Program-Education Did Not Improve Dietary Outcomes Except for Vitamin D Among Lower-Income Women in Indiana.
Authors: Qin Y. , Rivera R.L. , Zhang Y. , Wang Q. , Tooze J.A. , Abbott A.R. , Maulding M.K. , Craig B.A. , Bailey R.L. , Eicher-Miller H.A. .
Source: Journal Of The Academy Of Nutrition And Dietetics, 2022-06-30 00:00:00.0; , .
EPub date: 2022-06-30 00:00:00.0.
PMID: 35781080
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The Total Nutrient Index is a Useful Measure for Assessing Total Micronutrient Exposures Among US Adults.
Authors: Cowan A.E. , Bailey R.L. , Jun S. , Dodd K.W. , Gahche J.J. , Eicher-Miller H.A. , Guenther P.M. , Dwyer J.T. , Potischman N. , Bhadra A. , et al. .
Source: The Journal Of Nutrition, 2022-03-03 00:00:00.0; 152(3), p. 863-871.
PMID: 34928350
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Do Multivitamin/Mineral Dietary Supplements for Young Children Fill Critical Nutrient Gaps?
Authors: Dwyer J.T. , Saldanha L.G. , Bailen R.A. , Gahche J.J. , Potischman N. , Bailey R.L. , Jun S. , Long Y. , Connor E. , Andrews K.W. , et al. .
Source: Journal Of The Academy Of Nutrition And Dietetics, 2022 03; 122(3), p. 525-532.
EPub date: 2021-10-20 00:00:00.0.
PMID: 34687947
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A narrative review of nutrient based indexes to assess diet quality and the proposed total nutrient index that reflects total dietary exposures.
Authors: Cowan A.E. , Jun S. , Tooze J.A. , Dodd K.W. , Gahche J.J. , Eicher-Miller H.A. , Guenther P.M. , Dwyer J.T. , Potischman N. , Bhadra A. , et al. .
Source: Critical Reviews In Food Science And Nutrition, 2021-09-02 00:00:00.0; , p. 1-11.
EPub date: 2021-09-02 00:00:00.0.
PMID: 34470512
Related Citations

Accurate Measurement of Nutrients and Nonnutritive Dietary Ingredients from Dietary Supplements Is Critical in the Precision Nutrition Era.
Authors: Gahche J.J. , Bailey R.L. .
Source: The Journal Of Nutrition, 2021-08-07 00:00:00.0; 151(8), p. 2094-2095.
PMID: 34293109
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Overview of dietary assessment methods for measuring intakes of foods, beverages, and dietary supplements in research studies.
Authors: Bailey R.L. .
Source: Current Opinion In Biotechnology, 2021 Aug; 70, p. 91-96.
EPub date: 2021-03-11 00:00:00.0.
PMID: 33714006
Related Citations

Public Health Decisions Are Made at the Tails of the Distribution: A Novel Tool to Estimate Usual Intake Distributions from Short-Term Dietary Assessment Methods.
Authors: Bailey R.L. , Jun S. .
Source: The Journal Of Nutrition, 2021-05-11 00:00:00.0; 151(5), p. 1059-1060.
PMID: 33847339
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Association of food insecurity with dietary intakes and nutritional biomarkers among US children, National Health and Nutrition Examination Survey (NHANES) 2011-2016.
Authors: Jun S. , Cowan A.E. , Dodd K.W. , Tooze J.A. , Gahche J.J. , Eicher-Miller H.A. , Guenther P.M. , Dwyer J.T. , Potischman N. , Bhadra A. , et al. .
Source: The American Journal Of Clinical Nutrition, 2021-05-08 00:00:00.0; , .
EPub date: 2021-05-08 00:00:00.0.
PMID: 33964856
Related Citations

Nutritional contributions of food pantries and other sources to the diets of rural, Midwestern food pantry users in the USA.
Authors: Liu Y. , Desmond N.E. , Wright B.N. , Bailey R.L. , Dong T. , Craig B.A. , Eicher-Miller H.A. .
Source: The British Journal Of Nutrition, 2021-04-28 00:00:00.0; 125(8), p. 891-901.
EPub date: 2020-09-02 00:00:00.0.
PMID: 32873361
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Trends in Nutrient- and Non-Nutrient-Containing Dietary Supplement Use among US Children from 1999 to 2016.
Authors: Panjwani A.A. , Cowan A.E. , Jun S. , Bailey R.L. .
Source: The Journal Of Pediatrics, 2021 Apr; 231, p. 131-140.e2.
EPub date: 2020-12-17 00:00:00.0.
PMID: 33340548
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Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop.
Authors: Maruvada P. , Stover P.J. , Mason J.B. , Bailey R.L. , Davis C.D. , Field M.S. , Finnell R.H. , Garza C. , Green R. , Gueant J.L. , et al. .
Source: The American Journal Of Clinical Nutrition, 2020-11-11 00:00:00.0; 112(5), p. 1390-1403.
PMID: 33022704
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Dietary Quality and Usual Intake of Underconsumed Nutrients and Related Food Groups Differ by Food Security Status for Rural, Midwestern Food Pantry Clients.
Authors: Wright B.N. , Tooze J.A. , Bailey R.L. , Liu Y. , Rivera R.L. , McCormack L. , Stluka S. , Franzen-Castle L. , Henne B. , Mehrle D. , et al. .
Source: Journal Of The Academy Of Nutrition And Dietetics, 2020 Sep; 120(9), p. 1457-1468.
EPub date: 2020-07-20 00:00:00.0.
PMID: 32703690
Related Citations

Older adults with obesity have higher risks of some micronutrient inadequacies and lower overall dietary quality compared to peers with a healthy weight, National Health and Nutrition Examination Surveys (NHANES), 2011-2014.
Authors: Jun S. , Cowan A.E. , Bhadra A. , Dodd K.W. , Dwyer J.T. , Eicher-Miller H.A. , Gahche J.J. , Guenther P.M. , Potischman N. , Tooze J.A. , et al. .
Source: Public Health Nutrition, 2020-05-29 00:00:00.0; , p. 1-12.
EPub date: 2020-05-29 00:00:00.0.
PMID: 32466808
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Comparison of 4 Methods to Assess the Prevalence of Use and Estimates of Nutrient Intakes from Dietary Supplements among US Adults.
Authors: Cowan A.E. , Jun S. , Tooze J.A. , Dodd K.W. , Gahche J.J. , Eicher-Miller H.A. , Guenther P.M. , Dwyer J.T. , Moshfegh A.J. , Rhodes D.G. , et al. .
Source: The Journal Of Nutrition, 2020-04-01 00:00:00.0; 150(4), p. 884-893.
PMID: 31851315
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Breakfast Consumption Is Positively Associated with Usual Nutrient Intakes among Food Pantry Clients Living in Rural Communities.
Authors: Liu Y. , Tooze J.A. , Zhang Y. , Leidy H.J. , Bailey R.L. , Wright B. , Ma M. , Stluka S. , Remley D.T. , McCormack L.A. , et al. .
Source: The Journal Of Nutrition, 2020-03-01 00:00:00.0; 150(3), p. 546-553.
PMID: 31711170
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Dietary Supplement Use and Its Micronutrient Contribution During Pregnancy and Lactation in the United States.
Authors: Jun S. , Gahche J.J. , Potischman N. , Dwyer J.T. , Guenther P.M. , Sauder K.A. , Bailey R.L. .
Source: Obstetrics And Gynecology, 2020 Mar; 135(3), p. 623-633.
PMID: 32028492
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Total Usual Micronutrient Intakes Compared to the Dietary Reference Intakes among U.S. Adults by Food Security Status.
Authors: Cowan A.E. , Jun S. , Tooze J.A. , Eicher-Miller H.A. , Dodd K.W. , Gahche J.J. , Guenther P.M. , Dwyer J.T. , Potischman N. , Bhadra A. , et al. .
Source: Nutrients, 2019-12-22 00:00:00.0; 12(1), .
EPub date: 2019-12-22 00:00:00.0.
PMID: 31877853
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Trends in Mean Nutrient Intakes of US Infants, Toddlers, and Young Children from 3 Feeding Infants and Toddlers Studies (FITS).
Authors: Eldridge A.L. , Catellier D.J. , Hampton J.C. , Dwyer J.T. , Bailey R.L. .
Source: The Journal Of Nutrition, 2019-07-01 00:00:00.0; 149(7), p. 1230-1237.
PMID: 31049587
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Estimation of Total Usual Dietary Intakes of Pregnant Women in the United States.
Authors: Bailey R.L. , Pac S.G. , Fulgoni V.L. , Reidy K.C. , Catalano P.M. .
Source: Jama Network Open, 2019-06-05 00:00:00.0; 2(6), p. e195967.
EPub date: 2019-06-05 00:00:00.0.
PMID: 31225890
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Children's Dietary Quality and Micronutrient Adequacy by Food Security in the Household and among Household Children.
Authors: Jun S. , Zeh M.J. , Eicher-Miller H.A. , Bailey R.L. .
Source: Nutrients, 2019-04-27 00:00:00.0; 11(5), .
EPub date: 2019-04-27 00:00:00.0.
PMID: 31035584
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Best Practices for Dietary Supplement Assessment and Estimation of Total Usual Nutrient Intakes in Population-Level Research and Monitoring.
Authors: Bailey R.L. , Dodd K.W. , Gahche J.J. , Dwyer J.T. , Cowan A.E. , Jun S. , Eicher-Miller H.A. , Guenther P.M. , Bhadra A. , Thomas P.R. , et al. .
Source: The Journal Of Nutrition, 2019-02-08 00:00:00.0; , .
EPub date: 2019-02-08 00:00:00.0.
PMID: 30753685
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Dietary Supplement Use among Infants and Toddlers Aged <24 Months in the United States, NHANES 2007-2014.
Authors: Gahche J.J. , Herrick K.A. , Potischman N. , Bailey R.L. , Ahluwalia N. , Dwyer J.T. .
Source: The Journal Of Nutrition, 2019-02-01 00:00:00.0; 149(2), p. 314-322.
PMID: 30753556
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Current regulatory guidelines and resources to support research of dietary supplements in the United States.
Authors: Bailey R.L. .
Source: Critical Reviews In Food Science And Nutrition, 2018-11-13 00:00:00.0; , p. 1-12.
EPub date: 2018-11-13 00:00:00.0.
PMID: 30421981
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Position of the Academy of Nutrition and Dietetics: Micronutrient Supplementation.
Authors: Marra M.V. , Bailey R.L. .
Source: Journal Of The Academy Of Nutrition And Dietetics, 2018 11; 118(11), p. 2162-2173.
PMID: 30366569
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Usual Nutrient Intakes from the Diets of US Children by WIC Participation and Income: Findings from the Feeding Infants and Toddlers Study (FITS) 2016.
Authors: Jun S. , Catellier D.J. , Eldridge A.L. , Dwyer J.T. , Eicher-Miller H.A. , Bailey R.L. .
Source: The Journal Of Nutrition, 2018-09-01 00:00:00.0; 148(9S), p. 1567S-1574S.
PMID: 29878136
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Dietary Supplement Use among U.S. Children by Family Income, Food Security Level, and Nutrition Assistance Program Participation Status in 2011⁻2014.
Authors: Jun S. , Cowan A.E. , Tooze J.A. , Gahche J.J. , Dwyer J.T. , Eicher-Miller H.A. , Bhadra A. , Guenther P.M. , Potischman N. , Dodd K.W. , et al. .
Source: Nutrients, 2018-09-01 00:00:00.0; 10(9), .
EPub date: 2018-09-01 00:00:00.0.
PMID: 30200511
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Dietary Supplement Use Differs by Socioeconomic and Health-Related Characteristics among U.S. Adults, NHANES 2011⁻2014.
Authors: Cowan A.E. , Jun S. , Gahche J.J. , Tooze J.A. , Dwyer J.T. , Eicher-Miller H.A. , Bhadra A. , Guenther P.M. , Potischman N. , Dodd K.W. , et al. .
Source: Nutrients, 2018-08-17 00:00:00.0; 10(8), .
EPub date: 2018-08-17 00:00:00.0.
PMID: 30126136
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Comparing Reported Dietary Supplement Intakes between Two 24-Hour Recall Methods: The Automated Self-Administered 24-Hour Dietary Assessment Tool and the Interview-Administered Automated Multiple Pass Method.
Authors: Pannucci T.E. , Thompson F.E. , Bailey R.L. , Dodd K.W. , Potischman N. , Kirkpatrick S.I. , Alexander G.L. , Coleman L.A. , Kushi L.H. , Groesbeck M. , et al. .
Source: Journal Of The Academy Of Nutrition And Dietetics, 2018 Jun; 118(6), p. 1080-1086.
PMID: 29803270
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