Grant Details
Grant Number: |
2U01CA215834-05A1 Interpret this number |
Primary Investigator: |
Bailey, Regan |
Organization: |
Texas A&M Agrilife Research |
Project Title: |
Development of a Total Nutrient Index |
Fiscal Year: |
2024 |
Abstract
PROJECT SUMMARY
Dietary indices and scores provide a comprehensive and robust approach for nutritional exposure assessment,
especially in relation to chronic disease risk. While dietary supplement (DS) use is very common among the
U.S. population, with over 52% of adults and 33% of children routinely taking one or more (predominantly
nutrient containing) products, no existing metrics assessed intakes from DS in addition to those from the diet.
For this reason, we developed the Total Nutrient Index (TNI), a measure designed to evaluate total usual
micronutrient intakes, inclusive of intakes from foods and DS, relative to the Dietary Reference Intakes for
eight micronutrients identified as under consumed among the U.S. population by the 2015-2020 Dietary
Guidelines for Americans (DGA) in the first period of this award. We examined the relative validity of the TNI
compared to biomarkers of nutritional status among a nationally representative sample of U.S. adults and
determined that 1) the TNI is a useful metric for total micronutrient exposure assessment, and 2) that the TNI
yielded higher correlations with nutritional biomarkers when compared with those obtained from dietary intake
alone. However, with the emergence of the precision nutrition era, understanding how unique combinations of
nutrients and specific amounts of these nutrients can optimize the nutritional and health status of different
population subgroups is of utmost importance. Accordingly, in the present competing continuation proposal, we
intend to update the TNI to accommodate a life stage approach, to utilize machine learning techniques to
identify critical nutrients and in what combinations optimally benefit the health and nutrition of individuals
across the life course, and relate the TNI to risk factors, health outcomes, and mortality. In Aim 1, we plan to
develop and validate the TNI-2, an updated extension of the TNI that is tailored to different life stages and
includes nutrients and food components of
Publications
Artificial intelligence in food and nutrition evidence: The challenges and opportunities.
Authors: Bailey R.L.
, MacFarlane A.J.
, Field M.S.
, Tagkopoulos I.
, Baranzini S.E.
, Edwards K.M.
, Rose C.J.
, Schork N.J.
, Singhal A.
, Wallace B.C.
, et al.
.
Source: Pnas Nexus, 2024 Dec; 3(12), p. pgae461.
EPub date: 2024-10-15 00:00:00.0.
PMID: 39677367
Related Citations
Eating Egg-Rich Diets and Modeling the Addition of One Daily Egg Reduced Risk of Nutrient Inadequacy among United States Adolescents with and without Food Insecurity.
Authors: Morales-Juárez A.
, Cowan-Pyle A.E.
, Bailey R.L.
, Eicher-Miller H.A.
.
Source: The Journal Of Nutrition, 2024 Nov; 154(11), p. 3475-3484.
EPub date: 2024-09-21 00:00:00.0.
PMID: 39307281
Related Citations
The Use of Ginger Bioactive Compounds in Pregnancy: An Evidence Scan and Umbrella Review of Existing Meta-Analyses.
Authors: Tiani K.A.
, Arenaz C.M.
, Spill M.K.
, Foster M.J.
, Davis J.S.
, Bailey R.L.
, Field M.S.
, Stover P.J.
, MacFarlane A.J.
.
Source: Advances In Nutrition (bethesda, Md.), 2024 Nov; 15(11), p. 100308.
EPub date: 2024-09-28 00:00:00.0.
PMID: 39343171
Related Citations
Dietary choline and betaine intake minimally impacts rate of annualized cognitive performance throughout the menopause transition: data from the Study of Women's Health Across the Nation.
Authors: Cowan-Pyle A.E.
, Wallace T.C.
, Klatt K.C.
, Slavin M.
, Bailey R.L.
.
Source: Menopause (new York, N.y.), 2024-10-01 00:00:00.0; 31(10), p. 853-861.
EPub date: 2024-07-30 00:00:00.0.
PMID: 39078663
Related Citations
Dietary Quality and Diet-Related Factors Among Emerging Adults (18-23 y) in the United States Are a Cause for Concern: National Health and Nutrition Examination Survey 2015-2018.
Authors: Cowan-Pyle A.E.
, Bailey R.L.
, Gao J.
, Hess J.M.
, Ademu L.O.
, Smith J.L.
, Mitchell D.C.
, Racine E.F.
.
Source: The Journal Of Nutrition, 2024 Aug; 154(8), p. 2524-2533.
EPub date: 2024-06-27 00:00:00.0.
PMID: 38944345
Related Citations
The Evolution of Science and Regulation of Dietary Supplements: Past, Present, and Future.
Authors: Coates P.M.
, Bailey R.L.
, Blumberg J.B.
, El-Sohemy A.
, Floyd E.
, Goldenberg J.Z.
, Gould Shunney A.
, Holscher H.D.
, Nkrumah-Elie Y.
, Rai D.
, et al.
.
Source: The Journal Of Nutrition, 2024 Aug; 154(8), p. 2335-2345.
EPub date: 2024-07-04 00:00:00.0.
PMID: 38971530
Related Citations
Snack frequency, size, and energy density are associated with diet quality among US adolescents.
Authors: Tripicchio G.L.
, Bailey R.L.
, Davey A.
, Croce C.M.
, Fisher J.O.
.
Source: Public Health Nutrition, 2023 Nov; 26(11), p. 2374-2382.
EPub date: 2023-08-07 00:00:00.0.
PMID: 37548183
Related Citations
Reply to E Ciappio et al.
Authors: Sauder K.A.
, Couzens G.L.
, Bailey R.L.
, Hockett C.W.
, Switkowski K.M.
, Lyall K.
, Kerver J.M.
, Dabelea D.
, Maldonado L.E.
, O'Connor T.G.
, et al.
.
Source: The American Journal Of Clinical Nutrition, 2023 Sep; 118(3), p. 731-732.
PMID: 37661110
Related Citations
Precision Nutrition: The Hype Is Exceeding the Science and Evidentiary Standards Needed to Inform Public Health Recommendations for Prevention of Chronic Disease.
Authors: Bailey R.L.
, Stover P.J.
.
Source: Annual Review Of Nutrition, 2023-08-21 00:00:00.0; 43, p. 385-407.
PMID: 37603433
Related Citations
Usual nutrient intakes and diet quality among United States older adults participating in the Supplemental Nutrition Assistance Program compared with income-eligible nonparticipants.
Authors: Qin Y.
, Cowan A.E.
, Bailey R.L.
, Jun S.
, Eicher-Miller H.A.
.
Source: The American Journal Of Clinical Nutrition, 2023 Jul; 118(1), p. 85-95.
EPub date: 2023-05-18 00:00:00.0.
PMID: 37407169
Related Citations
Major Gaps in Understanding Dietary Supplement Use in Health and Disease.
Authors: Bailey R.L.
, Jun S.
, Cowan A.E.
, Eicher-Miller H.A.
, Gahche J.J.
, Dwyer J.T.
, Hartman T.J.
, Mitchell D.C.
, Seguin-Fowler R.A.
, Carroll R.J.
, et al.
.
Source: Annual Review Of Nutrition, 2023-05-17 00:00:00.0; , .
EPub date: 2023-05-17 00:00:00.0.
PMID: 37196365
Related Citations
Evaluating a Food Pantry-Based Intervention to Improve Food Security, Dietary Intake, and Quality in Midwestern Food Pantries.
Authors: Eicher-Miller H.A.
, Wright B.N.
, Tooze J.A.
, Craig B.A.
, Liu Y.
, Bailey R.L.
, McCormack L.A.
, Stluka S.
, Franzen-Castle L.
, Henne B.
, et al.
.
Source: Journal Of The Academy Of Nutrition And Dietetics, 2022 11; 122(11), p. 2060-2071.
EPub date: 2022-02-26 00:00:00.0.
PMID: 35231664
Related Citations
Trends in overall and micronutrient-containing dietary supplement use among U.S. adults and children, NHANES 2007-2018.
Authors: Cowan A.E.
, Tooze J.A.
, Gahche J.J.
, Eicher-Miller H.A.
, Guenther P.M.
, Dwyer J.T.
, Potischman N.
, Bhadra A.
, Carroll R.J.
, Bailey R.L.
.
Source: The Journal Of Nutrition, 2022-08-02 00:00:00.0; , .
EPub date: 2022-08-02 00:00:00.0.
PMID: 35918260
Related Citations
A Randomized Intervention of Supplemental Nutrition Assistance Program-Education Did Not Improve Dietary Outcomes Except for Vitamin D Among Lower-Income Women in Indiana.
Authors: Qin Y.
, Rivera R.L.
, Zhang Y.
, Wang Q.
, Tooze J.A.
, Abbott A.R.
, Maulding M.K.
, Craig B.A.
, Bailey R.L.
, Eicher-Miller H.A.
.
Source: Journal Of The Academy Of Nutrition And Dietetics, 2022-06-30 00:00:00.0; , .
EPub date: 2022-06-30 00:00:00.0.
PMID: 35781080
Related Citations
The Total Nutrient Index is a Useful Measure for Assessing Total Micronutrient Exposures Among US Adults.
Authors: Cowan A.E.
, Bailey R.L.
, Jun S.
, Dodd K.W.
, Gahche J.J.
, Eicher-Miller H.A.
, Guenther P.M.
, Dwyer J.T.
, Potischman N.
, Bhadra A.
, et al.
.
Source: The Journal Of Nutrition, 2022-03-03 00:00:00.0; 152(3), p. 863-871.
PMID: 34928350
Related Citations
Do Multivitamin/Mineral Dietary Supplements for Young Children Fill Critical Nutrient Gaps?
Authors: Dwyer J.T.
, Saldanha L.G.
, Bailen R.A.
, Gahche J.J.
, Potischman N.
, Bailey R.L.
, Jun S.
, Long Y.
, Connor E.
, Andrews K.W.
, et al.
.
Source: Journal Of The Academy Of Nutrition And Dietetics, 2022 03; 122(3), p. 525-532.
EPub date: 2021-10-20 00:00:00.0.
PMID: 34687947
Related Citations
A narrative review of nutrient based indexes to assess diet quality and the proposed total nutrient index that reflects total dietary exposures.
Authors: Cowan A.E.
, Jun S.
, Tooze J.A.
, Dodd K.W.
, Gahche J.J.
, Eicher-Miller H.A.
, Guenther P.M.
, Dwyer J.T.
, Potischman N.
, Bhadra A.
, et al.
.
Source: Critical Reviews In Food Science And Nutrition, 2021-09-02 00:00:00.0; , p. 1-11.
EPub date: 2021-09-02 00:00:00.0.
PMID: 34470512
Related Citations
Accurate Measurement of Nutrients and Nonnutritive Dietary Ingredients from Dietary Supplements Is Critical in the Precision Nutrition Era.
Authors: Gahche J.J.
, Bailey R.L.
.
Source: The Journal Of Nutrition, 2021-08-07 00:00:00.0; 151(8), p. 2094-2095.
PMID: 34293109
Related Citations
Overview of dietary assessment methods for measuring intakes of foods, beverages, and dietary supplements in research studies.
Authors: Bailey R.L.
.
Source: Current Opinion In Biotechnology, 2021 Aug; 70, p. 91-96.
EPub date: 2021-03-11 00:00:00.0.
PMID: 33714006
Related Citations
Public Health Decisions Are Made at the Tails of the Distribution: A Novel Tool to Estimate Usual Intake Distributions from Short-Term Dietary Assessment Methods.
Authors: Bailey R.L.
, Jun S.
.
Source: The Journal Of Nutrition, 2021-05-11 00:00:00.0; 151(5), p. 1059-1060.
PMID: 33847339
Related Citations
Association of food insecurity with dietary intakes and nutritional biomarkers among US children, National Health and Nutrition Examination Survey (NHANES) 2011-2016.
Authors: Jun S.
, Cowan A.E.
, Dodd K.W.
, Tooze J.A.
, Gahche J.J.
, Eicher-Miller H.A.
, Guenther P.M.
, Dwyer J.T.
, Potischman N.
, Bhadra A.
, et al.
.
Source: The American Journal Of Clinical Nutrition, 2021-05-08 00:00:00.0; , .
EPub date: 2021-05-08 00:00:00.0.
PMID: 33964856
Related Citations
Nutritional contributions of food pantries and other sources to the diets of rural, Midwestern food pantry users in the USA.
Authors: Liu Y.
, Desmond N.E.
, Wright B.N.
, Bailey R.L.
, Dong T.
, Craig B.A.
, Eicher-Miller H.A.
.
Source: The British Journal Of Nutrition, 2021-04-28 00:00:00.0; 125(8), p. 891-901.
EPub date: 2020-09-02 00:00:00.0.
PMID: 32873361
Related Citations
Trends in Nutrient- and Non-Nutrient-Containing Dietary Supplement Use among US Children from 1999 to 2016.
Authors: Panjwani A.A.
, Cowan A.E.
, Jun S.
, Bailey R.L.
.
Source: The Journal Of Pediatrics, 2021 Apr; 231, p. 131-140.e2.
EPub date: 2020-12-17 00:00:00.0.
PMID: 33340548
Related Citations
Knowledge gaps in understanding the metabolic and clinical effects of excess folates/folic acid: a summary, and perspectives, from an NIH workshop.
Authors: Maruvada P.
, Stover P.J.
, Mason J.B.
, Bailey R.L.
, Davis C.D.
, Field M.S.
, Finnell R.H.
, Garza C.
, Green R.
, Gueant J.L.
, et al.
.
Source: The American Journal Of Clinical Nutrition, 2020-11-11 00:00:00.0; 112(5), p. 1390-1403.
PMID: 33022704
Related Citations
Dietary Quality and Usual Intake of Underconsumed Nutrients and Related Food Groups Differ by Food Security Status for Rural, Midwestern Food Pantry Clients.
Authors: Wright B.N.
, Tooze J.A.
, Bailey R.L.
, Liu Y.
, Rivera R.L.
, McCormack L.
, Stluka S.
, Franzen-Castle L.
, Henne B.
, Mehrle D.
, et al.
.
Source: Journal Of The Academy Of Nutrition And Dietetics, 2020 Sep; 120(9), p. 1457-1468.
EPub date: 2020-07-20 00:00:00.0.
PMID: 32703690
Related Citations
Older adults with obesity have higher risks of some micronutrient inadequacies and lower overall dietary quality compared to peers with a healthy weight, National Health and Nutrition Examination Surveys (NHANES), 2011-2014.
Authors: Jun S.
, Cowan A.E.
, Bhadra A.
, Dodd K.W.
, Dwyer J.T.
, Eicher-Miller H.A.
, Gahche J.J.
, Guenther P.M.
, Potischman N.
, Tooze J.A.
, et al.
.
Source: Public Health Nutrition, 2020-05-29 00:00:00.0; , p. 1-12.
EPub date: 2020-05-29 00:00:00.0.
PMID: 32466808
Related Citations
Comparison of 4 Methods to Assess the Prevalence of Use and Estimates of Nutrient Intakes from Dietary Supplements among US Adults.
Authors: Cowan A.E.
, Jun S.
, Tooze J.A.
, Dodd K.W.
, Gahche J.J.
, Eicher-Miller H.A.
, Guenther P.M.
, Dwyer J.T.
, Moshfegh A.J.
, Rhodes D.G.
, et al.
.
Source: The Journal Of Nutrition, 2020-04-01 00:00:00.0; 150(4), p. 884-893.
PMID: 31851315
Related Citations
Breakfast Consumption Is Positively Associated with Usual Nutrient Intakes among Food Pantry Clients Living in Rural Communities.
Authors: Liu Y.
, Tooze J.A.
, Zhang Y.
, Leidy H.J.
, Bailey R.L.
, Wright B.
, Ma M.
, Stluka S.
, Remley D.T.
, McCormack L.A.
, et al.
.
Source: The Journal Of Nutrition, 2020-03-01 00:00:00.0; 150(3), p. 546-553.
PMID: 31711170
Related Citations
Dietary Supplement Use and Its Micronutrient Contribution During Pregnancy and Lactation in the United States.
Authors: Jun S.
, Gahche J.J.
, Potischman N.
, Dwyer J.T.
, Guenther P.M.
, Sauder K.A.
, Bailey R.L.
.
Source: Obstetrics And Gynecology, 2020 Mar; 135(3), p. 623-633.
PMID: 32028492
Related Citations
Total Usual Micronutrient Intakes Compared to the Dietary Reference Intakes among U.S. Adults by Food Security Status.
Authors: Cowan A.E.
, Jun S.
, Tooze J.A.
, Eicher-Miller H.A.
, Dodd K.W.
, Gahche J.J.
, Guenther P.M.
, Dwyer J.T.
, Potischman N.
, Bhadra A.
, et al.
.
Source: Nutrients, 2019-12-22 00:00:00.0; 12(1), .
EPub date: 2019-12-22 00:00:00.0.
PMID: 31877853
Related Citations
Trends in Mean Nutrient Intakes of US Infants, Toddlers, and Young Children from 3 Feeding Infants and Toddlers Studies (FITS).
Authors: Eldridge A.L.
, Catellier D.J.
, Hampton J.C.
, Dwyer J.T.
, Bailey R.L.
.
Source: The Journal Of Nutrition, 2019-07-01 00:00:00.0; 149(7), p. 1230-1237.
PMID: 31049587
Related Citations
Estimation of Total Usual Dietary Intakes of Pregnant Women in the United States.
Authors: Bailey R.L.
, Pac S.G.
, Fulgoni V.L.
, Reidy K.C.
, Catalano P.M.
.
Source: Jama Network Open, 2019-06-05 00:00:00.0; 2(6), p. e195967.
EPub date: 2019-06-05 00:00:00.0.
PMID: 31225890
Related Citations
Children's Dietary Quality and Micronutrient Adequacy by Food Security in the Household and among Household Children.
Authors: Jun S.
, Zeh M.J.
, Eicher-Miller H.A.
, Bailey R.L.
.
Source: Nutrients, 2019-04-27 00:00:00.0; 11(5), .
EPub date: 2019-04-27 00:00:00.0.
PMID: 31035584
Related Citations
Best Practices for Dietary Supplement Assessment and Estimation of Total Usual Nutrient Intakes in Population-Level Research and Monitoring.
Authors: Bailey R.L.
, Dodd K.W.
, Gahche J.J.
, Dwyer J.T.
, Cowan A.E.
, Jun S.
, Eicher-Miller H.A.
, Guenther P.M.
, Bhadra A.
, Thomas P.R.
, et al.
.
Source: The Journal Of Nutrition, 2019-02-08 00:00:00.0; , .
EPub date: 2019-02-08 00:00:00.0.
PMID: 30753685
Related Citations
Dietary Supplement Use among Infants and Toddlers Aged <24 Months in the United States, NHANES 2007-2014.
Authors: Gahche J.J.
, Herrick K.A.
, Potischman N.
, Bailey R.L.
, Ahluwalia N.
, Dwyer J.T.
.
Source: The Journal Of Nutrition, 2019-02-01 00:00:00.0; 149(2), p. 314-322.
PMID: 30753556
Related Citations
Current regulatory guidelines and resources to support research of dietary supplements in the United States.
Authors: Bailey R.L.
.
Source: Critical Reviews In Food Science And Nutrition, 2018-11-13 00:00:00.0; , p. 1-12.
EPub date: 2018-11-13 00:00:00.0.
PMID: 30421981
Related Citations
Position of the Academy of Nutrition and Dietetics: Micronutrient Supplementation.
Authors: Marra M.V.
, Bailey R.L.
.
Source: Journal Of The Academy Of Nutrition And Dietetics, 2018 11; 118(11), p. 2162-2173.
PMID: 30366569
Related Citations
Usual Nutrient Intakes from the Diets of US Children by WIC Participation and Income: Findings from the Feeding Infants and Toddlers Study (FITS) 2016.
Authors: Jun S.
, Catellier D.J.
, Eldridge A.L.
, Dwyer J.T.
, Eicher-Miller H.A.
, Bailey R.L.
.
Source: The Journal Of Nutrition, 2018-09-01 00:00:00.0; 148(9S), p. 1567S-1574S.
PMID: 29878136
Related Citations
Dietary Supplement Use among U.S. Children by Family Income, Food Security Level, and Nutrition Assistance Program Participation Status in 2011⁻2014.
Authors: Jun S.
, Cowan A.E.
, Tooze J.A.
, Gahche J.J.
, Dwyer J.T.
, Eicher-Miller H.A.
, Bhadra A.
, Guenther P.M.
, Potischman N.
, Dodd K.W.
, et al.
.
Source: Nutrients, 2018-09-01 00:00:00.0; 10(9), .
EPub date: 2018-09-01 00:00:00.0.
PMID: 30200511
Related Citations
Dietary Supplement Use Differs by Socioeconomic and Health-Related Characteristics among U.S. Adults, NHANES 2011⁻2014.
Authors: Cowan A.E.
, Jun S.
, Gahche J.J.
, Tooze J.A.
, Dwyer J.T.
, Eicher-Miller H.A.
, Bhadra A.
, Guenther P.M.
, Potischman N.
, Dodd K.W.
, et al.
.
Source: Nutrients, 2018-08-17 00:00:00.0; 10(8), .
EPub date: 2018-08-17 00:00:00.0.
PMID: 30126136
Related Citations
Comparing Reported Dietary Supplement Intakes between Two 24-Hour Recall Methods: The Automated Self-Administered 24-Hour Dietary Assessment Tool and the Interview-Administered Automated Multiple Pass Method.
Authors: Pannucci T.E.
, Thompson F.E.
, Bailey R.L.
, Dodd K.W.
, Potischman N.
, Kirkpatrick S.I.
, Alexander G.L.
, Coleman L.A.
, Kushi L.H.
, Groesbeck M.
, et al.
.
Source: Journal Of The Academy Of Nutrition And Dietetics, 2018 Jun; 118(6), p. 1080-1086.
PMID: 29803270
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