Grant Number:	1R03CA289066-01 Interpret this number
Primary Investigator:	Anderson, Elizabeth
Organization:	University Of Missouri-Columbia
Project Title:	Nurses Surviving Breast Cancer: an Exploration of Breast Cancer Diagnosis, Reported Lymphedema Symptoms, and Lifestyle Status in the Nurses' Health Study Survey
Fiscal Year:	2024

Project Summary/Abstract Breast cancer-related lymphedema (BCRL) is a side-effect of anticancer treatment. Caused by damage to the lymphatic system secondary to surgery, chemotherapy, and radiotherapy treatments, protein-rich lymphatic fluid moves from the lymphatic channels into the surrounding interstitial tissues, causing pain, swelling, decreased physical function, and emotional distress. Every person treated for breast cancer has a lifetime risk of developing this condition. Currently, there is no cure for this anticancer treatment sequelae. Early, timely, and consistent surveillance, diagnosis, and treatment is critical to successful management. Lifetime treatment involves a two-phase program of lymphedema therapist-guided treatment and personal self- management activities. As survivors age, support and surveillance needs change with additional comorbidities, psychosocial changes, and health navigation challenges which complicate lymphedema self-management. Studies have explored incidence, symptom association factors, and self-management issues in small samples of breast cancer survivors living with BCRL. To date, no BCRL studies have used a large, longitudinal, prospective database. The Nurses’ Health Study is a large, national, longitudinal database that explores reproductive and chronic disease health issues in women. Launched in 1976, researchers sought to examine reproductive health and chronic illness risk over time. Over 280, 000 professional nurses have responded to survey questions focused on lifestyle and health status. In 2010, questions developed by our team to address breast cancer treatment and lymphedema symptoms were added to the biennial survey. From 2010-2017, five waves of survey data were collected. In this study we seek to 1) explore patterns of incidence of self-reported BCRL symptoms of limb, breast, or chest heaviness and swelling across race, socioeconomic status, and time since diagnosis; and 2) examine patterns of associations between self-reported lifestyle- and health-related factors and BCRL symptoms of limb, breast, or chest heaviness and swelling. Five biennial waves of the survey data will be analyzed. We will model the association between self-reported lifestyle- and health-related factors and BCRL symptoms of limb, breast, or chest heaviness and swelling using Generalized Linear Mixed models across the five biennial waves of data. This study will provide the first rigorous evidence about the incidence and prevalence and patterns of breast cancer diagnosis and self-reported BCRL symptoms in nurses who are breast cancer survivors. These findings will help generate future questions about additional factors that may impact survivorship for nurses living with BCRL and lay the foundation for future research in BCRL self-management intervention development.





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