Skip to main content

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted.

The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit cc.nih.gov.

Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

An official website of the United States government
Grant Details

Grant Number: 5R01CA271589-02 Interpret this number
Primary Investigator: Dave, Sandeep
Organization: Duke University
Project Title: Genetic Origins of Adverse Outcomes in African Americans with Lymphoma
Fiscal Year: 2024


Abstract

ABSTRACT Diffuse large B cell lymphoma (DLBCL) is the most common form of blood cancer and is characterized by a striking degree of genetic heterogeneity. It has been known for some time that African American patients have poorer outcomes than Caucasian patients. After correcting for potential differences in socioeconomics and access to care, our data indicate that the poorer outcomes in African Americans arise primarily from distinct genetics of their tumors. The underlying genetic causes of these poorer outcomes have not been studied systematically. Here, we propose to investigate tumor and germline genetics of African Americans to comprehensively understand the genetic basis of their poorer outcomes. Preliminary genomic analysis of African American DLBCL patients has revealed more frequent mutations in histone methyltransferase genes and other genes. In this proposal, we seek to comprehensively define the genetic origins of poor outcomes in African Americans with DLBCL and perform functional characterization of selected genomic alterations.



Publications

Error Notice

The database may currently be offline for maintenance and should be operational soon. If not, we have been notified of this error and will be reviewing it shortly.

We apologize for the inconvenience.
- The DCCPS Team.

Back to Top