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Grant Details

Grant Number: 5U01AI069197-21 Interpret this number
Primary Investigator: Petersdorf, Effie
Organization: Fred Hutchinson Cancer Center
Project Title: Hematopoietic Stem Cell and Cord Blood Transplantation
Fiscal Year: 2024


Abstract

PROJECT SUMMARY/ABSTRACT Hematopoietic cell transplantation from unrelated donors, haploidentical related donors and cord blood units can cure life-threatening blood disorders; however, graft-versus-host disease (GVHD), relapse and survivorship disparities across different ancestries remain the major obstacles. When matched donors are not available, the properties of HLA mismatches that govern (non)-permissivity are not well-defined. Furthermore, the role of KIR/HLA interactions in modulating relapse remain to be clarified. These deficiencies have important implications for a large fraction of patients who lack HLA-matched donors, and for all patients at risk for disease relapse. We have demonstrated that HLA class I leader peptides, HLA-DP expression, and HLA/KIR interactions each contribute to GVHD, relapse and mortality. The unmet needs are to understand the mechanisms through which HLA and KIR genes modulate transplant risks, and a means to apply the research findings to clinical care. We propose to define the underlying mechanisms through which HLA and KIR genes and proteins function in transplantation, and develop tools for using HLA and KIR in the selection of the optimal transplant donor and cord blood unit. The specific aims are to: define the role of HLA-DP expression and peptide-binding groove pocket in GVHD; define NKG2/HLA-E interactions and HLA-G in GVHD and relapse; define the role for KIR and HLA interaction in relapse after HCT for acute leukemia, and design tools to evaluate gene features in clinical practice. The goals will be achieved through systemic analysis of individual gene variation, haplotypes of genes, and receptor/ligand recognition in large ethnically diverse transplant populations with complete clinical data. This proposal will fill the knowledge gap in the immunobiological basis of GVHD, relapse and survivorship disparities in transplantation. The information will increase the safety, efficacy and availability of transplantation for all patients in need of this life-saving therapy.



Publications

A Tool for the Assessment of HLA-DQ Heterodimer Variation in Hematopoietic Cell Transplantation.
Authors: Sajulga R.W. , Bolon Y.T. , Maiers M.J. , Petersdorf E.W. .
Source: Transplantation And Cellular Therapy, 2024 Nov; 30(11), p. 1084.e1-1084.e15.
EPub date: 2024-08-15 00:00:00.0.
PMID: 39151729
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CAST Regimen for GvHD Prophylaxis: A CIBMTR Propensity Score-Matched Analysis.
Authors: Al-Homsi A.S. , DeFor T.E. , Cole K. , Cirrone F. , King S. , Suarez-Londono A. , Yaghmour G. , Boisclair S. , Bupp C. , Spellman S.R. .
Source: Transplantation And Cellular Therapy, 2024 Nov; 30(11), p. 1092-1098.
EPub date: 2024-08-30 00:00:00.0.
PMID: 39209024
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Interplay between donor age and HLA-DP matching in 10/10 HLA-matched unrelated donor HCT.
Authors: Mehta R.S. , Petersdorf E.W. , Wang T. , Spellman S.R. , Lee S.J. .
Source: Blood Advances, 2024-10-22 00:00:00.0; 8(20), p. 5438-5449.
PMID: 39008717
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Polygenic polymorphism is associated with NKG2A repertoire and influences lymphocyte phenotype and function.
Authors: Le Luduec J.B. , Kontopoulos T. , Panjwani M.K. , Sottile R. , Liu H. , Schäfer G. , Massalski C. , Lange V. , Hsu K.C. .
Source: Blood Advances, 2024-10-22 00:00:00.0; 8(20), p. 5382-5399.
PMID: 39158076
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Applying Implementation Science in the Field of Transplant and Cellular Therapy.
Authors: DeSalvo A.M. , Spellman S.R. , Coles J.A.S. , Robb D. , McCann M. , Yusuf R.A. , Hengen M. , Auletta J.J. .
Source: Transplantation And Cellular Therapy, 2024 Sep; 30(9), p. 864-875.
EPub date: 2024-06-21 00:00:00.0.
PMID: 38909780
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Real-world and clinical trial outcomes in large B-cell lymphoma with axicabtagene ciloleucel across race and ethnicity.
Authors: Locke F.L. , Siddiqi T. , Jacobson C.A. , Ghobadi A. , Ahmed S. , Miklos D.B. , Perales M.A. , Munoz J. , Fingrut W.B. , Pennisi M. , et al. .
Source: Blood, 2024-06-27 00:00:00.0; 143(26), p. 2722-2734.
PMID: 38635762
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Combined effect of unrelated donor age and HLA peptide-binding motif match status on HCT outcomes.
Authors: Mehta R.S. , Petersdorf E.W. , Spellman S.R. , Lee S.J. .
Source: Blood Advances, 2024-05-14 00:00:00.0; 8(9), p. 2235-2242.
PMID: 38467032
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Prediction of KIR3DL1/Human Leukocyte Antigen binding.
Authors: Maiers M. , Louzoun Y. , Pymm P. , Vivian J.P. , Rossjohn J. , Brooks A.G. , Saunders P.M. .
Source: Biorxiv : The Preprint Server For Biology, 2024-05-05 00:00:00.0; , .
EPub date: 2024-05-05 00:00:00.0.
PMID: 38746109
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Benefit of axicabtagene ciloleucel versus chemoimmunotherapy in older patients and/or patients with poor ECOG performance status with relapsed or refractory large B-cell lymphoma after 2 or more lines of prior therapy.
Authors: Lunning M.A. , Wang H.L. , Hu Z.H. , Locke F.L. , Siddiqi T. , Jacobson C.A. , Ahmed S. , Miklos D.B. , Lin Y. , Hill B.T. , et al. .
Source: American Journal Of Hematology, 2024 May; 99(5), p. 880-889.
EPub date: 2024-03-19 00:00:00.0.
PMID: 38504387
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HLA Haplotypes and Relapse After Hematopoietic Cell Transplantation.
Authors: Petersdorf E.W. , McKallor C. , Malkki M. , He M. , Spellman S.R. , Gooley T. , Stevenson P. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2024-03-10 00:00:00.0; 42(8), p. 886-897.
EPub date: 2023-12-05 00:00:00.0.
PMID: 38051980
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Control of nutrient uptake by IRF4 orchestrates innate immune memory.
Authors: Santosa E.K. , Kim H. , Rückert T. , Le Luduec J.B. , Abbasi A.J. , Wingert C.K. , Peters L. , Frost J.N. , Hsu K.C. , Romagnani C. , et al. .
Source: Nature Immunology, 2023 Oct; 24(10), p. 1685-1697.
EPub date: 2023-09-11 00:00:00.0.
PMID: 37697097
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Assessment of HLA-DPB1 genetic variation using an HLA-DP tool and its implications in clinical transplantation.
Authors: Sajulga R. , Bolon Y.T. , Maiers M.J. , Petersdorf E.W. .
Source: Blood Advances, 2023-09-12 00:00:00.0; 7(17), p. 4809-4821.
PMID: 37126658
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Role of NKG2D ligands and receptor in haploidentical related donor hematopoietic cell transplantation.
Authors: Petersdorf E.W. , McKallor C. , Malkki M. , He M. , Spellman S.R. , Hsu K.C. , Strong R.K. , Gooley T. , Stevenson P. .
Source: Blood Advances, 2023-06-27 00:00:00.0; 7(12), p. 2888-2896.
PMID: 36763517
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Race and Survival in Unrelated Hematopoietic Cell Transplantation.
Authors: Morishima Y. , Morishima S. , Stevenson P. , Kodera Y. , Horowitz M. , McKallor C. , Malkki M. , Spellman S.R. , Gooley T. , Petersdorf E.W. , et al. .
Source: Transplantation And Cellular Therapy, 2022 07; 28(7), p. 357.e1-357.e6.
EPub date: 2022-04-08 00:00:00.0.
PMID: 35405366
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HLA-DQ heterodimers in hematopoietic cell transplantation.
Authors: Petersdorf E.W. , Bengtsson M. , Horowitz M. , McKallor C. , Spellman S.R. , Spierings E. , Gooley T.A. , Stevenson P. , International Histocompatibility Working Group in Hematopoietic Cell Transplantation .
Source: Blood, 2022-05-19 00:00:00.0; 139(20), p. 3009-3017.
PMID: 35271697
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HLA-DQ heterodimers in hematopoietic cell transplantation.
Authors: Petersdorf E.W. , Bengtsson M. , Horowitz M. , McKallor C. , Spellman S.R. , Spierings E. , Gooley T.A. , Stevenson P. , International Histocompatibility Working Group in Hematopoietic Cell Transplantation .
Source: Blood, 2022-05-19 00:00:00.0; 139(20), p. 3009-3017.
PMID: 35271697
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Impact of Induction Therapy with VRD versus VCD on Outcomes in Patients with Multiple Myeloma in Partial Response or Better Undergoing Upfront Autologous Stem Cell Transplantation.
Authors: Sidana S. , Kumar S. , Fraser R. , Estrada-Merly N. , Giralt S. , Agrawal V. , Anderson L.D. , Aljurf M. , Banerjee R. , Bashey A. , et al. .
Source: Transplantation And Cellular Therapy, 2022 Feb; 28(2), p. 83.e1-83.e9.
EPub date: 2021-11-12 00:00:00.0.
PMID: 34781066
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An adapted European LeukemiaNet genetic risk stratification for acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplant. A CIBMTR analysis.
Authors: Jimenez Jimenez A.M. , De Lima M. , Komanduri K.V. , Wang T.P. , Zhang M.J. , Chen K. , Abdel-Azim H. , Abid M.B. , Aljurf M. , Alkhateeb H. , et al. .
Source: Bone Marrow Transplantation, 2021 Dec; 56(12), p. 3068-3077.
EPub date: 2021-09-28 00:00:00.0.
PMID: 34584240
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Outcomes of upfront autologous hematopoietic cell transplantation in patients with multiple myeloma who are 75 years old or older.
Authors: Munshi P.N. , Vesole D.H. , St Martin A. , Davila O. , Kumar S. , Qazilbash M. , Shah N. , Hari P.N. , D'Souza A. .
Source: Cancer, 2021-11-15 00:00:00.0; 127(22), p. 4233-4239.
EPub date: 2021-08-10 00:00:00.0.
PMID: 34374445
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Human Cytomegalovirus Infection Promotes Expansion of a Functionally Superior Cytoplasmic CD3+ NK Cell Subset with a Bcl11b-Regulated T Cell Signature.
Authors: Wu Z. , Lau C.M. , Sottile R. , Le Luduec J.B. , Panjwani M.K. , Conaty P.M. , Srpan K. , Laib Sampaio K. , Mertens T. , Adler S.P. , et al. .
Source: Journal Of Immunology (baltimore, Md. : 1950), 2021-11-15 00:00:00.0; 207(10), p. 2534-2544.
EPub date: 2021-10-08 00:00:00.0.
PMID: 34625521
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HLA Informs Risk Predictions after Haploidentical Stem Cell Transplantation with Post-transplantation Cyclophosphamide.
Authors: Fuchs E.J. , McCurdy S.R. , Solomon S.R. , Wang T. , Herr M.M. , Modi D. , Grunwald M.R. , Nishihori T. , Kuxhausen M. , Fingerson S. , et al. .
Source: Blood, 2021-11-01 00:00:00.0; , .
EPub date: 2021-11-01 00:00:00.0.
PMID: 34724567
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Barriers to Access to Hematopoietic Cell Transplantation among Patients with Acute Myeloid Leukemia in Virginia.
Authors: Mock J. , Meyer C. , Mau L.W. , Nguyen C. , Arora P. , Heron C. , Balkrishnan R. , Burns L. , Devine S. , Ballen K. .
Source: Transplantation And Cellular Therapy, 2021 10; 27(10), p. 869.e1-869.e9.
EPub date: 2021-07-02 00:00:00.0.
PMID: 34224915
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Novel genetic variants associated with mortality after unrelated donor allogeneic hematopoietic cell transplantation.
Authors: Hahn T. , Wang J. , Preus L.M. , Karaesmen E. , Rizvi A. , Clay-Gilmour A.I. , Zhu Q. , Wang Y. , Yan L. , Liu S. , et al. .
Source: Eclinicalmedicine, 2021 Oct; 40, p. 101093.
EPub date: 2021-08-25 00:00:00.0.
PMID: 34746714
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Human cytomegalovirus expands a CD8+ T cell population with loss of BCL11B expression and gain of NK cell identity.
Authors: Sottile R. , Panjwani M.K. , Lau C.M. , Daniyan A.F. , Tanaka K. , Barker J.N. , Brentjens R.J. , Sun J.C. , Le Luduec J.B. , Hsu K.C. .
Source: Science Immunology, 2021-09-24 00:00:00.0; 6(63), p. eabe6968.
EPub date: 2021-09-24 00:00:00.0.
PMID: 34559552
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Assessment of HLA-B Genetic Variation with an HLA-B Leader Tool and Implications in Clinical Transplantation.
Authors: Sajulga R. , Bolon Y.T. , Maiers M. , Petersdorf E.W. .
Source: Blood Advances, 2021-09-16 00:00:00.0; , .
EPub date: 2021-09-16 00:00:00.0.
PMID: 34529780
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American Society of Transplantation and Cellular Therapy, Center of International Blood and Marrow Transplant Research, and European Society for Blood and Marrow Transplantation Clinical Practice Recommendations for Transplantation and Cellular Therapies in Mantle Cell Lymphoma.
Authors: Munshi P.N. , Hamadani M. , Kumar A. , Dreger P. , Friedberg J.W. , Dreyling M. , Kahl B. , Jerkeman M. , Kharfan-Dabaja M.A. , Locke F.L. , et al. .
Source: Transplantation And Cellular Therapy, 2021 Sep; 27(9), p. 720-728.
PMID: 34452722
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Hematopoietic Cell Transplantation Outcomes among Medicaid and Privately Insured Patients with Sickle Cell Disease.
Authors: Mupfudze T.G. , Meyer C. , Preussler J.M. , Mau L.W. , Bolon Y.T. , Steinert P. , Arnold S.D. , Saber W. , Krishnamurti L. .
Source: Transplantation And Cellular Therapy, 2021 08; 27(8), p. 685.e1-685.e8.
EPub date: 2021-04-22 00:00:00.0.
PMID: 33895405
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Impact of Previously Unrecognized HLA Mismatches Using Ultrahigh Resolution Typing in Unrelated Donor Hematopoietic Cell Transplantation.
Authors: Mayor N.P. , Wang T. , Lee S.J. , Kuxhausen M. , Vierra-Green C. , Barker D.J. , Auletta J. , Bhatt V.R. , Gadalla S.M. , Gragert L. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2021-07-20 00:00:00.0; 39(21), p. 2397-2409.
EPub date: 2021-04-09 00:00:00.0.
PMID: 33835855
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Superior survival with pediatric-style chemotherapy compared to myeloablative allogeneic hematopoietic cell transplantation in older adolescents and young adults with Ph-negative acute lymphoblastic leukemia in first complete remission: analysis from CALGB 10403 and the CIBMTR.
Authors: Wieduwilt M.J. , Stock W. , Advani A. , Luger S. , Larson R.A. , Tallman M. , Appelbaum F. , Zhang M.J. , Bo-Subait K. , Wang H.L. , et al. .
Source: Leukemia, 2021 Jul; 35(7), p. 2076-2085.
EPub date: 2021-03-30 00:00:00.0.
PMID: 33785862
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Breaking the Age Barrier: Physicians' Perceptions of Candidacy for Allogeneic Hematopoietic Cell Transplantation in Older Adults.
Authors: Mishra A. , Preussler J.M. , Bhatt V.R. , Bredeson C. , Chhabra S. , D'Souza A. , Dahi P.B. , Hacker E.D. , Gowda L. , Hashmi S.K. , et al. .
Source: Transplantation And Cellular Therapy, 2021 Jul; 27(7), p. 617.e1-617.e7.
EPub date: 2021-04-06 00:00:00.0.
PMID: 33836312
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Posttransplant cyclophosphamide is associated with increased cytomegalovirus infection: a CIBMTR analysis.
Authors: Goldsmith S.R. , Abid M.B. , Auletta J.J. , Bashey A. , Beitinjaneh A. , Castillo P. , Chemaly R.F. , Chen M. , Ciurea S. , Dandoy C.E. , et al. .
Source: Blood, 2021-06-10 00:00:00.0; 137(23), p. 3291-3305.
PMID: 33657221
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Shorter Interdonation Interval Contributes to Lower Cell Counts in Subsequent Stem Cell Donations.
Authors: Panch S.R. , Logan B. , Sees J.A. , Bo-Subait S. , Savani B. , Shah N.N. , Hsu J.W. , Switzer G. , Lazarus H.M. , Anderlini P. , et al. .
Source: Transplantation And Cellular Therapy, 2021 Jun; 27(6), p. 503.e1-503.e8.
EPub date: 2021-03-09 00:00:00.0.
PMID: 33823169
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Deconvoluting global cytokine signaling networks in natural killer cells.
Authors: Wiedemann G.M. , Santosa E.K. , Grassmann S. , Sheppard S. , Le Luduec J.B. , Adams N.M. , Dang C. , Hsu K.C. , Sun J.C. , Lau C.M. .
Source: Nature Immunology, 2021 05; 22(5), p. 627-638.
EPub date: 2021-04-15 00:00:00.0.
PMID: 33859404
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Optimal Donor Selection for Hematopoietic Cell Transplantation Using Bayesian Machine Learning.
Authors: Logan B.R. , Maiers M.J. , Sparapani R.A. , Laud P.W. , Spellman S.R. , McCulloch R.E. , Shaw B.E. .
Source: Jco Clinical Cancer Informatics, 2021 05; 5, p. 494-507.
PMID: 33950708
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Systematic Reviews in Hematopoietic Cell Transplantation and Cellular Therapy: Considerations and Guidance from the American Society for Transplantation and Cellular Therapy, European Society for Blood and Marrow Transplantation, and Center for International Blood and Marrow Transplant Research Late Effects and Quality of Life Working Committee.
Authors: Sharma A. , Badawy S.M. , Suelzer E.M. , Murthy H.S. , Prasad P. , Eissa H. , Carpenter P.A. , Hamadani M. , Labopin M. , Schoemans H. , et al. .
Source: Transplantation And Cellular Therapy, 2021 05; 27(5), p. 380-388.
EPub date: 2021-01-28 00:00:00.0.
PMID: 33965174
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COVID-19 and Hematopoietic Cell Transplant Center-specific survival analysis: Can we adjust for the impact of the pandemic? Recommendations of the COVID-19 Taskforce of the 2020 CIBMTR Center Outcomes Forum.
Authors: Wingard J.R. , Ahn K.W. , Dandoy C. , Perales M.A. , Wood W.A. , Logan B. , Riches M. , Rizzo J.D. .
Source: Transplantation And Cellular Therapy, 2021-04-22 00:00:00.0; , .
EPub date: 2021-04-22 00:00:00.0.
PMID: 33895401
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Systematic reviews in hematopoietic cell transplantation and cellular therapy: considerations and guidance from the American Society for Transplantation and Cellular Therapy, European Society for Blood and Marrow Transplantation, and the Center for International Blood and Marrow Transplant Research late effects and quality of life working committee.
Authors: Sharma A. , Badawy S.M. , Suelzer E.M. , Murthy H.S. , Prasad P. , Eissa H. , Carpenter P.A. , Hamadani M. , Labopin M. , Schoemans H. , et al. .
Source: Bone Marrow Transplantation, 2021 Apr; 56(4), p. 786-797.
EPub date: 2021-01-29 00:00:00.0.
PMID: 33514917
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Serious Adverse Events in Related Donors: A Report from the Related Donor Safe Study.
Authors: Seftel M.D. , Chitphakdithai P. , Miller J.P. , Kobusingye H. , Logan B.R. , Linenberger M. , Artz A.S. , Haight A.E. , Jacobsohn D.A. , Litzow M.R. , et al. .
Source: Transplantation And Cellular Therapy, 2021 Apr; 27(4), p. 352.e1-352.e5.
EPub date: 2021-01-15 00:00:00.0.
PMID: 33836890
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Bortezomib-Based Induction Is Associated with Superior Outcomes in Light Chain Amyloidosis Patients Treated with Autologous Hematopoietic Cell Transplantation Regardless of Plasma Cell Burden.
Authors: Cornell R.F. , Fraser R. , Costa L. , Goodman S. , Estrada-Merly N. , Lee C. , Hildebrandt G. , Gergis U. , Farhadfar N. , Freytes C.O. , et al. .
Source: Transplantation And Cellular Therapy, 2021 Mar; 27(3), p. 264.e1-264.e7.
EPub date: 2020-12-16 00:00:00.0.
PMID: 33781533
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Specific Class I HLA Supertypes but Not HLA Zygosity or Expression Are Associated with Outcomes following HLA-Matched Allogeneic Hematopoietic Cell Transplant: HLA Supertypes Impact Allogeneic HCT Outcomes.
Authors: Camacho-Bydume C. , Wang T. , Sees J.A. , Fernandez-Viña M. , Abid M.B. , Askar M. , Beitinjaneh A. , Brown V. , Castillo P. , Chhabra S. , et al. .
Source: Transplantation And Cellular Therapy, 2021 Feb; 27(2), p. 142.e1-142.e11.
EPub date: 2020-10-11 00:00:00.0.
PMID: 33053450
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Broad-Spectrum Antibiotics and Risk of Graft-versus-Host Disease in Pediatric Patients Undergoing Transplantation for Acute Leukemia: Association of Carbapenem Use with the Risk of Acute Graft-versus-Host Disease
Authors: Elgarten C.W. , Li Y. , Getz K.D. , Hemmer M. , Huang Y.V. , Hall M. , Wang T. , Kitko C.L. , Jagasia M.H. , Nishihori T. , et al. .
Source: Transplantation And Cellular Therapy, 2021 02; 27(2), p. 177.e1-177.e8.
EPub date: 2020-12-21 00:00:00.0.
PMID: 33718896
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Neighborhood poverty and pediatric allogeneic hematopoietic cell transplantation outcomes: a CIBMTR analysis.
Authors: Bona K. , Brazauskas R. , He N. , Lehmann L. , Abdel-Azim H. , Ahmed I.A. , Al-Homsi A.S. , Aljurf M. , Arnold S.D. , Badawy S.M. , et al. .
Source: Blood, 2021-01-28 00:00:00.0; 137(4), p. 556-568.
PMID: 33104215
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Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: an observational cohort study.
Authors: Sharma A. , Bhatt N.S. , St Martin A. , Abid M.B. , Bloomquist J. , Chemaly R.F. , Dandoy C. , Gauthier J. , Gowda L. , Perales M.A. , et al. .
Source: The Lancet. Haematology, 2021-01-19 00:00:00.0; , .
EPub date: 2021-01-19 00:00:00.0.
PMID: 33482113
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Prognostic impact of serum CXC chemokine ligands 4 and 7 on myelodysplastic syndromes post allogeneic hematopoietic cell transplant.
Authors: Dhakal B. , Wang T. , Kuxhausen M. , Zhu F. , Taylor C. , Spellman S.R. , Verneris M.R. , Hsu K. , Fleischhauer K. , Lee S.J. , et al. .
Source: Leukemia & Lymphoma, 2021 01; 62(1), p. 229-233.
EPub date: 2020-09-13 00:00:00.0.
PMID: 32924688
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Busulfan, melphalan, and bortezomib compared to melphalan as a high dose regimen for autologous hematopoietic stem cell transplantation in multiple myeloma: long term follow up of a novel high dose regimen.
Authors: Hagen P. , D'Souza A. , Hari P. , Davila O. , Zhang M.J. , Vesole D.H. , Smith S.E. , Rodriguez T.E. , Stiff P.J. .
Source: Leukemia & Lymphoma, 2020 12; 61(14), p. 3484-3492.
EPub date: 2020-08-31 00:00:00.0.
PMID: 32865474
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Age no bar: A CIBMTR analysis of elderly patients undergoing autologous hematopoietic cell transplantation for multiple myeloma.
Authors: Munshi P.N. , Vesole D. , Jurczyszyn A. , Zaucha J.M. , St Martin A. , Davila O. , Agrawal V. , Badawy S.M. , Battiwalla M. , Chhabra S. , et al. .
Source: Cancer, 2020-12-01 00:00:00.0; 126(23), p. 5077-5087.
EPub date: 2020-09-23 00:00:00.0.
PMID: 32965680
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Pre-transplant marital status and hematopoietic cell transplantation outcomes.
Authors: Tay J. , Beattie S. , Bredeson C. , Brazauskas R. , He N. , Ahmed I.A. , Aljurf M. , Askar M. , Atsuta Y. , Badawy S. , et al. .
Source: Current Oncology (toronto, Ont.), 2020 12; 27(6), p. e596-e606.
EPub date: 2020-12-01 00:00:00.0.
PMID: 33380875
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Real-world evidence of tisagenlecleucel for pediatric acute lymphoblastic leukemia and non-Hodgkin lymphoma.
Authors: Pasquini M.C. , Hu Z.H. , Curran K. , Laetsch T. , Locke F. , Rouce R. , Pulsipher M.A. , Phillips C.L. , Keating A. , Frigault M.J. , et al. .
Source: Blood Advances, 2020-11-10 00:00:00.0; 4(21), p. 5414-5424.
PMID: 33147337
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Genetic factors rather than blast reduction determine outcomes of allogeneic HCT in BCR-ABL-negative MPN in blast phase.
Authors: Gupta V. , Kennedy J.A. , Capo-Chichi J.M. , Kim S. , Hu Z.H. , Alyea E.P. , Popat U.R. , Sobecks R.M. , Scott B.L. , Gerds A.T. , et al. .
Source: Blood Advances, 2020-11-10 00:00:00.0; 4(21), p. 5562-5573.
PMID: 33170935
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Novel prognostic scoring system for autologous hematopoietic cell transplantation in multiple myeloma.
Authors: Dhakal B. , D'Souza A. , Callander N. , Chhabra S. , Fraser R. , Davila O. , Anderson K. , Assal A. , Badawy S.M. , Berdeja J. , et al. .
Source: British Journal Of Haematology, 2020 11; 191(3), p. 442-452.
EPub date: 2020-10-23 00:00:00.0.
PMID: 33094839
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