Grant Number:	5U01CA199240-08 Interpret this number
Primary Investigator:	Schwartz, Ann
Organization:	Wayne State University
Project Title:	Detroit Research on Cancer Survivors (Detroit Rocs)
Fiscal Year:	2024

Project Summary/Abstract Despite progress made in early detection and treatment, African Americans continue to experience disproportionately higher cancer incidence rates, are first diagnosed with more advanced stage disease, and suffer higher mortality rates than other populations. The Detroit Research on Cancer Survivors (ROCS) study (U01CA199240) is the largest single cohort of African American cancer survivors aimed at understanding the multiplex causes of poorer outcomes in this population. Detroit ROCS has been collecting survey data and biospecimens with a goal of enrolling 5,000 population-based African Americans diagnosed with lung, breast, prostate, colorectal, and endometrial cancers and any early- onset cancer (diagnosed age 20-49 years) and supporting studies addressing determinants of cancer outcomes and quality of life. In this renewal application, we will continue to follow cohort survivors annually for up to 9 years to address the determinants of longer term outcomes (e.g., disease recurrence, second primary diagnoses, treatment related comorbidities and death) and quality of life. The broad research agenda will be developed with our community partners. We propose to: 1) conduct annual follow-up surveys on all living, enrolled participants for up to five additional years and collect additional biospecimens; 2) engage with members of the community to set new research priorities and to obtain input into the retention of participants and dissemination of research findings back to the community; 3) link Detroit ROCS patient data to other existing sources of health-related and exposure data to supplement patient-reported information; and 4) extend collaborations to facilitate use of the data and biospecimens by the broader research community. Detroit ROCS is providing substantial data and biospecimens to facilitate studies aimed at understanding and addressing determinants of poor outcomes in this population.




Correlates of health-related quality of life in African Americans diagnosed with cancer: a review of survivorship studies and the Detroit research on cancer survivors cohort.
Authors: Trendowski M.R. , Ruterbusch J.J. , Baird T.E. , Wenzlaff A.S. , Pandolfi S.S. , Hastert T.A. , Schwartz A.G. , Beebe-Dimmer J.L. .
Source: Cancer Metastasis Reviews, 2024-07-20 00:00:00.0; , .
EPub date: 2024-07-20 00:00:00.0.
PMID: 39033236
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Sleep health and quality of life in the Detroit Research on Cancer Survivors cohort.
Authors: Trendowski M.R. , Ruterbusch J.J. , Baird T. , Kyko J.M. , Martin J.L. , Schwartz A.G. , Markey G.E. , Badr M.S. , Beebe-Dimmer J.L. .
Source: Journal Of Cancer Survivorship : Research And Practice, 2024-03-20 00:00:00.0; , .
EPub date: 2024-03-20 00:00:00.0.
PMID: 38506953
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Age at diagnosis and social risks among Black cancer survivors: Results from the Detroit Research on Cancer Survivors cohort.
Authors: Hastert T.A. , McDougall J.A. , Robinson J.R.M. , Palakshappa D. , Seaton R. , Ruterbusch J.J. , Beebe-Dimmer J.L. , Schwartz A.G. .
Source: Cancer, 2024-01-27 00:00:00.0; , .
EPub date: 2024-01-27 00:00:00.0.
PMID: 38280205
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Housing instability and psychological distress in African American cancer survivors: findings from the Detroit Research on Cancer Survivors study.
Authors: Robinson J.R.M. , Hastert T.A. , Beebe-Dimmer J.L. , Schwartz A.G. , Ruterbusch J.J. , Pandolfi S.S. , Rundle A.G. .
Source: Journal Of Cancer Survivorship : Research And Practice, 2023-10-06 00:00:00.0; , .
EPub date: 2023-10-06 00:00:00.0.
PMID: 37798594
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The impact of preexisting comorbidities on receipt of cancer therapy among women with Stage I-III breast cancer in the Detroit Research on Cancer Survivors cohort.
Authors: Raychaudhuri S. , Kyko J.M. , Ruterbusch J.J. , Pandolfi S.S. , Beebe-Dimmer J.L. , Schwartz A.G. , Simon M.S. .
Source: Cancer Medicine, 2023-08-11 00:00:00.0; , .
EPub date: 2023-08-11 00:00:00.0.
PMID: 37563982
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Use of electronic cigarettes among African American cancer survivors.
Authors: Wharram C.E. , Kyko J.M. , Ruterbusch J.J. , Beebe-Dimmer J.L. , Schwartz A.G. , Cote M.L. .
Source: Cancer, 2023-07-03 00:00:00.0; , .
EPub date: 2023-07-03 00:00:00.0.
PMID: 37395113
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Quality of life in endometrial cancer survivors by grade of disease.
Authors: Banning K. , Fucinari J. , Fielder A. , Ruterbusch J.J. , Beebe-Dimmer J.L. , Schwartz A.G. , Wallbillich J.J. , Cote M.L. .
Source: Cancer Medicine, 2023-05-06 00:00:00.0; , .
EPub date: 2023-05-06 00:00:00.0.
PMID: 37148545
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Association between major discrimination and deficit accumulation in African American cancer survivors: The Detroit Research on Cancer Survivors Study.
Authors: Mandelblatt J.S. , Ruterbusch J.J. , Thompson H.S. , Zhou X. , Bethea T.N. , Adams-Campbell L. , Purrington K. , Schwartz A.G. .
Source: Cancer, 2023-03-20 00:00:00.0; , .
EPub date: 2023-03-20 00:00:00.0.
PMID: 36935617
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Chemotherapy-induced peripheral neuropathy in the detroit research on cancer survivors (ROCS) cohort.
Authors: Sreeram K. , Seaton R. , Greenwald M.K. , Kamgar M. , Assad H. , Baird T. , Schwartz A.G. , Ruterbusch J. , Simon M.S. .
Source: Cancer Causes & Control : Ccc, 2023-03-19 00:00:00.0; , .
EPub date: 2023-03-19 00:00:00.0.
PMID: 36934365
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Caregiver costs and financial burden in caregivers of African American cancer survivors.
Authors: Hastert T.A. , Kyko J.M. , Ruterbusch J.J. , Robinson J.R.M. , Kamen C.S. , Beebe-Dimmer J.L. , Nair M. , Thompson H.S. , Schwartz A.G. .
Source: Journal Of Cancer Survivorship : Research And Practice, 2022-10-24 00:00:00.0; , .
EPub date: 2022-10-24 00:00:00.0.
PMID: 36274101
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Evaluation of health behaviors and overall quality of life in younger adult African American cancer survivors.
Authors: Trendowski M.R. , Kyko J.M. , Lusk C.M. , Ruterbusch J.J. , Hastert T.A. , Harper F.W.K. , Thompson H. , Beebe-Dimmer J.L. , Schwartz A.G. .
Source: Cancer Medicine, 2022-06-02 00:00:00.0; , .
EPub date: 2022-06-02 00:00:00.0.
PMID: 35655423
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Financial Hardship by Age at Diagnosis Including in Young Adulthood among African American Cancer Survivors.
Authors: Hastert T.A. , Ruterbusch J.J. , Abrams J. , Nair M. , Wenzlaff A.S. , Beebe-Dimmer J.L. , Pandolfi S.S. , Schwartz A.G. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2022-04-01 00:00:00.0; 31(4), p. 876-884.
PMID: 35064060
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The impact of the COVID-19 pandemic on African American cancer survivors.
Authors: Beebe-Dimmer J.L. , Lusk C.M. , Ruterbusch J.J. , Baird T.E. , Pandolfi S.S. , Wenzlaff A.S. , Hastert T.A. , Harper F.W.K. , Thompson H.S. , Schwartz A.G. .
Source: Cancer, 2021-10-27 00:00:00.0; , .
EPub date: 2021-10-27 00:00:00.0.
PMID: 34706056
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Chemotherapy-induced peripheral neuropathy in African American cancer survivors: Risk factors and quality of life outcomes.
Authors: Trendowski M.R. , Lusk C.M. , Ruterbusch J.J. , Seaton R. , Simon M.S. , Greenwald M.K. , Harper F.W.K. , Beebe-Dimmer J.L. , Schwartz A.G. .
Source: Cancer Medicine, 2021-10-23 00:00:00.0; , .
EPub date: 2021-10-23 00:00:00.0.
PMID: 34687150
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Neighborhood walkability and body mass index in African American cancer survivors: The Detroit Research on Cancer Survivors study.
Authors: Robinson J.R.M. , Beebe-Dimmer J.L. , Schwartz A.G. , Ruterbusch J.J. , Baird T.E. , Pandolfi S.S. , Hastert T.A. , Quinn J.W. , Rundle A.G. .
Source: Cancer, 2021-08-18 00:00:00.0; , .
EPub date: 2021-08-18 00:00:00.0.
PMID: 34406654
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Social needs and health-related quality of life among African American cancer survivors: Results from the Detroit Research on Cancer Survivors study.
Authors: Hastert T.A. , McDougall J.A. , Strayhorn S.M. , Nair M. , Beebe-Dimmer J.L. , Schwartz A.G. .
Source: Cancer, 2020-11-23 00:00:00.0; , .
EPub date: 2020-11-23 00:00:00.0.
PMID: 33225460
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Work changes and individual, cancer-related, and work-related predictors of decreased work participation among African American cancer survivors.
Authors: Hastert T.A. , Kirchhoff A.C. , Banegas M.P. , Morales J.F. , Nair M. , Beebe-Dimmer J.L. , Pandolfi S.S. , Baird T.E. , Schwartz A.G. .
Source: Cancer Medicine, 2020-11-07 00:00:00.0; , .
EPub date: 2020-11-07 00:00:00.0.
PMID: 33159501
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Caregiving burden among informal caregivers of African American cancer survivors.
Authors: Schwartz K. , Beebe-Dimmer J. , Hastert T.A. , Ruterbusch J.J. , Mantey J. , Harper F. , Thompson H. , Pandolfi S. , Schwartz A.G. .
Source: Journal Of Cancer Survivorship : Research And Practice, 2020-10-17 00:00:00.0; , .
EPub date: 2020-10-17 00:00:00.0.
PMID: 33067774
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Heritable Susceptibility to Breast Cancer among African-American Women in the Detroit Research on Cancer Survivors Study.
Authors: Purrington K.S. , Raychaudhuri S. , Simon M.S. , Clark J. , Ratliff V. , Dyson G. , Craig D.B. , Boerner J.L. , Beebe-Dimmer J.L. , Schwartz A.G. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2020-08-31 00:00:00.0; , .
EPub date: 2020-08-31 00:00:00.0.
PMID: 32868316
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Continued smoking in African American cancer survivors: The Detroit Research on Cancer Survivors Cohort.
Authors: Malburg C.M. , Fucinari J. , Ruterbusch J.J. , Ledgerwood D.M. , Beebe-Dimmer J.L. , Schwartz A.G. , Cote M.L. .
Source: Cancer Medicine, 2020-08-21 00:00:00.0; , .
EPub date: 2020-08-21 00:00:00.0.
PMID: 32822118
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Patterns of cancer family history and genetic counseling eligibility among African Americans with breast, prostate, lung, and colorectal cancers: A Detroit Research on Cancer Survivors cohort study.
Authors: Purrington K.S. , Schwartz A.G. , Ruterbusch J.J. , Manning M.A. , Nair M. , Wenzlaff A.S. , Pandolfi S.S. , Simon M.S. , Beebe-Dimmer J. .
Source: Cancer, 2020-08-04 00:00:00.0; , .
EPub date: 2020-08-04 00:00:00.0.
PMID: 32749684
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Physical activity and quality of life in African American cancer survivors: The Detroit Research on Cancer Survivors study.
Authors: Beebe-Dimmer J.L. , Ruterbusch J.J. , Harper F.W.K. , Baird T.M. , Finlay D.G. , Rundle A.G. , Pandolfi S.S. , Hastert T.A. , Schwartz K.L. , Bepler G. , et al. .
Source: Cancer, 2020-02-24 00:00:00.0; , .
EPub date: 2020-02-24 00:00:00.0.
PMID: 32090322
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Employment Outcomes, Financial Burden, Anxiety, and Depression Among Caregivers of African American Cancer Survivors.
Authors: Hastert T.A. , Ruterbusch J.J. , Nair M. , Noor M.I. , Beebe-Dimmer J.L. , Schwartz K. , Baird T.E. , Harper F.W.K. , Thompson H. , Schwartz A.G. .
Source: Journal Of Oncology Practice, 2019-09-07 00:00:00.0; , p. JOP1900410.
EPub date: 2019-09-07 00:00:00.0.
PMID: 31496392
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Financial Hardship and Quality of Life among African American and White Cancer Survivors: The Role of Limiting Care Due to Cost.
Authors: Hastert T.A. , Kyko J.M. , Reed A.R. , Harper F.W.K. , Beebe-Dimmer J.L. , Baird T.E. , Schwartz A.G. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2019 Jul; 28(7), p. 1202-1211.
EPub date: 2019-05-06 00:00:00.0.
PMID: 31061097
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The Detroit Research on Cancer Survivors (ROCS) Pilot Study: A focus on outcomes after cancer in a racially-diverse patient population.
Authors: Beebe-Dimmer J.L. , Albrecht T.L. , Baird T.E. , Ruterbusch J.J. , Hastert T. , Harper F.W.K. , Simon M.S. , Abrams J. , Schwartz K.L. , Schwartz A.G. .
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2018-11-27 00:00:00.0; , .
EPub date: 2018-11-27 00:00:00.0.
PMID: 30482875
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