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Grant Details

Grant Number: 5R37CA246565-04 Interpret this number
Primary Investigator: Hua, May
Organization: Columbia University Health Sciences
Project Title: Determinants of Palliative Care Effectiveness for Patients with Metastatic Cancer
Fiscal Year: 2024


Project Summary Palliative care is an interdisciplinary model of care with the overarching goal of improving quality of life for patients with serious illness through symptom management, provision of psychosocial support, elicitation of preferences and aiding decision-making. Prior studies have demonstrated that specialist palliative care is associated with decreases in treatment intensity and improvements in quality of life, but have also suggested that existing heterogeneity among palliative care teams may be associated with variability in their effectiveness. Early integration of specialist palliative care for patients with advanced cancer has been recommended by the American Society of Clinical Oncology. However, as hospitals race to implement palliative care programs to meet these guidelines, there is little evidence to guide them as to which ingredients are necessary for effective care delivery. The proposed research will target this important knowledge gap by 1) quantifying the association between use of specialist palliative care and end-of-life quality metrics in cancer care, 2) examining whether differences in specialist palliative care implementation (as measured by key variables reflecting team attributes and operational characteristics) are associated with improvements in quality metrics and 3) using qualitative research methods to understand how programs operationalize care delivery within different hospital settings. This project will create and utilize a novel data source that combines nationwide patient and hospital-level data, detailed data on palliative care programs and valid information on receipt of specialist palliative care. Quantitative analyses of this unique dataset will be followed by in-depth site visits to six select palliative care programs; together, these data will be used to develop an actionable roadmap that may be used to refine existing palliative care programs and inform implementation of future programs to ensure effective delivery of palliative care for patients with cancer. This project represents an important advance in understanding the role of palliative care specialists in cancer care, as prior work has focused on whether specialist palliative care is associated with improved outcomes, while this work will focus identifying the conditions under which specialist palliative care may achieve improved outcomes.


Specialist Palliative Care Use and End-of-Life Care in Patients With Metastatic Cancer.
Authors: Hua M. , Guo L. , Ing C. , Lackraj D. , Wang S. , Morrison R.S. .
Source: Journal of pain and symptom management, 2024 May; 67(5), p. 357-365.e15.
EPub date: 2024-01-24.
PMID: 38278187
Related Citations

A Multivariable Model Predictive of Unplanned Postoperative Intubation in Infant Surgical Patients.
Authors: Eisler L.D. , Hua M. , Li G. , Sun L.S. , Kim M. .
Source: Anesthesia and analgesia, 2019 Dec; 129(6), p. 1645-1652.
PMID: 31743186
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