Grant Number:	5R01CA270546-02 Interpret this number
Primary Investigator:	Evans-Polce, Rebecca
Organization:	University Of Michigan At Ann Arbor
Project Title:	E-Cigarette Use Among U.S. Adolescents and Young Adults: Longitudinal Associations with Tobacco Use and Health and Dimensions of Risk and Protection
Fiscal Year:	2024

PROJECT SUMMARY/ABSTRACT One-third of U.S. adolescents and young adults (AYAs) report e-cigarette (EC) use, making it the leading nicotine/tobacco product used by AYAs. Most longitudinal studies of e-cigarette use only focus on short-term outcomes 1-3 years later, do not fully examine newer vs. older generation e-cigarette products, and do not consider potential differences by sex, age, race/ethnicity, educational attainment, or sexual orientation. Potential bias in e-cigarette estimates over time is not well understood. These gaps warrant longer-term prospective investigations with clinically relevant measures in diverse national samples of AYAs. This project will identify longitudinal trajectories of e-cigarette use and their relationships with cigarette smoking, other nicotine/tobacco products, other substance use, tobacco use disorder (TUD) symptoms, nicotine/tobacco cessation, and health consequences related to nicotine/tobacco use among U.S. AYAs. Our study aims to: (1) Compare state-of-the-art statistical approaches for reducing nonresponse bias in estimates of trajectories and survival models for EC use due to differential attrition, and evaluate the reporting bias associated with self- reports of EC use using biomarker data; (2) Examine the initiation of e-cigarette use and transitions with other nicotine/tobacco product use and other substance use in AYAs over 4- and 7-year time periods of longitudinal data; (3) Identify the trajectories of EC, cigarette, and other tobacco use and their longitudinal relationships with adverse health consequences (e.g., TUD symptoms, health problems) measured with survey and biomarker data in AYAs over 4- and 7-year time periods, and determine if trajectories or consequences differ by age, sex, race/ethnicity, education, sexual orientation, or newer vs. older e-cigarette products; and (4) Based on the Social Ecological Model, assess multiple levels of risk and protective factors (and interactions across levels) for EC use trajectories and their associations with other nicotine/tobacco use, tobacco cessation, and health consequences over 4- and 7-year time periods, and examine if EC use trajectories and their associations with other nicotine/tobacco use, tobacco cessation, and health consequences differ by age, sex, race/ethnicity, education, sexual orientation, or newer vs. older EC products. An experienced team will conduct secondary analyses of longitudinal data from the Monitoring the Future (MTF) and Population Assessment of Tobacco and Health (PATH) studies. These two epidemiological studies are the most recent and largest nationally representative longitudinal studies that allow for the identification of long-term trajectories and consequences of EC use among AYAs. This project will use longitudinal data from a nationally representative sample of 9,800 secondary students measured between 2014 and 2020 in the MTF study, and a prospective nationally representative sample of 13,651 adolescents (12-17 years), 9,802 young adults (18-25 years), and 22,506 adults (26 and older) measured across six waves in the PATH study (2013/2014-2020).




Risk and Protective Factors Associated With Susceptibility to Electronic Nicotine Delivery Systems Initiation in Adolescence.
Authors: Staff J. , Mongilio J.M. , Vuolo M. , Maggs J.L. , Kelly B.C. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2026-06-23 00:00:00.0; 28(7), p. 1156-1162.
PMID: 41439576
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Nicotine and tobacco transitions among US youth using electronic nicotine delivery systems (ENDS): Associations with frequency, nicotine dependence, and biomarkers of exposure.
Authors: Evans-Polce R.J. , Lim C. , Smith D.M. , Mongilio J.M. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2026-05-18 00:00:00.0; , .
EPub date: 2026-05-18 00:00:00.0.
PMID: 42149979
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Comprehensive E-Cigarette Policies Are Associated With Lower Use Among U.S. Adolescents and Young Adults.
Authors: Kcomt L. , Mongilio J. , Lim C. , Clift J. , Pasman E. , Evans-Polce R.J. .
Source: Journal Of Studies On Alcohol And Drugs, 2026-03-24 00:00:00.0; , .
EPub date: 2026-03-24 00:00:00.0.
PMID: 41874188
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Comprehensive E-Cigarette Policies Are Associated With Lower Use Among U.S. Adolescents and Young Adults.
Authors: Kcomt L. , Mongilio J. , Lim C. , Clift J. , Pasman E. , Evans-Polce R.J. .
Source: Journal Of Studies On Alcohol And Drugs, 2026-03-24 00:00:00.0; , .
EPub date: 2026-03-24 00:00:00.0.
PMID: 41874188
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Comprehensive E-Cigarette Policies Are Associated With Lower Use Among U.S. Adolescents and Young Adults.
Authors: Kcomt L. , Mongilio J. , Lim C. , Clift J. , Pasman E. , Evans-Polce R.J. .
Source: Journal Of Studies On Alcohol And Drugs, 2026-03-24 00:00:00.0; , .
EPub date: 2026-03-24 00:00:00.0.
PMID: 41874188
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Parental death and parental substance use problems during childhood and the risk of DSM-5 subsance use, suicidality and mental health disorders.
Authors: Giang C.W. , Evans-Polce R.J. , Kcomt L. , Dickinson K. , Gurnik H. , Truchan J. , Hess I. , McCabe S.E. .
Source: Social Psychiatry And Psychiatric Epidemiology, 2026-03-13 00:00:00.0; , .
EPub date: 2026-03-13 00:00:00.0.
PMID: 41824018
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Variation in quantity of puffs per day among U.S. adolescents and young adults using electronic nicotine delivery systems.
Authors: Mongilio J.M. , Kcomt L. , Evans-Polce R.J. .
Source: Drug And Alcohol Dependence, 2026-03-11 00:00:00.0; 282, p. 113121.
EPub date: 2026-03-11 00:00:00.0.
PMID: 41832857
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Childhood Mortality by Parental Cause of Death.
Authors: McCabe S.E. , Kcomt L. , Evans-Polce R.J. , Radford G. , Tennant S.D. , Hulsey E. , McCabe V.V. .
Source: Jama Network Open, 2026-03-02 00:00:00.0; 9(3), p. e262790.
EPub date: 2026-03-02 00:00:00.0.
PMID: 41870432
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Childhood Mortality by Parental Cause of Death.
Authors: McCabe S.E. , Kcomt L. , Evans-Polce R.J. , Radford G. , Tennant S.D. , Hulsey E. , McCabe V.V. .
Source: Jama Network Open, 2026-03-02 00:00:00.0; 9(3), p. e262790.
EPub date: 2026-03-02 00:00:00.0.
PMID: 41870432
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Childhood Mortality by Parental Cause of Death.
Authors: McCabe S.E. , Kcomt L. , Evans-Polce R.J. , Radford G. , Tennant S.D. , Hulsey E. , McCabe V.V. .
Source: Jama Network Open, 2026-03-02 00:00:00.0; 9(3), p. e262790.
EPub date: 2026-03-02 00:00:00.0.
PMID: 41870432
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Changes in ENDS Harm Perceptions Predict Intentions to Initiate ENDS Use in Tobacco-Naive Adolescents.
Authors: Mongilio J.M. , Kcomt L. , Staff J. , Evans-Polce R.J. .
Source: Journal Of Studies On Alcohol And Drugs, 2026-02-16 00:00:00.0; , .
EPub date: 2026-02-16 00:00:00.0.
PMID: 41696861
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Patterns of ENDS-Related Content Exposure on Social Media among U.S. Adolescents and Young Adults.
Authors: Mongilio J.M. , Kcomt L. , Lanza S.T. , Pasman E. , Clift J. , Evans-Polce R.J. .
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2025-12-19 00:00:00.0; , .
EPub date: 2025-12-19 00:00:00.0.
PMID: 41416739
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Heterogeneity in Nicotine, Tobacco, and Cannabis Use Among U.S. Adolescents and Adults Aged 12-34 Years.
Authors: Evans-Polce R.J. , Mongilio J.M. , McCabe S.E. , Veliz P.T. .
Source: American Journal Of Preventive Medicine, 2025 Nov; 69(5), p. 108033.
EPub date: 2025-08-05 00:00:00.0.
PMID: 40763833
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Patterns of substance use on a given day in a national sample of U.S. young adults.
Authors: Evans-Polce R.J. , Arterberry B.J. , Lanza S.T. , Patrick M.E. .
Source: Addictive Behaviors, 2025 Sep; 168, p. 108376.
EPub date: 2025-04-29 00:00:00.0.
PMID: 40319792
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Risk of adolescent cigarette use in three UK birth cohorts before and after e-cigarettes.
Authors: Mongilio J.M. , Staff J. , Seto C.H. , Maggs J.L. , Evans-Polce R.J. .
Source: Tobacco Control, 2025-07-29 00:00:00.0; , .
EPub date: 2025-07-29 00:00:00.0.
PMID: 40730479
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Trends and Sociodemographic Differences in Tobacco/Nicotine Transitions Among U.S. Adolescents and Young Adults Using e-cigarettes, 2014-2023.
Authors: Evans-Polce R.J. , Mongilio J.M. , Kcomt L. , Chen B. , McCabe S.E. .
Source: The Journal Of Adolescent Health : Official Publication Of The Society For Adolescent Medicine, 2025 May; 76(5), p. 920-927.
EPub date: 2025-02-19 00:00:00.0.
PMID: 39969469
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Attention-Deficit/Hyperactivity Disorder Symptoms and Later E-Cigarette and Tobacco Use in US Youths.
Authors: McCabe S.E. , Pasman E. , Wilens T. , Boyd C.J. , Veliz P. , McCabe V. , Chen B. , Dickinson K. , Evans-Polce R.J. .
Source: Jama Network Open, 2025-02-03 00:00:00.0; 8(2), p. e2458834.
EPub date: 2025-02-03 00:00:00.0.
PMID: 39932711
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Assessing the Association Between Respiratory Symptoms and Nicotine and Cannabis Use Through Traditional and E-Product Devices in the U.S.
Authors: Veliz P. , Jardine J. , Kcomt L. , Boyd C. , McCabe S.E. , Evans-Polce R. .
Source: Ajpm Focus, 2025 Feb; 4(1), p. 100291.
EPub date: 2024-10-22 00:00:00.0.
PMID: 40225959
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Longitudinal associations of e-cigarette use with cigarette, marijuana, and other drug use initiation among US adolescents and young adults: Findings from the population assessment of tobacco and health study (Waves 1-6).
Authors: Evans-Polce R.J. , Chen B. , McCabe S.E. , West B.T. .
Source: Drug And Alcohol Dependence, 2024-10-01 00:00:00.0; 263, p. 111402.
EPub date: 2024-07-26 00:00:00.0.
PMID: 39137612
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Cigarette and e-cigarette use trajectories and prospective prescription psychotherapeutic drug misuse among adolescents and young adults.
Authors: Harton M.R. , Seo D.C. , Evans-Polce R.J. , Nguyen I. , Parker M.A. .
Source: Addictive Behaviors, 2023 Dec; 147, p. 107818.
EPub date: 2023-07-28 00:00:00.0.
PMID: 37540966
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Cigarette and e-cigarette use trajectories and prospective prescription psychotherapeutic drug misuse among adolescents and young adults.
Authors: Harton M.R. , Seo D.C. , Evans-Polce R.J. , Nguyen I. , Parker M.A. .
Source: Addictive Behaviors, 2023 Dec; 147, p. 107818.
EPub date: 2023-07-28 00:00:00.0.
PMID: 37540966
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Cigarette and e-cigarette use trajectories and prospective prescription psychotherapeutic drug misuse among adolescents and young adults.
Authors: Harton M.R. , Seo D.C. , Evans-Polce R.J. , Nguyen I. , Parker M.A. .
Source: Addictive Behaviors, 2023 Dec; 147, p. 107818.
EPub date: 2023-07-28 00:00:00.0.
PMID: 37540966
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Social Ecological Influences on Nicotine/Tobacco Use Among Gender-Varying and Gender-Stable Adolescents and Adults in the USA.
Authors: Kcomt L. , Evans-Polce R.J. , Engstrom C.W. , Takahashi J. , Matthews P.A. , Veliz P.T. , West B.T. , McCabe S.E. .
Source: Annals Of Behavioral Medicine : A Publication Of The Society Of Behavioral Medicine, 2023-11-20 00:00:00.0; , .
EPub date: 2023-11-20 00:00:00.0.
PMID: 37983126
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Sexual Identity Differences in Tobacco (Re)Uptake: Testing Mediation by Internalizing and Externalizing Symptoms.
Authors: Evans-Polce R.J. , Schuler M.S. , Kcomt L. , McCabe V.V. , McCabe S.E. .
Source: American Journal Of Preventive Medicine, 2023 Jun; 64(6), p. 824-833.
EPub date: 2023-02-09 00:00:00.0.
PMID: 36774307
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Examining sexual identity stability and change over time and associations with tobacco use in a nationally representative US sample.
Authors: Evans-Polce R.J. , Veliz P. , Kcomt L. , Boyd C.J. , Esteban McCabe S. .
Source: Addictive Behaviors, 2023 Jun; 141, p. 107661.
EPub date: 2023-02-11 00:00:00.0.
PMID: 36821882
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