Grant Details
Grant Number: |
4R00CA256525-03 Interpret this number |
Primary Investigator: |
Huang, Brian |
Organization: |
University Of Southern California |
Project Title: |
Integrating Epidemiologic, Clinical, Genomic and Metabolomic Profiles to Predict Pancreatic Cancer Risk in a Multiethnic Population |
Fiscal Year: |
2023 |
Abstract
ABSTRACT
Pancreatic cancer is a highly lethal malignancy that has a very poor prognosis in the United States. It has a 5-
year survival rate of only 9% and is projected to become the second most common cancer death by 2030.
Pancreatic cancer also has a disproportionate burden across race/ethnicity, with higher incidence rates observed
among minority groups, such African Americans, Japanese Americans, and Native Hawaiians. Past prediction
models have been developed to identify high-risk individuals and improve the earlier detection of this disease.
However, these models were designed in individuals of primarily European or Asian ancestry and have not been
validated in multiethnic populations. In addition, these models included mainly known epidemiologic risk factors
and only a few incorporated data on genetic variants or health conditions. Thus, a model that employs more
granular data, such as comorbidities/symptoms, genomics and metabolomics, for the prediction of pancreatic
cancer across multiple races/ethnicities does not exist. In this study, we seek to apply an integrative systems
biology approach to enhance the prediction of pancreatic cancer risk using data from the Multiethnic Cohort
(MEC) Study. The MEC is a long-standing prospective cohort of over 215,000 racially diverse individuals that
has comprehensive lifestyle, environmental, clinical, and genetic data. We will use data from existing resources
of the MEC, including epidemiologic risk factors from questionnaires, clinical health conditions from Medicare
claims, genetic data from a large biorepository of blood samples, and cancer incidence and mortality information
from SEER Cancer registries and state and national mortality databases. We will also generate new metabolomic
data for a subset of MEC participants. Our specific aims are: 1) to identify clusters or patterns of clinical conditions
associated with pancreatic cancer risk; 2) to validate existing prediction models in a multiethnic population and
develop an enhanced prediction model that incorporates epidemiologic, clinical and genomic data; 3) to identify
metabolites associated with pancreatic cancer in a multiethnic population; and 4) to integrate epidemiologic,
clinical, genomic and metabolomic data to identify individuals at high risk of pancreatic cancer. Results from this
study are expected to elucidate etiologic mechanisms and improve the prediction of pancreatic cancer risk for
heterogeneous populations. This will have significant implications for improving strategies for earlier detection
and reducing the overwhelming burden of this fatal cancer.
Publications
Response to Zhou.
Authors: Yamazaki H.
, Heni M.
, Wagner R.
, Huang B.Z.
.
Source: The American Journal Of Gastroenterology, 2024-11-20 00:00:00.0; , .
EPub date: 2024-11-20 00:00:00.0.
PMID: 39564999
Related Citations
The Causal Effect of Intra-Pancreatic Fat Deposition on Acute and Chronic Pancreatitis: A Mendelian Randomization Study.
Authors: Yamazaki H.
, Heni M.
, Wagner R.
, Fukuhara S.
, Grossman S.R.
, Han S.
, Wu L.
, Streicher S.A.
, Huang B.Z.
.
Source: The American Journal Of Gastroenterology, 2024-08-20 00:00:00.0; , .
EPub date: 2024-08-20 00:00:00.0.
PMID: 39162745
Related Citations
Genetic Evidence for a Causal Link between Intra-Pancreatic Fat Deposition and Pancreatitis: a Mendelian Randomization Study.
Authors: Yamazaki H.
, Heni M.
, Wagner R.
, Fukuhara S.
, Grossman S.R.
, Han S.
, Wu L.
, Streicher S.A.
, Huang B.Z.
.
Source: Medrxiv : The Preprint Server For Health Sciences, 2024-06-04 00:00:00.0; , .
EPub date: 2024-06-04 00:00:00.0.
PMID: 38883800
Related Citations
Genetically Determined Circulating Lactase/Phlorizin Hydrolase Concentrations and Risk of Colorectal Cancer: A Two-Sample Mendelian Randomization Study.
Authors: Han S.
, Yao J.
, Yamazaki H.
, Streicher S.A.
, Rao J.
, Nianogo R.A.
, Zhang Z.
, Huang B.Z.
.
Source: Nutrients, 2024-03-12 00:00:00.0; 16(6), .
EPub date: 2024-03-12 00:00:00.0.
PMID: 38542719
Related Citations
Epigenome-wide association study of total nicotine equivalents in multiethnic current smokers from three prospective cohorts.
Authors: Huang B.Z.
, Binder A.M.
, Quon B.
, Patel Y.M.
, Lum-Jones A.
, Tiirikainen M.
, Murphy S.E.
, Loo L.
, Maunakea A.K.
, Haiman C.A.
, et al.
.
Source: American Journal Of Human Genetics, 2024-03-07 00:00:00.0; 111(3), p. 456-472.
EPub date: 2024-02-16 00:00:00.0.
PMID: 38367619
Related Citations
Evidence for a causal link between intra-pancreatic fat deposition and pancreatic cancer: A prospective cohort and Mendelian randomization study.
Authors: Yamazaki H.
, Streicher S.A.
, Wu L.
, Fukuhara S.
, Wagner R.
, Heni M.
, Grossman S.R.
, Lenz H.J.
, Setiawan V.W.
, Le Marchand L.
, et al.
.
Source: Cell Reports. Medicine, 2024-02-20 00:00:00.0; 5(2), p. 101391.
EPub date: 2024-01-26 00:00:00.0.
PMID: 38280379
Related Citations
Rising Incidence and Racial Disparities of Early-Onset Pancreatic Cancer in the United States, 1995-2018.
Authors: Huang B.Z.
, Liu L.
, Zhang J.
, USC Pancreas Research Team
, Pandol S.J.
, Grossman S.R.
, Setiawan V.W.
.
Source: Gastroenterology, 2022 Jul; 163(1), p. 310-312.e1.
EPub date: 2022-03-11 00:00:00.0.
PMID: 35288111
Related Citations
Healthcare Utilization Among Patients Diagnosed with COVID-19 in a Large Integrated Health System.
Authors: Huang B.Z.
, Creekmur B.
, Yoo M.S.
, Broder B.
, Subject C.
, Sharp A.L.
.
Source: Journal Of General Internal Medicine, 2022 03; 37(4), p. 830-837.
EPub date: 2022-01-06 00:00:00.0.
PMID: 34993879
Related Citations
Pre-Existing Pancreatitis and Elevated Risks of COVID-19 Severity and Mortality.
Authors: Huang B.Z.
, Sidell M.A.
, Wu B.U.
, Setiawan V.W.
, Chen Z.
, Xiang A.H.
.
Source: Gastroenterology, 2022-02-08 00:00:00.0; , .
EPub date: 2022-02-08 00:00:00.0.
PMID: 35149034
Related Citations
Asthma Disease Status, COPD, and COVID-19 Severity in a Large Multiethnic Population.
Authors: Huang B.Z.
, Chen Z.
, Sidell M.A.
, Eckel S.P.
, Martinez M.P.
, Lurmann F.
, Thomas D.C.
, Gilliland F.D.
, Xiang A.H.
.
Source: The Journal Of Allergy And Clinical Immunology. In Practice, 2021 10; 9(10), p. 3621-3628.e2.
EPub date: 2021-08-10 00:00:00.0.
PMID: 34389242
Related Citations
Red meat consumption, cooking mutagens, NAT1/2 genotypes and pancreatic cancer risk in two ethnically diverse prospective cohorts.
Authors: Huang B.Z.
, Wang S.
, Bogumil D.
, Wilkens L.R.
, Wu L.
, Blot W.J.
, Zheng W.
, Shu X.O.
, Pandol S.J.
, Le Marchand L.
, et al.
.
Source: International Journal Of Cancer, 2021-04-12 00:00:00.0; , .
EPub date: 2021-04-12 00:00:00.0.
PMID: 33844845
Related Citations