Grant Details
Grant Number: |
5U2CCA252971-03 Interpret this number |
Primary Investigator: |
Lenz, Heinz Josef |
Organization: |
University Of Southern California |
Project Title: |
Usc Pe-Gcs: Optimizing Engagement of Hispanic Colorectal Cancer Patients in Cancer Genomic Characterization Studies |
Fiscal Year: |
2023 |
Abstract
ABSTRACT
Colorectal Cancer (CRC) is the second leading cause of cancer death in the US. Hispanic/Latinos are the largest
and fasting growing ethnic group in the US, and cancer is the leading cause of death among H/L in the US.
Therefore, we need to fully understand the full complexity of the molecular etiology of cancer in this ethnic group.
For instance, although incidence rates of CRC are lower among Latinos as compared to Whites or African
Americans, Hispanics with metastatic disease have shorter overall survival when adjusted for health care setting,
demographics, disease characteristics and treatment factors. H/L also tend to be diagnosed at a younger age
and with higher stage, and we have previously reported that Mexican H/L in California have the greatest
proportion of young (<50 years of age) diagnoses compared to other H/L subgroups. Moreover, Mexican H/L
showed higher prevalence of rectal cancer cases compared to other H/L and NHW. Although socio-economics
and access to care might influence these differences, we need to take a complete look at the biology of disease
in this ethnic group to determine once and for all if these clinical differences are related to differences in molecular
etiology. The Cancer Genome Atlas has provided a deep overview of the molecular taxonomy of CRC in 594
cases, however, less than 1% of the cases (n=5) were H/L. Therefore, it is imperative for us to take more detailed
assessment of the molecular genomic landscape of CRC in H/L. One of the major issues likely limiting our ability
to perform these large genomic initiatives in minority patients is that Patient or Participant Engagement practices
may not been investigated to identify best practices for accruing and consenting patients into clinical translational
biomedical research studies. This concept of Participant Engagement is critically important for both the patients
and the translational cancer research community. Optimizing and improving our approaches for directly
engaging patients at initial contact, throughout the course of a translational genomic study, and during the time
of return of results is likely to lead to stronger relationships between the medical community and patients, but
could also lead to significant improvement in outcomes for patients and for the cancer care community as a
whole. As such, we propose the creation of the USC Center for Optimization of Participant Engagement in
Cancer Characterization (COPECC) with a focus on optimizing the engagement of Latinos in CRC Genomic
Characterization research studies. USC COPECC would serve as a member of the NCI U2C Participant
Engagement and Cancer Genome Sequencing (PE-CGS) Network. Our investigative team includes experts in
all relevant areas of research for genomic characterization, participant engagement, and engagement
optimization. We have an established platform for consenting patients into cancer genomics studies that will
serve as a standard process. The overall goal of USC COPECC is to generate results on participant engagement
optimization and CRC genomic research that will be shared with the broader community to distribute best
practices for engaging Latinos in hopes of improving overall outcomes for CRC in this underserved population.
Publications
Integrative multi-omics profiling of colorectal cancer from a Hispanic/Latino cohort of patients.
Authors: Waldrup B.
, Carranza F.
, Jin Y.
, Amzaleg Y.
, Postel M.
, Craig D.W.
, Carpten J.D.
, Salhia B.
, Ricker C.N.
, Culver J.O.
, et al.
.
Source: Medrxiv : The Preprint Server For Health Sciences, 2024-11-15 00:00:00.0; , .
EPub date: 2024-11-15 00:00:00.0.
PMID: 39606335
Related Citations
Colorectal cancer outcomes among Hispanic/Latino patients in the United States: a scoping review protocol.
Authors: Sanchez-Mendez J.
, Quino J.E.
, Xiong W.
, Stern M.C.
.
Source: Jbi Evidence Synthesis, 2024-07-01 00:00:00.0; 22(7), p. 1347-1354.
EPub date: 2024-07-01 00:00:00.0.
PMID: 38745480
Related Citations
Genetic risk impacts the association of menopausal hormone therapy with colorectal cancer risk.
Authors: Tian Y.
, Lin Y.
, Qu C.
, Arndt V.
, Baurley J.W.
, Berndt S.I.
, Bien S.A.
, Bishop D.T.
, Brenner H.
, Buchanan D.D.
, et al.
.
Source: British Journal Of Cancer, 2024 Jun; 130(10), p. 1687-1696.
EPub date: 2024-04-01 00:00:00.0.
PMID: 38561434
Related Citations
Genome-Wide Gene-Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk.
Authors: Stern M.C.
, Sanchez Mendez J.
, Kim A.E.
, Obón-Santacana M.
, Moratalla-Navarro F.
, Martín V.
, Moreno V.
, Lin Y.
, Bien S.A.
, Qu C.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2024-03-01 00:00:00.0; 33(3), p. 400-410.
PMID: 38112776
Related Citations
Disparities among Black and Hispanic colorectal cancer patients: Findings from the California Cancer Registry.
Authors: Mendez J.S.
, Wang R.
, Liu L.
, Zhang J.
, Schmitt S.L.
, Figueiredo J.
, Lenz H.J.
, Stern M.C.
.
Source: Cancer Medicine, 2023-11-01 00:00:00.0; , .
EPub date: 2023-11-01 00:00:00.0.
PMID: 37909220
Related Citations
Priorities to promote participant engagement in the Participant Engagement and Cancer Genome Sequencing (PE-CGS) Network.
Authors: Schuster A.L.R.
, Crossnohere N.L.
, Bachini M.
, Blair C.K.
, Carpten J.D.
, Claus E.B.
, Colditz G.A.
, Ding L.
, Drake B.F.
, Fields R.C.
, et al.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2023-02-15 00:00:00.0; , .
EPub date: 2023-02-15 00:00:00.0.
PMID: 36791345
Related Citations
Barriers and Facilitators to Genetic Education, Risk Assessment, and Testing: Considerations on Advancing Equitable Genetics Care.
Authors: Rodriguez N.J.
, Ricker C.
, Stoffel E.M.
, Syngal S.
.
Source: Gastroenterology, 2023 Jan; 164(1), p. 5-8.
PMID: 36529467
Related Citations
Barriers and Facilitators to Genetic Education, Risk Assessment, and Testing: Considerations on Advancing Equitable Genetics Care.
Authors: Rodriguez N.J.
, Ricker C.
, Stoffel E.M.
, Syngal S.
.
Source: Clinical Gastroenterology And Hepatology : The Official Clinical Practice Journal Of The American Gastroenterological Association, 2023 Jan; 21(1), p. 3-7.
PMID: 36549838
Related Citations
Transcriptome analysis provides critical answers to the "variants of uncertain significance" conundrum.
Authors: Postel M.D.
, Culver J.O.
, Ricker C.
, Craig D.W.
.
Source: Human Mutation, 2022-05-05 00:00:00.0; , .
EPub date: 2022-05-05 00:00:00.0.
PMID: 35510381
Related Citations