Grant Number:	5P50CA244688-05 Interpret this number
Primary Investigator:	Glasgow, Russell
Organization:	University Of Colorado Denver
Project Title:	Pragmatic Implementation Science Approaches to Assess and Enhance Value of Cancer Prevention and Control in Rural Primary Care
Fiscal Year:	2023

Project Summary/Abstract – Overall The theme of our proposed Implementation Science Center is “Pragmatic implementation science approaches to assess and enhance the value of cancer prevention and control in rural primary care.” We will apply and advance frameworks, pragmatic methods, and measures related to cost, benefits, and value that are rigorous, but also generalizable across rural primary care settings that are often struggling with low resources, and a high need population. These models and methods will be used to guide selection and implementation of evidence-based programs for cancer prevention and control (CPC). We will initially focus on lung cancer screening in rural primary care settings, first in Colorado and then nationally through collaboration with a well- established primary care network (i.e., National Research Network). Our overarching framework will be our enhanced RE-AIM/PRISM model, which is an extension of the broadly used Reach, Effectiveness, Adoption, Implementation, and Maintenance framework with the addition of contextual factors (e.g., Intervention characteristics, implementation and sustainability infrastructure). It will serve as the basis to develop and test innovative assessments of costs, benefits, and value from the perspective of different stakeholders to understand and guide implementation. We will meaningfully engage with and include the perspectives of patients, providers, and staff stakeholders in all our studies. Our pilot Implementation Study will adapt, implement, and evaluate strategies using stakeholder-engaged approaches to value to guide the implementation of shared decision-making and smoking cessation related to lung cancer screening. Our Methods Unit will refine and evaluate our pragmatic cost assessment methods to determine implementation/replication costs from the perspective(s) of patients, providers, and delivery staff and then develop and pilot test brief survey measures of preferences regarding the relative benefit of different RE-AIM outcomes. We will then assess relationships among RE-AIM outcomes preferences and selection of different CPC programs. Finally, our Outreach and Network Unit will engage in a) outreach activities targeted at junior and mid-career investigators and practitioners including online professional development (e.g., graduate certificate program, micro-certification) and tailored mentoring and technical assistance approaches; b) dissemination activities to support the packaging and communication of research findings; and c) collaboration activities to facilitate partnerships on CPC and implementation science using multiple channels and including development of shared pragmatic D&I measures and data.




Supporting teams with designing for dissemination and sustainability: the design, development, and usability of a digital interactive platform.
Authors: Kepper M.M. , L'Hotta A.J. , Shato T. , Kwan B.M. , Glasgow R.E. , Luke D. , Graham A.K. , Baumann A.A. , Brownson R.C. , Morse B. .
Source: Implementation Science : Is, 2024-12-31 00:00:00.0; 19(1), p. 82.
EPub date: 2024-12-31 00:00:00.0.
PMID: 39741305
Related Citations

Adapting Public Health and Health Services Interventions in Diverse, Real-World Settings: Documentation and Iterative Guidance of Adaptations.
Authors: Rabin B.A. , Cain K.L. , Glasgow R.E. .
Source: Annual Review Of Public Health, 2024-12-10 00:00:00.0; , .
EPub date: 2024-12-10 00:00:00.0.
PMID: 39656960
Related Citations

Building capacity in dissemination and implementation research: the presence and impact of advice networks.
Authors: L'Hotta A.J. , Jacob R.R. , Mazzucca-Ragan S. , Glasgow R.E. , Straus S.E. , Norton W.E. , Brownson R.C. .
Source: Implementation Science : Is, 2024-11-29 00:00:00.0; 19(1), p. 78.
EPub date: 2024-11-29 00:00:00.0.
PMID: 39614389
Related Citations

Applying Implementation Science to Advance Electronic Health Record-Driven Learning Health Systems: Case Studies, Challenges, and Recommendations.
Authors: Trinkley K.E. , Maw A.M. , Torres C.H. , Huebschmann A.G. , Glasgow R.E. .
Source: Journal Of Medical Internet Research, 2024-10-07 00:00:00.0; 26, p. e55472.
EPub date: 2024-10-07 00:00:00.0.
PMID: 39374069
Related Citations

Use of the iPRISM webtool in a learning community to assess implementation context and fit of a novel clinical decision support tool for physical therapy triage in acute care hospitals.
Authors: Johnson J.K. , Sullivan J.L. , Trinkley K.E. , Lapin B. , Passek S. , Asp V. , Ford B. , Rabin B.A. .
Source: Pm & R : The Journal Of Injury, Function, And Rehabilitation, 2024-06-27 00:00:00.0; , .
EPub date: 2024-06-27 00:00:00.0.
PMID: 38934486
Related Citations

Supporting Teams with Designing for Dissemination and Sustainability: the Design, Development, and Usability of a Digital Interactive Platform.
Authors: Kepper M. , L'Hotta A. , Shato T. , Kwan B.M. , Glasgow R.E. , Luke D. , Graham A.K. , Baumann A.A. , Brownson R.C. , Morse B. .
Source: Research Square, 2024-05-28 00:00:00.0; , .
EPub date: 2024-05-28 00:00:00.0.
PMID: 38853949
Related Citations

Implementation of Health IT for Cancer Screening in US Primary Care: Scoping Review.
Authors: Owens-Jasey C. , Chen J. , Xu R. , Angier H. , Huebschmann A.G. , Ito Fukunaga M. , Chaiyachati K.H. , Rendle K.A. , Robien K. , DiMartino L. , et al. .
Source: Jmir Cancer, 2024-04-30 00:00:00.0; 10, p. e49002.
EPub date: 2024-04-30 00:00:00.0.
PMID: 38687595
Related Citations

Aligning the planning, development, and implementation of complex interventions to local contexts with an equity focus: application of the PRISM/RE-AIM Framework.
Authors: Jolles M.P. , Fort M.P. , Glasgow R.E. .
Source: International Journal For Equity In Health, 2024-02-27 00:00:00.0; 23(1), p. 41.
EPub date: 2024-02-27 00:00:00.0.
PMID: 38408990
Related Citations

Leveraging artificial intelligence to advance implementation science: potential opportunities and cautions.
Authors: Trinkley K.E. , An R. , Maw A.M. , Glasgow R.E. , Brownson R.C. .
Source: Implementation Science : Is, 2024-02-21 00:00:00.0; 19(1), p. 17.
EPub date: 2024-02-21 00:00:00.0.
PMID: 38383393
Related Citations

The Role of Pragmatic Implementation Science Methods in Achieving Equitable and Effective Use of Artificial Intelligence in Healthcare.
Authors: Maw A.M. , Trinkley K.E. , Glasgow R.E. .
Source: Journal Of General Internal Medicine, 2024-01-03 00:00:00.0; , .
EPub date: 2024-01-03 00:00:00.0.
PMID: 38172408
Related Citations

Designing for dissemination among public health and clinical practitioners in the USA.
Authors: Shato T. , Kepper M.M. , McLoughlin G.M. , Tabak R.G. , Glasgow R.E. , Brownson R.C. .
Source: Journal Of Clinical And Translational Science, 2024; 8(1), p. e8.
EPub date: 2023-12-14 00:00:00.0.
PMID: 38384897
Related Citations

Usability Testing of a Web Tool for Dissemination and Implementation Science Models.
Authors: Gomes R.N. , Ford B.S. , Tabak R.G. , Brownson R.C. , Malone S. , Padek M. , Glasgow R.E. , Rabin B. .
Source: Global Implementation Research And Applications, 2024; 4(3), p. 296-308.
EPub date: 2024-06-14 00:00:00.0.
PMID: 39309221
Related Citations

Clinician Awareness of Patient-Reported Health-Related Social Needs: There's Room for Improvement.
Authors: Nederveld A. , Bertin K.B. , Dickinson L.M. , Beall S. , Nelson J. , Glasgow R.E. , Huebschmann A.G. .
Source: Journal Of Primary Care & Community Health, 2024 Jan-Dec; 15, p. 21501319241290887.
PMID: 39431568
Related Citations

The Application and Evolution of the Practical, Robust Implementation and Sustainability Model (PRISM): History and Innovations.
Authors: Glasgow R.E. , Trinkley K.E. , Ford B. , Rabin B.A. .
Source: Global Implementation Research And Applications, 2024; 4(4), p. 404-420.
EPub date: 2024-08-31 00:00:00.0.
PMID: 39568619
Related Citations

Implementation science for cancer control: One center's experience addressing context, adaptation, equity, and sustainment.
Authors: Glasgow R.E. , Ford B.S. , Bradley C.J. .
Source: Translational Behavioral Medicine, 2023-12-30 00:00:00.0; , .
EPub date: 2023-12-30 00:00:00.0.
PMID: 38159246
Related Citations

RE-AIM implementation outcomes and service outcomes: what's the connection? results of a cross-sectional survey.
Authors: Studts C.R. , Ford B. , Glasgow R.E. .
Source: Bmc Health Services Research, 2023-12-15 00:00:00.0; 23(1), p. 1417.
EPub date: 2023-12-15 00:00:00.0.
PMID: 38102634
Related Citations

RE-AIM implementation outcomes and service outcomes: what's the connection? results of a cross-sectional survey.
Authors: Studts C.R. , Ford B. , Glasgow R.E. .
Source: Bmc Health Services Research, 2023-12-15 00:00:00.0; 23(1), p. 1417.
EPub date: 2023-12-15 00:00:00.0.
PMID: 38102634
Related Citations

The iPRISM webtool: an interactive tool to pragmatically guide the iterative use of the Practical, Robust Implementation and Sustainability Model in public health and clinical settings.
Authors: Trinkley K.E. , Glasgow R.E. , D'Mello S. , Fort M.P. , Ford B. , Rabin B.A. .
Source: Implementation Science Communications, 2023-09-19 00:00:00.0; 4(1), p. 116.
EPub date: 2023-09-19 00:00:00.0.
PMID: 37726860
Related Citations

Participatory logic modeling in a multi-site initiative to advance implementation science.
Authors: Easterling D.V. , Jacob R.R. , Brownson R.C. , Haire-Joshu D. , Gundersen D.A. , Angier H. , DeVoe J.E. , Likumahuwa-Ackman S. , Vu T. , Glasgow R.E. , et al. .
Source: Implementation Science Communications, 2023-08-29 00:00:00.0; 4(1), p. 106.
EPub date: 2023-08-29 00:00:00.0.
PMID: 37644495
Related Citations

Advancing health equity through implementation science: Identifying and examining measures of the outer setting.
Authors: Warner E.T. , Huguet N. , Fredericks M. , Gundersen D. , Nederveld A. , Brown M.C. , Houston T.K. , Davis K.L. , Mazzucca S. , Rendle K.A. , et al. .
Source: Social Science & Medicine (1982), 2023 Aug; 331, p. 116095.
EPub date: 2023-07-17 00:00:00.0.
PMID: 37473542
Related Citations

Participatory Logic Modeling in a Multi-Site Initiative to Advance Implementation Science.
Authors: Easterling D. , Jacob R.R. , Brownson R.C. , Haire-Joshu D. , Gundersen D.A. , Angier H. , DeVoe J.E. , Likumahuwa-Ackman S. , Vu T. , Glasgow R.E. , et al. .
Source: Research Square, 2023-05-18 00:00:00.0; , .
EPub date: 2023-05-18 00:00:00.0.
PMID: 37292912
Related Citations

Implementation strategies preferred by primary care clinicians to facilitate cancer prevention and control activities.
Authors: Glasgow R.E. , Brtnikova M. , Dickinson L.M. , Carroll J.K. , Studts J.L. .
Source: Journal Of Behavioral Medicine, 2023-04-08 00:00:00.0; , .
EPub date: 2023-04-08 00:00:00.0.
PMID: 37031347
Related Citations

Lung cancer screening in rural primary care practices in Colorado: time for a more team-based approach?
Authors: Gomes R. , Nederveld A. , Glasgow R.E. , Studts J.L. , Holtrop J.S. .
Source: Bmc Primary Care, 2023-03-03 00:00:00.0; 24(1), p. 62.
EPub date: 2023-03-03 00:00:00.0.
PMID: 36869308
Related Citations

Creating research-ready partnerships: the initial development of seven implementation laboratories to advance cancer control.
Authors: Kruse G.R. , Hale E. , Bekelman J.E. , DeVoe J.E. , Gold R. , Hannon P.A. , Houston T.K. , James A.S. , Johnson A. , Klesges L.M. , et al. .
Source: Bmc Health Services Research, 2023-02-21 00:00:00.0; 23(1), p. 174.
EPub date: 2023-02-21 00:00:00.0.
PMID: 36810066
Related Citations

Speeding implementation in cancer: The National Cancer Institute's Implementation Science Centers in Cancer Control.
Authors: Oh A.Y. , Emmons K.M. , Brownson R.C. , Glasgow R.E. , Foley K.L. , Lewis C.C. , Schnoll R. , Huguet N. , Caplon A. , Chambers D.A. .
Source: Journal Of The National Cancer Institute, 2023-02-08 00:00:00.0; 115(2), p. 131-138.
PMID: 36315080
Related Citations

Developing a dissemination and implementation research agenda for aging and public health: The what, when, how, and why?
Authors: Estabrooks P.A. , Glasgow R.E. .
Source: Frontiers In Public Health, 2023; 11, p. 1123349.
EPub date: 2023-02-06 00:00:00.0.
PMID: 36815160
Related Citations

Applying an equity lens to assess context and implementation in public health and health services research and practice using the PRISM framework.
Authors: Fort M.P. , Manson S.M. , Glasgow R.E. .
Source: Frontiers In Health Services, 2023; 3, p. 1139788.
EPub date: 2023-04-13 00:00:00.0.
PMID: 37125222
Related Citations

Editorial: Understanding, assessing, and guiding adaptations in public health and health systems interventions: current and future directions.
Authors: Ayele R.A. , Rabin B.A. , McCreight M. , Battaglia C. .
Source: Frontiers In Public Health, 2023; 11, p. 1228437.
EPub date: 2023-06-27 00:00:00.0.
PMID: 37457241
Related Citations

Primary Care Research Is Hard to Do During COVID-19: Challenges and Solutions.
Authors: Holtrop J.S. , Davis M.M. .
Source: Annals Of Family Medicine, 2022 Nov-Dec; 20(6), p. 568-572.
PMID: 36443077
Related Citations

How Dissemination and Implementation Science Can Contribute to the Advancement of Learning Health Systems.
Authors: Trinkley K.E. , Ho P.M. , Glasgow R.E. , Huebschmann A.G. .
Source: Academic Medicine : Journal Of The Association Of American Medical Colleges, 2022-10-01 00:00:00.0; 97(10), p. 1447-1458.
EPub date: 2022-09-23 00:00:00.0.
PMID: 35796045
Related Citations

Priorities for improvement across cancer and non-cancer related preventive services among rural and non-rural clinicians.
Authors: Brtnikova M. , Studts J.L. , Robertson E. , Dickinson L.M. , Carroll J.K. , Krist A.H. , Cronin J.T. , Glasgow R.E. .
Source: Bmc Primary Care, 2022-09-09 00:00:00.0; 23(1), p. 231.
EPub date: 2022-09-09 00:00:00.0.
PMID: 36085005
Related Citations

Applying dissemination and implementation research methods to translate a school-based asthma program.
Authors: Szefler S.J. , Cicutto L. , Brewer S.E. , Gleason M. , McFarlane A. , DeCamp L.R. , Brinton J.T. , Huebschmann A.G. .
Source: The Journal Of Allergy And Clinical Immunology, 2022 09; 150(3), p. 535-548.
EPub date: 2022-05-13 00:00:00.0.
PMID: 35569568
Related Citations

Sex Differences in Physical Activity Among Individuals With Type 2 Diabetes Across the Life Span: A Systematic Review and Meta-analysis.
Authors: Whipple M.O. , Pinto A.J. , Abushamat L.A. , Bergouignan A. , Chapman K. , Huebschmann A.G. , Masters K.S. , Nadeau K.J. , Scalzo R.L. , Schauer I.E. , et al. .
Source: Diabetes Care, 2022-09-01 00:00:00.0; 45(9), p. 2163-2177.
PMID: 36044665
Related Citations

Methods to improve the translation of evidence-based interventions: A primer on dissemination and implementation science for occupational safety and health researchers and practitioners.
Authors: Guerin R.J. , Glasgow R.E. , Tyler A. , Rabin B.A. , Huebschmann A.G. .
Source: Safety Science, 2022 Aug; 152, .
EPub date: 2022-04-13 00:00:00.0.
PMID: 37854304
Related Citations

Health Economics Research in Cancer Screening: Research Opportunities, Challenges, and Future Directions.
Authors: Shih Y.T. , Sabik L.M. , Stout N.K. , Halpern M.T. , Lipscomb J. , Ramsey S. , Ritzwoller D.P. .
Source: Journal Of The National Cancer Institute. Monographs, 2022-07-05 00:00:00.0; 2022(59), p. 42-50.
PMID: 35788368
Related Citations

Pragmatic considerations and approaches for measuring staff time as an implementation cost in health systems and clinics: key issues and applied examples.
Authors: Huebschmann A.G. , Trinkley K.E. , Gritz M. , Glasgow R.E. .
Source: Implementation Science Communications, 2022-04-15 00:00:00.0; 3(1), p. 44.
EPub date: 2022-04-15 00:00:00.0.
PMID: 35428326
Related Citations

Revisiting concepts of evidence in implementation science.
Authors: Brownson R.C. , Shelton R.C. , Geng E.H. , Glasgow R.E. .
Source: Implementation Science : Is, 2022-04-12 00:00:00.0; 17(1), p. 26.
EPub date: 2022-04-12 00:00:00.0.
PMID: 35413917
Related Citations

Using economic evaluations in implementation science to increase transparency in costs and outcomes for organizational decision-makers.
Authors: Saldana L. , Ritzwoller D.P. , Campbell M. , Block E.P. .
Source: Implementation Science Communications, 2022-04-11 00:00:00.0; 3(1), p. 40.
EPub date: 2022-04-11 00:00:00.0.
PMID: 35410434
Related Citations

Designing for Dissemination and Sustainability to Promote Equitable Impacts on Health.
Authors: Kwan B.M. , Brownson R.C. , Glasgow R.E. , Morrato E.H. , Luke D.A. .
Source: Annual Review Of Public Health, 2022-04-05 00:00:00.0; 43, p. 331-353.
EPub date: 2022-01-04 00:00:00.0.
PMID: 34982585
Related Citations

Values and Meaning in Rural Primary Care Practices: Implications for Interventions Within Context.
Authors: Holtrop J.S. , Nederveld A. , Lum H.D. , Glasgow R.E. , Gomes R. .
Source: Journal Of Primary Care & Community Health, 2022 Jan-Dec; 13, p. 21501319221139371.
PMID: 36433703
Related Citations

Use of the reach, effectiveness, adoption, implementation, and maintenance (RE-AIM) framework to guide iterative adaptations: Applications, lessons learned, and future directions.
Authors: Glasgow R.E. , Battaglia C. , McCreight M. , Ayele R. , Maw A.M. , Fort M.P. , Holtrop J.S. , Gomes R.N. , Rabin B.A. .
Source: Frontiers In Health Services, 2022; 2, p. 959565.
EPub date: 2022-10-17 00:00:00.0.
PMID: 36925843
Related Citations

Dissemination and Implementation Science Approaches for Occupational Safety and Health Research: Implications for Advancing Total Worker Health.
Authors: Guerin R.J. , Harden S.M. , Rabin B.A. , Rohlman D.S. , Cunningham T.R. , TePoel M.R. , Parish M. , Glasgow R.E. .
Source: International Journal Of Environmental Research And Public Health, 2021-10-21 00:00:00.0; 18(21), .
EPub date: 2021-10-21 00:00:00.0.
PMID: 34769573
Related Citations

Implementation science issues in understanding, collecting, and using cost estimates: a multi-stakeholder perspective.
Authors: Eisman A.B. , Quanbeck A. , Bounthavong M. , Panattoni L. , Glasgow R.E. .
Source: Implementation Science : Is, 2021-08-03 00:00:00.0; 16(1), p. 75.
EPub date: 2021-08-03 00:00:00.0.
PMID: 34344411
Related Citations

Acute effects of sedentary breaks on vascular health in adults at risk for type 2 diabetes: A systematic review.
Authors: Whipple M.O. , Masters K.S. , Huebschmann A.G. , Scalzo R.L. , Reusch J.E. , Bergouignan A. , Regensteiner J.G. .
Source: Vascular Medicine (london, England), 2021 08; 26(4), p. 448-458.
EPub date: 2021-05-12 00:00:00.0.
PMID: 33977799
Related Citations

Shared Decision-Making for Left Ventricular Assist Devices: Rationale and Design of a Nationwide Dissemination and Implementation Project.
Authors: Thompson J.S. , Fitzgerald M.D. , Allen L.A. , McIlvennan C.K. , Glasgow R.E. , Wynia M. , Morris M.A. , Beilenson J. , Gherst C. , Matlock D.D. .
Source: Circulation. Cardiovascular Quality And Outcomes, 2021 Feb; 14(2), p. e007256.
EPub date: 2021-02-03 00:00:00.0.
PMID: 33530698
Related Citations

Roles dissemination and implementation scientists can play in supporting research teams.
Authors: Tabak R.G. , Bauman A.A. , Holtrop J.S. .
Source: Implementation Science Communications, 2021-01-15 00:00:00.0; 2(1), p. 9.
EPub date: 2021-01-15 00:00:00.0.
PMID: 33451364
Related Citations

Editorial: Use of the RE-AIM Framework: Translating Research to Practice With Novel Applications and Emerging Directions.
Authors: Estabrooks P.A. , Gaglio B. , Glasgow R.E. , Harden S.M. , Ory M.G. , Rabin B.A. , Smith M.L. .
Source: Frontiers In Public Health, 2021; 9, p. 691526.
EPub date: 2021-06-11 00:00:00.0.
PMID: 34178933
Related Citations

The Importance of Mental Models in Implementation Science.
Authors: Holtrop J.S. , Scherer L.D. , Matlock D.D. , Glasgow R.E. , Green L.A. .
Source: Frontiers In Public Health, 2021; 9, p. 680316.
EPub date: 2021-07-06 00:00:00.0.
PMID: 34295871
Related Citations

Understanding and applying the RE-AIM framework: Clarifications and resources.
Authors: Holtrop J.S. , Estabrooks P.A. , Gaglio B. , Harden S.M. , Kessler R.S. , King D.K. , Kwan B.M. , Ory M.G. , Rabin B.A. , Shelton R.C. , et al. .
Source: Journal Of Clinical And Translational Science, 2021; 5(1), p. e126.
EPub date: 2021-05-14 00:00:00.0.
PMID: 34367671
Related Citations

Development of a Health Information Technology Tool for Behavior Change to Address Obesity and Prevent Chronic Disease Among Adolescents: Designing for Dissemination and Sustainment Using the ORBIT Model.
Authors: Kepper M.M. , Walsh-Bailey C. , Brownson R.C. , Kwan B.M. , Morrato E.H. , Garbutt J. , de Las Fuentes L. , Glasgow R.E. , Lopetegui M.A. , Foraker R. .
Source: Frontiers In Digital Health, 2021; 3, p. 648777.
EPub date: 2021-03-10 00:00:00.0.
PMID: 34713122
Related Citations