Skip to main content
An official website of the United States government
Grant Details

Grant Number: 5P50CA244432-05 Interpret this number
Primary Investigator: Weiner, Bryan
Organization: University Of Washington
Project Title: Optimizing Implementation in Cancer Control: Opticc
Fiscal Year: 2023


OVERALL SUMMARY The mission of the OPTICC (Optimizing Implementation in Cancer Control) Center is to improve cancer outcomes by supporting optimized implementation of evidence-based interventions (EBIs) in cancer control. Optimized implementation occurs when: (1) the strategies employed to implement EBIs address the key barriers to implementation that are active in the specific settings in which implementation occurs, and (2) those strategies reflect the best possible methods for addressing the barriers. Despite two decades of progress in implementation science (IS), practical tools and guidance to support optimized EBI implementation are lacking; as a result, strategies are often mismatched to barriers and are often not optimized for effectiveness, efficiency, or fit with local resources. The result is suboptimal implementation in the form of lost time, effort, and resources and, ultimately, poorer cancer outcomes. The OPTICC Center will advance IS and, in turn, improve EBI implementation in cancer control by developing, testing, and refining innovative methods for optimizing EBI implementation. The OPTICC Center is a strategic collaboration of the University of Washington (UW), Kaiser Permanente Washington Health Research Institute (KPWHRI), and the Fred Hutchinson Cancer Research Center (FHCRC). Three cores will support its work. The Administrative Core will promote multidisciplinary collaboration, research excellence, and methodological innovation. It will also lead Center outreach and dissemination efforts, evaluate Center impact, and coordinate Center activities. The Research Program Core will conduct innovative implementation studies, method and measurement studies, and small pilot studies that advance the Center’s “grand challenge” IS theme of optimizing EBI implementation. A three-stage approach to optimizing EBI implementation will be taken—identify and prioritize barriers, match strategies, and test strategies—with measurement development spanning all three stages. The Implementation Laboratory Core will establish and coordinate a network of diverse clinical and community sites to conduct “in vivo” IS studies, implement cancer control EBIs, and shape the Center’s research agenda. The Center’s initial studies will focus on optimizing implementation of screening EBIs for cervical, colorectal, breast, and ovarian cancer. However, the methods for optimizing EBI implementation that the Center will develop, test, and refine can be applied broadly across the cancer care continuum, for a wide range of cancers, to answer a wide range of IS questions.


Health System-Provided Rideshare Is Safe and Addresses Barriers to Colonoscopy Completion.
Authors: Issaka R.B. , Bell-Brown A. , Hopkins T. , Chew L.D. , Strate L.L. , Weiner B.J. , Endoscopy Rideshare Working Group .
Source: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2024 May; 22(5), p. 1130-1132.e1.
EPub date: 2023-10-06.
PMID: 37806371
Related Citations

Leveraging human-centered design and causal pathway diagramming toward enhanced specification and development of innovative implementation strategies: a case example of an outreach tool to address racial inequities in breast cancer screening.
Authors: Marcotte L.M. , Langevin R. , Hempstead B.H. , Ganguly A. , Lyon A.R. , Weiner B.J. , Akinsoto N. , Houston P.L. , Fang V. , Hsieh G. .
Source: Implementation science communications, 2024-03-28; 5(1), p. 31.
EPub date: 2024-03-28.
PMID: 38549174
Related Citations

Advancing health equity through implementation science: Identifying and examining measures of the outer setting.
Authors: Warner E.T. , Huguet N. , Fredericks M. , Gundersen D. , Nederveld A. , Brown M.C. , Houston T.K. , Davis K.L. , Mazzucca S. , Rendle K.A. , et al. .
Source: Social science & medicine (1982), 2023 Aug; 331, p. 116095.
EPub date: 2023-07-17.
PMID: 37473542
Related Citations

Participatory Logic Modeling in a Multi-Site Initiative to Advance Implementation Science.
Authors: Easterling D. , Jacob R.R. , Brownson R.C. , Haire-Joshu D. , Gundersen D.A. , Angier H. , DeVoe J.E. , Likumahuwa-Ackman S. , Vu T. , Glasgow R.E. , et al. .
Source: Research square, 2023-05-18; , .
EPub date: 2023-05-18.
PMID: 37292912
Related Citations

Creating research-ready partnerships: the initial development of seven implementation laboratories to advance cancer control.
Authors: Kruse G.R. , Hale E. , Bekelman J.E. , DeVoe J.E. , Gold R. , Hannon P.A. , Houston T.K. , James A.S. , Johnson A. , Klesges L.M. , et al. .
Source: BMC health services research, 2023-02-21; 23(1), p. 174.
EPub date: 2023-02-21.
PMID: 36810066
Related Citations

Speeding implementation in cancer: The National Cancer Institute's Implementation Science Centers in Cancer Control.
Authors: Oh A.Y. , Emmons K.M. , Brownson R.C. , Glasgow R.E. , Foley K.L. , Lewis C.C. , Schnoll R. , Huguet N. , Caplon A. , Chambers D.A. .
Source: Journal of the National Cancer Institute, 2023-02-08; 115(2), p. 131-138.
PMID: 36315080
Related Citations

Understanding tailoring to support the implementation of evidence-based interventions in healthcare: The CUSTOMISE research programme protocol.
Authors: McHugh S.M. , Riordan F. , Kerins C. , Curran G. , Lewis C.C. , Presseau J. , Wolfenden L. , Powell B.J. .
Source: HRB open research, 2023; 6, p. 7.
EPub date: 2023-01-25.
PMID: 37361339
Related Citations

Theorizing is for everybody: Advancing the process of theorizing in implementation science.
Authors: Meza R.D. , Moreland J.C. , Pullmann M.D. , Klasnja P. , Lewis C.C. , Weiner B.J. .
Source: Frontiers in health services, 2023; 3, p. 1134931.
EPub date: 2023-03-10.
PMID: 36926499
Related Citations

Collaboration networks of the implementation science centers for cancer control: a social network analysis.
Authors: Jacob R.R. , Korn A.R. , Huang G.C. , Easterling D. , Gundersen D.A. , Ramanadhan S. , Vu T. , Angier H. , Brownson R.C. , Haire-Joshu D. , et al. .
Source: Implementation science communications, 2022-04-13; 3(1), p. 41.
EPub date: 2022-04-13.
PMID: 35418309
Related Citations

Operationalizing a Rideshare Intervention for Colonoscopy Completion: Barriers, Facilitators, and Process Recommendations.
Authors: Bell-Brown A. , Chew L. , Weiner B.J. , Strate L. , Balmadrid B. , Lewis C.C. , Hannon P. , Inadomi J.M. , Ramsey S.D. , Issaka R.B. .
Source: Frontiers in health services, 2022 Jan; 1, .
EPub date: 2022-01-17.
PMID: 35128543
Related Citations

Optimizing Implementation in Cancer Control (OPTICC): protocol for an implementation science center.
Authors: Lewis C.C. , Hannon P.A. , Klasnja P. , Baldwin L.M. , Hawkes R. , Blackmer J. , Johnson A. , OPTICC Consortium, represented by Bryan J. Weiner .
Source: Implementation science communications, 2021-04-23; 2(1), p. 44.
EPub date: 2021-04-23.
PMID: 33892822
Related Citations

Back to Top