Grant Details
Grant Number: |
3R37CA237245-04S1 Interpret this number |
Primary Investigator: |
Mcclure, Erin |
Organization: |
Medical University Of South Carolina |
Project Title: |
Determining the Impact of Cannabis Use and Severity on Tobacco Cessation Outcomes: a Prospective Tobacco Treatment Trial |
Fiscal Year: |
2022 |
Abstract
Project Summary/Abstract
This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT-
CA-22-070: Administrative Supplements for Examining Patterns of Tobacco and Cannabis Use. This
supplement request will support additional data collection as part of the NCI-funded award (R37 CA237245, PI
McClure, 07/01/2019-06/30/2024) entitled, “Determining the impact of cannabis use and severity on tobacco
cessation outcomes: A prospective tobacco treatment trial.” The overall goal of the funded parent R37 MERIT
award is to conduct a prospective tobacco treatment study evaluating the impact of cannabis co-use on tobacco
cessation outcomes. The NOSI NOT-CA-22-070 supplement is an ideal fit for the funded parent award and will
allow for the addition of real-time, ecologically valid data collection via bursts of ecological momentary
assessment (EMA) on patterns of cannabis-tobacco co-use for participants enrolled in the parent trial. While the
parent study is collecting weekly data on patterns of cannabis and tobacco co-use, current measures may be
not be sensitive enough to categorize co-users into profiles of use patterns and determine relationships during
specific use events. The literature on cannabis-tobacco co-use suggests that a great deal remains unknown
regarding patterns of co-use, how patterns vary across those who co-use, and how co-use patterns may
adversely impact health and treatment outcomes. Real-time data collection on co-use patterns throughout the
parent tobacco treatment trial will provide more accurate and refined data on patterns of co-use to inform
treatment implications and future work in this area. For the 1-year supplement, we anticipate enrolling 48
cannabis-tobacco co-use participants to engage in additional EMA data collection. EMA data collection will be
conducted in four bursts across the trial to assess detailed patterns of cannabis-tobacco co-use among
participants, and how those patterns change during tobacco treatment. We will conduct 1-week bursts of EMA
data collection at 4 time points during the trial: 1) baseline/pre-medication, 2) Week 1 (starting at the target quit
date), 3) Week 11 (ending at the Week 12 end-of-treatment visit, and 4) Week 25 (ending at the Week 26 final
follow-up visit). By conducting multiple bursts of EMA data collection, we will be able to compare co-use patterns
within an individual across the pre-quit phase, treatment phase and at follow-up after medication has been
terminated. We will also be able to make comparisons in co-use patterns between participants to assess for
varying patterns of co-use. Together with the original aims of the R37 award, this supplement will allow for the
exploration of individual co-use patterns and changes in patterns during tobacco treatment among those who
co-use cannabis and tobacco. This additional data collection on patterns of tobacco-cannabis co-use will help to
inform the literature and provide preliminary data for follow-up studies focused on varying patterns of co-use and
their associated treatment implications among those who use tobacco and cannabis products.
Publications
None. See parent grant details.