||3R01CA239701-01A1S3 Interpret this number
||University Of Minnesota
||Admixture Analysis of Acute Lymphoblastic Leukemia in African American Children: the Admiral Study
This application is being submitted in response to the Notice of Special Interest (NOSI) identified as “NOT-CA-
22-057”. In our parent project titled “Admixture analysis of acute lymphoblastic leukemia (ALL) in African
American children (ADMIRAL Study; R01CA239701), we are performing admixture mapping to identify ancestral
genomic loci that may account for differential risk and unfavorable clinical phenotypes of ALL in African American
(AA) children. In this Administrative Supplement Opportunity to Stimulate or Strengthen Global Cancer Health
Disparities Research, we propose synergistic molecular epidemiology research to identify leukemia biology
factors that potentially underly the same clinical problem (unfavorable ALL phenotypes) among children in Africa.
The high burden of childhood ALL and urgent importance to effectively control the cancer in Africa is highlighted
by the World Health Organization’s Global Initiative for Childhood Cancer. The goal of the proposed
supplemental research project is to leverage this African childhood ALL cohort as a triangulating comparator that
shares genetic ancestry with AA but lacks European admixture and has a distinctively different landscape of
environmental immune challenges, namely, endemic viral infections. The purpose is to identify the biological
underpinnings of unfavorable ALL prognostic factors in AA and African children that can be targeted to reduce
ALL survival disparities in these populations. Our overarching approach is to characterize somatic, inherited, and
environmental determinants of clinical differences in childhood ALL among world populations; the Specific Aims
are to: 1. Identify the cytogenetic abnormalities that may underpin unfavorable ALL clinical phenotypes among
children of African ancestry and their association with African/European genetic admixture. 2. Compare the
prevalence of replicated inherited single nucleotide variants (SNVs) that are reported in the literature to be
associated with ALL risk and outcomes among African, AA and EA children. 3. Characterize the plasma
exogenous virome in children with ALL in Africa.
None. See parent grant details.