||3R01CA240319-03S1 Interpret this number
||University Of South Florida
||A Mixed Methods Approach to Evaluating the Role of Individual Differences: Impact on Fruit and Vegetable Intake Outcomes in Nourish-T+ Parents of Pediatric Cancer Survivors
Interventions successfully addressing healthy lifestyle behavior (e.g., healthy eating, physical activity) in
pediatric cancer survivors (PCS) are urgently needed as approximately 40% to 50% of PCS have
overweight/obesity. Modifiable behaviors, such as unhealthy dietary intake and sedentary behavior are key to
post-treatment weight gain among PCS. Improving eating behaviors and physical activity in PCS decreases
the risk of negative late effects and chronic illness. The parent grant to this application, R01CA240319, is the
first large scale multi-site, randomized controlled clinical trial of an intervention (NOURISH-T+) that targets
obesity in a diverse group of English and Spanish speaking PCS and their parents.
The intervention program, NOURISH-T+, tested in the parent grant is an efficacy trial and does not
investigate the variability in intervention outcomes that has been described in the scientific literature as
important in increasing understanding of goal attainment and behavior change. The potential for intervention
outcome variability in NOURISH-T+ raises the importance of examining individual differences that might
explain intervention efficacy, maximize intervention impact, and inform future tailoring of this approach,
consistent with the trend to personalized medicine. Relatively little is known about what key factors explain
individual variability in behavior change outcomes. There are major gaps in our understanding of the
mechanistic role of motivation and other individual differences. The proposed project addresses this knowledge
gap by exploring, through a mixed-methods design, the role of individual differences on fruit and vegetable
(F/V) intake, a standard index related to behavioral change.
Aim 1: Examine the variability in primary F/V intake outcomes at 3-months post-intervention.
o Aim 1a: Identify F/V intake extreme observations (i.e., highest adherence to F/V
guidelines vs. lowest adherence) to guide the selection of participants to interview.
o Aim 1b: Examine the relation between potential individual difference variables and F/V
intake to inform the construction of the semi-structured interview guide.
Aim 2: Describe parents' perceptions of potential individual difference variables most important
to them in eliciting behavior change via semi-structured interviews.
During this diversity supplement, I will gain further experience that will enable me to take my cancer research
career to the next level. My long-term career goal is to become an independent cancer research clinician-
scientist focused on the design and implementation of culturally adapted health behavior change interventions
designed to improve lifestyle, quality of life, and survivorship in children, adolescents and young adults, and
their families. My short-term career goals include completing my Ph.D. studies, gaining the skills necessary to
compete for a top post-doctoral fellowship in cancer control, and writing a successful F32 grant.
None. See parent grant details.