||1R01CA265945-01A1 Interpret this number
||Rosser, B R Simon
||University Of Minnesota
||Testing Effective Methods to Recruit Sexual and Gender Minority Cancer Patients for Cancer Studies
Recently, NCI called for research to effectively study small or rare populations relevant to cancer research.
Sexual and gender minorities (SGM) are small populations at disproportionate risk for cancer but who have
been under-researched in cancer studies. The principal challenge common across lesbian, gay, bisexual, and
transgender populations is to develop effective methods to identify and recruit patients and survivors who are
SGM into NCI cancer studies. Two technical advances have transformative potential to advance research on
health disparities in SGM cancer patients. First, online recruitment has yielded large SGM samples in other
areas of research (e.g., HIV primary prevention), but using online methods to recruit SGM cancer patients has
not been rigorously studied. Second, cancer clinics have begun to include sexual orientation and gender
identity (SOGI) data in the electronic medical record, but we need to test protocols on how to recruit SGM
cancer patients using this data source. This application is based upon our recent success in overcoming
challenges to recruit over 400 gay and bisexual prostate cancer patients into an R01 intervention trial of
tailored rehabilitation for this population. We will replicate and expand upon these clinic-based and online
methods to study how to recruit three small SGM populations – (1) sexual minority cisgender men, (2) sexual
minority cisgender women, and (3) transgender and gender non-binary cancer patients - into cancer research
studies. We have three specific aims. In Aim 1, we will document, in depth, SGM’s attitudes towards
participating in NIH cancer research, identifying the facilitators and barriers that each group reports influences
their willingness to participate. We will also investigate any impact poor cancer care and discrimination has on
research participation. We will investigate these in cisgender SM men, cisgender SM women and gender
minority cancer patients (n=15 per group) and compare experiences within these small populations and
between SGM and a cisgender, heterosexual patient comparison group. In Aim 2, we will test the
effectiveness, efficiency, cost, and workload in using two clinic SOGI-based strategies and three online
strategies to recruit SGM small populations (150 each) compared to recruiting a sample of cisgender,
heterosexual cancer patients. We predict size of the small population will negatively correlate with work, cost,
and time involved, but positively correlate with yield. In Aim 3, we will conduct an online quantitative survey of
willingness to participate in cancer research with 450 SGM cancer patients (150 per group) versus a cisgender
heterosexual group (150 men and 150 women). Key measures assess facilitators and barriers to participation
in NIH cancer research. To advance measures, we will assess performance of each group on five validated
cancer scales to compare cancer care experience, discrimination in treatment, and outcomes. Finally, we will
integrate and triangulate findings and assess intersectionality with race/ethnicity. This study will establish what
recruitment strategies are effective across SGM populations, and which may be specific to each subgroup.
Every urologist and oncologist should know about treating sexual and gender minority prostate cancer patients: translating research findings into clinical practice.
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Translational andrology and urology, 2021 Jul; 10(7), p. 3208-3225.