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Grant Details

Grant Number: 5UG3CA267907-02 Interpret this number
Primary Investigator: Pearce, Celeste
Organization: University Of Michigan At Ann Arbor
Project Title: MI-CARES: the Michigan Cancer and Research on the Environment Study
Fiscal Year: 2022


Abstract

Many communities around the U.S. have been failed by private enterprise and governmental stewardship in protecting their local environments and thus health. The goal of this proposal is to establish MI-CARES: The Michigan Cancer and Research on the Environment Study to describe and quantify the impact of known and novel environmental exposures on cancer risk. With MI-CARES we will examine well-established environmental carcinogens such as air pollution and heavy metals, but also focus on less characterized exposures including per- and polyfluoroalkyl substances (PFAS), noise, and chemicals in personal care products for which there are urgent needs to assess carcinogenicity. As disparities in these exposures are common by geographic region, socioeconomic status, race/ethnicity, and lifestyle, research is required to understand how these factors impact the relationships between the environment and cancer risk. Michigan (MI) is an ideal location to carry out research on environmental exposures and cancer risk. Michiganders have experienced a tragic suite of environmental exposures ranging from contaminated animal feed with polybrominated biphenyls (PBBs) in the 1970s, to the lead contamination of Flint’s water supply, and the highest known PFAS levels of any state. The “Tri-Cities” area of metro Detroit, a predominantly Black and Hispanic community, is the most polluted region in Michigan and high-ranking in the entire U.S. These exposures in MI are profound and the strong history of community engagement makes MI-CARES feasible. In this project, we hypothesize that environmental exposures impact inflammation, cellular aging, epigenetic regulation, and immune function to ultimately increase cancer risk. To investigate this hypothesis, we propose to establish MI-CARES, a racially/ethnically diverse cohort of 100,000 cancer-free men and women aged 25-44 residing in environmental injustice hotspots in MI: the Detroit metropolitan area, Flint, Grand Rapids, Kalamazoo, Lansing, and Saginaw. We will recruit equal numbers of Black, Hispanic, Middle Eastern and North African (MENA), and White participants; all but the latter are underrepresented in environmental and cancer research. Questionnaire, community-level data, and birth records will be collected for all participants using a life course approach to capture data during critical windows of susceptibility. Data collection will include information on individual sociodemographics, residential histories, health, and lifestyle. Lifetime exposures to environmental pollutants will be ascertained through questionnaire, residential proximity-based measures or models. In addition, biospecimens (blood spots and saliva) will be collected on all participants. Within MI-CARES, we will form an enhanced measurement cohort (n=1,000 cancer- free cohort members) and a nested case-control sample (n=250 cancer cases and 250 matched cancer-free cohort controls) in whom a comprehensive laboratory-based exposure and intermediate cancer biomarker assessment will be conducted, including PFAS, metals, untargeted metabolomics, DNA methylation, and inflammation biomarkers.



Publications

A synthetic data integration framework to leverage external summary-level information from heterogeneous populations.
Authors: Gu T. , Taylor J.M.G. , Mukherjee B. .
Source: Biometrics, 2023 Dec; 79(4), p. 3831-3845.
EPub date: 2023-04-04.
PMID: 36876883
Related Citations

Methods for mediation analysis with high-dimensional DNA methylation data: Possible choices and comparisons.
Authors: Clark-Boucher D. , Zhou X. , Du J. , Liu Y. , Needham B.L. , Smith J.A. , Mukherjee B. .
Source: PLoS genetics, 2023 Nov; 19(11), p. e1011022.
EPub date: 2023-11-07.
PMID: 37934796
Related Citations

Exploratory profiles of phenols, parabens, and per- and poly-fluoroalkyl substances among NHANES study participants in association with previous cancer diagnoses.
Authors: Cathey A.L. , Nguyen V.K. , Colacino J.A. , Woodruff T.J. , Reynolds P. , Aung M.T. .
Source: Journal of exposure science & environmental epidemiology, 2023 Sep; 33(5), p. 687-698.
EPub date: 2023-09-18.
PMID: 37718377
Related Citations

Methods for large-scale single mediator hypothesis testing: Possible choices and comparisons.
Authors: Du J. , Zhou X. , Clark-Boucher D. , Hao W. , Liu Y. , Smith J.A. , Mukherjee B. .
Source: Genetic epidemiology, 2023 Mar; 47(2), p. 167-184.
EPub date: 2022-12-08.
PMID: 36465006
Related Citations

Methods for Mediation Analysis with High-Dimensional DNA Methylation Data: Possible Choices and Comparison.
Authors: Clark-Boucher D. , Zhou X. , Du J. , Liu Y. , Needham B.L. , Smith J.A. , Mukherjee B. .
Source: medRxiv : the preprint server for health sciences, 2023-02-14; , .
EPub date: 2023-02-14.
PMID: 36824903
Related Citations

Harmonized US National Health and Nutrition Examination Survey 1988-2018 for high throughput exposome-health discovery.
Authors: Nguyen V.K. , Middleton L.Y.M. , Huang L. , Zhao N. , Verly E. , Kvasnicka J. , Sagers L. , Patel C.J. , Colacino J. , Jolliet O. .
Source: medRxiv : the preprint server for health sciences, 2023-02-08; , .
EPub date: 2023-02-08.
PMID: 36798185
Related Citations

Comparative impact assessment of COVID-19 policy interventions in five South Asian countries using reported and estimated unreported death counts during 2020-2021.
Authors: Kundu R. , Datta J. , Ray D. , Mishra S. , Bhattacharyya R. , Zimmermann L. , Mukherjee B. .
Source: PLOS global public health, 2023; 3(12), p. e0002063.
EPub date: 2023-12-27.
PMID: 38150465
Related Citations




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