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Grant Details

Grant Number: 5P50CA244433-04 Interpret this number
Primary Investigator: Emmons, Karen
Organization: Harvard School Of Public Health
Project Title: The Implementation Science Center for Cancer Control Equity
Fiscal Year: 2022


Abstract - Overall After decades of research developing and testing interventions for cancer control, we have the evidence needed to prevent more than half of all cancers. The impact of these strategies on cancer outcomes is significant for both the general population and low income and under-represented groups that bear a disproportionate share of preventable cancer burden, but evidence-based interventions have not been uniformly used across population groups. Gaps in implementation of the evidence base can be seen for nearly all known cancer prevention and early detection strategies. As a result, we incur substantial avoidable cancer morbidity and mortality and tolerate preventable inequities. The Implementation Science Center for Cancer Control Equity (ISCCCE) will create an ecosystem for robust implementation science (IS) related to cancer prevention and control in Massachusetts community health centers (CHCs) and their local communities. Our theme, improving community health by integrating health equity and implementation science for evidence-based cancer control, reflects our critical mass of expertise in cancer disparities, IS, and community-based cancer prevention and control research. Our “grand challenge” is to address the inequitable implementation and limited scale of evidence-based interventions by developing and testing implementation strategies aimed at narrowing health inequities and by advancing methods that carefully consider the low-resource, complex nature of CHCs where adaptation and cost-effective solutions are needed most. The implementation studies we conduct will address inequities within CHC clinical practice as well as prevention interventions that link to community resources and assets. Our I-Lab is comprised of 31 CHCs who are members of the Mass League of Community Health Centers and use a common EHR vendor- neutral population management system that has extensive reporting capability within and across CHCs, which will allow us to study implementation outcomes in different geographic settings across the state using common measures. Given that achieving equity in community health requires clinical, community, and policy-level interventions, our pilots will also examine how to expand the impact and sustainability of CHCs’ cancer prevention efforts through effective partnerships in community and policy settings. Our Network Unit connects us directly with other Moonshot IS initiatives and national community health leadership, and expands opportunities for collaboration and synergy, building IS capacity in our own institutions and across the nation.


The Impact of the Social Determinants of Health on Disparities in Inflammatory Bowel Disease.
Authors: Anyane-Yeboa A. , Quezada S. , Rubin D.T. , Balzora S. .
Source: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 2022 Nov; 20(11), p. 2427-2434.
EPub date: 2022-03-17.
PMID: 35307597
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Stakeholder and Equity Data-Driven Implementation: a Mixed Methods Pilot Feasibility Study.
Authors: Aschbrenner K.A. , Kruse G. , Emmons K.M. , Singh D. , Barber-Dubois M.E. , Miller A.M. , Thomas A.N. , Bartels S.J. .
Source: Prevention science : the official journal of the Society for Prevention Research, 2022-10-04; , p. 1-11.
EPub date: 2022-10-04.
PMID: 36194312
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Expanding COVID-19 vaccine access to underserved populations through implementation of mobile vaccination units.
Authors: Gupta P.S. , Mohareb A.M. , Valdes C. , Price C. , Jollife M. , Regis C. , Munshi N. , Taborda E. , Lautenschlager M. , Fox A. , et al. .
Source: Preventive medicine, 2022 Oct; 163, p. 107226.
EPub date: 2022-08-25.
PMID: 36029925
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Applying mixed methods to pilot feasibility studies to inform intervention trials.
Authors: Aschbrenner K.A. , Kruse G. , Gallo J.J. , Plano Clark V.L. .
Source: Pilot and feasibility studies, 2022-09-26; 8(1), p. 217.
EPub date: 2022-09-26.
PMID: 36163045
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Inflammatory bowel disease in underserved populations: lessons for practice.
Authors: Odufalu F.D. , Aboubakr A. , Anyane-Yeboa A. .
Source: Current opinion in gastroenterology, 2022-07-01; 38(4), p. 321-327.
PMID: 35762691
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Implementing expanded COVID-19 testing in Massachusetts community health centers through community partnerships: Protocol for an interrupted time series and stepped wedge study design.
Authors: Kruse G.R. , Pelton-Cairns L. , Taveras E.M. , Dargon-Hart S. , Gundersen D.A. , Lee R.M. , Bierer B.E. , Lawlor E. , LaRocque R.C. , Marcus J.L. , et al. .
Source: Contemporary clinical trials, 2022 Jul; 118, p. 106783.
EPub date: 2022-05-06.
PMID: 35533978
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Social determinants of health and cancer screening implementation and outcomes in the USA: a systematic review protocol.
Authors: Korn A.R. , Walsh-Bailey C. , Pilar M. , Sandler B. , Bhattacharjee P. , Moore W.T. , Brownson R.C. , Emmons K.M. , Oh A.Y. .
Source: Systematic reviews, 2022-06-08; 11(1), p. 117.
EPub date: 2022-06-08.
PMID: 35676720
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Collaboration networks of the implementation science centers for cancer control: a social network analysis.
Authors: Jacob R.R. , Korn A.R. , Huang G.C. , Easterling D. , Gundersen D.A. , Ramanadhan S. , Vu T. , Angier H. , Brownson R.C. , Haire-Joshu D. , et al. .
Source: Implementation science communications, 2022-04-13; 3(1), p. 41.
EPub date: 2022-04-13.
PMID: 35418309
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The Prevalence of Dissemination and Implementation Research and Training Grants at National Cancer Institute-Designated Cancer Centers.
Authors: Mueller N.M. , Hsieh A. , Ramanadhan S. , Lee R.M. , Emmons K.M. .
Source: JNCI cancer spectrum, 2022 Feb; 6(1), .
EPub date: 2021-12-15.
PMID: 35005429
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The mental health burden of racial and ethnic minorities during the COVID-19 pandemic.
Authors: Nguyen L.H. , Anyane-Yeboa A. , Klaser K. , Merino J. , Drew D.A. , Ma W. , Mehta R.S. , Kim D.Y. , Warner E.T. , Joshi A.D. , et al. .
Source: PloS one, 2022; 17(8), p. e0271661.
EPub date: 2022-08-10.
PMID: 35947543
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Addressing COVID-19 Testing Inequities Among Underserved Populations in Massachusetts: A Rapid Qualitative Exploration of Health Center Staff, Partner, and Resident Perceptions.
Authors: Lee R.M. , Handunge V.L. , Augenbraun S.L. , Nguyen H. , Torres C.H. , Ruiz A. , Emmons K.M. , RADx-MA Research Partnership .
Source: Frontiers in public health, 2022; 10, p. 838544.
EPub date: 2022-03-24.
PMID: 35400042
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COVID-19 mitigation for high-risk populations in Springfield Massachusetts USA: a health systems approach.
Authors: Pirraglia P.A. , Torres C.H. , Collins J. , Garb J. , Kent M. , McAdoo S.P. , Oloruntola-Coates Y. , Smith J.M. , Thomas A. .
Source: International journal for equity in health, 2021-10-19; 20(1), p. 230.
EPub date: 2021-10-19.
PMID: 34666781
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Walking the talk on multi-level interventions: The power of parsimony.
Authors: McBride C.M. , Cooper H.L. , Williams D.R. , Emmons K.M. .
Source: Social science & medicine (1982), 2021 Aug; 283, p. 114189.
EPub date: 2021-07-04.
PMID: 34246031
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Pragmatic approaches to analyzing qualitative data for implementation science: an introduction.
Authors: Ramanadhan S. , Revette A.C. , Lee R.M. , Aveling E.L. .
Source: Implementation science communications, 2021-06-29; 2(1), p. 70.
EPub date: 2021-06-29.
PMID: 34187595
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Building Trust in COVID-19 Vaccines and Beyond Through Authentic Community Investment.
Authors: Ojikutu B.O. , Stephenson K.E. , Mayer K.H. , Emmons K.M. .
Source: American journal of public health, 2021 Mar; 111(3), p. 366-368.
EPub date: 2020-12-10.
PMID: 33301352
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Applying an Equity Lens to Characterizing the Process and Reasons for an Adaptation to an Evidenced-based Practice.
Authors: Aschbrenner K.A. , Mueller N.M. , Banerjee S. , Bartels S.J. .
Source: Implementation research and practice, 2021 Jan-Dec; 2, .
EPub date: 2021-05-26.
PMID: 34514417
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Building the Next Generation of Researchers: Mentored Training in Dissemination and Implementation Science.
Authors: Brownson R.C. , Jacob R.R. , Carothers B.J. , Chambers D.A. , Colditz G.A. , Emmons K.M. , Haire-Joshu D. , Kerner J.F. , Padek M. , Pfund C. , et al. .
Source: Academic medicine : journal of the Association of American Medical Colleges, 2021-01-01; 96(1), p. 86-92.
PMID: 32941251
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Mentored training and its association with dissemination and implementation research output: a quasi-experimental evaluation.
Authors: Jacob R.R. , Gacad A. , Padek M. , Colditz G.A. , Emmons K.M. , Kerner J.F. , Chambers D.A. , Brownson R.C. .
Source: Implementation science : IS, 2020-05-11; 15(1), p. 30.
EPub date: 2020-05-11.
PMID: 32393285
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Training scholars in dissemination and implementation research for cancer prevention and control: a mentored approach.
Authors: Padek M. , Mir N. , Jacob R.R. , Chambers D.A. , Dobbins M. , Emmons K.M. , Kerner J. , Kumanyika S. , Pfund C. , Proctor E.K. , et al. .
Source: Implementation science : IS, 2018-01-22; 13(1), p. 18.
EPub date: 2018-01-22.
PMID: 29357876
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