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Grant Details

Grant Number: 5R50CA243692-04 Interpret this number
Primary Investigator: Mcdowell, Bradley
Organization: University Of Iowa
Project Title: Building a Patient-Centered Cancer Data Mart in a Rural State
Fiscal Year: 2022


Abstract The University of Iowa Holden Comprehensive Cancer Center (HCCC) is an NCI-funded comprehensive cancer center with a strong culture of transdisciplinary collaboration. It is the only academic cancer center in the state of Iowa and serves a rural population with unique environmental exposures. The Population Research Core is a HCCC shared resource that provides centralized leadership for harnessing clinical and population-based tools and data resources, eliminating barriers to their use. Led by its Director, Dr. Bradley McDowell, the Core provides epidemiology expertise, study design, enhanced data sharing, and distributed prep-to-research queries that promote rigorous retrospective and prospective studies using robust data collection and data curation methods. Dr. McDowell's expertise in these areas is particularly important as we apply big data approaches that integrate social, population, clinical, patient-generated, and molecular data to generate evidence to personalize cancer care. The ultimate goal is to provide researchers with a complete picture of cancer patients' experiences prior to diagnosis, during treatment, and through long-term survival. This will be accomplished by integrating existing hospital data with state cancer-registry data, insurance claims, and other cancer-related datasets to create a multi-purpose data mart that will serve as a resource for standardized data queries. This work will be performed while continuing to oversee a mature support core for population science activities of the HCCC.


Assessing Completeness of Cancer Treatment Data from an Academic Medical Center's Tumor Registry Through Comparison to the Central Registry.
Authors: McDowell B.D. , Bentler S.E. , West M.M. , Kahl A.R. , Nash S.H. , Brubaker J.T. , Matt B. , Charlton M.E. .
Source: Journal of registry management, 2023 Summer; 50(2), p. 52-56.
PMID: 37575555
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Cardiac Adverse Events Associated With Chemo-Radiation Versus Chemotherapy for Resectable Stage III Non-Small-Cell Lung Cancer: A Surveillance, Epidemiology and End Results-Medicare Study.
Authors: Herbach E. , O'Rorke M.A. , Carnahan R.M. , McDowell B.D. , Allen B. , Grumbach I. , London B. , Smith B.J. , Spitz D.R. , Seaman A. , et al. .
Source: Journal of the American Heart Association, 2022-12-06; 11(23), p. e027288.
EPub date: 2022-12-01.
PMID: 36453633
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The Influence of Hospital Characteristics on Patient Survival in Surgically Managed Metastatic Disease of Bone: An Analysis of the SEER-Medicare Linked Database.
Authors: Herbach E.L. , McDowell B.D. , Chrischilles E.A. , Miller B.J. .
Source: American journal of clinical oncology, 2022-08-01; 45(8), p. 344-351.
EPub date: 2022-07-06.
PMID: 35792549
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Cancer Registry Data Linkage of Electronic Health Record Data From ASCO's CancerLinQ: Evaluation of Advantages, Limitations, and Lessons Learned.
Authors: Charlton M.E. , Kahl A.R. , McDowell B.D. , Miller R.S. , Komatsoulis G. , Koskimaki J.E. , Rivera D.R. , Cronin K.A. .
Source: JCO clinical cancer informatics, 2022 Mar; 6, p. e2100149.
PMID: 35483002
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Trends and practices for managing low-risk prostate cancer: a SEER-Medicare study.
Authors: Hoffman R.M. , Mott S.L. , McDowell B.D. , Anand S.T. , Nepple K.G. .
Source: Prostate cancer and prostatic diseases, 2022 Mar; 25(1), p. 100-108.
EPub date: 2021-06-09.
PMID: 34108645
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Relationships between health literacy, having a cancer care coordinator, and long-term health-related quality of life among cancer survivors.
Authors: Del Vecchio N.J. , McDowell B.D. , Carter K.D. , Askelson N.M. , Chrischilles E. , Lynch C.F. , Charlton M.E. .
Source: Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2021 Dec; 29(12), p. 7913-7924.
EPub date: 2021-06-30.
PMID: 34191127
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Exploration of PCORnet Data Resources for Assessing Use of Molecular-Guided Cancer Treatment.
Authors: Carnahan R.M. , Waitman L.R. , Charlton M.E. , Schroeder M.C. , Bossler A.D. , Campbell W.S. , Campbell J.R. , McDowell B.D. , Smith N.C. , Gryzlak B.M. , et al. .
Source: JCO clinical cancer informatics, 2020 Aug; 4, p. 724-735.
PMID: 32795185
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MicroRNA-based risk scoring system to identify early-stage oral squamous cell carcinoma patients at high-risk for cancer-specific mortality.
Authors: Yoon A.J. , Wang S. , Kutler D.I. , Carvajal R.D. , Philipone E. , Wang T. , Peters S.M. , LaRoche D. , Hernandez B.Y. , McDowell B.D. , et al. .
Source: Head & neck, 2020 Aug; 42(8), p. 1699-1712.
EPub date: 2020-01-25.
PMID: 31981257
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