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Grant Details

Grant Number: 5U01CA253858-03 Interpret this number
Primary Investigator: Meza, Rafael
Organization: University Of Michigan At Ann Arbor
Project Title: Comparative Modeling of Lung Cancer Prevention, Early Detection and Treatment Interventions
Fiscal Year: 2022


Project Summary Abstract Lung cancer remains the leading cause of cancer related mortality in the US and globally— responsible for ~1.8 million deaths annually. As collaborative investigators of the Cancer Intervention and Surveillance Modeling Network (CISNET) Lung Working Group (LWG), we have contributed to the development of US national strategies for reducing the lung cancer burden by quantifying the impact of tobacco control on smoking, lung cancer, and overall mortality, and by evaluating the population benefits and harms of lung cancer screening in the US. Due to ongoing reductions in smoking in the US, lung cancer mortality is projected to continue declining. However, lung cancer is still expected to result in over 4 million deaths over the next 50 years. Thus, in addition to tobacco control efforts, a focus on early detection and treatment interventions will be critical to further reduce the lung cancer burden in the US. Moreover, as new tobacco products, such as e-cigarettes (e-cigs), become more popular, there are concerns that the gains achieved in the fight against smoking could reverse. We propose to continue our work and extend our models to assess the impact of 1) future tobacco control interventions in the ever-changing tobacco market landscape, 2) improvements in lung cancer screening and other emerging early detection strategies, 3) innovations in lung cancer treatment, and importantly, 4) their synergistic interactions on lung cancer rates and overall mortality in the US and globally.


Evaluation of benefits and harms of adaptive screening schedules for lung cancer: A microsimulation study.
Authors: Cao P. , Jeon J. , Meza R. .
Source: Journal of medical screening, 2022 Dec; 29(4), p. 260-267.
EPub date: 2022-08-22.
PMID: 35989646
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Sociodemographic Survival Disparities for Lung Cancer in the United States, 2000-2016.
Authors: Brouwer A.F. , Engle J.M. , Jeon J. , Meza R. .
Source: Journal of the National Cancer Institute, 2022-11-14; 114(11), p. 1492-1500.
PMID: 35866998
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Factors Influencing the False Positive Rate in CT Lung Cancer Screening.
Authors: Hammer M.M. , Byrne S.C. , Kong C.Y. .
Source: Academic radiology, 2022 Feb; 29 Suppl 2(Suppl 2), p. S18-S22.
EPub date: 2020-09-03.
PMID: 32893112
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Impact of Joint Lung Cancer Screening and Cessation Interventions Under the New Recommendations of the U.S. Preventive Services Task Force.
Authors: Meza R. , Cao P. , Jeon J. , Taylor K.L. , Mandelblatt J.S. , Feuer E.J. , Lowy D.R. .
Source: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2022 Jan; 17(1), p. 160-166.
EPub date: 2021-10-12.
PMID: 34648947
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Cost-effectiveness Evaluation of the 2021 US Preventive Services Task Force Recommendation for Lung Cancer Screening.
Authors: Toumazis I. , de Nijs K. , Cao P. , Bastani M. , Munshi V. , Ten Haaf K. , Jeon J. , Gazelle G.S. , Feuer E.J. , de Koning H.J. , et al. .
Source: JAMA oncology, 2021-12-01; 7(12), p. 1833-1842.
PMID: 34673885
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Evaluation of Alternative Diagnostic Follow-up Intervals for Lung Reporting and Data System Criteria on the Effectiveness of Lung Cancer Screening.
Authors: Bastani M. , Toumazis I. , Hedou' J. , Leung A. , Plevritis S.K. .
Source: Journal of the American College of Radiology : JACR, 2021 Dec; 18(12), p. 1614-1623.
EPub date: 2021-08-19.
PMID: 34419477
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The Potential Impact of Widespread Cessation Treatment for Smokers With Depression.
Authors: Tam J. , Warner K.E. , Zivin K. , Taylor G.M.J. , Meza R. .
Source: American journal of preventive medicine, 2021 Nov; 61(5), p. 674-682.
EPub date: 2021-07-07.
PMID: 34244005
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Cost-Effectiveness of Smoking Cessation Interventions in the Lung Cancer Screening Setting: A Simulation Study.
Authors: Cadham C.J. , Cao P. , Jayasekera J. , Taylor K.L. , Levy D.T. , Jeon J. , Elkin E.B. , Foley K.L. , Joseph A. , Kong C.Y. , et al. .
Source: Journal of the National Cancer Institute, 2021-08-02; 113(8), p. 1065-1073.
PMID: 33484569
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A comparison of tobacco product prevalence by different frequency of use thresholds across three US surveys.
Authors: Sánchez-Romero L.M. , Cadham C.J. , Hirschtick J.L. , Mattingly D.T. , Cho B. , Fleischer N.L. , Brouwer A. , Mistry R. , Land S.R. , Jeon J. , et al. .
Source: BMC public health, 2021-06-24; 21(1), p. 1203.
EPub date: 2021-06-24.
PMID: 34162379
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US Nicotine Vaping Product SimSmoke Simulation Model: The Effect of Vaping and Tobacco Control Policies on Smoking Prevalence and Smoking-Attributable Deaths.
Authors: Levy D.T. , Sánchez-Romero L.M. , Travis N. , Yuan Z. , Li Y. , Skolnick S. , Jeon J. , Tam J. , Meza R. .
Source: International journal of environmental research and public health, 2021-05-03; 18(9), .
EPub date: 2021-05-03.
PMID: 34063672
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Public health implications of vaping in the USA: the smoking and vaping simulation model.
Authors: Levy D.T. , Tam J. , Sanchez-Romero L.M. , Li Y. , Yuan Z. , Jeon J. , Meza R. .
Source: Population health metrics, 2021-04-17; 19(1), p. 19.
EPub date: 2021-04-17.
PMID: 33865410
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Evaluation of the Benefits and Harms of Lung Cancer Screening With Low-Dose Computed Tomography: Modeling Study for the US Preventive Services Task Force.
Authors: Meza R. , Jeon J. , Toumazis I. , Ten Haaf K. , Cao P. , Bastani M. , Han S.S. , Blom E.F. , Jonas D.E. , Feuer E.J. , et al. .
Source: JAMA, 2021-03-09; 325(10), p. 988-997.
PMID: 33687469
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The Mexico SimSmoke tobacco control policy model: Development of a simulation model of daily and nondaily cigarette smoking.
Authors: Sánchez-Romero L.M. , Zavala-Arciniega L. , Reynales-Shigematsu L.M. , de Miera-Juárez B.S. , Yuan Z. , Li Y. , Lau Y.K. , Fleischer N.L. , Meza R. , Thrasher J.F. , et al. .
Source: PloS one, 2021; 16(6), p. e0248215.
EPub date: 2021-06-21.
PMID: 34153063
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