Grant Details
Grant Number: |
5R01CA207491-06 Interpret this number |
Primary Investigator: |
Mead-Morse, Erin |
Organization: |
University Of Connecticut Sch Of Med/Dnt |
Project Title: |
Electronic Cigarette Use During Pregnancy |
Fiscal Year: |
2022 |
Abstract
Abstract:
Electronic cigarettes are rapidly becoming popular as a substitute for cigarette smoking and as an adjunct
for smoking cessation. Unfortunately, little is known about use of these new tobacco products in pregnant
women. Although the best option would be for pregnant women to stop using tobacco products entirely, a
central question for women who do not quit smoking is “Are electronic cigarettes a net benefit or harm in terms
of toxicant exposure and birth outcomes?” Because electronic cigarettes do not burn tobacco, they may reduce
carbon monoxide (CO) exposure (a toxin that may contribute to low birth weight and neurotoxicity) and
carcinogen exposure, which has been linked to low birth weight and childhood cancer. However, a concern
exists that electronic cigarettes may present risks in pregnancy that match or exceed those of cigarette
smoking such as increased nicotine exposure (particularly in dual users), and an increase formaldehyde
exposure, which has been linked to adverse reproductive outcomes in nonsmokers.
We will recruit 125 pregnant smokers and 250 pregnant electronic cigarette users (125 women who use e-
cigs exclusively during pregnancy, and 125 dual users). We will advise women to stop all tobacco use, and
provide written materials and quitline referrals. Maternal toxicant exposure levels of the tobacco-specific
carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), formaldehyde, and cotinine (major
metabolite of nicotine) will be obtained throughout pregnancy and infant levels of NNAL and cotinine will be
obtained at the time of delivery. We will also obtain data on birth weight, gestational age, and other
reproductive outcomes.
Our primary objective is to compare toxicant exposure in pregnant women who use electronic cigarettes
compared to women who smoke conventional cigarettes. We hypothesize that women who smoke
conventional cigarettes exclusively will have higher NNAL and cotinine concentrations throughout pregnancy
and at delivery than electronic cigarette users. We will also explore differences in urine formaldehyde levels.
Another primary objective is to examine the impact of conventional cigarettes compared to electronic cigarettes
on birth weight. We hypothesize that infants born to exclusive conventional cigarette smokers will have lower
birth weights than those of electronic cigarette users. We will also examine mechanisms by which conventional
and electronic cigarettes could impact birth weight and other reproductive outcomes using toxicant biomarkers
as well as biomarkers of inflammation.
Results from this project can be used to better inform clinicians who may be in a position to counsel
pregnant women about the potential effects of electronic cigarette use during pregnancy.
Publications
Examining Demand and Substitutability of Usual Brand Little Cigars/Cigarillos and Cigarettes in Young Adults Who Dual Use.
Authors: Mead-Morse E.L.
, Cassidy R.N.
, Kpormegbey D.E.
, Moore T.
, Oncken C.
, Tidey J.W.
, Delnevo C.D.
, Litt M.
.
Source: Nicotine & Tobacco Research : Official Journal Of The Society For Research On Nicotine And Tobacco, 2024-07-22 00:00:00.0; 26(8), p. 1057-1065.
PMID: 38365185
Related Citations
Transcriptomic responses in the blood and sputum of cigarette smokers compared to e-cigarette vapers.
Authors: Perez M.F.
, Yurieva M.
, Poddutoori S.
, Mortensen E.M.
, Crotty Alexander L.E.
, Williams A.
.
Source: Respiratory Research, 2023-05-18 00:00:00.0; 24(1), p. 134.
EPub date: 2023-05-18 00:00:00.0.
PMID: 37208747
Related Citations
Exploring the hypothetical impact of flavored cigar sales restrictions among black young adult cigar smokers: a semi-structured in-depth interview investigation.
Authors: Pakdaman S.
, Broun A.
, Duarte D.A.
, Ajith A.
, Jewett B.
, Wong N.
, Mead-Morse E.L.
, Choi K.
, Chen-Sankey J.
.
Source: Journal Of Ethnicity In Substance Abuse, 2022-08-09 00:00:00.0; , p. 1-19.
EPub date: 2022-08-09 00:00:00.0.
PMID: 35943488
Related Citations
Characteristics of Cheyenne little filtered cigar Instagram ads, 2019-2020.
Authors: Mead-Morse E.L.
, Delnevo C.D.
, Singh B.
, Wackowski O.A.
.
Source: Tobacco Control, 2022-06-21 00:00:00.0; , .
EPub date: 2022-06-21 00:00:00.0.
PMID: 35728933
Related Citations
Validity of a little cigars/cigarillos purchase task in dual users of cigars and cigarettes.
Authors: Mead-Morse E.L.
, Cassidy R.N.
, Oncken C.
, Tidey J.W.
, Delnevo C.D.
, Litt M.
.
Source: Addictive Behaviors, 2022-02-17 00:00:00.0; 130, p. 107285.
EPub date: 2022-02-17 00:00:00.0.
PMID: 35255241
Related Citations
Exclusive and Dual Cigarette and Hookah Smoking Is Associated with Adverse Perinatal Outcomes among Pregnant Women in Cairo, Egypt.
Authors: El-Shahawy O.
, Labib K.
, Stevens E.
, Kahn L.G.
, Anwar W.
, Oncken C.
, Loney T.
, Sherman S.E.
, Mead-Morse E.L.
.
Source: International Journal Of Environmental Research And Public Health, 2021-12-09 00:00:00.0; 18(24), .
EPub date: 2021-12-09 00:00:00.0.
PMID: 34948585
Related Citations
Cigar-Smoking-Cessation Interest and Experience among Black Young Adults: A Semi-Structured In-Depth Interview Investigation.
Authors: Ajith A.
, Broun A.
, Duarte D.A.
, Jewett B.
, Phan L.
, Mead-Morse E.L.
, Guy M.C.
, Choi K.
, Chen-Sankey J.
.
Source: International Journal Of Environmental Research And Public Health, 2021-07-08 00:00:00.0; 18(14), .
EPub date: 2021-07-08 00:00:00.0.
PMID: 34299759
Related Citations
Biomarkers of Toxicant Exposure and Inflammation Among Women of Reproductive Age Who Use Electronic or Conventional Cigarettes.
Authors: Perez M.F.
, Mead E.L.
, Atuegwu N.C.
, Mortensen E.M.
, Goniewicz M.
, Oncken C.
.
Source: Journal Of Women's Health (2002), 2021-02-02 00:00:00.0; , .
EPub date: 2021-02-02 00:00:00.0.
PMID: 33534627
Related Citations
The inflammatory biomarker YKL-40 is elevated in the serum, but not the sputum, of E-cigarette users.
Authors: Perez M.F.
, Atuegwu N.C.
, Mortensen E.M.
, Oncken C.
.
Source: Experimental Lung Research, 2021 Feb-Mar; 47(2), p. 55-66.
EPub date: 2020-11-17 00:00:00.0.
PMID: 33200966
Related Citations
Cigar-Smoking Patterns by Race/Ethnicity and Cigar Type: A Nationally Representative Survey Among U.S. Adults.
Authors: Chen-Sankey J.C.
, Mead-Morse E.L.
, Le D.
, Rose S.W.
, Quisenberry A.J.
, Delnevo C.D.
, Choi K.
.
Source: American Journal Of Preventive Medicine, 2021 Jan; 60(1), p. 87-94.
PMID: 33341182
Related Citations
E-cigarette use is associated with a self-reported diagnosis of prediabetes in never cigarette smokers: Results from the behavioral risk factor surveillance system survey.
Authors: Atuegwu N.C.
, Perez M.F.
, Oncken C.
, Mead E.L.
, Maheshwari N.
, Mortensen E.M.
.
Source: Drug And Alcohol Dependence, 2019-12-01 00:00:00.0; 205, p. 107692.
EPub date: 2019-10-28 00:00:00.0.
PMID: 31707269
Related Citations
Association between Regular Electronic Nicotine Product Use and Self-reported Periodontal Disease Status: Population Assessment of Tobacco and Health Survey.
Authors: Atuegwu N.C.
, Perez M.F.
, Oncken C.
, Thacker S.
, Mead E.L.
, Mortensen E.M.
.
Source: International Journal Of Environmental Research And Public Health, 2019-04-09 00:00:00.0; 16(7), .
EPub date: 2019-04-09 00:00:00.0.
PMID: 30970567
Related Citations