Grant Number:	5U01CA253915-04 Interpret this number
Primary Investigator:	Etzioni, Ruth
Organization:	Fred Hutchinson Cancer Center
Project Title:	Modeling Precision Interventions for Prostate Cancer Control
Fiscal Year:	2022

PROJECT SUMMARY/ABSTRACT Prostate cancer is the most common solid tumor in men and the second most common cause of cancer death in the United States. The Cancer Intervention and Surveillance Modeling Network (CISNET) Prostate Working Group (PWG) was formed in the year 2000 to address a wide range of questions about effective prostate cancer control. The PWG studied the rapid increase in prostate cancer diagnoses after PSA screening started in the late 1980s to estimate lead time and overdiagnosis associated with the test. The PWG studied the decline in prostate cancer mortality that began in the early 1990s to quantify the plausible contributions of PSA screening and changes in primary treatments. The PWG also studied how to interpret trends in racial disparities in incidence and survival, how to manage men with low-risk disease on active surveillance, and how to reconcile apparently discordant randomized trials of PSA screening and radical prostatectomy. In recent years, technologies surrounding prostate cancer screening and treatment have evolved rapidly, and opportunities to improve patient care using personalized data abound. Genetic testing can identify men at increased risk for developing aggressive disease, new biomarkers and imaging tools can help men avoid unnecessary biopsies, and new hormonal treatments can lengthen survival for men with advanced disease. The objective of this application is to extend PWG models to evaluate optimal ways to utilize personalized data to improve patient care while limiting harms and costs. We will determine whether we can improve early detection using novel stratification approaches and whether we can safely limit overtreatment and other harms by tailored choices of primary and secondary therapies. These approaches will be applied in the United States and in international cancer control settings with different resources and priorities. Our specific aims are as follows. Aim 1: Precision early detection, including risk-stratified screening and biopsy using genetic tests, novel biomarkers, and imaging technology. Aim 2: Precision active surveillance, including adaptive biopsy intervals and imaging technology. Aim 3: Precision treatment, including type and timing of initial and salvage therapies. Aim 4: Targeting screening, biopsy, and treatment policies to reduce racial disparities. Aim 5: Prioritizing screening and treatment interventions in international settings. These aims are highly responsive to the funding opportunity announcement, addressing 7 of the 9 targeted priority areas to varying degrees. Our cumulative expertise in prostate modeling, our existing models, and our close ties with clinical experts who provide access to large, high-quality datasets for model validation and calibration put us in a strong position to answer critical and impactful questions about how best to control this most common cancer in men.




Reducing Prostate Cancer Overdiagnosis.
Authors: Gulati R. .
Source: The New England journal of medicine, 2022-12-08; 387(23), p. 2187-2188.
PMID: 36477037
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Cost-Effectiveness Analysis of Prostate Cancer Screening in the UK: A Decision Model Analysis Based on the CAP Trial.
Authors: Keeney E. , Sanghera S. , Martin R.M. , Gulati R. , Wiklund F. , Walsh E.I. , Donovan J.L. , Hamdy F. , Neal D.E. , Lane J.A. , et al. .
Source: PharmacoEconomics, 2022 Dec; 40(12), p. 1207-1220.
EPub date: 2022-10-06.
PMID: 36201131
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Editorial Comment.
Authors: Gulati R. , Nyame Y.A. .
Source: The Journal of urology, 2022 Nov; 208(5), p. 1027.
EPub date: 2022-09-06.
PMID: 36065679
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Correction: Estimating patient health in prostate cancer treatment counseling.
Authors: Chesnut G.T. , Tin A.L. , Fleshner K.A. , Benfante N.E. , Vickers A.J. , Eastham J.A. , Sjoberg D.D. , Carlsson S.V. .
Source: Prostate cancer and prostatic diseases, 2022 Sep; 25(3), p. 598.
PMID: 35361969
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Corrigendum to definitive and sustained increase in prostate cancer metastases in the United States.
Authors: Patel N.A. , Sedrakyan A. , Bianco F. , Etzioni R. , Gorin M.A. , Hsu W.C. , Mao J. , Nguyen P.L. , Schaeffer E. , Shoag J. , et al. .
Source: Urologic oncology, 2022 Jul; 40(7), p. 354.
EPub date: 2022-05-30.
PMID: 35654645
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Harm-to-Benefit of Three Decades of Prostate Cancer Screening in Black Men.
Authors: Basourakos S.P. , Gulati R. , Vince R.A. , Spratt D.E. , Lewicki P.J. , Hill A. , Nyame Y.A. , Cullen J. , Markt S.C. , Barbieri C.E. , et al. .
Source: NEJM evidence, 2022 Jun; 1(6), .
EPub date: 2022-05-15.
PMID: 35721307
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Evaluation of Prostate Cancer Screening Strategies in a Low-Resource, High-risk Population in the Bahamas.
Authors: Heijnsdijk E.A.M. , Gulati R. , Lange J.M. , Tsodikov A. , Roberts R. , Etzioni R. .
Source: JAMA health forum, 2022 May; 3(5), p. e221116.
EPub date: 2022-05-20.
PMID: 35977253
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Scalable proximal methods for cause-specific hazard modeling with time-varying coefficients.
Authors: Wu W. , Taylor J.M.G. , Brouwer A.F. , Luo L. , Kang J. , Jiang H. , He K. .
Source: Lifetime data analysis, 2022 Apr; 28(2), p. 194-218.
EPub date: 2022-01-29.
PMID: 35092553
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Impact of cancer screening on metastasis: A prostate cancer case study.
Authors: Lange J. , Remmers S. , Gulati R. , Bill-Axelson A. , Johansson J.E. , Kwiatkowski M. , Auvinen A. , Hugosson J. , Hu J.C. , Roobol M.J. , et al. .
Source: Journal of medical screening, 2021 Dec; 28(4), p. 480-487.
EPub date: 2021-02-09.
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Divining Harm-Benefit Tradeoffs of Magnetic Resonance Imaging-targeted Biopsy.
Authors: Etzioni R. , Haffner M.C. , Gulati R. .
Source: European urology, 2021 Nov; 80(5), p. 573-574.
EPub date: 2021-09-01.
PMID: 34479754
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Clarifying the Trade-Offs of Risk-Stratified Screening for Prostate Cancer: A Cost-Effectiveness Study.
Authors: Hendrix N. , Gulati R. , Jiao B. , Kader A.K. , Ryan S.T. , Etzioni R. .
Source: American journal of epidemiology, 2021-10-01; 190(10), p. 2064-2074.
PMID: 34023874
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The Impact of Intensifying Prostate Cancer Screening in Black Men: A Model-Based Analysis.
Authors: Nyame Y.A. , Gulati R. , Heijnsdijk E.A.M. , Tsodikov A. , Mariotto A.B. , Gore J.L. , Etzioni R. .
Source: Journal of the National Cancer Institute, 2021-10-01; 113(10), p. 1336-1342.
PMID: 33963850
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Economic Evaluation of Urine-Based or Magnetic Resonance Imaging Reflex Tests in Men With Intermediate Prostate-Specific Antigen Levels in the United States.
Authors: Jiao B. , Gulati R. , Hendrix N. , Gore J.L. , Rais-Bahrami S. , Morgan T.M. , Etzioni R. .
Source: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 2021 Aug; 24(8), p. 1111-1117.
EPub date: 2021-04-22.
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When to Discuss Prostate Cancer Screening With Average-Risk Men.
Authors: Gulati R. , Carlsson S.V. , Etzioni R. .
Source: American journal of preventive medicine, 2021 Aug; 61(2), p. 294-298.
EPub date: 2021-05-06.
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Cost-effectiveness of multiparametric magnetic resonance imaging and MRI-guided biopsy in a population-based prostate cancer screening setting using a micro-simulation model.
Authors: Getaneh A.M. , Heijnsdijk E.A. , de Koning H.J. .
Source: Cancer medicine, 2021 Jun; 10(12), p. 4046-4053.
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Prostate Cancer Screening Guidelines for Black Men: Spotlight on an Empty Stage.
Authors: Etzioni R. , Nyame Y.A. .
Source: Journal of the National Cancer Institute, 2021-06-01; 113(6), p. 650-651.
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Preoperative exercise interventions to optimize continence outcomes following radical prostatectomy.
Authors: Mungovan S.F. , Carlsson S.V. , Gass G.C. , Graham P.L. , Sandhu J.S. , Akin O. , Scardino P.T. , Eastham J.A. , Patel M.I. .
Source: Nature reviews. Urology, 2021 May; 18(5), p. 259-281.
EPub date: 2021-04-08.
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Problems with Numbers in Decision Aids for Prostate-specific Antigen Screening: A Critical Review.
Authors: Carlsson S.V. , Vickers A.J. , Gonsky J.P. , Hay J.L. , Hu J.C. .
Source: European urology, 2021 Mar; 79(3), p. 330-333.
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Surgeon heterogeneity significantly affects functional and oncological outcomes after radical prostatectomy in the Swedish LAPPRO trial.
Authors: Nyberg M. , Sjoberg D.D. , Carlsson S.V. , Wilderäng U. , Carlsson S. , Stranne J. , Wiklund P. , Steineck G. , Haglind E. , Hugosson J. , et al. .
Source: BJU international, 2021 Mar; 127(3), p. 361-368.
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Prostate-Specific Antigen Screening and Recent Increases in Advanced Prostate Cancer.
Authors: Nyame Y.A. , Gulati R. , Tsodikov A. , Gore J.L. , Etzioni R. .
Source: JNCI cancer spectrum, 2021 Feb; 5(1), .
EPub date: 2020-10-26.
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Assessment of harms, benefits, and cost-effectiveness of prostate cancer screening: A micro-simulation study of 230 scenarios.
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"PSA Surveillance in the Septuagenarian": A Proposed New Terminology for Clinical Follow-up to Assess Risk of Prostate Cancer in Men Aged 70 Years and Older.
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Risk of Recurrent Disease 6 Years After Open or Robotic-assisted Radical Prostatectomy in the Prospective Controlled Trial LAPPRO.
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