Skip to main content
An official website of the United States government
Grant Details

Grant Number: 5R01CA240092-04 Interpret this number
Primary Investigator: Wheeler, Stephanie
Organization: Univ Of North Carolina Chapel Hill
Project Title: Addressing Cancer-Related Financial Toxicity in Rural Oncology Care Settings
Fiscal Year: 2022


Abstract

PROJECT SUMMARY & ABSTRACT Financial toxicity (FT), a term used to describe the high cost and cost-related psychosocial burden that cancer care places on patients and their families, is a major and underappreciated problem affecting at least 20% of all cancer patients, with potentially devastating effects on outcomes. FT disproportionately affects patients in rural settings due to multiple socioeconomic, access, and clinical factors. A recent review of cancer-related financial hardship characterized the burden of FT as belonging to one of three domains: (1) material hardship, including high out-of-pocket expenses and lost wages; (2) psychological burden from distress and anxiety caused by high cancer costs; and (3) behavioral changes resulting from high cancer care costs, including changes in both medical and non-medical spending. Across cancer sites and stages, the considerable material hardship caused by cancer has been linked consistently to negative psychological and behavioral outcomes, including lower health-related quality of life, higher emotional distress, treatment delay/discontinuation, and filing for bankruptcy. Importantly, FT is also associated with increased mortality. Harmful psychological effects and care-altering behavioral responses, such as delaying or foregoing treatment, are more common in rural patients who also face considerable geographic barriers to care and greater financial vulnerability (e.g., lack of health insurance), likely contributing to widely-observed rural/urban disparities in cancer mortality. Interventions are urgently needed to prevent and mitigate high FT for cancer patients living in rural areas. Our prior work with patients, cancer care professionals, and a regional network of rural oncology practices argues strongly for intervening with financial navigation (FN), due to the complex material, structural, and psychological needs in this setting, fragmentation of existing financial support resources, and complicated assistance eligibility requirements. FN is one type of evidence-based intervention implemented at the practice or system level that can identify patients at high risk for FT, assess eligibility for existing federal, nonprofit, manufacturer, and local financial support resources, clarify treatment cost expectations, and develop strategies to cope with high costs of care. Our long-term goal is to improve cancer care delivery, reduce FT, and improve outcomes in underserved, rural populations through sustainable, scalable interventions. The objectives of this application are to: (1) understand the rural oncology practice context to optimize tailored strategies to support FN implementation; (2) assess FN intervention implementation in rural oncology practices; and (3) evaluate the effects of FN implementation on patient outcomes, including FT and health-related quality of life, in rural oncology practices. Our proposal is directly responsive to RFA-CA-18-026, which seeks to “improve the reach and quality of cancer care in rural populations”. Expected outcomes are the development and refinement of the operational and logistical processes needed to deliver effective FN in rural settings and reduction in FT, with potential to reduce rural outcome disparities.



Publications

Financial burden among metastatic breast cancer patients: a qualitative inquiry of costs, financial assistance, health insurance, and financial coping behaviors.
Authors: Waters A.R. , Petermann V.M. , Planey A.M. , Manning M. , Spencer J.C. , Spees L.P. , Rosenstein D.L. , Gellin M. , Padilla N. , Reeder-Hayes K.E. , et al. .
Source: Cancer causes & control : CCC, 2024 Jun; 35(6), p. 955-961.
EPub date: 2024-02-22.
PMID: 38388859
Related Citations

Structural Factors and Racial/Ethnic Inequities in Travel Times to Acute Care Hospitals in the Rural US South, 2007-2018.
Authors: Planey A.M. , Planey D.A. , Wong S. , McLafferty S.L. , Ko M.J. .
Source: The Milbank quarterly, 2023 Sep; 101(3), p. 922-974.
EPub date: 2023-05-15.
PMID: 37190885
Related Citations

Extending critical race, racialization, and racism literatures to the adoption, implementation, and sustainability of data equity policies and data (dis)aggregation practices in health research.
Authors: Lee M. , Sumibcay J.R.C. , Cory H. , Duarte C. , Planey A.M. .
Source: Health services research, 2023 Aug; 58 Suppl 2(Suppl 2), p. 262-267.
EPub date: 2023-05-18.
PMID: 37202904
Related Citations

Multidimensional financial hardship among uninsured and insured young adult patients with metastatic breast cancer.
Authors: Wheeler S.B. , Spencer J.C. , Manning M.L. , Samuel C.A. , Reeder-Hayes K.E. , Greenup R.A. , Spees L.P. , Rosenstein D.L. .
Source: Cancer medicine, 2023 May; 12(10), p. 11930-11940.
EPub date: 2023-05-06.
PMID: 37148550
Related Citations

Assessing the pre-implementation context for financial navigation in rural and non-rural oncology clinics.
Authors: Petermann V.M. , Biddell C.B. , Planey A.M. , Spees L.P. , Rosenstein D.L. , Manning M. , Gellin M. , Padilla N. , Samuel-Ryals C.A. , Birken S.A. , et al. .
Source: Frontiers in health services, 2023; 3, p. 1148887.
EPub date: 2023-10-23.
PMID: 37941608
Related Citations

Lessening the Impact of Financial Toxicity (LIFT): a protocol for a multi-site, single-arm trial examining the effect of financial navigation on financial toxicity in adult patients with cancer in rural and non-rural settings.
Authors: Wheeler S.B. , Biddell C.B. , Manning M.L. , Gellin M.S. , Padilla N.R. , Spees L.P. , Rogers C.D. , Rodriguez-O'Donnell J. , Samuel-Ryals C. , Birken S.A. , et al. .
Source: Trials, 2022-10-03; 23(1), p. 839.
EPub date: 2022-10-03.
PMID: 36192802
Related Citations

Financial Assistance Processes and Mechanisms in Rural and Nonrural Oncology Care Settings.
Authors: Biddell C.B. , Spees L.P. , Petermann V. , Rosenstein D.L. , Manning M. , Gellin M. , Padilla N. , Samuel-Ryals C.A. , Birken S.A. , Reeder-Hayes K. , et al. .
Source: JCO oncology practice, 2022 Sep; 18(9), p. e1392-e1406.
EPub date: 2022-05-12.
PMID: 35549521
Related Citations

Racial differences in employment and cost-management behaviors in patients with metastatic breast cancer.
Authors: Samuel C.A. , Spencer J.C. , Rosenstein D.L. , Reeder-Hayes K.E. , Manning M.L. , Sellers J.B. , Wheeler S.B. .
Source: Breast cancer research and treatment, 2020 Jan; 179(1), p. 207-215.
EPub date: 2019-09-25.
PMID: 31555940
Related Citations




Back to Top