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Grant Details

Grant Number: 5R01CA231141-05 Interpret this number
Primary Investigator: Afshar-Kharghan, Vahid
Organization: University Of Tx Md Anderson Can Ctr
Project Title: Genetics of Graft-Versus-Host Disease
Fiscal Year: 2022


Abstract

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only curative therapy for many advanced hematologic malignancies. Allo-HSCT is associated with significant morbidities and mortality, mainly because of the graft-versus-host disease (GVHD) caused by donor T cells recognizing antigens present in recipient tissues, and initiating an alloimmune response resulting in damage to many organs including the skin, GI tract, and liver in recipient. More than half of all allo-HSCT recipients develop different degrees of GVHD (grade I-IV). About 20% of recipients develop severe GVHD (grade III-IV) that is associated with a very high morbidity and mortality. The most important factor determining the severity of GVHD is the genetic disparities between donors and recipients, as is reflected in HLA haplotypes that are routinely checked for donor selection. But even when donors and recipients are HLA-identical many recipients develop severe GVHD. As a result, non-HLA antigens are important determinants of acute GVHD. An interesting and unique aspect of GVHD is that it is the consequence of an interaction between antigens present in one individual with the immune system of another individual. As a result, genotypes of both donor and recipient, and their interactions affect the pathogenesis of GVHD. To determine the genetic risk factors for GVHD, in the first aim (discovery phase), we will conduct Genome-Wide Association Studies (GWAS) in 3,000 patients who underwent allo-HSCT and in their respective donors (6000 DNA samples) that are provided to us by the National Marrow Donor Program (NMDP) and the Center for International Blood and Marrow Transplant Research (CIBMTR). This part of our grant is approved by the Center for Inherited Disease Research (CIDR) and will be conducted in their sequencing facility. We expect that 3000 recipients will be stratified into 1200 subjects with moderate to severe acute GVHD (grades II-IV) versus 1800 individuals with none to mild GVHD (grade 0-I). We will also include the existing GWAS and clinical outcome data on 7047 donor/recipient pairs available from two previous studies to augment our cohort with an estimated 2830 pairs with grade II-IV and 4244 pairs with grade 0-I GVHD, and investigate an association between the severity of acute GVHD and genotypes in donors or recipients, or mismatch of certain genotypes (other than HLA). In the second aim, we will validate the association between high risk genotypes detected in the aim 1 and severe GVHD in 1,750 donors and 1,750 recipients of allo-HSCT, and perform the joint analysis with the discovery samples (an estimated 4730 pairs with grade II-IV vs 7094 pairs with Grade 0-I GVHD). We will determine the frequency of 5000 single nucleotide polymorphisms (SNP), that GWAS in the aim 1 showed to be associated with severe GVHD and correlate it to the severity of GVHD. In the third aim, we will investigate the functional effect of SNPs detected and validated to be significantly correlated with the severity of acute GVHD in mixed lymphocyte reaction (MLR), as an Ex vivo surrogate for an alloimmune response.



Publications

Real-world outcomes with tisagenlecleucel in aggressive B-cell lymphoma: subgroup analyses from the CIBMTR registry.
Authors: Landsburg D.J. , Frigault M.J. , Heim M. , Foley S.R. , Hill B. , Schofield G. , Jacobson C.A. , Jaglowski S. , Locke F.L. , Ram R. , et al. .
Source: Journal For Immunotherapy Of Cancer, 2025-02-09 00:00:00.0; 13(2), .
EPub date: 2025-02-09 00:00:00.0.
PMID: 39924174
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Multiscale 3D spatial analysis of the tumor microenvironment using whole-tissue digital histopathology.
Authors: Kermany D.S. , Ahn J.Y. , Vasquez M. , Zhang W. , Wang L. , Liu K. , Xu Z. , Cho M.S. , Carlos-Alcalde W. , Lee H. , et al. .
Source: Cancer Communications (london, England), 2025-01-03 00:00:00.0; , .
EPub date: 2025-01-03 00:00:00.0.
PMID: 39749685
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CAST Regimen for GvHD Prophylaxis: A CIBMTR Propensity Score-Matched Analysis.
Authors: Al-Homsi A.S. , DeFor T.E. , Cole K. , Cirrone F. , King S. , Suarez-Londono A. , Yaghmour G. , Boisclair S. , Bupp C. , Spellman S.R. .
Source: Transplantation And Cellular Therapy, 2024 Nov; 30(11), p. 1092-1098.
EPub date: 2024-08-30 00:00:00.0.
PMID: 39209024
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Applying Implementation Science in the Field of Transplant and Cellular Therapy.
Authors: DeSalvo A.M. , Spellman S.R. , Coles J.A.S. , Robb D. , McCann M. , Yusuf R.A. , Hengen M. , Auletta J.J. .
Source: Transplantation And Cellular Therapy, 2024 Sep; 30(9), p. 864-875.
EPub date: 2024-06-21 00:00:00.0.
PMID: 38909780
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The effect of ADAMTS13 on graft-versus-host disease.
Authors: Li D. , Cho M.S. , Gonzalez-Delgado R. , Liang X. , Dong J.F. , Cruz M.A. , Ma Q. , Afshar-Kharghan V. .
Source: Journal Of Cellular And Molecular Medicine, 2024 Jul; 28(13), p. e18457.
PMID: 38963011
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Real-world and clinical trial outcomes in large B-cell lymphoma with axicabtagene ciloleucel across race and ethnicity.
Authors: Locke F.L. , Siddiqi T. , Jacobson C.A. , Ghobadi A. , Ahmed S. , Miklos D.B. , Perales M.A. , Munoz J. , Fingrut W.B. , Pennisi M. , et al. .
Source: Blood, 2024-06-27 00:00:00.0; 143(26), p. 2722-2734.
PMID: 38635762
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Prediction of KIR3DL1/Human Leukocyte Antigen binding.
Authors: Maiers M. , Louzoun Y. , Pymm P. , Vivian J.P. , Rossjohn J. , Brooks A.G. , Saunders P.M. .
Source: Biorxiv : The Preprint Server For Biology, 2024-05-05 00:00:00.0; , .
EPub date: 2024-05-05 00:00:00.0.
PMID: 38746109
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Benefit of axicabtagene ciloleucel versus chemoimmunotherapy in older patients and/or patients with poor ECOG performance status with relapsed or refractory large B-cell lymphoma after 2 or more lines of prior therapy.
Authors: Lunning M.A. , Wang H.L. , Hu Z.H. , Locke F.L. , Siddiqi T. , Jacobson C.A. , Ahmed S. , Miklos D.B. , Lin Y. , Hill B.T. , et al. .
Source: American Journal Of Hematology, 2024 May; 99(5), p. 880-889.
EPub date: 2024-03-19 00:00:00.0.
PMID: 38504387
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Mechanical Venous Thrombectomy for Deep Venous Thrombosis in Cancer Patients: A Single-Center Retrospective Study.
Authors: Patel R.M. , Pal K. , Ahmed S.H. , Kuban J.D. , Patel M. , Shah K. , Habibollahi P. , Metwalli Z. , Gurusamy V. , Gupta S. , et al. .
Source: Cardiovascular And Interventional Radiology, 2024 May; 47(5), p. 556-566.
EPub date: 2024-03-28 00:00:00.0.
PMID: 38548981
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Role of circulating mitochondria in venous thrombosis in glioblastoma.
Authors: Gonzalez-Delgado R. , Muñoz N.M. , Carlos-Alcalde W. , Cho M.S. , Lee H. , Jin J. , Serpas V. , Gorlova O. , Sheth R.A. , Afshar-Kharghan V. .
Source: Journal Of Thrombosis And Haemostasis : Jth, 2023 Aug; 21(8), p. 2202-2212.
EPub date: 2023-05-11 00:00:00.0.
PMID: 37178770
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Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population.
Authors: Shi J. , Shiraishi K. , Choi J. , Matsuo K. , Chen T.Y. , Dai J. , Hung R.J. , Chen K. , Shu X.O. , Kim Y.T. , et al. .
Source: Nature Communications, 2023-05-26 00:00:00.0; 14(1), p. 3043.
EPub date: 2023-05-26 00:00:00.0.
PMID: 37236969
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Methylation of nonessential genes in cutaneous melanoma - Rule Out hypothesis.
Authors: Gorlov I.P. , Conway K. , Edmiston S.N. , Parrish E.A. , Hao H. , Amos C.I. , Tsavachidis S. , Gorlova O.Y. , Begg C. , Hernando E. , et al. .
Source: Melanoma Research, 2023-02-20 00:00:00.0; , .
EPub date: 2023-02-20 00:00:00.0.
PMID: 36805567
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Association between abnormal lipid profile and inflammation and progression of myelodysplastic syndrome to acute leukemia.
Authors: Qiao W. , Young E. , Feng C. , Liu S. , Jin J. , Noor L. , Rojas Hernandez C.M. , Borthakur G. , Gorlova O. , Afshar-Kharghan V. .
Source: Experimental Hematology & Oncology, 2022-09-16 00:00:00.0; 11(1), p. 58.
EPub date: 2022-09-16 00:00:00.0.
PMID: 36114519
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Novel Markers for Liquid Biopsies in Cancer Management: Circulating Platelets and Extracellular Vesicles.
Authors: Corvigno S. , Johnson A.M. , Wong K.K. , Cho M.S. , Afshar-Kharghan V. , Menter D.G. , Sood A.K. .
Source: Molecular Cancer Therapeutics, 2022-07-05 00:00:00.0; 21(7), p. 1067-1075.
PMID: 35545008
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Platelets Increase the Expression of PD-L1 in Ovarian Cancer.
Authors: Cho M.S. , Lee H. , Gonzalez-Delgado R. , Li D. , Sasano T. , Carlos-Alcalde W. , Ma Q. , Liu J. , Sood A.K. , Afshar-Kharghan V. .
Source: Cancers, 2022-05-19 00:00:00.0; 14(10), .
EPub date: 2022-05-19 00:00:00.0.
PMID: 35626102
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Molecular Correlates of Venous Thromboembolism (VTE) in Ovarian Cancer.
Authors: Glassman D. , Bateman N.W. , Lee S. , Zhao L. , Yao J. , Tan Y. , Ivan C. , Rangel K.M. , Zhang J. , Conrads K.A. , et al. .
Source: Cancers, 2022-03-15 00:00:00.0; 14(6), .
EPub date: 2022-03-15 00:00:00.0.
PMID: 35326647
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Impact of Induction Therapy with VRD versus VCD on Outcomes in Patients with Multiple Myeloma in Partial Response or Better Undergoing Upfront Autologous Stem Cell Transplantation.
Authors: Sidana S. , Kumar S. , Fraser R. , Estrada-Merly N. , Giralt S. , Agrawal V. , Anderson L.D. , Aljurf M. , Banerjee R. , Bashey A. , et al. .
Source: Transplantation And Cellular Therapy, 2022 Feb; 28(2), p. 83.e1-83.e9.
EPub date: 2021-11-12 00:00:00.0.
PMID: 34781066
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Of vascular defense, hemostasis, cancer, and platelet biology: an evolutionary perspective.
Authors: Menter D.G. , Afshar-Kharghan V. , Shen J.P. , Martch S.L. , Maitra A. , Kopetz S. , Honn K.V. , Sood A.K. .
Source: Cancer Metastasis Reviews, 2022-01-12 00:00:00.0; , .
EPub date: 2022-01-12 00:00:00.0.
PMID: 35022962
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SNP characteristics and validation success in genome wide association studies.
Authors: Gorlova O.Y. , Xiao X. , Tsavachidis S. , Amos C.I. , Gorlov I.P. .
Source: Human Genetics, 2022-01-04 00:00:00.0; , .
EPub date: 2022-01-04 00:00:00.0.
PMID: 34981173
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Identification of lung cancer drivers by comparison of the observed and the expected numbers of missense and nonsense mutations in individual human genes.
Authors: Gorlova O.Y. , Kimmel M. , Tsavachidis S. , Amos C.I. , Gorlov I.P. .
Source: Oncotarget, 2022; 13, p. 756-767.
EPub date: 2022-05-25 00:00:00.0.
PMID: 35634240
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An adapted European LeukemiaNet genetic risk stratification for acute myeloid leukemia patients undergoing allogeneic hematopoietic cell transplant. A CIBMTR analysis.
Authors: Jimenez Jimenez A.M. , De Lima M. , Komanduri K.V. , Wang T.P. , Zhang M.J. , Chen K. , Abdel-Azim H. , Abid M.B. , Aljurf M. , Alkhateeb H. , et al. .
Source: Bone Marrow Transplantation, 2021 Dec; 56(12), p. 3068-3077.
EPub date: 2021-09-28 00:00:00.0.
PMID: 34584240
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Outcomes of upfront autologous hematopoietic cell transplantation in patients with multiple myeloma who are 75 years old or older.
Authors: Munshi P.N. , Vesole D.H. , St Martin A. , Davila O. , Kumar S. , Qazilbash M. , Shah N. , Hari P.N. , D'Souza A. .
Source: Cancer, 2021-11-15 00:00:00.0; 127(22), p. 4233-4239.
EPub date: 2021-08-10 00:00:00.0.
PMID: 34374445
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Allogeneic Transplantation to Treat Therapy-Related Myelodysplastic Syndrome and Acute Myelogenous Leukemia in Adults.
Authors: Metheny L. , Callander N.S. , Hall A.C. , Zhang M.J. , Bo-Subait K. , Wang H.L. , Agrawal V. , Al-Homsi A.S. , Assal A. , Bacher U. , et al. .
Source: Transplantation And Cellular Therapy, 2021 11; 27(11), p. 923.e1-923.e12.
EPub date: 2021-08-21 00:00:00.0.
PMID: 34428556
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Podoplanin promotes tumor growth, platelet aggregation, and venous thrombosis in murine models of ovarian cancer.
Authors: Sasano T. , Gonzalez-Delgado R. , Muñoz N.M. , Carlos-Alcade W. , Cho M.S. , Sheth R.A. , Sood A.K. , Afshar-Kharghan V. .
Source: Journal Of Thrombosis And Haemostasis : Jth, 2021-10-04 00:00:00.0; , .
EPub date: 2021-10-04 00:00:00.0.
PMID: 34608736
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Barriers to Access to Hematopoietic Cell Transplantation among Patients with Acute Myeloid Leukemia in Virginia.
Authors: Mock J. , Meyer C. , Mau L.W. , Nguyen C. , Arora P. , Heron C. , Balkrishnan R. , Burns L. , Devine S. , Ballen K. .
Source: Transplantation And Cellular Therapy, 2021 10; 27(10), p. 869.e1-869.e9.
EPub date: 2021-07-02 00:00:00.0.
PMID: 34224915
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Novel genetic variants associated with mortality after unrelated donor allogeneic hematopoietic cell transplantation.
Authors: Hahn T. , Wang J. , Preus L.M. , Karaesmen E. , Rizvi A. , Clay-Gilmour A.I. , Zhu Q. , Wang Y. , Yan L. , Liu S. , et al. .
Source: Eclinicalmedicine, 2021 Oct; 40, p. 101093.
EPub date: 2021-08-25 00:00:00.0.
PMID: 34746714
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American Society of Transplantation and Cellular Therapy, Center of International Blood and Marrow Transplant Research, and European Society for Blood and Marrow Transplantation Clinical Practice Recommendations for Transplantation and Cellular Therapies in Mantle Cell Lymphoma.
Authors: Munshi P.N. , Hamadani M. , Kumar A. , Dreger P. , Friedberg J.W. , Dreyling M. , Kahl B. , Jerkeman M. , Kharfan-Dabaja M.A. , Locke F.L. , et al. .
Source: Transplantation And Cellular Therapy, 2021 Sep; 27(9), p. 720-728.
PMID: 34452722
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Hematopoietic Cell Transplantation Outcomes among Medicaid and Privately Insured Patients with Sickle Cell Disease.
Authors: Mupfudze T.G. , Meyer C. , Preussler J.M. , Mau L.W. , Bolon Y.T. , Steinert P. , Arnold S.D. , Saber W. , Krishnamurti L. .
Source: Transplantation And Cellular Therapy, 2021 08; 27(8), p. 685.e1-685.e8.
EPub date: 2021-04-22 00:00:00.0.
PMID: 33895405
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Impact of Previously Unrecognized HLA Mismatches Using Ultrahigh Resolution Typing in Unrelated Donor Hematopoietic Cell Transplantation.
Authors: Mayor N.P. , Wang T. , Lee S.J. , Kuxhausen M. , Vierra-Green C. , Barker D.J. , Auletta J. , Bhatt V.R. , Gadalla S.M. , Gragert L. , et al. .
Source: Journal Of Clinical Oncology : Official Journal Of The American Society Of Clinical Oncology, 2021-07-20 00:00:00.0; 39(21), p. 2397-2409.
EPub date: 2021-04-09 00:00:00.0.
PMID: 33835855
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Superior survival with pediatric-style chemotherapy compared to myeloablative allogeneic hematopoietic cell transplantation in older adolescents and young adults with Ph-negative acute lymphoblastic leukemia in first complete remission: analysis from CALGB 10403 and the CIBMTR.
Authors: Wieduwilt M.J. , Stock W. , Advani A. , Luger S. , Larson R.A. , Tallman M. , Appelbaum F. , Zhang M.J. , Bo-Subait K. , Wang H.L. , et al. .
Source: Leukemia, 2021 Jul; 35(7), p. 2076-2085.
EPub date: 2021-03-30 00:00:00.0.
PMID: 33785862
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Breaking the Age Barrier: Physicians' Perceptions of Candidacy for Allogeneic Hematopoietic Cell Transplantation in Older Adults.
Authors: Mishra A. , Preussler J.M. , Bhatt V.R. , Bredeson C. , Chhabra S. , D'Souza A. , Dahi P.B. , Hacker E.D. , Gowda L. , Hashmi S.K. , et al. .
Source: Transplantation And Cellular Therapy, 2021 Jul; 27(7), p. 617.e1-617.e7.
EPub date: 2021-04-06 00:00:00.0.
PMID: 33836312
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Losing control to bad relatives.
Authors: Afshar-Kharghan V. .
Source: Blood, 2021-06-24 00:00:00.0; 137(25), p. 3462-3463.
PMID: 34165547
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Posttransplant cyclophosphamide is associated with increased cytomegalovirus infection: a CIBMTR analysis.
Authors: Goldsmith S.R. , Abid M.B. , Auletta J.J. , Bashey A. , Beitinjaneh A. , Castillo P. , Chemaly R.F. , Chen M. , Ciurea S. , Dandoy C.E. , et al. .
Source: Blood, 2021-06-10 00:00:00.0; 137(23), p. 3291-3305.
PMID: 33657221
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Shorter Interdonation Interval Contributes to Lower Cell Counts in Subsequent Stem Cell Donations.
Authors: Panch S.R. , Logan B. , Sees J.A. , Bo-Subait S. , Savani B. , Shah N.N. , Hsu J.W. , Switzer G. , Lazarus H.M. , Anderlini P. , et al. .
Source: Transplantation And Cellular Therapy, 2021 Jun; 27(6), p. 503.e1-503.e8.
EPub date: 2021-03-09 00:00:00.0.
PMID: 33823169
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Optimal Donor Selection for Hematopoietic Cell Transplantation Using Bayesian Machine Learning.
Authors: Logan B.R. , Maiers M.J. , Sparapani R.A. , Laud P.W. , Spellman S.R. , McCulloch R.E. , Shaw B.E. .
Source: Jco Clinical Cancer Informatics, 2021 05; 5, p. 494-507.
PMID: 33950708
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Systematic Reviews in Hematopoietic Cell Transplantation and Cellular Therapy: Considerations and Guidance from the American Society for Transplantation and Cellular Therapy, European Society for Blood and Marrow Transplantation, and Center for International Blood and Marrow Transplant Research Late Effects and Quality of Life Working Committee.
Authors: Sharma A. , Badawy S.M. , Suelzer E.M. , Murthy H.S. , Prasad P. , Eissa H. , Carpenter P.A. , Hamadani M. , Labopin M. , Schoemans H. , et al. .
Source: Transplantation And Cellular Therapy, 2021 05; 27(5), p. 380-388.
EPub date: 2021-01-28 00:00:00.0.
PMID: 33965174
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COVID-19 and Hematopoietic Cell Transplant Center-specific survival analysis: Can we adjust for the impact of the pandemic? Recommendations of the COVID-19 Taskforce of the 2020 CIBMTR Center Outcomes Forum.
Authors: Wingard J.R. , Ahn K.W. , Dandoy C. , Perales M.A. , Wood W.A. , Logan B. , Riches M. , Rizzo J.D. .
Source: Transplantation And Cellular Therapy, 2021-04-22 00:00:00.0; , .
EPub date: 2021-04-22 00:00:00.0.
PMID: 33895401
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The effect of platelet G proteins on platelet extravasation and tumor growth in the murine model of ovarian cancer.
Authors: Cho M.S. , Li J. , Gonzalez-Delgado R. , Lee H. , Vasquez M. , He T. , He Y. , Liu K. , Sasano T. , Nürnberg B. , et al. .
Source: Blood Advances, 2021-04-13 00:00:00.0; 5(7), p. 1947-1951.
PMID: 33821990
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Systematic reviews in hematopoietic cell transplantation and cellular therapy: considerations and guidance from the American Society for Transplantation and Cellular Therapy, European Society for Blood and Marrow Transplantation, and the Center for International Blood and Marrow Transplant Research late effects and quality of life working committee.
Authors: Sharma A. , Badawy S.M. , Suelzer E.M. , Murthy H.S. , Prasad P. , Eissa H. , Carpenter P.A. , Hamadani M. , Labopin M. , Schoemans H. , et al. .
Source: Bone Marrow Transplantation, 2021 Apr; 56(4), p. 786-797.
EPub date: 2021-01-29 00:00:00.0.
PMID: 33514917
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Serious Adverse Events in Related Donors: A Report from the Related Donor Safe Study.
Authors: Seftel M.D. , Chitphakdithai P. , Miller J.P. , Kobusingye H. , Logan B.R. , Linenberger M. , Artz A.S. , Haight A.E. , Jacobsohn D.A. , Litzow M.R. , et al. .
Source: Transplantation And Cellular Therapy, 2021 Apr; 27(4), p. 352.e1-352.e5.
EPub date: 2021-01-15 00:00:00.0.
PMID: 33836890
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Is autologous transplant in relapsed DLBCL patients achieving only a PET+ PR appropriate in the CAR T-cell era?
Authors: Shah N.N. , Ahn K.W. , Litovich C. , He Y. , Sauter C. , Fenske T.S. , Hamadani M. .
Source: Blood, 2021-03-11 00:00:00.0; 137(10), p. 1416-1423.
PMID: 33120429
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Bortezomib-Based Induction Is Associated with Superior Outcomes in Light Chain Amyloidosis Patients Treated with Autologous Hematopoietic Cell Transplantation Regardless of Plasma Cell Burden.
Authors: Cornell R.F. , Fraser R. , Costa L. , Goodman S. , Estrada-Merly N. , Lee C. , Hildebrandt G. , Gergis U. , Farhadfar N. , Freytes C.O. , et al. .
Source: Transplantation And Cellular Therapy, 2021 Mar; 27(3), p. 264.e1-264.e7.
EPub date: 2020-12-16 00:00:00.0.
PMID: 33781533
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Specific Class I HLA Supertypes but Not HLA Zygosity or Expression Are Associated with Outcomes following HLA-Matched Allogeneic Hematopoietic Cell Transplant: HLA Supertypes Impact Allogeneic HCT Outcomes.
Authors: Camacho-Bydume C. , Wang T. , Sees J.A. , Fernandez-Viña M. , Abid M.B. , Askar M. , Beitinjaneh A. , Brown V. , Castillo P. , Chhabra S. , et al. .
Source: Transplantation And Cellular Therapy, 2021 Feb; 27(2), p. 142.e1-142.e11.
EPub date: 2020-10-11 00:00:00.0.
PMID: 33053450
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Broad-Spectrum Antibiotics and Risk of Graft-versus-Host Disease in Pediatric Patients Undergoing Transplantation for Acute Leukemia: Association of Carbapenem Use with the Risk of Acute Graft-versus-Host Disease
Authors: Elgarten C.W. , Li Y. , Getz K.D. , Hemmer M. , Huang Y.V. , Hall M. , Wang T. , Kitko C.L. , Jagasia M.H. , Nishihori T. , et al. .
Source: Transplantation And Cellular Therapy, 2021 02; 27(2), p. 177.e1-177.e8.
EPub date: 2020-12-21 00:00:00.0.
PMID: 33718896
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Neighborhood poverty and pediatric allogeneic hematopoietic cell transplantation outcomes: a CIBMTR analysis.
Authors: Bona K. , Brazauskas R. , He N. , Lehmann L. , Abdel-Azim H. , Ahmed I.A. , Al-Homsi A.S. , Aljurf M. , Arnold S.D. , Badawy S.M. , et al. .
Source: Blood, 2021-01-28 00:00:00.0; 137(4), p. 556-568.
PMID: 33104215
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Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: an observational cohort study.
Authors: Sharma A. , Bhatt N.S. , St Martin A. , Abid M.B. , Bloomquist J. , Chemaly R.F. , Dandoy C. , Gauthier J. , Gowda L. , Perales M.A. , et al. .
Source: The Lancet. Haematology, 2021-01-19 00:00:00.0; , .
EPub date: 2021-01-19 00:00:00.0.
PMID: 33482113
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Prognostic impact of serum CXC chemokine ligands 4 and 7 on myelodysplastic syndromes post allogeneic hematopoietic cell transplant.
Authors: Dhakal B. , Wang T. , Kuxhausen M. , Zhu F. , Taylor C. , Spellman S.R. , Verneris M.R. , Hsu K. , Fleischhauer K. , Lee S.J. , et al. .
Source: Leukemia & Lymphoma, 2021 01; 62(1), p. 229-233.
EPub date: 2020-09-13 00:00:00.0.
PMID: 32924688
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The Provocative Roles of Platelets in Liver Disease and Cancer.
Authors: Kanikarla Marie P. , Fowlkes N.W. , Afshar-Kharghan V. , Martch S.L. , Sorokin A. , Shen J.P. , Morris V.K. , Dasari A. , You N. , Sood A.K. , et al. .
Source: Frontiers In Oncology, 2021; 11, p. 643815.
EPub date: 2021-07-21 00:00:00.0.
PMID: 34367949
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Busulfan, melphalan, and bortezomib compared to melphalan as a high dose regimen for autologous hematopoietic stem cell transplantation in multiple myeloma: long term follow up of a novel high dose regimen.
Authors: Hagen P. , D'Souza A. , Hari P. , Davila O. , Zhang M.J. , Vesole D.H. , Smith S.E. , Rodriguez T.E. , Stiff P.J. .
Source: Leukemia & Lymphoma, 2020 12; 61(14), p. 3484-3492.
EPub date: 2020-08-31 00:00:00.0.
PMID: 32865474
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Age no bar: A CIBMTR analysis of elderly patients undergoing autologous hematopoietic cell transplantation for multiple myeloma.
Authors: Munshi P.N. , Vesole D. , Jurczyszyn A. , Zaucha J.M. , St Martin A. , Davila O. , Agrawal V. , Badawy S.M. , Battiwalla M. , Chhabra S. , et al. .
Source: Cancer, 2020-12-01 00:00:00.0; 126(23), p. 5077-5087.
EPub date: 2020-09-23 00:00:00.0.
PMID: 32965680
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