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Grant Details

Grant Number: 5R37CA233777-05 Interpret this number
Primary Investigator: Akinyemiju, Tomi
Organization: Duke University
Project Title: A Role of Multilevel Healthcare Access Dimensions in Ovarian Cancer Disparities
Fiscal Year: 2022


Abstract

Less than 40% of ovarian cancer (OC) patients in the US receive stage-appropriate guideline- adherent surgery and chemotherapy; Black OC patients are even less likely to receive such treatment. While 5-year relative survival for White OC patients improved by 47% between 1975 and 2009, it declined by 27% for Black patients during this same period. Among cancer survivors, Black patients are also observed to have significantly higher depression, pain, and fatigue than White survivors. These racial disparities are likely due largely to differences in healthcare access – specifically, access to high quality initial treatment and post- treatment supportive care. Healthcare access is a complex subject; however, the Penchansky healthcare access framework proposed that it comprises of five specific dimensions: availability, affordability, accessibility, accommodation and acceptability of health care services. Our study will comprehensively evaluate all five dimensions of healthcare access (HCA) among Black and White patients to identify and quantify the specific factors contributing to the striking racial differences in OC care and survival. More specifically, we will utilize data from SEER-Medicare (8,060 OC patients) along with primary survey data from a population-based sample of 1,010 OC patients, linked with several existing datasets (e.g., American Community Survey, Area Healthcare Resource File), to characterize racial differences in associations between each HCA dimension and three outcomes: quality of initial treatment and supportive care, quality of life based on patient-reported outcomes in prevalent yet manageable symptoms, and survival. We will evaluate HCA dimensions across patient, neighborhood, provider and hospital levels, and utilize hierarchical regression models with random effects to account for clustering, and multilevel structural equation models to estimate the total, direct and indirect effect of race on treatment mediated through HCA dimensions. Our preliminary studies suggest that certain under-studied dimensions (e.g., acceptability) may outweigh other dimensions (e.g., availability) in determining quality of care. Moreover, the impact of the various HCA dimensions may vary by race. By analyzing high-quality multilevel datasets with Black and White patients, we can fully characterize the nature of racial disparities, assess the relative importance of race-specific barriers to care, and identify race-specific modifiable factors. Our study will provide novel, empirical, and generalizable insights regarding the distinct and collective influence of HCA dimensions on OC outcomes. These insights will help identify and prioritize specific modifiable factors that can then be targeted to reduce disparities and improve care for all patients.



Publications

The Intersectionality between Race, Ethnicity, and Residential-Level Socioeconomic Status in Disparities of Head and Neck Cancer Outcomes: A SEER Study.
Authors: Karanth S.D. , Akinyemiju T. , Walker C.J. , Yang D. , Migliorati C.A. , Yoon H.S. , Hong Y.R. , Washington C.J. , Lattimore C. , Fredenburg K.M. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2023-04-03; 32(4), p. 516-523.
PMID: 36780193
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Health-care access dimensions and ovarian cancer survival: SEER-Medicare analysis of the ORCHiD study.
Authors: Montes de Oca M.K. , Chen Q. , Howell E. , Wilson L.E. , Meernik C. , Previs R.A. , Huang B. , Pisu M. , Liang M.I. , Ward K.C. , et al. .
Source: JNCI cancer spectrum, 2023-03-01; 7(2), .
PMID: 36794910
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Factor Analysis of Health Care Access With Ovarian Cancer Surgery and Gynecologic Oncologist Consultation.
Authors: Gupta A. , Chen Q. , Wilson L.E. , Huang B. , Pisu M. , Liang M. , Previs R.A. , Moss H.A. , Ward K.C. , Schymura M.J. , et al. .
Source: JAMA network open, 2023-02-01; 6(2), p. e2254595.
EPub date: 2023-02-01.
PMID: 36723938
Related Citations

Healthcare Access Domains Mediate Racial Disparities in Ovarian Cancer Treatment Quality in a US Patient Cohort: A Structural Equation Modelling Analysis.
Authors: Akinyemiju T. , Chen Q. , Wilson L.E. , Previs R.A. , Joshi A. , Liang M. , Pisu M. , Ward K.C. , Berchuck A. , Schymura M.J. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2023-01-09; 32(1), p. 74-81.
PMID: 36306380
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Development and Psychometric Evaluation of Healthcare Access Measures among Women with Ovarian Cancer.
Authors: Akinyemiju T. , Joshi A. , Deveaux A. , Wilson L.E. , Chen D. , Meernik C. , Bevel M. , Gathings J. , Fish L. , Barrett N. , et al. .
Source: Cancers, 2022-12-19; 14(24), .
EPub date: 2022-12-19.
PMID: 36551751
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Race, Affordability and Utilization of Supportive Care in Ovarian Cancer Patients.
Authors: Anyanwu M.C. , Ohamadike O. , Wilson L.E. , Meernik C. , Huang B. , Pisu M. , Liang M. , Previs R.A. , Joshi A. , Ward K.C. , et al. .
Source: Journal of pain and symptom management, 2022 Dec; 64(6), p. 537-545.
EPub date: 2022-09-02.
PMID: 36058401
Related Citations

Healthcare Access Dimensions and Guideline-Concordant Ovarian Cancer Treatment: SEER-Medicare Analysis of the ORCHiD Study.
Authors: Montes de Oca M.K. , Wilson L.E. , Previs R.A. , Gupta A. , Joshi A. , Huang B. , Pisu M. , Liang M. , Ward K.C. , Schymura M.J. , et al. .
Source: Journal of the National Comprehensive Cancer Network : JNCCN, 2022 Nov; 20(11), p. 1255-1266.e11.
PMID: 36351338
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Association of area-level socioeconomic status and non-small cell lung cancer stage by race/ethnicity and health care-level factors: Analysis of the National Cancer Database.
Authors: Gupta A. , Omeogu C.H. , Islam J.Y. , Joshi A.R. , Akinyemiju T.F. .
Source: Cancer, 2022-08-15; 128(16), p. 3099-3108.
EPub date: 2022-06-20.
PMID: 35719098
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Associations of Healthcare Affordability, Availability, and Accessibility with Quality Treatment Metrics in Patients with Ovarian Cancer.
Authors: Akinyemiju T.F. , Wilson L.E. , Diaz N. , Gupta A. , Huang B. , Pisu M. , Deveaux A. , Liang M. , Previs R.A. , Moss H.A. , et al. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2022-07-01; 31(7), p. 1383-1393.
PMID: 35477150
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Ovarian Cancer Epidemiology, Healthcare Access and Disparities (ORCHiD): methodology for a population-based study of black, Hispanic and white patients with ovarian cancer.
Authors: Akinyemiju T. , Deveaux A. , Wilson L. , Gupta A. , Joshi A. , Bevel M. , Omeogu C. , Ohamadike O. , Huang B. , Pisu M. , et al. .
Source: BMJ open, 2021-10-04; 11(10), p. e052808.
EPub date: 2021-10-04.
PMID: 34607872
Related Citations

Health Care Access Measures and Palliative Care Use by Race/Ethnicity among Metastatic Gynecological Cancer Patients in the United States.
Authors: Islam J.Y. , Saraiya V. , Previs R.A. , Akinyemiju T. .
Source: International journal of environmental research and public health, 2021-06-04; 18(11), .
EPub date: 2021-06-04.
PMID: 34199732
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Racial disparities in palliative care utilization among metastatic gynecological cancer patients living at last follow-up: An analysis of the National Cancer Data Base.
Authors: Islam J.Y. , Deveaux A. , Previs R.A. , Akinyemiju T. .
Source: Data in brief, 2021 Feb; 34, p. 106705.
EPub date: 2020-12-30.
PMID: 33473361
Related Citations

Racial and ethnic disparities in palliative care utilization among gynecological cancer patients.
Authors: Islam J.Y. , Deveaux A. , Previs R.A. , Akinyemiju T. .
Source: Gynecologic oncology, 2021 Feb; 160(2), p. 469-476.
EPub date: 2020-12-02.
PMID: 33276985
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Race, Socioeconomic Status, and Health-Care Access Disparities in Ovarian Cancer Treatment and Mortality: Systematic Review and Meta-Analysis.
Authors: Karanth S. , Fowler M.E. , Mao X. , Wilson L.E. , Huang B. , Pisu M. , Potosky A. , Tucker T. , Akinyemiju T. .
Source: JNCI cancer spectrum, 2019 Dec; 3(4), p. pkz084.
EPub date: 2019-10-09.
PMID: 31840133
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