Skip to main content
Grant Details

Grant Number: 2U01CA199240-06 Interpret this number
Primary Investigator: Schwartz, Ann
Organization: Wayne State University
Project Title: Detroit Research on Cancer Survivors (Detroit Rocs)
Fiscal Year: 2022


Abstract

Project Summary/Abstract Despite progress made in early detection and treatment, African Americans continue to experience disproportionately higher cancer incidence rates, are first diagnosed with more advanced stage disease, and suffer higher mortality rates than other populations. The Detroit Research on Cancer Survivors (ROCS) study (U01CA199240) is the largest single cohort of African American cancer survivors aimed at understanding the multiplex causes of poorer outcomes in this population. Detroit ROCS has been collecting survey data and biospecimens with a goal of enrolling 5,000 population-based African Americans diagnosed with lung, breast, prostate, colorectal, and endometrial cancers and any early- onset cancer (diagnosed age 20-49 years) and supporting studies addressing determinants of cancer outcomes and quality of life. In this renewal application, we will continue to follow cohort survivors annually for up to 9 years to address the determinants of longer term outcomes (e.g., disease recurrence, second primary diagnoses, treatment related comorbidities and death) and quality of life. The broad research agenda will be developed with our community partners. We propose to: 1) conduct annual follow-up surveys on all living, enrolled participants for up to five additional years and collect additional biospecimens; 2) engage with members of the community to set new research priorities and to obtain input into the retention of participants and dissemination of research findings back to the community; 3) link Detroit ROCS patient data to other existing sources of health-related and exposure data to supplement patient-reported information; and 4) extend collaborations to facilitate use of the data and biospecimens by the broader research community. Detroit ROCS is providing substantial data and biospecimens to facilitate studies aimed at understanding and addressing determinants of poor outcomes in this population.



Publications

Evaluation of health behaviors and overall quality of life in younger adult African American cancer survivors.
Authors: Trendowski M.R. , Kyko J.M. , Lusk C.M. , Ruterbusch J.J. , Hastert T.A. , Harper F.W.K. , Thompson H. , Beebe-Dimmer J.L. , Schwartz A.G. .
Source: Cancer medicine, 2022-06-02; , .
EPub date: 2022-06-02.
PMID: 35655423
Related Citations

Financial Hardship by Age at Diagnosis Including in Young Adulthood among African American Cancer Survivors.
Authors: Hastert T.A. , Ruterbusch J.J. , Abrams J. , Nair M. , Wenzlaff A.S. , Beebe-Dimmer J.L. , Pandolfi S.S. , Schwartz A.G. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2022-04-01; 31(4), p. 876-884.
PMID: 35064060
Related Citations

The impact of the COVID-19 pandemic on African American cancer survivors.
Authors: Beebe-Dimmer J.L. , Lusk C.M. , Ruterbusch J.J. , Baird T.E. , Pandolfi S.S. , Wenzlaff A.S. , Hastert T.A. , Harper F.W.K. , Thompson H.S. , Schwartz A.G. .
Source: Cancer, 2022-02-15; 128(4), p. 839-848.
EPub date: 2021-10-27.
PMID: 34706056
Related Citations

Neighborhood walkability and body mass index in African American cancer survivors: The Detroit Research on Cancer Survivors study.
Authors: Robinson J.R.M. , Beebe-Dimmer J.L. , Schwartz A.G. , Ruterbusch J.J. , Baird T.E. , Pandolfi S.S. , Hastert T.A. , Quinn J.W. , Rundle A.G. .
Source: Cancer, 2021-12-15; 127(24), p. 4687-4693.
EPub date: 2021-08-18.
PMID: 34406654
Related Citations

Chemotherapy-induced peripheral neuropathy in African American cancer survivors: Risk factors and quality of life outcomes.
Authors: Trendowski M.R. , Lusk C.M. , Ruterbusch J.J. , Seaton R. , Simon M.S. , Greenwald M.K. , Harper F.W.K. , Beebe-Dimmer J.L. , Schwartz A.G. .
Source: Cancer medicine, 2021 11; 10(22), p. 8151-8161.
EPub date: 2021-10-23.
PMID: 34687150
Related Citations

Caregiving burden among informal caregivers of African American cancer survivors.
Authors: Schwartz K. , Beebe-Dimmer J. , Hastert T.A. , Ruterbusch J.J. , Mantey J. , Harper F. , Thompson H. , Pandolfi S. , Schwartz A.G. .
Source: Journal of cancer survivorship : research and practice, 2021 08; 15(4), p. 630-640.
EPub date: 2020-10-17.
PMID: 33067774
Related Citations

Social needs and health-related quality of life among African American cancer survivors: Results from the Detroit Research on Cancer Survivors study.
Authors: Hastert T.A. , McDougall J.A. , Strayhorn S.M. , Nair M. , Beebe-Dimmer J.L. , Schwartz A.G. .
Source: Cancer, 2021-02-01; 127(3), p. 467-475.
EPub date: 2020-11-23.
PMID: 33225460
Related Citations

Work changes and individual, cancer-related, and work-related predictors of decreased work participation among African American cancer survivors.
Authors: Hastert T.A. , Kirchhoff A.C. , Banegas M.P. , Morales J.F. , Nair M. , Beebe-Dimmer J.L. , Pandolfi S.S. , Baird T.E. , Schwartz A.G. .
Source: Cancer medicine, 2020 12; 9(23), p. 9168-9177.
EPub date: 2020-11-07.
PMID: 33159501
Related Citations

Heritable Susceptibility to Breast Cancer among African-American Women in the Detroit Research on Cancer Survivors Study.
Authors: Purrington K.S. , Raychaudhuri S. , Simon M.S. , Clark J. , Ratliff V. , Dyson G. , Craig D.B. , Boerner J.L. , Beebe-Dimmer J.L. , Schwartz A.G. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2020 11; 29(11), p. 2369-2375.
EPub date: 2020-08-31.
PMID: 32868316
Related Citations

Patterns of cancer family history and genetic counseling eligibility among African Americans with breast, prostate, lung, and colorectal cancers: A Detroit Research on Cancer Survivors cohort study.
Authors: Purrington K.S. , Schwartz A.G. , Ruterbusch J.J. , Manning M.A. , Nair M. , Wenzlaff A.S. , Pandolfi S.S. , Simon M.S. , Beebe-Dimmer J. .
Source: Cancer, 2020-11-01; 126(21), p. 4744-4752.
EPub date: 2020-08-04.
PMID: 32749684
Related Citations

Continued smoking in African American cancer survivors: The Detroit Research on Cancer Survivors Cohort.
Authors: Malburg C.M. , Fucinari J. , Ruterbusch J.J. , Ledgerwood D.M. , Beebe-Dimmer J.L. , Schwartz A.G. , Cote M.L. .
Source: Cancer medicine, 2020 10; 9(20), p. 7763-7771.
EPub date: 2020-08-21.
PMID: 32822118
Related Citations

Employment Outcomes, Financial Burden, Anxiety, and Depression Among Caregivers of African American Cancer Survivors.
Authors: Hastert T.A. , Ruterbusch J.J. , Nair M. , Noor M.I. , Beebe-Dimmer J.L. , Schwartz K. , Baird T.E. , Harper F.W.K. , Thompson H. , Schwartz A.G. .
Source: JCO oncology practice, 2020 03; 16(3), p. e221-e233.
EPub date: 2019-09-07.
PMID: 31496392
Related Citations

Physical activity and quality of life in African American cancer survivors: The Detroit Research on Cancer Survivors study.
Authors: Beebe-Dimmer J.L. , Ruterbusch J.J. , Harper F.W.K. , Baird T.M. , Finlay D.G. , Rundle A.G. , Pandolfi S.S. , Hastert T.A. , Schwartz K.L. , Bepler G. , et al. .
Source: Cancer, 2020-01-01; 126(9), p. 1987-1994.
EPub date: 2020-02-24.
PMID: 32090322
Related Citations

Financial Hardship and Quality of Life among African American and White Cancer Survivors: The Role of Limiting Care Due to Cost.
Authors: Hastert T.A. , Kyko J.M. , Reed A.R. , Harper F.W.K. , Beebe-Dimmer J.L. , Baird T.E. , Schwartz A.G. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019 07; 28(7), p. 1202-1211.
EPub date: 2019-05-06.
PMID: 31061097
Related Citations

The Detroit Research on Cancer Survivors (ROCS) Pilot Study: A Focus on Outcomes after Cancer in a Racially Diverse Patient Population.
Authors: Beebe-Dimmer J.L. , Albrecht T.L. , Baird T.E. , Ruterbusch J.J. , Hastert T. , Harper F.W.K. , Simon M.S. , Abrams J. , Schwartz K.L. , Schwartz A.G. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019 04; 28(4), p. 666-674.
EPub date: 2018-11-27.
PMID: 30482875
Related Citations




Back to Top