Grant Number:	5R01CA236793-04 Interpret this number
Primary Investigator:	Whitney, David
Organization:	University Of California Berkeley
Project Title:	Isolating and Mitigating Sequentially Dependent Perceptual Errors in Clinical Visual Search
Fiscal Year:	2022

Project Summary When looking at an x-ray, radiologists are typically asked to localize a tumor (if present), and to classify it, judging its size, class, position and so on. Importantly, during this task, radiologists examine on a daily basis hundreds and hundreds of x-rays, seeing several images one after the other. A main underlying assumption of this task is that radiologists’ percepts and decisions on a current X-ray are completely independent of prior events. Recent results showed that this is not true: our perception and decisions are strongly biased by our past visual experience. Although serial dependencies were proposed to be a purposeful mechanism to achieve perceptual stability of our otherwise noisy visual input, serial dependencies play a crucial and deleterious role in the everyday task performed by radiologists. For example, an x-ray containing a tumor can be classified as benign depending on the content of the previously seen x-ray. Given the importance and the impact of serial dependencies in clinical tasks, in this proposal, we plan to (1) establish, (2) identify and (3) mitigate the conditions under which serial effects determine our percepts and decisions in tumor search tasks. In Aim 1, we will establish the presence of serial effects in four different clinically relevant domains: tumor detection, tumor classification, tumor position and recognition speed. In Aim 2, we plan to identify the specific boundary conditions under which visual serial dependence impacts tumor search in radiology. In Aim 3, once we will fully understand these boundary conditions in Aim 2, we will propose a series of task and stimulus manipulations to control and mitigate the deleterious effects of visual serial dependence on tumor search. As a result of these manipulations, visual search performance should improve in measurable ways (detection, classification, position, speed). Aim 3 is particularly crucial because it will allow us to propose new guidelines which will greatly improve tumor recognition in x-ray images, making this task even more effective and reliable. Taken together, the proposed studies in Aim 1, 2, and 3 will allow us to establish, identify, and mitigate the deleterious effect of serial dependencies in radiological search tasks, which could have a significant impact on the health and well-being of patients everywhere. ! ! !




Serial dependence in visual perception: A meta-analysis and review.
Authors: Manassi M. , Murai Y. , Whitney D. .
Source: Journal Of Vision, 2023-08-01 00:00:00.0; 23(8), p. 18.
PMID: 37642639
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Serial dependence in perception across naturalistic generative adversarial network-generated mammogram.
Authors: Ren Z. , Canas-Bajo T. , Ghirardo C. , Manassi M. , Yu S.X. , Whitney D. .
Source: Journal Of Medical Imaging (bellingham, Wash.), 2023 Jul; 10(4), p. 045501.
EPub date: 2023-07-04 00:00:00.0.
PMID: 37408983
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Inferential Emotion Tracking reveals impaired context-based emotion processing in individuals with high Autism Quotient scores.
Authors: Ortega J. , Chen Z. , Whitney D. .
Source: Scientific Reports, 2023-05-19 00:00:00.0; 13(1), p. 8093.
EPub date: 2023-05-19 00:00:00.0.
PMID: 37208368
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Serial Dependence in Dermatological Judgments.
Authors: Ren Z. , Li X. , Pietralla D. , Manassi M. , Whitney D. .
Source: Diagnostics (basel, Switzerland), 2023-05-17 00:00:00.0; 13(10), .
EPub date: 2023-05-17 00:00:00.0.
PMID: 37238260
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Serial dependence in emotion perception mirrors the autocorrelations in natural emotion statistics.
Authors: Ortega J. , Chen Z. , Whitney D. .
Source: Journal Of Vision, 2023-03-01 00:00:00.0; 23(3), p. 12.
PMID: 36951852
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Individual differences in classification images of Mooney faces.
Authors: Canas-Bajo T. , Whitney D. .
Source: Journal Of Vision, 2022-12-01 00:00:00.0; 22(13), p. 3.
PMID: 36458961
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Searching for serial dependencies in the brain.
Authors: Whitney D. , Manassi M. , Murai Y. .
Source: Plos Biology, 2022 09; 20(9), p. e3001788.
EPub date: 2022-09-07 00:00:00.0.
PMID: 36070292
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Relative tuning of holistic face processing towards the fovea.
Authors: Canas-Bajo T. , Whitney D. .
Source: Vision Research, 2022 08; 197, p. 108049.
EPub date: 2022-04-20 00:00:00.0.
PMID: 35461170
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The test-retest reliability and spatial tuning of serial dependence in orientation perception.
Authors: Kondo A. , Murai Y. , Whitney D. .
Source: Journal Of Vision, 2022-03-02 00:00:00.0; 22(4), p. 5.
PMID: 35293956
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Illusion of visual stability through active perceptual serial dependence.
Authors: Manassi M. , Whitney D. .
Source: Science Advances, 2022-01-14 00:00:00.0; 8(2), p. eabk2480.
EPub date: 2022-01-12 00:00:00.0.
PMID: 35020432
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Idiosyncratic biases in the perception of medical images.
Authors: Wang Z. , Manassi M. , Ren Z. , Ghirardo C. , Canas-Bajo T. , Murai Y. , Zhou M. , Whitney D. .
Source: Frontiers In Psychology, 2022; 13, p. 1049831.
EPub date: 2022-12-19 00:00:00.0.
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Controllable Medical Image Generation via GAN.
Authors: Ren Z. , Yu S.X. , Whitney D. .
Source: Journal Of Perceptual Imaging, 2022 Jan; 5, p. 0005021-50215.
EPub date: 2022-03-18 00:00:00.0.
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Global and high-level effects in crowding cannot be predicted by either high-dimensional pooling or target cueing.
Authors: Bornet A. , Choung O.H. , Doerig A. , Whitney D. , Herzog M.H. , Manassi M. .
Source: Journal Of Vision, 2021-11-01 00:00:00.0; 21(12), p. 10.
PMID: 34812839
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Serial dependence in the perceptual judgments of radiologists.
Authors: Manassi M. , Ghirardo C. , Canas-Bajo T. , Ren Z. , Prinzmetal W. , Whitney D. .
Source: Cognitive Research: Principles And Implications, 2021-10-14 00:00:00.0; 6(1), p. 65.
EPub date: 2021-10-14 00:00:00.0.
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Serial dependence revealed in history-dependent perceptual templates.
Authors: Murai Y. , Whitney D. .
Source: Current Biology : Cb, 2021-07-26 00:00:00.0; 31(14), p. 3185-3191.e3.
EPub date: 2021-06-03 00:00:00.0.
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Holistic ensemble perception.
Authors: Han L. , Yamanashi Leib A. , Chen Z. , Whitney D. .
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EPub date: 2020-11-25 00:00:00.0.
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Inferential affective tracking reveals the remarkable speed of context-based emotion perception.
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Source: Cognition, 2021 03; 208, p. 104549.
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Controllable Medical Image Generation via Generative Adversarial Networks.
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Source: Is&t International Symposium On Electronic Imaging, 2021; 33, .
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Idiosyncratic perception: a link between acuity, perceived position and apparent size.
Authors: Wang Z. , Murai Y. , Whitney D. .
Source: Proceedings. Biological Sciences, 2020-07-08 00:00:00.0; 287(1930), p. 20200825.
EPub date: 2020-07-08 00:00:00.0.
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Visual crowding in driving.
Authors: Xia Y. , Manassi M. , Nakayama K. , Zipser K. , Whitney D. .
Source: Journal Of Vision, 2020-06-03 00:00:00.0; 20(6), p. 1.
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Author Correction: Serial dependence in a simulated clinical visual search task.
Authors: Manassi M. , Kristjánsson Á. , Whitney D. .
Source: Scientific Reports, 2020-02-18 00:00:00.0; 10(1), p. 3221.
EPub date: 2020-02-18 00:00:00.0.
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Serial dependence in a simulated clinical visual search task.
Authors: Manassi M. , Kristjánsson Á. , Whitney D. .
Source: Scientific Reports, 2019-12-27 00:00:00.0; 9(1), p. 19937.
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