Grant Details
Grant Number: |
5R01CA242737-03 Interpret this number |
Primary Investigator: |
Martin, Michelle |
Organization: |
University Of Tennessee Health Sci Ctr |
Project Title: |
Increasing Recruitment of Underrepresented Cancer Survivors with Awareness Enhancing Interventions (Run Awei) |
Fiscal Year: |
2022 |
Abstract
Critical to eliminating cancer health disparities is the ability to engage racial and ethnic minorities in research.
Inadequate representation of African Americans (AAs) in research severely limits the opportunity to
understand underlying causes of disparate health outcomes between AAs and other race groups and the
opportunity to advance knowledge on how to reduce the cancer burden in this vulnerable population. Finding
ways to increase recruitment of AA cancer survivors in research is urgent. The question is how. We
propose that one mechanism is to increase awareness about research in AA potential participants, a solution
supported both by our previous observational study (IMPaCT) in AA cancer survivors, and research by others,
in which survivors indicated that having information about clinical trials was important in their decision-making
regarding trial participation. However, evidence-based methods to increase awareness in AAs remain largely
absent. Unknown is what type of strategy, information, and perspective, is needed. We will test awareness-
enhancing interventions (AWEI) that vary in these dimensions among AA cancer survivors for whom
disparities in cancer incidence and mortality are widely documented and concerning. We propose a highly
innovative and efficient factorial trial design embedded into the recruitment effort for AMPLIFI (P01 CA22997).
AMPLIFI will recruit 652 cancer survivors to be randomized to lifestyle interventions. Participants will be from
four southeastern states with a high burden of cancer in AAs. During the AMPLIFI recruitment process, 2,000
AA cancer survivors will be randomized to one of 8 AWEI conditions that vary by type of strategy, type of
information, and perspective, or to the AMPLIFI basic recruitment strategy (No AWEI). Aims are: 1: Determine
the impact of AWEIs on recruitment of AA cancer survivors. We hypothesize that AWEIs will have a
significantly higher recruitment yield than the basic AMPLIFI recruitment strategy (H1). In line with IMPaCT, we
expect AWEI to have a significant impact doubling the recruitment yield; 2: Identify the AWEI key features
that increase recruitment of AA cancer survivors. We will test whether AWEI-navigation vs. AWEI-
brochure (type of strategy, H2), study-specific vs general research messages (type of information, H3), and,
survivor “voice” vs. not (type of perspective, H4) will result in higher recruitment yield; and 3: Determine the
optimal AWEI combination in terms of recruitment yield and cost. We hypothesize that AWEI
combination of navigation with study-specific messages and the survivor “voice” will be the most efficacious
and may be most cost-effective compared to the other combinations. In summary, building on an important trial
that will oversample minorities in underserved US states, our expert team will adopt this innovative and
rigorous study design to advance the science of recruitment and have a high impact on representation of AAs
in research.
Publications
None