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Grant Details

Grant Number: 5R01CA246540-03 Interpret this number
Primary Investigator: Lutgendorf, Susan
Organization: University Of Iowa
Project Title: Living Well: a Web-Based Intervention to Improve Quality of Life in Rural and Urban Ovarian Cancer Survivors
Fiscal Year: 2022


Abstract Over the last two decades, we and others have documented the chronic and often debilitating experience of ovarian cancer survivorship which may include poor health related quality of life (HRQOL), elevated anxiety and depression, poor sleep, fatigue, multiple symptoms/side effects, existential concerns, and a generally poor prognosis. Because of compromises to many aspects of HRQOL combined with low rates of survival for the majority of these patients, development of innovative approaches for improving HRQOL and potentially improving clinical outcomes is of paramount importance. This need is particularly true in rural settings where women may have less access to clinic-based support systems. Despite the multiple challenges experienced by ovarian cancer survivors, research targeting the potential efficacy of psychosocial interventions in enhancing HRQOL has been extremely limited. Over the last several years this research team has developed and piloted a web-based group conferencing intervention entitled Living Well (Web-Enhanced Lessons for Living) targeting key concerns of ovarian cancer survivors and developed with input from survivors. The overarching goal of the present submission is to examine the efficacy of the Living Well intervention vs. a Health Promotion active control intervention in a randomized controlled trial in 256 ovarian cancer survivors who have completed primary treatment and are less than 5-years post-diagnosis. We hypothesize that the Living Well Intervention will be efficacious in improving HRQOL, decreasing perceived stress (primary outcomes) and in decreasing depressive mood, anxiety, and fatigue (secondary outcomes). This application is highly innovative because it combines elements of evidence-based psychosocial interventions in a novel way to target the needs of ovarian cancer survivors, using a state-of-the-art web and video conferencing platform that allows wide dissemination, including to rural survivors. This work is highly translational as it is a direct application of findings from mechanistic stress-related research to testing an intervention to reduce stress in ovarian cancer survivors. The significance of the application is that this intervention has the potential to overcome prior barriers to the implementation of such psychosocial interventions and improve HRQOL, thus providing public health benefits to an understudied and compromised cancer population with a high likelihood of recurrence.


The biology of hope: Inflammatory and neuroendocrine profiles in ovarian cancer patients.
Authors: Lutgendorf S.K. , Telles R.M. , Whitney B. , Thaker P.H. , Slavich G.M. , Goodheart M.J. , Penedo F.J. , Noble A.E. , Cole S.W. , Sood A.K. , et al. .
Source: Brain, behavior, and immunity, 2024 Feb; 116, p. 362-369.
EPub date: 2023-12-09.
PMID: 38081436
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Well-being and stress vulnerability in ovarian cancer survivors during the COVID-19 pandemic.
Authors: Telles R. , Zia S. , Greteman B.B. , Thaker P.H. , Penedo F. , Charlton M.E. , Goodheart M.J. , Armer J.S. , Noble A. , Sood A.K. , et al. .
Source: Journal of psychosocial oncology, 2024; 42(3), p. 299-314.
EPub date: 2023-08-17.
PMID: 37587850
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Pain interference and fatigue in limb-girdle muscular dystrophy R9.
Authors: Reelfs A.M. , Stephan C.M. , Mockler S.R.H. , Laubscher K.M. , Zimmerman M.B. , Mathews K.D. .
Source: Neuromuscular disorders : NMD, 2023 Jun; 33(6), p. 523-530.
EPub date: 2023-05-19.
PMID: 37247532
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Rural and urban differences in perceptions, behaviors, and health care disruptions during the COVID-19 pandemic.
Authors: Greteman B.B. , Garcia-Auguste C.J. , Gryzlak B.M. , Kahl A.R. , Lutgendorf S.K. , Chrischilles E.A. , Charlton M.E. .
Source: The Journal of rural health : official journal of the American Rural Health Association and the National Rural Health Care Association, 2022 Sep; 38(4), p. 932-944.
EPub date: 2022-04-24.
PMID: 35466479
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Biobehavioral Pathways and Cancer Progression: Insights for Improving Well-Being and Cancer Outcomes.
Authors: Chang A. , Sloan E.K. , Antoni M.H. , Knight J.M. , Telles R. , Lutgendorf S.K. .
Source: Integrative cancer therapies, 2022 Jan-Dec; 21, p. 15347354221096081.
PMID: 35579197
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Diagnostic delay in patients with FKRP-related muscular dystrophy.
Authors: Coffey L.N. , Stephan C.M. , Zimmerman M.B. , Decker C.K. , Mathews K.D. .
Source: Neuromuscular disorders : NMD, 2021 Dec; 31(12), p. 1235-1240.
EPub date: 2021-09-06.
PMID: 34857438
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The Role of Psychologic Stress in Cancer Initiation: Clinical Relevance and Potential Molecular Mechanisms.
Authors: Falcinelli M. , Thaker P.H. , Lutgendorf S.K. , Conzen S.D. , Flaherty R.L. , Flint M.S. .
Source: Cancer research, 2021-10-15; 81(20), p. 5131-5140.
EPub date: 2021-07-15.
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Rural residence is related to shorter survival in epithelial ovarian cancer patients.
Authors: Lutgendorf S.K. , Ramirez E. , Schrepf A. , Valentine M.C. , Charlton M. , Zimmerman M.B. , Goodheart M.J. , Zia S. , Sood A.K. , Thaker P.H. .
Source: Gynecologic oncology, 2021 Oct; 163(1), p. 22-28.
EPub date: 2021-08-13.
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Mitochondria in epithelial ovarian carcinoma exhibit abnormal phenotypes and blunted associations with biobehavioral factors.
Authors: Bindra S. , McGill M.A. , Triplett M.K. , Tyagi A. , Thaker P.H. , Dahmoush L. , Goodheart M.J. , Ogden R.T. , Owusu-Ansah E. , R Karan K. , et al. .
Source: Scientific reports, 2021-06-02; 11(1), p. 11595.
EPub date: 2021-06-02.
PMID: 34078919
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Positive Psychosocial Factors and Oxytocin in the Ovarian Tumor Microenvironment.
Authors: Cuneo M.G. , Szeto A. , Schrepf A. , Thaker P.H. , Goodheart M. , Cole S.W. , Sood A.K. , McCabe P.M. , Mendez A.J. , Lutgendorf S.K. .
Source: Psychosomatic medicine, 2021-06-01; 83(5), p. 417-422.
PMID: 34080583
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Chronic difficulties are associated with poorer psychosocial functioning in the first year post-diagnosis in epithelial ovarian cancer patients.
Authors: Garvin L. , Slavich G.M. , Schrepf A. , Davis L.Z. , Thaker P.H. , Goodheart M.J. , Cole S.W. , Sood A.K. , Lutgendorf S.K. .
Source: Psycho-oncology, 2021 Jun; 30(6), p. 954-961.
EPub date: 2021-04-01.
PMID: 33760306
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Epithelial-mesenchymal transition polarization in ovarian carcinomas from patients with high social isolation.
Authors: Lutgendorf S.K. , Penedo F. , Goodheart M.J. , Dahmoush L. , Arevalo J.M.G. , Thaker P.H. , Slavich G.M. , Sood A.K. , Cole S.W. .
Source: Cancer, 2020-10-01; 126(19), p. 4407-4413.
EPub date: 2020-07-21.
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The Impact of Yoga on Fatigue in Cancer Survivorship: A Meta-Analysis.
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