Grant Number:	5R01CA222147-05 Interpret this number
Primary Investigator:	Vanderweele, Tyler
Organization:	Harvard School Of Public Health
Project Title:	Theory and Methods for Mediation and Interaction
Fiscal Year:	2022

Project Summary The proposed research will develop novel methods to assess mediation and interaction between genetic and environmental exposures and different disease subtypes so as to better tailor treatments and prevention efforts to individuals' characteristics and so as to better understand the mechanisms governing disease. Methods will be developed for settings in which there are multiple disease subtypes and these disease subtypes may have different prognosis for survival and may be more amenable to different types of treatment and preventive efforts. Methodology for assessing the role of interaction in understanding mechanisms will also be developed. This will include elucidating the role of gene-environment interaction in the heritability of disease, understanding mediating pathways from exposure to disease in the presence of interaction, and identifying sufficient cause interaction for diseases or disease subtypes such that an outcome would occur if two (or more) exposures are present, but not if only one or the other were present. The methodology will be applied to understand prognosis, treatment decisions, preventive interventions, and mechanisms for colorectal cancer, and also for the development of skin lesions; the methodology will also be applied to understand the role of gene-environment interaction in the heritability of numerous traits.




Re: Benchmarking social isolation, loneliness, and smoking: challenges and opportunities for public health.
Authors: VanderWeele T.J. , Kim E.S. .
Source: American Journal Of Epidemiology, 2024-10-07 00:00:00.0; 193(10), p. 1497-1498.
PMID: 38702997
Related Citations

Universal Difference-in-Differences for Causal Inference in Epidemiology.
Authors: Tchetgen Tchetgen E.J. , Park C. , Richardson D.B. .
Source: Epidemiology (cambridge, Mass.), 2024-01-01 00:00:00.0; 35(1), p. 16-22.
EPub date: 2023-11-27 00:00:00.0.
PMID: 38032801
Related Citations

Prediction sets adaptive to unknown covariate shift.
Authors: Qiu H. , Dobriban E. , Tchetgen Tchetgen E. .
Source: Journal Of The Royal Statistical Society. Series B, Statistical Methodology, 2023 Nov; 85(5), p. 1680-1705.
EPub date: 2023-07-17 00:00:00.0.
PMID: 38312527
Related Citations

Mendelian randomization mixed-scale treatment effect robust identification and estimation for causal inference.
Authors: Liu Z. , Ye T. , Sun B. , Schooling M. , Tchetgen E.T. .
Source: Biometrics, 2023 Sep; 79(3), p. 2208-2219.
EPub date: 2022-09-28 00:00:00.0.
PMID: 35950778
Related Citations

Effect Measure Modification by Covariates in Mediation: Extending Regression-based Causal Mediation Analysis.
Authors: Li Y. , Mathur M.B. , Solomon D.H. , Ridker P.M. , Glynn R.J. , Yoshida K. .
Source: Epidemiology (cambridge, Mass.), 2023-09-01 00:00:00.0; 34(5), p. 661-672.
EPub date: 2023-07-31 00:00:00.0.
PMID: 37527449
Related Citations

Proximal Causal Inference without Uniqueness Assumptions.
Authors: Zhang J. , Li W. , Miao W. , Tchetgen E.T. .
Source: Statistics & Probability Letters, 2023 Jul; 198, .
EPub date: 2023-03-21 00:00:00.0.
PMID: 38405420
Related Citations

Generalized Difference-in-Differences.
Authors: Richardson D.B. , Ye T. , Tchetgen Tchetgen E.J. .
Source: Epidemiology (cambridge, Mass.), 2023-03-01 00:00:00.0; 34(2), p. 167-174.
EPub date: 2022-11-29 00:00:00.0.
PMID: 36722798
Related Citations

A brief primer on conducting regression-based causal mediation analysis.
Authors: Li Y. , Yoshida K. , Kaufman J.S. , Mathur M.B. .
Source: Psychological Trauma : Theory, Research, Practice And Policy, 2023-01-26 00:00:00.0; , .
EPub date: 2023-01-26 00:00:00.0.
PMID: 36701540
Related Citations

Variation across analysts in statistical significance, yet consistently small effect sizes.
Authors: Mathur M.B. , Covington C. , VanderWeele T.J. .
Source: Proceedings Of The National Academy Of Sciences Of The United States Of America, 2023-01-17 00:00:00.0; 120(3), p. e2218957120.
EPub date: 2023-01-09 00:00:00.0.
PMID: 36623183
Related Citations

On the double-robustness and semiparametric efficiency of matching-adjusted indirect comparisons.
Authors: Cheng D. , Tchetgen E.T. , Signorovitch J. .
Source: Research Synthesis Methods, 2022-12-20 00:00:00.0; , .
EPub date: 2022-12-20 00:00:00.0.
PMID: 36537355
Related Citations

A Semiparametric Approach to Model-Based Sensitivity Analysis in Observational Studies.
Authors: Zhang B. , Tchetgen Tchetgen E.J. .
Source: Journal Of The Royal Statistical Society. Series A, (statistics In Society), 2022 Dec; 185(Suppl 2), p. S668-S691.
EPub date: 2022-11-24 00:00:00.0.
PMID: 36777968
Related Citations

The Authors Respond.
Authors: Mathur M.B. , VanderWeele T.J. .
Source: Epidemiology (cambridge, Mass.), 2022-11-01 00:00:00.0; 33(6), p. e22-e23.
EPub date: 2022-10-05 00:00:00.0.
PMID: 36220586
Related Citations

A statistical test to reject the structural interpretation of a latent factor model.
Authors: VanderWeele T.J. , Vansteelandt S. .
Source: Journal Of The Royal Statistical Society. Series B, Statistical Methodology, 2022 Nov; 84(5), p. 2032-2054.
EPub date: 2022-11-22 00:00:00.0.
PMID: 36818188
Related Citations

Using selection models to assess sensitivity to publication bias: A tutorial and call for more routine use.
Authors: Maier M. , VanderWeele T.J. , Mathur M.B. .
Source: Campbell Systematic Reviews, 2022 Sep; 18(3), p. e1256.
EPub date: 2022-07-01 00:00:00.0.
PMID: 36909879
Related Citations

A New Tool for Reporting Mediation Analyses.
Authors: VanderWeele T.J. , Cashin A.G. , McAuley J.H. , Lee H. .
Source: Epidemiology (cambridge, Mass.), 2022-07-01 00:00:00.0; 33(4), p. e16-e18.
EPub date: 2022-03-08 00:00:00.0.
PMID: 35447630
Related Citations

Regression-based negative control of homophily in dyadic peer effect analysis.
Authors: Liu L. , Tchetgen Tchetgen E. .
Source: Biometrics, 2022 Jun; 78(2), p. 668-678.
EPub date: 2021-05-31 00:00:00.0.
PMID: 33914905
Related Citations

E-values for effect heterogeneity and approximations for causal interaction.
Authors: Mathur M.B. , Smith L.H. , Yoshida K. , Ding P. , VanderWeele T.J. .
Source: International Journal Of Epidemiology, 2022-04-23 00:00:00.0; , .
EPub date: 2022-04-23 00:00:00.0.
PMID: 35460421
Related Citations

Ikigai and subsequent health and wellbeing among Japanese older adults: Longitudinal outcome-wide analysis.
Authors: Okuzono S.S. , Shiba K. , Kim E.S. , Shirai K. , Kondo N. , Fujiwara T. , Kondo K. , Lomas T. , Trudel-Fitzgerald C. , Kawachi I. , et al. .
Source: The Lancet Regional Health. Western Pacific, 2022 Apr; 21, p. 100391.
EPub date: 2022-02-03 00:00:00.0.
PMID: 35141667
Related Citations

RE: "SYNTHETIC CONTROL METHODS FOR THE EVALUATION OF SINGLE-UNIT INTERVENTIONS IN EPIDEMIOLOGY: A TUTORIAL".
Authors: Tchetgen Tchetgen E.J. , Dukes O. , Shi X. , Miao W. , Richardson D. .
Source: American Journal Of Epidemiology, 2022-03-24 00:00:00.0; 191(5), p. 965-966.
PMID: 35136907
Related Citations

Double Negative Control Inference in Test-Negative Design Studies of Vaccine Effectiveness.
Authors: Li K.Q. , Shi X. , Miao W. , Tchetgen E.T. .
Source: Arxiv, 2022-03-23 00:00:00.0; , .
EPub date: 2022-03-23 00:00:00.0.
PMID: 35350548
Related Citations

Assessing Uncontrolled Confounding in Associations of Being Overweight With All-Cause Mortality.
Authors: Mathur M.B. , VanderWeele T.J. .
Source: Jama Network Open, 2022-03-01 00:00:00.0; 5(3), p. e222614.
EPub date: 2022-03-01 00:00:00.0.
PMID: 35344049
Related Citations

How to report E-values for meta-analyses: Recommended improvements and additions to the new GRADE approach.
Authors: Mathur M.B. , VanderWeele T.J. .
Source: Environment International, 2022 02; 160, p. 107032.
EPub date: 2021-12-24 00:00:00.0.
PMID: 34954645
Related Citations

Marginal Structural Models for Life-Course Theories and Social Epidemiology: Definitions, Sources of Bias, and Simulated Illustrations.
Authors: Gilsanz P. , Young J.G. , Glymour M.M. , Tchetgen Tchetgen E.J. , Eng C.W. , Koenen K.C. , Kubzansky L.D. .
Source: American Journal Of Epidemiology, 2022-01-24 00:00:00.0; 191(2), p. 349-359.
PMID: 34668974
Related Citations

Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration.
Authors: Skrivankova V.W. , Richmond R.C. , Woolf B.A.R. , Davies N.M. , Swanson S.A. , VanderWeele T.J. , Timpson N.J. , Higgins J.P.T. , Dimou N. , Langenberg C. , et al. .
Source: Bmj (clinical Research Ed.), 2021-10-26 00:00:00.0; 375, p. n2233.
EPub date: 2021-10-26 00:00:00.0.
PMID: 34702754
Related Citations

Are Greenland, Ioannidis and Poole opposed to the Cornfield conditions? A defence of the E-value.
Authors: VanderWeele T.J. .
Source: International Journal Of Epidemiology, 2021-10-13 00:00:00.0; , .
EPub date: 2021-10-13 00:00:00.0.
PMID: 34643669
Related Citations

Constructed measures and causal inference: towards a new model of measurement for psychosocial constructs.
Authors: VanderWeele T.J. .
Source: Epidemiology (cambridge, Mass.), 2021-10-13 00:00:00.0; , .
EPub date: 2021-10-13 00:00:00.0.
PMID: 34669630
Related Citations

Facets of optimism: Comment on Scheier et al. (2021).
Authors: VanderWeele T.J. , Kubzansky L.D. .
Source: The American Psychologist, 2021 10; 76(7), p. 1191-1193.
PMID: 34990174
Related Citations

A Guideline for Reporting Mediation Analyses of Randomized Trials and Observational Studies: The AGReMA Statement.
Authors: Lee H. , Cashin A.G. , Lamb S.E. , Hopewell S. , Vansteelandt S. , VanderWeele T.J. , MacKinnon D.P. , Mansell G. , Collins G.S. , Golub R.M. , et al. .
Source: Jama, 2021-09-21 00:00:00.0; 326(11), p. 1045-1056.
PMID: 34546296
Related Citations

Methods to Address Confounding and Other Biases in Meta-Analyses: Review and Recommendations.
Authors: Mathur M.B. , VanderWeele T.J. .
Source: Annual Review Of Public Health, 2021-09-17 00:00:00.0; , .
EPub date: 2021-09-17 00:00:00.0.
PMID: 34535060
Related Citations

Multiple-bias Sensitivity Analysis Using Bounds.
Authors: Smith L.H. , Mathur M.B. , VanderWeele T.J. .
Source: Epidemiology (cambridge, Mass.), 2021-09-01 00:00:00.0; 32(5), p. 625-634.
PMID: 34224471
Related Citations

Changes in Attributable Fractions and Causal Inference for Schizophrenia and Other Psychiatric Outcomes.
Authors: VanderWeele T.J. .
Source: Jama Psychiatry, 2021-09-01 00:00:00.0; 78(9), p. 949-950.
PMID: 34287638
Related Citations

Are all domains of life satisfaction equal? Differential associations with health and well-being in older adults.
Authors: Nakamura J.S. , Delaney S.W. , Diener E. , VanderWeele T.J. , Kim E.S. .
Source: Quality Of Life Research : An International Journal Of Quality Of Life Aspects Of Treatment, Care And Rehabilitation, 2021-08-31 00:00:00.0; , .
EPub date: 2021-08-31 00:00:00.0.
PMID: 34463862
Related Citations

Correction of 'Bias factor, maximum bias and the E-value'.
Authors: Sjölander A. , VanderWeele T.J. .
Source: International Journal Of Epidemiology, 2021-08-30 00:00:00.0; 50(4), p. 1394-1395.
PMID: 33779748
Related Citations

Associations Between Purpose in Life and Mortality by SES.
Authors: Shiba K. , Kubzansky L.D. , Williams D.R. , VanderWeele T.J. , Kim E.S. .
Source: American Journal Of Preventive Medicine, 2021 Aug; 61(2), p. e53-e61.
EPub date: 2021-05-18 00:00:00.0.
PMID: 34020851
Related Citations

Meta-regression methods to characterize evidence strength using meaningful-effect percentages conditional on study characteristics.
Authors: Mathur M.B. , VanderWeele T.J. .
Source: Research Synthesis Methods, 2021-07-01 00:00:00.0; , .
EPub date: 2021-07-01 00:00:00.0.
PMID: 34196505
Related Citations

Identifying loci with different allele frequencies among cases of eight psychiatric disorders using CC-GWAS.
Authors: Peyrot W.J. , Price A.L. .
Source: Nature Genetics, 2021-03-08 00:00:00.0; , .
EPub date: 2021-03-08 00:00:00.0.
PMID: 33686288
Related Citations

Life Satisfaction and Subsequent Physical, Behavioral, and Psychosocial Health in Older Adults.
Authors: Kim E.S. , Delaney S.W. , Tay L. , Chen Y. , Diener E.D. , Vanderweele T.J. .
Source: The Milbank Quarterly, 2021 03; 99(1), p. 209-239.
EPub date: 2021-02-02 00:00:00.0.
PMID: 33528047
Related Citations

Population-specific causal disease effect sizes in functionally important regions impacted by selection.
Authors: Shi H. , Gazal S. , Kanai M. , Koch E.M. , Schoech A.P. , Siewert K.M. , Kim S.S. , Luo Y. , Amariuta T. , Huang H. , et al. .
Source: Nature Communications, 2021-02-17 00:00:00.0; 12(1), p. 1098.
EPub date: 2021-02-17 00:00:00.0.
PMID: 33597505
Related Citations

Religious-service attendance and subsequent health and well-being throughout adulthood: evidence from three prospective cohorts.
Authors: Chen Y. , Kim E.S. , VanderWeele T.J. .
Source: International Journal Of Epidemiology, 2021-01-23 00:00:00.0; 49(6), p. 2030-2040.
PMID: 32793951
Related Citations

Psychometric Properties of Flourishing Scales From a Comprehensive Well-Being Assessment.
Authors: Weziak-Bialowolska D. , Bialowolski P. , Lee M.T. , Chen Y. , VanderWeele T.J. , McNeely E. .
Source: Frontiers In Psychology, 2021; 12, p. 652209.
EPub date: 2021-04-21 00:00:00.0.
PMID: 33967913
Related Citations

A semiparametric instrumental variable approach to optimal treatment regimes under endogeneity.
Authors: Cui Y. , Tchetgen E.T. .
Source: Journal Of The American Statistical Association, 2021; 116(533), p. 162-173.
EPub date: 2020-08-04 00:00:00.0.
PMID: 33994604
Related Citations

Machine intelligence for individualized decision making under a counterfactual world: A rejoinder.
Authors: Cui Y. , Tchetgen E.T. .
Source: Journal Of The American Statistical Association, 2021; 116(533), p. 200-206.
EPub date: 2021-03-09 00:00:00.0.
PMID: 34040267
Related Citations

Auto-G-Computation of Causal Effects on a Network.
Authors: Tchetgen Tchetgen E.J. , Fulcher I.R. , Shpitser I. .
Source: Journal Of The American Statistical Association, 2021; 116(534), p. 833-844.
EPub date: 2020-10-01 00:00:00.0.
PMID: 34366505
Related Citations

Invited Commentary: Frontiers of Power Assessment in Mediation Analysis.
Authors: VanderWeele T.J. .
Source: American Journal Of Epidemiology, 2020-12-01 00:00:00.0; 189(12), p. 1568-1570.
PMID: 32415833
Related Citations

A Selective Review of Negative Control Methods in Epidemiology.
Authors: Shi X. , Miao W. , Tchetgen E.T. .
Source: Current Epidemiology Reports, 2020 Dec; 7(4), p. 190-202.
EPub date: 2020-10-15 00:00:00.0.
PMID: 33996381
Related Citations

Controversy and debate on credibility ceilings. Paper 3: errors in the statistical justification for the "credibility ceiling" method remain uncorrected.
Authors: Mathur M.B. , VanderWeele T.J. .
Source: Journal Of Clinical Epidemiology, 2020 Nov; 127, p. 214-216.
EPub date: 2020-05-20 00:00:00.0.
PMID: 32442482
Related Citations

Controversy and debate on credibility ceilings. Paper 1: Fundamental problems with the "credibility ceiling" method for meta-analyses.
Authors: Mathur M.B. , VanderWeele T.J. .
Source: Journal Of Clinical Epidemiology, 2020 Nov; 127, p. 208-210.
EPub date: 2020-05-23 00:00:00.0.
PMID: 32450128
Related Citations

E Values and Incidence Density Sampling.
Authors: VanderWeele T.J. , Martin J.N. , Mathur M.B. .
Source: Epidemiology (cambridge, Mass.), 2020 Nov; 31(6), p. e51-e52.
PMID: 32769478
Related Citations

Sensitivity analysis for publication bias in meta-analyses.
Authors: Mathur M.B. , VanderWeele T.J. .
Source: Journal Of The Royal Statistical Society. Series C, Applied Statistics, 2020 Nov; 69(5), p. 1091-1119.
EPub date: 2020-08-28 00:00:00.0.
PMID: 33132447
Related Citations

Estimating publication bias in meta-analyses of peer-reviewed studies: A meta-meta-analysis across disciplines and journal tiers.
Authors: Mathur M.B. , VanderWeele T.J. .
Source: Research Synthesis Methods, 2020-10-27 00:00:00.0; , .
EPub date: 2020-10-27 00:00:00.0.
PMID: 33108053
Related Citations