Spatial in situ mapping of RNA-chromatin interactions in human vasculature
A breakthrough of this project is to simultaneously improve the state-of-art spatial resolution, dynamic range of
RNA quantification, and applicable dimensions of human tissue by one to several orders of magnitude. This
breakthrough will deliver to users extremely high-resolution, high-density, high-fidelity and reproducible spatial
mapping slides (HiFi slides) for spatial transcriptome analysis or spatial mapping of modified- or interacting-
nucleic acids. We will leverage HiFi slides to provide spatial transcriptome and spatial RNA-chromatin
interactome mapping tools in unprecedented resolution. This project will generate HiFi spatial transcriptome,
HiFi spatial RNA-crhomatin interactome, and high-resolution protein spatial profiles of 96 proteins from
mesenteric arteries of veins, and the microvasculature from pancreas, liver and brain. These datasets will form
the initial human EC biomolecular map (HuEC-MAP). These data will offer unprecedented insights to the
molecular nature of the tissue-specific morphologies and functions of the blood vessel endothelium, which are
critical to the development and functions of the associated tissues.
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