||5R01CA244500-02 Interpret this number
||Weill Medical Coll Of Cornell Univ
||Delirium in Children Undergoing Hematopoietic Stem Cell Transplants
Delirium -- defined as an acute change in awareness and cognition that occurs in the setting of an underlying
illness -- is a common complication of hematopoietic stem cell transplantation (HSCT) in adults, with
associated morbidity and mortality. This has never been studied in children, where risk factors may vary
substantially from adults. The central hypothesis of this study is that children undergoing HSCT are at
extremely high-risk for delirium during the peri-transplant period, and that delirium is linked to poor outcomes.
The objectives of this application are: to define the epidemiology of delirium, and measure its effect on
outcomes. This prospective longitudinal cohort study will prospectively establish the incidence of delirium in
1000 children in the peri-transplant period, and identify modifiable risk factors that predispose to delirium
development. This study will also define the effect of delirium on important clinical outcomes, including
neurocognitive function. These results will lead to a paradigm shift in the care delivered to children in the peri-
transplant period. This study will be executed by a research consortium of five leading pediatric oncologic
transplant centers in North America, in collaboration with the leading pediatric delirium research group in the
United States. This innovative proposal will leverage the combined experience of the pediatric delirium and
HSCT teams to expand urgently needed delirium research into a unique and unstudied population. By reducing
delirium rates, outcomes after pediatric HSCT can be optimized. This proposal is consistent with the NIH’s new
policy to ensure research ‘Inclusion Across the Lifespan’, and will further the National Cancer Institute’s
mission to advance scientific knowledge in order to help people with cancer live longer, healthier lives.
Factors Associated With Delirium in Children: A Systematic Review and Meta-Analysis.
, Traube C.
, de Neef M.
, Schieveld J.
, Knoester H.
, Molag M.
, Kudchadkar S.R.
, Strik J.
, Dutch Multidisciplinary Pediatric Delirium Guideline Group
Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2023-05-01; 24(5), p. 372-381.
Should We Intubate Pediatric Hematopoietic Cell Transplant Patients With Respiratory Failure Sooner?
, Zinter M.S.
Critical care medicine, 2022-07-01; 50(7), p. 1163-1167.
Acute Neurologic Dysfunction in Critically Ill Children: The PODIUM Consensus Conference.
, Guilliams K.
, Kannan S.
, Simon D.W.
, Tasker R.C.
, Traube C.
, Pineda J.
, Pediatric Organ Dysfunction Information Update Mandate (PODIUM) Collaborative
Pediatrics, 2022-01-01; 149(1 Suppl 1), p. S32-S38.
Delirium in Children Undergoing Hematopoietic Cell Transplantation: A Multi-Institutional Point Prevalence Study.
, Gerber L.M.
, Mauer E.A.
, Small K.
, Broglie L.
, Chopra Y.R.
, Duncan C.N.
, Ebens C.L.
, Fitzgerald J.C.
, Freedman J.L.
, et al.
Frontiers in oncology, 2021; 11, p. 627726.