Grant Number:	5R01CA212014-05 Interpret this number
Primary Investigator:	Henderson, Louise
Organization:	Univ Of North Carolina Chapel Hill
Project Title:	Evaluating Lung Cancer Screening Patterns and Outcomes Through a North Carolina Registry
Fiscal Year:	2021

PROJECT SUMMARY/ABSTRACT There is a need to understand how the results of the National Lung Screening Trial (NLST) and the U.S. Pre- ventive Services Task Force (USPSTF) guidelines will impact the use of low-dose computed tomography (LDCT) for lung cancer screening in the general population. Given the high incidence and mortality rates of lung cancer, developing evidence on the utility of a screening test that can reduce lung cancer mortality will likely lead to a significant improvement in public health. Our long-term goal is to examine the delivery, quality and outcomes of lung cancer screening in North Carolina by utilizing prospective population-based lung cancer screening data that captures patient, radiologist, and pathology information to inform clinical practice. The objective of this application is to evaluate the extent to which disparities in intermediate lung cancer screening outcomes exist. We plan to accomplish this objective by pursuing the following four specific aims: (1) Deter- mine the agreement between radiologists' use of the lung imaging reporting and data system (Lung-RADS) assessment code and follow-up recommendations with the American College of Radiology (ACR) guidelines; (2) Evaluate recall rates of lung cancer screening with LDCT by patient socio-demographics and risk factors; (3) Compare rates of follow-up receipt after a positive lung cancer screening test result by patient socio- demographics and risk factors; (4) Perform a data linkage between lung cancer screening data and lung can- cer outcomes from the North Carolina Central Cancer Registry (NCCCR) to examine false positive rates. With the USPSTF recommending LDCT for lung cancer screening in high-risk individuals, there is a growing need to monitor the screening experience as academic centers and community practices begin to adopt this technolo- gy. This is an innovative study that uses established methods in population-based registry development to ex- plore an emerging clinically relevant cancer screening area for which limited data exist. The proposed research is significant because it will provide evidence on lung cancer screening with LDCT in a general population to inform the delivery, quality, and outcomes of lung cancer screening as it diffuses into clinical practice.




Delays in Follow-up after a Positive Lung Cancer Screening Exam: Is the Benefit of Screening Compromised?
Authors: Rivera M.P. , Henderson L.M. , Sakoda L.C. .
Source: Annals of the American Thoracic Society, 2023 Aug; 20(8), p. 1102-1104.
PMID: 37311217
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Variability in Reporting of Incidental Findings Detected on Lung Cancer Screening.
Authors: Henderson L.M. , Chiles C. , Perera P. , Durham D.D. , Lamb D. , Lane L.M. , Rivera M.P. .
Source: Annals of the American Thoracic Society, 2023 Apr; 20(4), p. 617-620.
PMID: 36538683
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Receipt of Recommended Follow-up Care After a Positive Lung Cancer Screening Examination.
Authors: Rivera M.P. , Durham D.D. , Long J.M. , Perera P. , Lane L. , Lamb D. , Metwally E. , Henderson L.M. .
Source: JAMA network open, 2022-11-01; 5(11), p. e2240403.
EPub date: 2022-11-01.
PMID: 36326760
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Lung Cancer Screening in Individuals With and Without Lung-Related Comorbidities.
Authors: Metwally E.M. , Rivera M.P. , Durham D.D. , Lane L. , Perera P. , Lamb D. , Henderson L.M. .
Source: JAMA network open, 2022-09-01; 5(9), p. e2230146.
EPub date: 2022-09-01.
PMID: 36066893
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Prospective Multisite Cohort Study to Evaluate Shared Decision-Making Utilization Among Individuals Screened for Lung Cancer.
Authors: Tailor T.D. , Rivera M.P. , Durham D.D. , Perera P. , Lane L. , Henderson L.M. .
Source: Journal of the American College of Radiology : JACR, 2022 Aug; 19(8), p. 945-953.
EPub date: 2022-04-16.
PMID: 35439440
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Complementary Approaches to Lung Cancer Detection in High-Risk Populations.
Authors: Rivera M.P. , Cupertino P. , Henderson L.M. .
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2022-07-01; 40(19), p. 2074-2077.
EPub date: 2022-05-23.
PMID: 35605172
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Randomized control trial of unconditional versus conditional incentives to increase study enrollment rates in participants at increased risk of lung cancer.
Authors: Kumar A.D. , Durham D.D. , Lane L. , Perera P. , Rivera M.P. , Henderson L.M. .
Source: Journal of clinical epidemiology, 2022 Jan; 141, p. 11-17.
EPub date: 2021-08-29.
PMID: 34469801
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Adherence to Lung Cancer Screening: What Exactly Are We Talking About?
Authors: Sakoda L.C. , Henderson L.M. , Rivera M.P. .
Source: Annals of the American Thoracic Society, 2021 Dec; 18(12), p. 1951-1952.
PMID: 34380008
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Cardiovascular Risk in the Lung Cancer Screening Population: A Multicenter Study Evaluating the Association Between Coronary Artery Calcification and Preventive Statin Prescription.
Authors: Tailor T.D. , Chiles C. , Yeboah J. , Rivera M.P. , Tong B.C. , Schwartz F.R. , Benefield T. , Lane L.M. , Stashko I. , Thomas S.M. , et al. .
Source: Journal of the American College of Radiology : JACR, 2021 Sep; 18(9), p. 1258-1266.
EPub date: 2021-02-26.
PMID: 33640340
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Impact of the COVID-19 Pandemic on Volumes and Disparities in Lung Cancer Screening.
Authors: Henderson L.M. , Benefield T. , Bosemani T. , Long J.M. , Rivera M.P. .
Source: Chest, 2021 Jul; 160(1), p. 379-382.
EPub date: 2021-01-05.
PMID: 33417898
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Lung Cancer Screening With Low Dose Computed Tomography in Patients With and Without Prior History of Cancer in the National Lung Screening Trial.
Authors: Henderson L.M. , Durham D.D. , Tammemägi M.C. , Benefield T. , Marsh M.W. , Rivera M.P. .
Source: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2021 Jun; 16(6), p. 980-989.
EPub date: 2021-02-10.
PMID: 33581343
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Patterns and Factors Associated With Adherence to Lung Cancer Screening in Diverse Practice Settings.
Authors: Sakoda L.C. , Rivera M.P. , Zhang J. , Perera P. , Laurent C.A. , Durham D. , Huamani Velasquez R. , Lane L. , Schwartz A. , Quesenberry C.P. , et al. .
Source: JAMA network open, 2021-04-01; 4(4), p. e218559.
EPub date: 2021-04-01.
PMID: 33929519
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Rates of positive lung cancer screening examinations in academic versus community practice.
Authors: Henderson L.M. , Bacchus L. , Benefield T. , Huamani Velasquez R. , Rivera M.P. .
Source: Translational lung cancer research, 2020 Aug; 9(4), p. 1528-1532.
PMID: 32953524
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Disparities in Lung Cancer Screening: A Review.
Authors: Haddad D.N. , Sandler K.L. , Henderson L.M. , Rivera M.P. , Aldrich M.C. .
Source: Annals of the American Thoracic Society, 2020 Apr; 17(4), p. 399-405.
PMID: 32017612
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Changes in Physician Knowledge, Attitudes, Beliefs, and Practices regarding Lung Cancer Screening.
Authors: Henderson L.M. , Benefield T.S. , Bearden S.C. , Reuland D.S. , Brenner A.T. , Goldstein A.O. , Throneburg A. , Rivera M.P. .
Source: Annals of the American Thoracic Society, 2019 Aug; 16(8), p. 1065-1069.
PMID: 31075047
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Lung cancer screening and shared decision making in cancer survivors: the long and winding road.
Authors: Rivera M.P. , Henderson L.M. .
Source: Translational lung cancer research, 2019 Apr; 8(2), p. 119-123.
PMID: 31106122
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