Grant Details
Grant Number: |
5R01CA216265-05 Interpret this number |
Primary Investigator: |
Christensen, Brock |
Organization: |
Dartmouth College |
Project Title: |
(PQ3) Immune Epigenetic Biomarkers of Bladder Cancer Outcomes |
Fiscal Year: |
2021 |
Abstract
ABSTRACT
There are an estimated 765,000 people with a diagnosis of bladder cancer living in the United States and risk
of disease recurrence and progression can be high. Frequent, invasive transurethral screening procedures to
monitor for recurrence and progression burden both patients and the health care system. A better
understanding of the tumor-associated immune responses in bladder cancer patients could provide for more
informed clinical decisions on the necessary frequency of invasive follow up procedures and reduce patient
morbidity. We propose to leverage an existing population-based study of bladder cancer that includes a range
of patient age groups, has several years of follow up, includes patient treatment and outcome data, as well as
matched tumor samples. Our collaborative group has developed and extensively validated epigenetic
biomarkers of leukocyte subtypes allowing the use of archival DNA to study immune profiles. Here we will use
our proven framework to expand our repertoire of leukocyte epigenetic biomarkers to include myeloid derived
suppressor cells (MDSC), and test and validate the relation of MDSC and other leukocyte subtypes (including
the neutrophil to lymphocyte ratio: NLR), and cell type activation states with bladder cancer outcomes;
recurrence, progression, and survival. We will use time-to-event analysis and aim to understand the
independent contributions of immune profiles, age at diagnosis, tumor stage and grade, smoking history, and
treatment (including BCG immunotherapy), with bladder cancer outcomes. In addition, we propose to measure
somatic alteration profiles of bladder tumors from matched subjects and assess the relation of blood immune
signatures with tumor methylation and survival to understand the crosstalk between tumor profiles and patient
immune responses. Finally, in an exploratory aim we will prospectively investigate both pre-treatment and post-
treatment immune signatures in bladder cancer patients. At this opportune time of emerging
immunomodulatory therapeutics our existing population-based study resource provides a cost-efficient setting
to advance towards improved risk projection in newly diagnosed patients by ushering in a novel and flexible
immune monitoring toolkit that can inform clinical decision-making using data on tumor-associated immune
responses.
Publications
Detailed immune profiling in pediatric Crohn's disease using methylation cytometry.
Authors: Reynolds S.R.
, Salas L.A.
, Chen J.Q.
, Christensen B.C.
.
Source: Epigenetics, 2024 Dec; 19(1), p. 2289786.
EPub date: 2023-12-13 00:00:00.0.
PMID: 38090774
Related Citations
Methylation cytometric pretreatment blood immune profiles with tumor mutation burden as prognostic indicators for survival outcomes in head and neck cancer patients on anti-PD-1 therapy.
Authors: Zhang Z.
, Sehgal K.
, Shirai K.
, Butler R.A.
, Wiencke J.K.
, Koestler D.C.
, Ramush G.
, Lee M.K.
, Molinaro A.M.
, Stolrow H.G.
, et al.
.
Source: Npj Precision Oncology, 2024-11-18 00:00:00.0; 8(1), p. 267.
EPub date: 2024-11-18 00:00:00.0.
PMID: 39558036
Related Citations
Glioma immune microenvironment composition calculator (GIMiCC): a method of estimating the proportions of eighteen cell types from DNA methylation microarray data.
Authors: Pike S.C.
, Wiencke J.K.
, Zhang Z.
, Molinaro A.M.
, Hansen H.M.
, Koestler D.C.
, Christensen B.C.
, Kelsey K.T.
, Salas L.A.
.
Source: Acta Neuropathologica Communications, 2024-10-28 00:00:00.0; 12(1), p. 170.
EPub date: 2024-10-28 00:00:00.0.
PMID: 39468647
Related Citations
Recalibrate concepts of epigenetic aging clocks in human health.
Authors: Zhang Z.
, Christensen B.C.
, Salas L.A.
.
Source: Aging, 2024-07-17 00:00:00.0; 16(14), p. 11125-11127.
EPub date: 2024-07-17 00:00:00.0.
PMID: 39028368
Related Citations
Identifying tumor type and cell type-specific gene expression alterations in pediatric central nervous system tumors.
Authors: Lee M.K.
, Azizgolshani N.
, Shapiro J.A.
, Nguyen L.N.
, Kolling F.W.
, Zanazzi G.J.
, Frost H.R.
, Christensen B.C.
.
Source: Nature Communications, 2024-04-30 00:00:00.0; 15(1), p. 3634.
EPub date: 2024-04-30 00:00:00.0.
PMID: 38688897
Related Citations
Associations in cell type-specific hydroxymethylation and transcriptional alterations of pediatric central nervous system tumors.
Authors: Lee M.K.
, Azizgolshani N.
, Zhang Z.
, Perreard L.
, Kolling F.W.
, Nguyen L.N.
, Zanazzi G.J.
, Salas L.A.
, Christensen B.C.
.
Source: Nature Communications, 2024-04-30 00:00:00.0; 15(1), p. 3635.
EPub date: 2024-04-30 00:00:00.0.
PMID: 38688903
Related Citations
Alteration of DNA methyltransferases by eribulin elicits broad DNA methylation changes with potential therapeutic implications for triple-negative breast cancer.
Authors: Bagheri M.
, Lee M.K.
, Muller K.E.
, Miller T.W.
, Pattabiraman D.R.
, Christensen B.C.
.
Source: Epigenomics, 2024-02-15 00:00:00.0; , .
EPub date: 2024-02-15 00:00:00.0.
PMID: 38356412
Related Citations
Matched analysis of detailed peripheral blood and tumor immune microenvironment profiles in bladder cancer.
Authors: Chen J.Q.
, Salas L.A.
, Wiencke J.K.
, Koestler D.C.
, Molinaro A.M.
, Andrew A.S.
, Seigne J.D.
, Karagas M.R.
, Kelsey K.T.
, Christensen B.C.
.
Source: Epigenomics, 2024-01-15 00:00:00.0; , .
EPub date: 2024-01-15 00:00:00.0.
PMID: 38221889
Related Citations
Tumor microenvironment deconvolution identifies cell-type-independent aberrant DNA methylation and gene expression in prostate cancer.
Authors: Reynolds S.R.
, Zhang Z.
, Salas L.A.
, Christensen B.C.
.
Source: Clinical Epigenetics, 2024-01-03 00:00:00.0; 16(1), p. 5.
EPub date: 2024-01-03 00:00:00.0.
PMID: 38173042
Related Citations
Immunomethylomic profiles of long-term head and neck squamous cell carcinoma survivors on immune checkpoint inhibitors.
Authors: Lee M.K.
, Zhang Z.
, Sehgal K.
, Butler R.
, Stolrow H.
, Ramush G.
, Shirai K.
, Koestler D.C.
, Salas L.A.
, Wiencke J.K.
, et al.
.
Source: Epigenomics, 2024; 16(11-12), p. 799-807.
EPub date: 2024-05-17 00:00:00.0.
PMID: 38869472
Related Citations
Deciphering the role of immune cell composition in epigenetic age acceleration: Insights from cell-type deconvolution applied to human blood epigenetic clocks.
Authors: Zhang Z.
, Reynolds S.R.
, Stolrow H.G.
, Chen J.Q.
, Christensen B.C.
, Salas L.A.
.
Source: Aging Cell, 2023-12-25 00:00:00.0; , p. e14071.
EPub date: 2023-12-25 00:00:00.0.
PMID: 38146185
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Distinct HOX Gene Family DNA Methylation Profiles in Histologically Normal Skin Dependent on Dermoscopic Pattern of Adjacent Nevi.
Authors: Muse M.E.
, Schaider H.
, Oey H.
, Soyer H.P.
, Christensen B.C.
, Stark M.S.
.
Source: The Journal Of Investigative Dermatology, 2023 Sep; 143(9), p. 1830-1834.e6.
EPub date: 2023-03-21 00:00:00.0.
PMID: 36958602
Related Citations
Genome-scale methylation analysis identifies immune profiles and age acceleration associations with bladder cancer outcomes.
Authors: Chen J.Q.
, Salas L.A.
, Wiencke J.K.
, Koestler D.C.
, Molinaro A.M.
, Andrew A.S.
, Seigne J.D.
, Karagas M.R.
, Kelsey K.T.
, Christensen B.C.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2023-08-01 00:00:00.0; , .
EPub date: 2023-08-01 00:00:00.0.
PMID: 37527159
Related Citations
Normal gastric tissue Helicobacter pylori infection is associated with epigenetic age acceleration, increased mitotic tick rate, tissue cell composition, and Natural Killer cell methylation alterations.
Authors: Vlasac I.M.
, Christensen B.C.
, Salas L.A.
.
Source: Biorxiv : The Preprint Server For Biology, 2023-06-29 00:00:00.0; , .
EPub date: 2023-06-29 00:00:00.0.
PMID: 37425894
Related Citations
Alteration of DNMT1/DNMT3A by eribulin elicits global DNA methylation changes with potential therapeutic implications for triple-negative breast cancer.
Authors: Bagheri M.
, Lee M.K.
, Muller K.E.
, Miller T.W.
, Pattabiraman D.R.
, Christensen B.C.
.
Source: Biorxiv : The Preprint Server For Biology, 2023-06-10 00:00:00.0; , .
EPub date: 2023-06-10 00:00:00.0.
PMID: 37333096
Related Citations
HiTAIC: hierarchical tumor artificial intelligence classifier traces tissue of origin and tumor type in primary and metastasized tumors using DNA methylation.
Authors: Zhang Z.
, Lu Y.
, Vosoughi S.
, Levy J.J.
, Christensen B.C.
, Salas L.A.
.
Source: Nar Cancer, 2023 Jun; 5(2), p. zcad017.
EPub date: 2023-04-19 00:00:00.0.
PMID: 37089814
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The Effect of Lung Resection for NSCLC on Circulating Immune Cells: A Pilot Study.
Authors: Phillips J.D.
, Fay K.A.
, Bergeron A.J.
, Zhang P.
, Mielcarz D.W.
, Calkins A.M.
, Searles T.G.
, Christensen B.C.
, Finley D.J.
, Turk M.J.
, et al.
.
Source: Current Oncology (toronto, Ont.), 2023-05-17 00:00:00.0; 30(5), p. 5116-5134.
EPub date: 2023-05-17 00:00:00.0.
PMID: 37232845
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Assessment of immune cell profiles among post-menopausal women in the Women's Health Initiative using DNA methylation-based methods.
Authors: Nissen E.
, Reiner A.
, Liu S.
, Wallace R.B.
, Molinaro A.M.
, Salas L.A.
, Christensen B.C.
, Wiencke J.K.
, Koestler D.C.
, Kelsey K.T.
.
Source: Clinical Epigenetics, 2023-04-28 00:00:00.0; 15(1), p. 69.
EPub date: 2023-04-28 00:00:00.0.
PMID: 37118842
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Down Syndrome Altered Cell Composition in Blood, Brain, and Buccal Swab Samples Profiled by DNA-Methylation-Based Cell-Type Deconvolution.
Authors: Zhang Z.
, Stolrow H.G.
, Christensen B.C.
, Salas L.A.
.
Source: Cells, 2023-04-15 00:00:00.0; 12(8), .
EPub date: 2023-04-15 00:00:00.0.
PMID: 37190077
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Identification of Spatial Proteomic Signatures of Colon Tumor Metastasis: A Digital Spatial Profiling Approach.
Authors: Levy J.J.
, Zavras J.P.
, Veziroglu E.M.
, Nasir-Moin M.
, Kolling F.W.
, Christensen B.C.
, Salas L.A.
, Barney R.E.
, Palisoul S.M.
, Ren B.
, et al.
.
Source: The American Journal Of Pathology, 2023-04-08 00:00:00.0; , .
EPub date: 2023-04-08 00:00:00.0.
PMID: 37037284
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Hydroxymethylation alterations in progenitor-like cell types of pediatric central nervous system tumors are associated with cell type-specific transcriptional changes.
Authors: Lee M.K.
, Azizgolshani N.
, Zhang Z.
, Perreard L.
, Kolling F.W.
, Nguyen L.N.
, Zanazzi G.J.
, Salas L.A.
, Christensen B.C.
.
Source: Research Square, 2023-02-28 00:00:00.0; , .
EPub date: 2023-02-28 00:00:00.0.
PMID: 36909536
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Tumor type and cell type-specific gene expression alterations in diverse pediatric central nervous system tumors identified using single nuclei RNA-seq.
Authors: Lee M.K.
, Azizgolshani N.
, Shapiro J.A.
, Nguyen L.N.
, Kolling F.W.
, Zanazzi G.J.
, Frost H.R.
, Christensen B.C.
.
Source: Research Square, 2023-02-23 00:00:00.0; , .
EPub date: 2023-02-23 00:00:00.0.
PMID: 36865335
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Application of novel breast biospecimen cell type adjustment identifies shared DNA methylation alterations in breast tissue and milk with breast cancer risk factors.
Authors: Muse M.E.
, Carroll C.D.
, Salas L.A.
, Karagas M.R.
, Christensen B.C.
.
Source: Cancer Epidemiology, Biomarkers & Prevention : A Publication Of The American Association For Cancer Research, Cosponsored By The American Society Of Preventive Oncology, 2023-02-10 00:00:00.0; , .
EPub date: 2023-02-10 00:00:00.0.
PMID: 36780234
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Hypertension Impacts Peripheral Blood Leukocyte Composition.
Authors: Salas L.A.
, Kelsey K.T.
.
Source: Hypertension (dallas, Tex. : 1979), 2023 Jan; 80(1), p. 54-56.
EPub date: 2022-12-07 00:00:00.0.
PMID: 36475861
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Inferring spatial transcriptomics markers from whole slide images to characterize metastasis-related spatial heterogeneity of colorectal tumors: A pilot study.
Authors: Fatemi M.
, Feng E.
, Sharma C.
, Azher Z.
, Goel T.
, Ramwala O.
, Palisoul S.M.
, Barney R.E.
, Perreard L.
, Kolling F.W.
, et al.
.
Source: Journal Of Pathology Informatics, 2023; 14, p. 100308.
EPub date: 2023-03-29 00:00:00.0.
PMID: 37114077
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Hierarchical deconvolution for extensive cell type resolution in the human brain using DNA methylation.
Authors: Zhang Z.
, Wiencke J.K.
, Kelsey K.T.
, Koestler D.C.
, Molinaro A.M.
, Pike S.C.
, Karra P.
, Christensen B.C.
, Salas L.A.
.
Source: Frontiers In Neuroscience, 2023; 17, p. 1198243.
EPub date: 2023-06-19 00:00:00.0.
PMID: 37404460
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Comparative analysis of the DNA methylation landscape in CD4, CD8, and B memory lineages.
Authors: Zhang Z.
, Butler R.
, Koestler D.C.
, Bell-Glenn S.
, Warrier G.
, Molinaro A.M.
, Christensen B.C.
, Wiencke J.K.
, Kelsey K.T.
, Salas L.A.
.
Source: Clinical Epigenetics, 2022-12-15 00:00:00.0; 14(1), p. 173.
EPub date: 2022-12-15 00:00:00.0.
PMID: 36522672
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HiTIMED: hierarchical tumor immune microenvironment epigenetic deconvolution for accurate cell type resolution in the tumor microenvironment using tumor-type-specific DNA methylation data.
Authors: Zhang Z.
, Wiencke J.K.
, Kelsey K.T.
, Koestler D.C.
, Christensen B.C.
, Salas L.A.
.
Source: Journal Of Translational Medicine, 2022-11-08 00:00:00.0; 20(1), p. 516.
EPub date: 2022-11-08 00:00:00.0.
PMID: 36348337
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Evaluation of cross-platform compatibility of a DNA methylation-based glucocorticoid response biomarker.
Authors: Tang E.
, Wiencke J.K.
, Warrier G.
, Hansen H.
, McCoy L.
, Rice T.
, Bracci P.M.
, Wrensch M.
, Taylor J.W.
, Clarke J.L.
, et al.
.
Source: Clinical Epigenetics, 2022-10-28 00:00:00.0; 14(1), p. 136.
EPub date: 2022-10-28 00:00:00.0.
PMID: 36307860
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Genome-Scale DNA Methylation Analysis Identifies Repeat Element Alterations that Modulate the Genomic Stability of Melanocytic Nevi.
Authors: Muse M.E.
, Bergman D.T.
, Salas L.A.
, Tom L.N.
, Tan J.M.
, Laino A.
, Lambie D.
, Sturm R.A.
, Schaider H.
, Soyer H.P.
, et al.
.
Source: The Journal Of Investigative Dermatology, 2022 Jul; 142(7), p. 1893-1902.e7.
EPub date: 2021-12-03 00:00:00.0.
PMID: 34871578
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Widespread redundancy in -omics profiles of cancer mutation states.
Authors: Crawford J.
, Christensen B.C.
, Chikina M.
, Greene C.S.
.
Source: Genome Biology, 2022-06-27 00:00:00.0; 23(1), p. 137.
EPub date: 2022-06-27 00:00:00.0.
PMID: 35761387
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A core of differentially methylated CpG loci in gMDSCs isolated from neonatal and adult sources.
Authors: Berglund-Brown I.
, Nissen E.
, Koestler D.C.
, Butler R.A.
, Eliot M.N.
, Padbury J.F.
, Salas L.A.
, Molinaro A.M.
, Christensen B.C.
, Wiencke J.K.
, et al.
.
Source: Clinical Epigenetics, 2022-02-21 00:00:00.0; 14(1), p. 27.
EPub date: 2022-02-21 00:00:00.0.
PMID: 35189960
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Enhanced cell deconvolution of peripheral blood using DNA methylation for high-resolution immune profiling.
Authors: Salas L.A.
, Zhang Z.
, Koestler D.C.
, Butler R.A.
, Hansen H.M.
, Molinaro A.M.
, Wiencke J.K.
, Kelsey K.T.
, Christensen B.C.
.
Source: Nature Communications, 2022-02-09 00:00:00.0; 13(1), p. 761.
EPub date: 2022-02-09 00:00:00.0.
PMID: 35140201
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Immune profiles and DNA methylation alterations related with non-muscle-invasive bladder cancer outcomes.
Authors: Chen J.Q.
, Salas L.A.
, Wiencke J.K.
, Koestler D.C.
, Molinaro A.M.
, Andrew A.S.
, Seigne J.D.
, Karagas M.R.
, Kelsey K.T.
, Christensen B.C.
.
Source: Clinical Epigenetics, 2022-01-21 00:00:00.0; 14(1), p. 14.
EPub date: 2022-01-21 00:00:00.0.
PMID: 35063012
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Navigating the hydroxymethylome: experimental biases and quality control tools for the tandem bisulfite and oxidative bisulfite Illumina microarrays.
Authors: Zhang Z.
, Lee M.K.
, Perreard L.
, Kelsey K.T.
, Christensen B.C.
, Salas L.A.
.
Source: Epigenomics, 2022-01-14 00:00:00.0; , .
EPub date: 2022-01-14 00:00:00.0.
PMID: 35029129
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Mixed Effects Machine Learning Models for Colon Cancer Metastasis Prediction using Spatially Localized Immuno-Oncology Markers.
Authors: Levy J.J.
, Bobak C.A.
, Nasir-Moin M.
, Veziroglu E.M.
, Palisoul S.M.
, Barney R.E.
, Salas L.A.
, Christensen B.C.
, Tsongalis G.J.
, Vaickus L.J.
.
Source: Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing, 2022; 27, p. 175-186.
PMID: 34890147
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Phase I Study of High-Dose L-methylfolate in Combination with Temozolomide and Bevacizumab in Recurrent IDH wild-type High-Grade Glioma.
Authors: Salas L.A.
, Stewart T.G.
, Mobley B.C.
, Peng C.
, Liu J.
, Loganathan S.N.
, Wang J.
, Ma Y.
, Berger M.S.
, Absher D.
, et al.
.
Source: Cancer Research Communications, 2022 Jan; 2(1), p. 1-9.
PMID: 35392283
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Exposure to extracellular vesicles from Pseudomonas aeruginosa result in loss of DNA methylation at enhancer and DNase hypersensitive site regions in lung macrophages.
Authors: Kyung Lee M.
, Armstrong D.A.
, Hazlett H.F.
, Dessaint J.A.
, Mellinger D.L.
, Aridgides D.S.
, Christensen B.C.
, Ashare A.
.
Source: Epigenetics, 2021 11; 16(11), p. 1187-1200.
EPub date: 2020-12-31 00:00:00.0.
PMID: 33380271
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DNA 5-hydroxymethylcytosine in pediatric central nervous system tumors may impact tumor classification and is a positive prognostic marker.
Authors: Azizgolshani N.
, Petersen C.L.
, Chen Y.
, Levy J.J.
, Salas L.A.
, Perreard L.
, Nguyen L.N.
, Christensen B.C.
.
Source: Clinical Epigenetics, 2021-09-19 00:00:00.0; 13(1), p. 176.
EPub date: 2021-09-19 00:00:00.0.
PMID: 34538273
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MethylSPWNet and MethylCapsNet: Biologically Motivated Organization of DNAm Neural Networks, Inspired by Capsule Networks.
Authors: Levy J.J.
, Chen Y.
, Azizgolshani N.
, Petersen C.L.
, Titus A.J.
, Moen E.L.
, Vaickus L.J.
, Salas L.A.
, Christensen B.C.
.
Source: Npj Systems Biology And Applications, 2021-08-20 00:00:00.0; 7(1), p. 33.
EPub date: 2021-08-20 00:00:00.0.
PMID: 34417465
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A large-scale internal validation study of unsupervised virtual trichrome staining technologies on nonalcoholic steatohepatitis liver biopsies.
Authors: Levy J.J.
, Azizgolshani N.
, Andersen M.J.
, Suriawinata A.
, Liu X.
, Lisovsky M.
, Ren B.
, Bobak C.A.
, Christensen B.C.
, Vaickus L.J.
.
Source: Modern Pathology : An Official Journal Of The United States And Canadian Academy Of Pathology, Inc, 2021 Apr; 34(4), p. 808-822.
EPub date: 2020-12-09 00:00:00.0.
PMID: 33299110
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Identification of a foetal epigenetic compartment in adult human kidney.
Authors: Wiencke J.K.
, Zhang Z.
, Koestler D.C.
, Salas L.A.
, Molinaro A.M.
, Christensen B.C.
, Kelsey K.T.
.
Source: Epigenetics, 2021-03-30 00:00:00.0; , p. 1-21.
EPub date: 2021-03-30 00:00:00.0.
PMID: 33783321
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Weight management intervention identifies association of decreased DNA methylation age with improved functional age measures in older adults with obesity.
Authors: Petersen C.L.
, Christensen B.C.
, Batsis J.A.
.
Source: Clinical Epigenetics, 2021-03-02 00:00:00.0; 13(1), p. 46.
EPub date: 2021-03-02 00:00:00.0.
PMID: 33653394
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Topological Feature Extraction and Visualization of Whole Slide Images using Graph Neural Networks.
Authors: Levy J.
, Haudenschild C.
, Barwick C.
, Christensen B.
, Vaickus L.
.
Source: Pacific Symposium On Biocomputing. Pacific Symposium On Biocomputing, 2021; 26, p. 285-296.
PMID: 33691025
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Using Satellite Images and Deep Learning to Identify Associations Between County-Level Mortality and Residential Neighborhood Features Proximal to Schools: A Cross-Sectional Study.
Authors: Levy J.J.
, Lebeaux R.M.
, Hoen A.G.
, Christensen B.C.
, Vaickus L.J.
, MacKenzie T.A.
.
Source: Frontiers In Public Health, 2021; 9, p. 766707.
EPub date: 2021-11-05 00:00:00.0.
PMID: 34805078
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Limiting Self-Renewal of the Basal Compartment by PKA Activation Induces Differentiation and Alters the Evolution of Mammary Tumors.
Authors: Ognjenovic N.B.
, Bagheri M.
, Mohamed G.A.
, Xu K.
, Chen Y.
, Mohamed Saleem M.A.
, Brown M.S.
, Nagaraj S.H.
, Muller K.E.
, Gerber S.A.
, et al.
.
Source: Developmental Cell, 2020-12-07 00:00:00.0; 55(5), p. 544-557.e6.
EPub date: 2020-10-28 00:00:00.0.
PMID: 33120014
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Altered immune phenotype and DNA methylation in panic disorder.
Authors: Petersen C.L.
, Chen J.Q.
, Salas L.A.
, Christensen B.C.
.
Source: Clinical Epigenetics, 2020-11-18 00:00:00.0; 12(1), p. 177.
EPub date: 2020-11-18 00:00:00.0.
PMID: 33208194
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Extracellular Vesicles from Pseudomonas aeruginosa Suppress MHC-Related Molecules in Human Lung Macrophages.
Authors: Armstrong D.A.
, Lee M.K.
, Hazlett H.F.
, Dessaint J.A.
, Mellinger D.L.
, Aridgides D.S.
, Hendricks G.M.
, Abdalla M.A.K.
, Christensen B.C.
, Ashare A.
.
Source: Immunohorizons, 2020-08-20 00:00:00.0; 4(8), p. 508-519.
EPub date: 2020-08-20 00:00:00.0.
PMID: 32819967
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Enrichment of CpG island shore region hypermethylation in epigenetic breast field cancerization.
Authors: Muse M.E.
, Titus A.J.
, Salas L.A.
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