Grant Number:	1U01CA260584-01 Interpret this number
Primary Investigator:	Skarbinski, Jacek
Organization:	Kaiser Foundation Research Institute
Project Title:	Sars-Cov-2 Serological Antibody Testing for Disease Surveillance and Clinical Use
Fiscal Year:	2020

Abstract Serologic testing for presence of SARS-CoV-2 antibodies is a critical tool for understanding the epidemiology and designing control strategies for the COVID-19 pandemic. Our understanding of the epidemiology of this pandemic is primarily derived from real-time data on the number of polymerase chain reaction (PCR)-positive COVID-19 patients in outpatient and inpatient settings, and thus misses patients with asymptomatic infection or who have not had SARS-CoV-2 PCR testing. Serologic testing for SARS-CoV-2 antibodies can identify persons who have been exposed and infected with SARS-CoV-2 at any time and might be a correlate of protective immunity. This project aims to advance our understanding of SARS-CoV-2 serological testing at the individual and population-level. To achieve this we will develop and implement a large-scale, population- based, flexible platform to assess SARS-CoV-2 sero-prevalence, sero-incidence, risk of sero-conversion and longevity of antibody response in a large, integrated health system with linked rich demographic, behavioral and clinical data. For Aim 1 we will establish a community cohort of Kaiser Permanente Northern California (KPNC) members; a random sample of community dwelling persons, age 7 years and older, will be invited to participate in ongoing surveillance of antibody development to assess population-level sero-prevalence and sero-incidence. For Aim 2, we will enroll a cohort of persons who are positive for SARS-CoV-2 PCR or antibodies and will follow them prospectively with repeat SARS-CoV-2 antibody testing for immune surveillance and to determine longevity of antibody response. For Aim 3, we will establish a data-only cohort of all persons who have been diagnosed with COVID-19 disease, or had SARS-CoV-2 PCR or antibody testing; As of July 15, 2020, there are about 290,000 such persons in KPNC and the number increases daily as we test ~10,000 persons per day. In this cohort, we will assess risk of SARS-CoV-2 re-infection and will have the opportunity to examine interactions with a personal history of cancer or cancer treatment and other clinical factors or comorbid conditions, to determine if these conditions influence the likelihood of development of COVID-19 or reinfection. For Aim 4, we will establish mechanisms for collaboration with other scientists in the Serological Sciences Network, including mechanisms for additional sample collection. This series of linked studies embedded in a large, integrated health system with a large number of COVID-19 patients and high SARS- CoV-2 testing capacity will enhance our understanding of the utility of commercially available, large-scale SARS-CoV-2 antibody testing for population-level and individual-level disease control.




Relative contribution of COVID-19 vaccination and SARS-CoV-2 infection to population-level seroprevalence of SARS-CoV-2 spike antibodies in a large integrated health system.
Authors: Chervo T.C. , Elkin E.P. , Nugent J.R. , Valice E. , Amsden L.B. , Ergas I.J. , Munneke J.R. , Flores M. , Saelee G.N. , Hsiao C.A. , et al. .
Source: Plos One, 2024; 19(6), p. e0303303.
EPub date: 2024-06-20 00:00:00.0.
PMID: 38900738
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Severe Acute Respiratory Syndrome Coronavirus 2 Delta Variant Genomic Variation Associated With Breakthrough Infection in Northern California: A Retrospective Cohort Study.
Authors: Skarbinski J. , Nugent J.R. , Wood M.S. , Liu L. , Bullick T. , Schapiro J.M. , Arunleung P. , Morales C. , Amsden L.B. , Hsiao C.A. , et al. .
Source: The Journal Of Infectious Diseases, 2023-10-03 00:00:00.0; 228(7), p. 878-888.
PMID: 37195913
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Mission, Organization, and Future Direction of the Serological Sciences Network for COVID-19 (SeroNet) Epidemiologic Cohort Studies.
Authors: Figueiredo J.C. , Hirsch F.R. , Kushi L.H. , Nembhard W.N. , Crawford J.M. , Mantis N. , Finster L. , Merin N.M. , Merchant A. , Reckamp K.L. , et al. .
Source: Open Forum Infectious Diseases, 2022 Jun; 9(6), p. ofac171.
EPub date: 2022-04-27 00:00:00.0.
PMID: 35765315
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