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Grant Details

Grant Number: 5U01HG009784-05 Interpret this number
Primary Investigator: Adebamowo, Clement
Organization: Institute Of Human Virology
Project Title: African Female Breast Cancer Epidermiology (AFBRECANE) Study
Fiscal Year: 2021


African Female Breast Cancer Epidemiology (AFBRECANE) Study Project summary Breast cancer is the commonest cancer in women globally and it is increasingly overtaking cervical cancer as the commonest female cancer in low and middle income countries (LMIC). The incidence of breast cancer Nigeria was 54.3 per 100,000 per year (24,750 new cases per year) in 2014 representing a rise from 20 per 100,000 in the 1970s (3,000 new cases per year). It is now a major cancer burden in Nigerian women. There are controversies about the epidemiology and molecular subtypes of breast cancer in African women including limited knowledge about the incidence of breast cancer and determinants of this incidence such as the role of different risk factors; incidence and prevalence of molecular subtypes of breast cancer and the contributions of indigenous African diets to breast cancer incidence. In the absence of prospective cohort studies, we engage innovative research design and analytic techniques to use data from population based cancer registries (PBCR) to study the epidemiological factors associated with incident breast cancer and molecular subtypes. There has also never been a genome wide association study (GWAS) of breast cancer in general and of molecular subtypes of breast cancer in indigenous African women. While many researchers suggest that African diets are associated with reduced risks of breast cancer, there have been very few systematic studies. We use the nutrition epidemiology tools that we previously developed and validated to study dietary intakes and breast cancer risk in African women. We focus in particular on the role of vitamin D and explore potential associations with breast cancer using nutrition epidemiology and genomics epidemiology tools.


Validation of self-report of uterine fibroid diagnosis using a transvaginal ultrasound scan.
Authors: Adebamowo C.A. , Morhason-Bello I.O. , ACCME Research Group as part of the H3Africa Consortium , Adebamowo S.N. .
Source: Scientific reports, 2023-06-05; 13(1), p. 9091.
EPub date: 2023-06-05.
PMID: 37277479
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Population-based study of the reproductive risk factors for Transvaginal Ultrasound diagnosed Uterine Fibroids in Nigerian women.
Authors: Adebamowo C.A. , Adebamowo S.N. , ACCME Research Group as part of the H3Africa Consortium .
Source: Research square, 2023-05-18; , .
EPub date: 2023-05-18.
PMID: 37292609
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Epidemiology of uterine fibroid in black African women: a systematic scoping review.
Authors: Morhason-Bello I.O. , Adebamowo C.A. .
Source: BMJ open, 2022-08-03; 12(8), p. e052053.
EPub date: 2022-08-03.
PMID: 35922099
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Leisure-time physical activity is associated with reduced risks of breast cancer and triple negative breast cancer in Nigerian women.
Authors: Bigman G. , Adebamowo S.N. , Yawe K.T. , Yilkudi M. , Olaomi O. , Badejo O. , Famooto A. , Ezeome E. , Salu I.K. , Miner E. , et al. .
Source: Cancer epidemiology, 2022 Aug; 79, p. 102195.
EPub date: 2022-06-16.
PMID: 35717688
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A matched case-control study of bean intake and breast cancer risk in urbanized Nigerian women.
Authors: Bigman G. , Adebamowo S.N. , Yawe K.T. , Yilkudi M. , Olaomi O. , Badejo O. , Famooto A. , Ezeome E. , Salu I.K. , Miner E. , et al. .
Source: Cancer causes & control : CCC, 2022 Jul; 33(7), p. 959-969.
EPub date: 2022-05-05.
PMID: 35511324
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The African Female Breast Cancer Epidemiology Study Protocol.
Authors: Ezeome E.R. , Yawe K.T. , Ayandipo O. , Badejo O. , Adebamowo S.N. , Achusi B. , Fowotade A. , Ogun G. , AFBRECANE Research Group , Adebamowo C.A. .
Source: Frontiers in oncology, 2022; 12, p. 856182.
EPub date: 2022-04-13.
PMID: 35494056
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Dietary Intake and Cancer in Sub-Saharan Africa: A Critical Review of Epidemiological Studies.
Authors: Bigman G. , Otieno L. , Adebamowo S.N. , Adebamowo C. .
Source: Nutrition and cancer, 2022; 74(8), p. 2803-2814.
EPub date: 2022-02-01.
PMID: 35102796
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Creative Approaches to Global Cancer Research and Control.
Authors: Rositch A.F. , Loffredo C. , Bourlon M.T. , Pearlman P.C. , Adebamowo C. .
Source: JCO global oncology, 2020 Jul; 6, p. 4-7.
PMID: 32716656
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Structural variation of centromeric endogenous retroviruses in human populations and their impact on cutaneous T-cell lymphoma, Sézary syndrome, and HIV infection.
Authors: Kaplan M.H. , Kaminski M. , Estes J.M. , Gitlin S.D. , Zahn J. , Elder J.T. , Tejasvi T. , Gensterblum E. , Sawalha A.H. , McGowan J.P. , et al. .
Source: BMC medical genomics, 2019-05-02; 12(1), p. 58.
EPub date: 2019-05-02.
PMID: 31046767
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Implementation of genomics research in Africa: challenges and recommendations.
Authors: Adebamowo S.N. , Francis V. , Tambo E. , Diallo S.H. , Landouré G. , Nembaware V. , Dareng E. , Muhamed B. , Odutola M. , Akeredolu T. , et al. .
Source: Global health action, 2018; 11(1), p. 1419033.
PMID: 29336236
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