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Grant Details

Grant Number: 5R37CA226081-04 Interpret this number
Primary Investigator: Han, Summer
Organization: Stanford University
Project Title: Evaluation of Genetic, Clinical, and Environmental Risk Factors to Establish Effective Screening Strategies for Second Primary Lung Cancer
Fiscal Year: 2021


Abstract

Lung cancer (LC) is a leading cause of cancer deaths in the U.S. The widespread adoption of computed tomography (CT) screening enables the early detection of lung cancer and is expected to increase the number of long-term LC survivors. The estimated number of LC survivors is approximately 412,230 as of 2012 and is projected to be over a half million in 2022. Recent studies show that LC survivors have a high risk of developing second primary lung cancer (SPLC), the incidence of which is around 4-6 times higher than that of initial primary lung cancer (IPLC) in the general population. While national lung screening guidelines have been established for IPLC by the U.S. Preventive Services Task Force (USPSTF), no such consensus guidelines exist for LC survivors who are exposed to a high risk of SPLC. Furthermore, the factors that contribute to the development of SPLC have not yet been established. Our long-term goal is to reduce the overall LC mortality in the U.S. population by focusing on SPLC. The overall objectives of this application are to identify the genetic, clinical, and environmental determinants for SPLC, to assess an individual’s risk of developing SPLC, and to evaluate efficient lung screening strategies for SPLC to help inform the development of consensus screening guidelines for LC survivors. Our aims are: (AIM 1) To identify the genetic, environmental, clinical, and demographic risk factors for SPLC and to develop a risk prediction model for SPLC. We will use cohort data from the Transdisciplinary Research in Cancer of the Lung (TRICL) and the International Lung Cancer Consortium (ILCCO) to evaluate risk factors for SPLC; (AIM 2) To evaluate optimal CT screening strategies for SPLC by estimating the population-level harms and benefits of CT screening under various selection criteria. We will develop a stochastic simulation model for SPLC that integrates the incidence, progression, and survival of SPLC to quantify the population-level harms and benefits of screening for SPLC under various risk- based selection criteria; (AIM 3) To estimate the lifetime costs and to assess the cost-effectiveness of CT screening strategies for SPLC in the general U.S. population. The contribution of our research will be significant because it will provide a better understanding of the etiology of SPLC by identifying various risk factors for SPLC using comprehensive population-based data. Second, the completion of our research will provide a valuable decision tool for evaluating an individual’s risk of developing SPLC, which can help identify high-risk individuals for screening. Finally, by evaluating the potential harms and benefits of lung cancer screening for SPLC under various criteria, our research will provide a set of optimal CT screening strategies, the results of which will reduce clinicians’ uncertainty on how to best guide LC survivors for CT screening.



Publications

Smoking Cessation After Lung Cancer Diagnosis and the Risk of Second Primary Lung Cancer: The Multiethnic Cohort Study.
Authors: Luo S.J. , Choi E. , Aredo J.V. , Wilkens L.R. , Tammemägi M.C. , Le Marchand L. , Cheng I. , Wakelee H.A. , Han S.S. .
Source: JNCI cancer spectrum, 2021 Oct; 5(5), p. pkab076.
EPub date: 2021-08-23.
PMID: 34611582
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A Robust Test for Additive Gene-Environment Interaction Under the Trend Effect of Genotype Using an Empirical Bayes-Type Shrinkage Estimator.
Authors: Sanyal N. , Napolioni V. , de Rochemonteix M. , Belloy M.E. , Caporaso N.E. , Landi M.T. , Greicius M.D. , Chatterjee N. , Han S.S. .
Source: American journal of epidemiology, 2021-09-01; 190(9), p. 1948-1960.
PMID: 33942053
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Development and Validation of a Risk Prediction Tool for Second Primary Lung Cancer.
Authors: Choi E. , Sanyal N. , Ding V.Y. , Gardner R.M. , Aredo J.V. , Lee J. , Wu J.T. , Hickey T.P. , Barrett B. , Riley T.L. , et al. .
Source: Journal of the National Cancer Institute, 2021-07-13; , .
EPub date: 2021-07-13.
PMID: 34255071
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Tobacco Smoking and Risk of Second Primary Lung Cancer.
Authors: Aredo J.V. , Luo S.J. , Gardner R.M. , Sanyal N. , Choi E. , Hickey T.P. , Riley T.L. , Huang W.Y. , Kurian A.W. , Leung A.N. , et al. .
Source: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2021 06; 16(6), p. 968-979.
EPub date: 2021-03-17.
PMID: 33722709
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Metabolomic profiling for second primary lung cancer: A pilot case-control study.
Authors: Aredo J.V. , Purington N. , Su L. , Luo S.J. , Diao N. , Christiani D.C. , Wakelee H.A. , Han S.S. .
Source: Lung cancer (Amsterdam, Netherlands), 2021 05; 155, p. 61-67.
EPub date: 2021-03-11.
PMID: 33743383
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A Likelihood Ratio Test for Gene-Environment Interaction Based on the Trend Effect of Genotype Under an Additive Risk Model Using the Gene-Environment Independence Assumption.
Authors: de Rochemonteix M. , Napolioni V. , Sanyal N. , Belloy M.E. , Caporaso N.E. , Landi M.T. , Greicius M.D. , Chatterjee N. , Han S.S. .
Source: American journal of epidemiology, 2021-01-04; 190(1), p. 129-141.
PMID: 32870973
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Disparities of National Lung Cancer Screening Guidelines in the US Population.
Authors: Han S.S. , Chow E. , Ten Haaf K. , Toumazis I. , Cao P. , Bastani M. , Tammemagi M. , Jeon J. , Feuer E.J. , Meza R. , et al. .
Source: Journal of the National Cancer Institute, 2020-11-01; 112(11), p. 1136-1142.
PMID: 32040195
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A Comparative Modeling Analysis of Risk-Based Lung Cancer Screening Strategies.
Authors: Ten Haaf K. , Bastani M. , Cao P. , Jeon J. , Toumazis I. , Han S.S. , Plevritis S.K. , Blom E.F. , Kong C.Y. , Tammemägi M.C. , et al. .
Source: Journal of the National Cancer Institute, 2020-05-01; 112(5), p. 466-479.
PMID: 31566216
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Caution Needed for Analyzing the Risks of Second Cancers.
Authors: Han S.S. , Plevritis S.K. , Wakelee H.A. .
Source: Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2018 09; 13(9), p. e172-e173.
PMID: 30166015
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