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Grant Details

Grant Number: 5R01CA228589-04 Interpret this number
Primary Investigator: Setiawan, Veronica
Organization: University Of Southern California
Project Title: Understanding the Determinants of Racial/Ethnic Disparities in Liver Cancer and Chronic Liver Disease in Understudied and High-Risk Populations
Fiscal Year: 2021


ABSTRACT Hepatocellular carcinoma (HCC) and chronic liver diseases (CLD) and are significant health problems in the United States affecting racial/ethnic minorities disproportionately. In the Multiethnic Cohort (MEC) Study, a long- standing ethnically diverse prospective cohort (>200,000 participants), we observed striking ethnic differences in HCC incidence with Latinos having the highest incidence followed by Native Hawaiians, African Americans, Japanese Americans, and whites. US-born Latinos, particularly men, experience the highest rates of HCC incidence in the cohort. We also found nonalcoholic fatty liver disease (NAFLD) to be the most common cause of CLD and an unexpectedly high NALFD prevalence in Japanese Americans and Native Hawaiians. These findings provide the groundwork for studies to elucidate the factors that account for health disparities across these populations. To date, no liver disease studies have included Japanese Americans and Native Hawaiians; thus, a large knowledge gap remains in understanding the factors underlying disparities in HCC and NALFD in these understudied high-risk populations. The MEC with its comprehensive lifestyle, environmental, and genetic data offers a unique opportunity to elucidate the determinants that account for these health disparities. In this study we will examine the association of lifestyle, genetic, social, and contextual factors with HCC and NAFLD among MEC participants to better understand disease etiology in high-risk minorities and the factors underlying ethnic disparities. We will use existing resources of the MEC with detailed demographic, lifestyle, neighborhood- level data, health condition data, and cancer incidence and mortality information from SEER Cancer registries and state and national mortality databases, as well as a large biorepository of blood samples. These data have been collected in a consistent fashion amongst all MEC participants to permit valid ethnic comparisons. Our specific aims are 1) To quantify the contribution of known risk factors (chronic hepatitis C and B, adiposity, metabolic syndrome, alcohol intake and tobacco smoking) to ethnic differences in HCC incidence and identify additional risk factors (lifestyle and social/contextual factors) explaining the remaining ethnic variation in HCC incidence which would suggest novel or ethnic-specific mechanisms; 2) To evaluate ethnic-specific lifestyle, social and contextual factors and genetic factors that are associated with NAFLD across five ethnic groups and quantify their contributions to racial/ethnic differences in NALFD risk. Upon completion of this study, we will improve understanding of risk factors most important in certain ethnic groups and factors underlying disparities in HCC and NAFLD. The identification and defining the contribution of risk factors to racial/ethnic differences in HCC and NAFLD will be paramount for improving strategies for primary prevention of these diseases.


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EPub date: 2023-11-20.
PMID: 37982329
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Healthful Plant-Based Dietary Pattern and Risk of Hepatocellular Carcinoma in a Multiethnic Population: A Cohort Study.
Authors: Kim J. , Setiawan V.W. , Wilkens L.R. , Le Marchand L. , Park S.Y. .
Source: The American journal of clinical nutrition, 2023 Jul; 118(1), p. 194-200.
EPub date: 2023-04-28.
PMID: 37121551
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Population-attributable risk of modifiable lifestyle factors to hepatocellular carcinoma: The multi-ethnic cohort.
Authors: Zhou K. , Lim T. , Dodge J.L. , Terrault N.A. , Wilkens L.R. , Setiawan V.W. .
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PMID: 37051717
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Exposure to perfluoroalkyl substances and risk of hepatocellular carcinoma in a multiethnic cohort.
Authors: Goodrich J.A. , Walker D. , Lin X. , Wang H. , Lim T. , McConnell R. , Conti D.V. , Chatzi L. , Setiawan V.W. .
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PMID: 36111068
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Cancer Mortality Patterns by Birthplace and Generation Status of Mexican Latinos: The Multiethnic Cohort.
Authors: Chen H. , Wu A.H. , Wang S. , Bookstein A. , Le Marchand L. , Wilkens L.R. , Haiman C.A. , Cheng I. , Monroe K.R. , Setiawan V.W. .
Source: Journal of the National Cancer Institute, 2022-07-11; 114(7), p. 959-968.
PMID: 35404450
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Association of Genetic Risk Score With NAFLD in An Ethnically Diverse Cohort.
Authors: Wang J. , Conti D.V. , Bogumil D. , Sheng X. , Noureddin M. , Wilkens L.R. , Le Marchand L. , Rosen H.R. , Haiman C.A. , Setiawan V.W. .
Source: Hepatology communications, 2021 Oct; 5(10), p. 1689-1703.
EPub date: 2021-06-18.
PMID: 34558842
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Etiology and Outcomes of Hepatocellular Carcinoma in an Ethnically Diverse Population: The Multiethnic Cohort.
Authors: Barzi A. , Zhou K. , Wang S. , Dodge J.L. , El-Khoueiry A. , Setiawan V.W. .
Source: Cancers, 2021-07-12; 13(14), .
EPub date: 2021-07-12.
PMID: 34298690
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Associations Between Reproductive and Hormone-Related Factors and Risk of Nonalcoholic Fatty Liver Disease in a Multiethnic Population.
Authors: Wang J. , Wu A.H. , Stanczyk F.Z. , Porcel J. , Noureddin M. , Terrault N.A. , Wilkens L.R. , Setiawan V.W. .
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EPub date: 2020-08-12.
PMID: 32801014
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Stratification of Residual Risk of HCC Following HCV Clearance With Direct-Acting Antivirals in Patients With Advanced Fibrosis and Cirrhosis.
Authors: Setiawan V.W. , Rosen H.R. .
Source: Hepatology (Baltimore, Md.), 2020 Dec; 72(6), p. 1897-1899.
PMID: 33205438
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Diet Associations With Nonalcoholic Fatty Liver Disease in an Ethnically Diverse Population: The Multiethnic Cohort.
Authors: Noureddin M. , Zelber-Sagi S. , Wilkens L.R. , Porcel J. , Boushey C.J. , Le Marchand L. , Rosen H.R. , Setiawan V.W. .
Source: Hepatology (Baltimore, Md.), 2020 Jun; 71(6), p. 1940-1952.
EPub date: 2020-02-14.
PMID: 31553803
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Diet Quality Association with Nonalcoholic Fatty Liver Disease by Cirrhosis Status: The Multiethnic Cohort.
Authors: Park S.Y. , Noureddin M. , Boushey C. , Wilkens L.R. , Setiawan V.W. .
Source: Current developments in nutrition, 2020 Mar; 4(3), p. nzaa024.
EPub date: 2020-02-20.
PMID: 32190810
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High-Quality Diets Are Associated With Reduced Risk of Hepatocellular Carcinoma and Chronic Liver Disease: The Multiethnic Cohort.
Authors: Bogumil D. , Park S.Y. , Le Marchand L. , Haiman C.A. , Wilkens L.R. , Boushey C.J. , Setiawan V.W. .
Source: Hepatology communications, 2019 Mar; 3(3), p. 437-447.
EPub date: 2019-01-31.
PMID: 30859154
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