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Grant Details

Grant Number: 1U01CA253915-01 Interpret this number
Primary Investigator: Etzioni, Ruth
Organization: Fred Hutchinson Cancer Research Center
Project Title: Modeling Precision Interventions for Prostate Cancer Control
Fiscal Year: 2020


PROJECT SUMMARY/ABSTRACT Prostate cancer is the most common solid tumor in men and the second most common cause of cancer death in the United States. The Cancer Intervention and Surveillance Modeling Network (CISNET) Prostate Working Group (PWG) was formed in the year 2000 to address a wide range of questions about effective prostate cancer control. The PWG studied the rapid increase in prostate cancer diagnoses after PSA screening started in the late 1980s to estimate lead time and overdiagnosis associated with the test. The PWG studied the decline in prostate cancer mortality that began in the early 1990s to quantify the plausible contributions of PSA screening and changes in primary treatments. The PWG also studied how to interpret trends in racial disparities in incidence and survival, how to manage men with low-risk disease on active surveillance, and how to reconcile apparently discordant randomized trials of PSA screening and radical prostatectomy. In recent years, technologies surrounding prostate cancer screening and treatment have evolved rapidly, and opportunities to improve patient care using personalized data abound. Genetic testing can identify men at increased risk for developing aggressive disease, new biomarkers and imaging tools can help men avoid unnecessary biopsies, and new hormonal treatments can lengthen survival for men with advanced disease. The objective of this application is to extend PWG models to evaluate optimal ways to utilize personalized data to improve patient care while limiting harms and costs. We will determine whether we can improve early detection using novel stratification approaches and whether we can safely limit overtreatment and other harms by tailored choices of primary and secondary therapies. These approaches will be applied in the United States and in international cancer control settings with different resources and priorities. Our specific aims are as follows. Aim 1: Precision early detection, including risk-stratified screening and biopsy using genetic tests, novel biomarkers, and imaging technology. Aim 2: Precision active surveillance, including adaptive biopsy intervals and imaging technology. Aim 3: Precision treatment, including type and timing of initial and salvage therapies. Aim 4: Targeting screening, biopsy, and treatment policies to reduce racial disparities. Aim 5: Prioritizing screening and treatment interventions in international settings. These aims are highly responsive to the funding opportunity announcement, addressing 7 of the 9 targeted priority areas to varying degrees. Our cumulative expertise in prostate modeling, our existing models, and our close ties with clinical experts who provide access to large, high-quality datasets for model validation and calibration put us in a strong position to answer critical and impactful questions about how best to control this most common cancer in men.


Impact of cancer screening on metastasis: A prostate cancer case study.
Authors: Lange J. , Remmers S. , Gulati R. , Bill-Axelson A. , Johansson J.E. , Kwiatkowski M. , Auvinen A. , Hugosson J. , Hu J.C. , Roobol M.J. , et al. .
Source: Journal of medical screening, 2021 12; 28(4), p. 480-487.
EPub date: 2021-02-09.
PMID: 33563084
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Clarifying the Trade-Offs of Risk-Stratified Screening for Prostate Cancer: A Cost-Effectiveness Study.
Authors: Hendrix N. , Gulati R. , Jiao B. , Kader A.K. , Ryan S.T. , Etzioni R. .
Source: American journal of epidemiology, 2021-10-01; 190(10), p. 2064-2074.
PMID: 34023874
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The Impact of Intensifying Prostate Cancer Screening in Black Men: A Model-Based Analysis.
Authors: Nyame Y.A. , Gulati R. , Heijnsdijk E.A.M. , Tsodikov A. , Mariotto A.B. , Gore J.L. , Etzioni R. .
Source: Journal of the National Cancer Institute, 2021-10-01; 113(10), p. 1336-1342.
PMID: 33963850
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Economic Evaluation of Urine-Based or Magnetic Resonance Imaging Reflex Tests in Men With Intermediate Prostate-Specific Antigen Levels in the United States.
Authors: Jiao B. , Gulati R. , Hendrix N. , Gore J.L. , Rais-Bahrami S. , Morgan T.M. , Etzioni R. .
Source: Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 2021 Aug; 24(8), p. 1111-1117.
EPub date: 2021-04-22.
PMID: 34372976
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When to Discuss Prostate Cancer Screening With Average-Risk Men.
Authors: Gulati R. , Carlsson S.V. , Etzioni R. .
Source: American journal of preventive medicine, 2021 08; 61(2), p. 294-298.
EPub date: 2021-05-06.
PMID: 33966938
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Cost-effectiveness of multiparametric magnetic resonance imaging and MRI-guided biopsy in a population-based prostate cancer screening setting using a micro-simulation model.
Authors: Getaneh A.M. , Heijnsdijk E.A. , de Koning H.J. .
Source: Cancer medicine, 2021 06; 10(12), p. 4046-4053.
EPub date: 2021-05-15.
PMID: 33991077
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Prostate Cancer Screening Guidelines for Black Men: Spotlight on an Empty Stage.
Authors: Etzioni R. , Nyame Y.A. .
Source: Journal of the National Cancer Institute, 2021-06-01; 113(6), p. 650-651.
PMID: 33146382
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Preoperative exercise interventions to optimize continence outcomes following radical prostatectomy.
Authors: Mungovan S.F. , Carlsson S.V. , Gass G.C. , Graham P.L. , Sandhu J.S. , Akin O. , Scardino P.T. , Eastham J.A. , Patel M.I. .
Source: Nature reviews. Urology, 2021 May; 18(5), p. 259-281.
EPub date: 2021-04-08.
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Problems with Numbers in Decision Aids for Prostate-specific Antigen Screening: A Critical Review.
Authors: Carlsson S.V. , Vickers A.J. , Gonsky J.P. , Hay J.L. , Hu J.C. .
Source: European urology, 2021 03; 79(3), p. 330-333.
EPub date: 2020-12-09.
PMID: 33309033
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Surgeon heterogeneity significantly affects functional and oncological outcomes after radical prostatectomy in the Swedish LAPPRO trial.
Authors: Nyberg M. , Sjoberg D.D. , Carlsson S.V. , Wilderäng U. , Carlsson S. , Stranne J. , Wiklund P. , Steineck G. , Haglind E. , Hugosson J. , et al. .
Source: BJU international, 2021 03; 127(3), p. 361-368.
EPub date: 2020-09-29.
PMID: 32916021
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Prostate-Specific Antigen Screening and Recent Increases in Advanced Prostate Cancer.
Authors: Nyame Y.A. , Gulati R. , Tsodikov A. , Gore J.L. , Etzioni R. .
Source: JNCI cancer spectrum, 2021 Feb; 5(1), p. pkaa098.
EPub date: 2020-10-26.
PMID: 33442662
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Assessment of harms, benefits, and cost-effectiveness of prostate cancer screening: A micro-simulation study of 230 scenarios.
Authors: Getaneh A.M. , Heijnsdijk E.A.M. , Roobol M.J. , de Koning H.J. .
Source: Cancer medicine, 2020 10; 9(20), p. 7742-7750.
EPub date: 2020-08-19.
PMID: 32813910
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"PSA Surveillance in the Septuagenarian": A Proposed New Terminology for Clinical Follow-up to Assess Risk of Prostate Cancer in Men Aged 70 Years and Older.
Authors: Carlsson S.V. , Eastham J.A. , Crawford E.D. , Harris R.G. .
Source: European urology, 2020 08; 78(2), p. 136-137.
EPub date: 2020-04-06.
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