Skip to main content

COVID-19 is an emerging, rapidly evolving situation.

What people with cancer should know: https://www.cancer.gov/coronavirus

Guidance for cancer researchers: https://www.cancer.gov/coronavirus-researchers

Get the latest public health information from CDC: https://www.coronavirus.gov

Get the latest research information from NIH: https://www.nih.gov/coronavirus

Grant Details

Grant Number: 2U01CA199277-06 Interpret this number
Primary Investigator: Lacey, James
Organization: Beckman Research Institute/City Of Hope
Project Title: Innovative Infrastructure to Enhance and Sustain the California Teachers Study Cohort
Fiscal Year: 2020


Abstract

PROJECT SUMMARY / ABSTRACT The California Teachers Study (CTS) has collected high-quality and detailed exposure, biospecimens, cancer, and clinical endpoint data on 133,477 female volunteers followed since 1995. The cancers, hospitalizations, and deaths to date are less than half of the total endpoints projected to occur in the CTS over the next 30 years. In the next 5 years, CTS follow-up will include over 37,000 cancers; 455,000 hospitalizations; and 41,000 deaths. This provides a solid foundation for collaborative research using these unique resources. Since 2013, the CTS collected new blood samples from 14,674 participants. Cloud computing and integrated mobile devices generated rich phenotype data and exceptionally low pre-analytical variability for 488,000 aliquots that are being stored as CTS follow-up continues. Since 2015, the CTS modernized its data collection, storage, and analysis infrastructure by implementing a secure data warehouse and flexible analytics environment designed for high-quality and integrated epidemiologic analysis. The CTS includes secure user authentication & authorization; a collaborative workspace with documents, data visualizations, tools, and workflows; metadata; application programming interface (API) capabilities; and a scalable data model. The CTS is now positioned to streamline its resources for long-term sustainability. The goals of this competing renewal are to preserve existing resources that enable research and strategically expand areas that create high-value opportunities. First, we will maintain existing CTS data and extend passive follow-up through efficient cancer, hospitalization, and mortality linkages. These ongoing linkages will generate additional endpoints used for future etiologic, consortial, aging, and other research. Second, we will store the 488,000 high-quality biospecimens collected since 2013. These specimens are all currently available to everyone; ongoing storage will ensure that they remain available to everyone. Third, we will expand capacity by integrating additional targeted geospatial data on climate, extreme weather, built environment, community characteristics, health access, environmental exposures, social vulnerability, and community resilience. The new CTS infrastructure efficiently enables everyone, regardless of their GIS expertise, to rigorously incorporate individual-level geospatial exposures into their analyses. Fourth, because most participants are now over age 65, we will link the CTS with Medicare outpatient data to complement existing data and expand infrastructure for aging, survivorship, comorbidity, and health services research. The recent CTS infrastructure updates added research-ready efficiencies to manage and process complex geospatial, administrative claims, and other CTS data in ways that help all researchers, especially those outside the CTS, conduct integrative, rigorous, and reproducible research. The CTS is an innovation leader with primed assets and decades of promising future research potential. This competing renewal will maintain high-value CTS resources that can address understudied research areas, facilitate broader use by the entire scientific community, and streamline the CTS for long-term sustainability.



Publications

Sleep deficiency and breast cancer risk among postmenopausal women in the California teachers study (CTS).
Authors: Hurley S. , Goldberg D. , Von Behren J. , Clague DeHart J. , Wang S. , Reynolds P. .
Source: Cancer causes & control : CCC, 2020 Dec; 31(12), p. 1115-1128.
EPub date: 2020-09-26.
PMID: 32981009
Related Citations

Association between rice consumption and risk of cancer incidence in the California Teachers Study.
Authors: Sanchez T.R. , Klu Y.A.K. , Genkinger J.M. , Lacey J.V. , Chung N.T. , Navas-Acien A. .
Source: Cancer causes & control : CCC, 2020 Dec; 31(12), p. 1129-1140.
EPub date: 2020-09-24.
PMID: 32974796
Related Citations

Outdoor artificial light at night and risk of non-Hodgkin lymphoma among women in the California Teachers Study cohort.
Authors: Zhong C. , Franklin M. , Wiemels J. , McKean-Cowdin R. , Chung N.T. , Benbow J. , Wang S.S. , Lacey J.V. , Longcore T. .
Source: Cancer epidemiology, 2020-09-28; 69, p. 101811.
EPub date: 2020-09-28.
PMID: 33002844
Related Citations

Adult weight change and premenopausal breast cancer risk: A prospective pooled analysis of data from 628,463 women.
Authors: Schoemaker M.J. , Nichols H.B. , Wright L.B. , Brook M.N. , Jones M.E. , O'Brien K.M. , Adami H.O. , Baglietto L. , Bernstein L. , Bertrand K.A. , et al. .
Source: International journal of cancer, 2020-09-01; 147(5), p. 1306-1314.
EPub date: 2020-02-15.
PMID: 32012248
Related Citations

Hypertension, antihypertensive medications use and risk of age-related macular degeneration in California Teachers Cohort.
Authors: Xu X. , Ritz B. , Coleman A. , Liew Z. , Deapen D. , Lee E. , Bernstein L. , Pinder R. , Marshall S. , Heck J.E. .
Source: Journal of human hypertension, 2020 Sep; 34(8), p. 568-576.
EPub date: 2019-10-08.
PMID: 31595025
Related Citations

Germline HOXB13 mutations p.G84E and p.R217C do not confer an increased breast cancer risk.
Authors: Liu J. , Prager-van der Smissen W.J.C. , Collée J.M. , Bolla M.K. , Wang Q. , Michailidou K. , Dennis J. , Ahearn T.U. , Aittomäki K. , Ambrosone C.B. , et al. .
Source: Scientific reports, 2020-06-16; 10(1), p. 9688.
EPub date: 2020-06-16.
PMID: 32546843
Related Citations

Assessment of interactions between 205 breast cancer susceptibility loci and 13 established risk factors in relation to breast cancer risk, in the Breast Cancer Association Consortium.
Authors: Kapoor P.M. , Lindström S. , Behrens S. , Wang X. , Michailidou K. , Bolla M.K. , Wang Q. , Dennis J. , Dunning A.M. , Pharoah P.D.P. , et al. .
Source: International journal of epidemiology, 2020-02-01; 49(1), p. 216-232.
PMID: 31605532
Related Citations

Serum Levels of Commonly Detected Persistent Organic Pollutants and Per- and Polyfluoroalkyl Substances (PFASs) and Mammographic Density in Postmenopausal Women.
Authors: Lee E. , Kinninger A. , Ursin G. , Tseng C. , Hurley S. , Wang M. , Wang Y. , Park J.S. , Petreas M. , Deapen D. , et al. .
Source: International journal of environmental research and public health, 2020-01-17; 17(2), .
EPub date: 2020-01-17.
PMID: 31963577
Related Citations

A network analysis to identify mediators of germline-driven differences in breast cancer prognosis.
Authors: Escala-Garcia M. , Abraham J. , Andrulis I.L. , Anton-Culver H. , Arndt V. , Ashworth A. , Auer P.L. , Auvinen P. , Beckmann M.W. , Beesley J. , et al. .
Source: Nature communications, 2020-01-16; 11(1), p. 312.
EPub date: 2020-01-16.
PMID: 31949161
Related Citations

Physical Activity, Hormone Therapy Use, and Stroke Risk among Women in the California Teachers Study Cohort.
Authors: Zhong C. , Voutsinas J. , Willey J.Z. , Lakshminarayan K. , Lacey J.V. , Chung N.T. , Woo D. , Elkind M.S.V. , Wang S.S. .
Source: Neuroepidemiology, 2020; 54(4), p. 320-325.
EPub date: 2020-02-11.
PMID: 32045925
Related Citations

Chronotype and postmenopausal breast cancer risk among women in the California Teachers Study.
Authors: Hurley S. , Goldberg D. , Von Behren J. , Clague DeHart J. , Wang S. , Reynolds P. .
Source: Chronobiology international, 2019 11; 36(11), p. 1504-1514.
EPub date: 2019-08-27.
PMID: 31452403
Related Citations

Two truncating variants in FANCC and breast cancer risk.
Authors: Dörk T. , Peterlongo P. , Mannermaa A. , Bolla M.K. , Wang Q. , Dennis J. , Ahearn T. , Andrulis I.L. , Anton-Culver H. , Arndt V. , et al. .
Source: Scientific reports, 2019-08-29; 9(1), p. 12524.
EPub date: 2019-08-29.
PMID: 31467304
Related Citations

Genome-wide association study of germline variants and breast cancer-specific mortality.
Authors: Escala-Garcia M. , Guo Q. , Dörk T. , Canisius S. , Keeman R. , Dennis J. , Beesley J. , Lecarpentier J. , Bolla M.K. , Wang Q. , et al. .
Source: British journal of cancer, 2019 03; 120(6), p. 647-657.
EPub date: 2019-02-21.
PMID: 30787463
Related Citations

Shared heritability and functional enrichment across six solid cancers.
Authors: Jiang X. , Finucane H.K. , Schumacher F.R. , Schmit S.L. , Tyrer J.P. , Han Y. , Michailidou K. , Lesseur C. , Kuchenbaecker K.B. , Dennis J. , et al. .
Source: Nature communications, 2019-01-25; 10(1), p. 431.
EPub date: 2019-01-25.
PMID: 30683880
Related Citations

The FANCM:p.Arg658* truncating variant is associated with risk of triple-negative breast cancer.
Authors: Figlioli G. , Bogliolo M. , Catucci I. , Caleca L. , Lasheras S.V. , Pujol R. , Kiiski J.I. , Muranen T.A. , Barnes D.R. , Dennis J. , et al. .
Source: NPJ breast cancer, 2019; 5, p. 38.
EPub date: 2019-11-01.
PMID: 31700994
Related Citations

Sugar-sweetened beverages and colorectal cancer risk in the California Teachers Study.
Authors: Pacheco L.S. , Anderson C.A.M. , Lacey J.V. , Giovannucci E.L. , Lemus H. , Araneta M.R.G. , Sears D.D. , Talavera G.A. , Martinez M.E. .
Source: PloS one, 2019; 14(10), p. e0223638.
EPub date: 2019-10-09.
PMID: 31596902
Related Citations

Identification of ten variants associated with risk of estrogen-receptor-negative breast cancer.
Authors: Milne R.L. , Kuchenbaecker K.B. , Michailidou K. , Beesley J. , Kar S. , Lindström S. , Hui S. , Lemaçon A. , Soucy P. , Dennis J. , et al. .
Source: Nature genetics, 2017 Dec; 49(12), p. 1767-1778.
EPub date: 2017-10-23.
PMID: 29058716
Related Citations

Association analysis identifies 65 new breast cancer risk loci.
Authors: Michailidou K. , Lindström S. , Dennis J. , Beesley J. , Hui S. , Kar S. , Lemaçon A. , Soucy P. , Glubb D. , Rostamianfar A. , et al. .
Source: Nature, 2017-11-02; 551(7678), p. 92-94.
EPub date: 2017-10-23.
PMID: 29059683
Related Citations

rs2735383, located at a microRNA binding site in the 3'UTR of NBS1, is not associated with breast cancer risk.
Authors: Liu J. , Lončar I. , Collée J.M. , Bolla M.K. , Dennis J. , Michailidou K. , Wang Q. , Andrulis I.L. , Barile M. , Beckmann M.W. , et al. .
Source: Scientific reports, 2016-11-15; 6, p. 36874.
EPub date: 2016-11-15.
PMID: 27845421
Related Citations

50 % Response rates: half-empty, or half-full?
Authors: Lacey J.V. , Savage K.E. .
Source: Cancer causes & control : CCC, 2016 06; 27(6), p. 805-8.
EPub date: 2016-04-21.
PMID: 27100357
Related Citations




Back to Top