||1R03CA252788-01 Interpret this number
||University Of North Texas
||Metabolomic Profiling of Retinoblastoma (MPR)
The Smoking and Embryonal Tumor (SETs) study is a population-based study of retinoblastoma
among California children. California has unique resources: 1) a large population allowing for sufficient cases
of disease to study rare cancers; 2) stored neonatal blood spots that the state makes available for research;
and 3) a Cancer Registry operating since 1988. We have almost a decade of experience studying the
epidemiology of retinoblastoma in California and worldwide and studying environmental and dietary exposures.
Using funding from California’s Tobacco-Related Disease Research Program, we previously conducted broad-
scale metabolomics of biosamples to examine biomarkers of tobacco use in 498 cases and 895 controls. We
propose to employ these data in a new and innovative manner combining our expertise in retinoblastoma
epidemiology with the resources in Dr. Jones’ laboratory to identify metabolomics exposure markers and
potential disease biomarkers for pediatric retinoblastoma. Metabolomics data analyses will be conducted in a
targeted as well as untargeted manner to identify and quantify a number of prenatal exposures and their
metabolites in neonatal blood spots. This novel approach will be used to identify exposure and disease
‘signatures’ from metabolites in human metabolic pathways and environmental exposures. This will help us test
existing and generate new hypotheses about maternal exposures (e.g. diet, environmental exposures) and
metabolic states that affect cancer development in the offspring. We expect this application to encourage
environmental policies and provide strategies for population-based prevention of cancer.
Child serum metabolome and traffic-related air pollution exposure in pregnancy.
, Yan Q.
, He D.
, Wu J.
, Walker D.I.
, Uppal K.
, Jones D.P.
, Heck J.E.
Environmental research, 2022 01; 203, p. 111907.