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Grant Details

Grant Number: 5R01CA229617-02 Interpret this number
Primary Investigator: Leventhal, Adam
Organization: University Of Southern California
Project Title: Vaping Nicotine and Cannabis Across Adolescence and Young Adulthood
Fiscal Year: 2020


! PROJECT SUMMARY In 2015, evidence that e-cigarette use (“vaping”) in adolescents and young adults (AYAs) had increased and was associated with increased risk of cigarette smoking initiation generated concern in the public health community. Subsequent research has left the field with several critical questions, including: (1) whether vaping truly has a causal effect on smoking or merely reflects a common liability toward deviancy among ‘high-risk’ AYAs with emotional or behavioral problems, (2) whether an emerging wave of new vaping products, including new nicotine products such as JUUL, and an increasingly diverse class of products dedicated to vaping cannabis plant, oils, and waxes, may increase the appeal and addictive potential of vaping, and (3) whether there exist particular characteristics of vaping products and biopsychosocial mechanisms that underlie the risk of AYA vaping initiation, progression, and transition to other forms of drug use that could be targeted in prevention efforts. The uncertainties regarding the impact of AYA vaping have left policy officials with little evidence to determine if AYA vaping should be prioritized in public health programs, and if so, the most effective strategies for prevention. To address the evidence needs and provide a flexible framework for future study of the impact of various vaping products on the AYA tobacco product and cannabis use burden, we will test a novel ‘catalyst model’ of AYA vaping. The catalyst model proposes two steps, which we will evaluate in Aims 1 and 2 of this proposal. Step 1 (AIM 1). To determine whether (a) AYAs with fewer emotional-behavioral risk factors who have been previously deterred from drug use in traditional (non-vaporized) forms are at risk of vaping initiation, (b) the unique qualities and product features of vaping (e.g., concealability, flavors, appealing technology, social acceptability, low perceived harm) increase risk of AYA vaping, and (c) features of vaping products disproportionately increase the risk of vaping initiation for low-risk AYAs. Step 2 (AIM 2). To determine whether (a) vaping increases the risk of cross-product transitions involving initiation of other vaping products, or combustible nicotine or cannabis, as well as increases risk of progression to problematic drug use outcomes, including dependence, poly-drug use, and chronic drug use through early adulthood, (b) rewarding effects from exposure to nicotine, cannabinoids, and other product components (e.g. flavorings) increases risk of cross-product transitions and problematic drug use outcomes, and (c) product characteristics modify this association. To test the model, we will leverage data collected from participants from age 14-19 (2013-2018) from our existing cohort and follow participants into early adulthood (20-23, from 2019-2023; N~2000). We will also recruit a new cohort of 9th grade students at age 14 (N=2500) at the same schools as part of a cohort-sequential design that will apply causal inference analytic approaches to determine whether observed associations are likely causal. Collectively, this project will provide critical information regarding the priority and potential targets of public health efforts aimed at reducing the potential adverse public health effects resulting from AYA vaping, including tobacco-related cancer.


Sexual and Gender Minority Young Adult Coping Disparities During the COVID-19 Pandemic.
Authors: Krueger E.A. , Barrington-Trimis J.L. , Unger J.B. , Leventhal A.M. .
Source: The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2021 11; 69(5), p. 746-753.
EPub date: 2021-08-17.
PMID: 34412952
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Sex differences in the association between parental monitoring and substance use initiation among adolescents.
Authors: Keogh-Clark F. , Whaley R.C. , Leventhal A.M. , Krueger E.A. .
Source: Addictive behaviors, 2021 11; 122, p. 107024.
EPub date: 2021-06-23.
PMID: 34182308
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Nicotine dependence symptoms in U.S. youth who use JUUL E-cigarettes.
Authors: Kechter A. , Cho J. , Miech R.A. , Barrington-Trimis J.L. , Leventhal A.M. .
Source: Drug and alcohol dependence, 2021-10-01; 227, p. 108941.
EPub date: 2021-08-04.
PMID: 34416679
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The association of type of cannabis product used and frequency of use with problematic cannabis use in a sample of young adult cannabis users.
Authors: Simpson K.A. , Cho J. , Barrington-Trimis J.L. .
Source: Drug and alcohol dependence, 2021-09-01; 226, p. 108865.
EPub date: 2021-06-24.
PMID: 34216861
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Distress tolerance and subsequent substance use throughout high school.
Authors: Kechter A. , Barrington-Trimis J.L. , Cho J. , Davis J.P. , Huh J. , Black D.S. , Leventhal A.M. .
Source: Addictive behaviors, 2021 09; 120, p. 106983.
EPub date: 2021-05-08.
PMID: 34010760
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Tobacco and cannabis poly-substance and poly-product use trajectories across adolescence and young adulthood.
Authors: Lanza H.I. , Bello M.S. , Cho J. , Barrington-Trimis J.L. , McConnell R. , Braymiller J.L. , Krueger E.A. , Leventhal A.M. .
Source: Preventive medicine, 2021 07; 148, p. 106545.
EPub date: 2021-04-01.
PMID: 33812854
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Effect of a hypothetical modified risk tobacco product claim on heated tobacco product use intention and perceptions in young adults.
Authors: Chen-Sankey J.C. , Kechter A. , Barrington-Trimis J. , McConnell R. , Krueger E.A. , Cruz T.B. , Unger J.B. , Chaffee B.W. , Leventhal A. .
Source: Tobacco control, 2021-05-31; , .
EPub date: 2021-05-31.
PMID: 34059552
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Prevalence of Young Adult Vaping, Substance Vaped, and Purchase Location Across Five Categories of Vaping Devices.
Authors: Cwalina S.N. , Braymiller J.L. , Leventhal A.M. , Unger J.B. , McConnell R. , Barrington-Trimis J.L. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2021-05-04; 23(5), p. 829-835.
PMID: 33196838
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Adolescent emotional disorder symptoms and transdiagnostic vulnerabilities as predictors of young adult substance use during the COVID-19 pandemic: mediation by substance-related coping behaviors.
Authors: Cho J. , Bello M.S. , Christie N.C. , Monterosso J.R. , Leventhal A.M. .
Source: Cognitive behaviour therapy, 2021 May-Jul; 50(4), p. 276-294.
EPub date: 2021-03-12.
PMID: 33706676
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Bidirectional associations between e-cigarette use and alcohol use across adolescence.
Authors: Lozano A. , Liu F. , Lee T.K. , Prado G. , Schwartz S.J. , Leventhal A.M. , Kelleghan A.R. , Unger J.B. , Barrington-Trimis J.L. .
Source: Drug and alcohol dependence, 2021-03-01; 220, p. 108496.
EPub date: 2020-12-31.
PMID: 33461153
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Association of Political Party Affiliation With Physical Distancing Among Young Adults During the COVID-19 Pandemic.
Authors: Leventhal A.M. , Dai H. , Barrington-Trimis J.L. , McConnell R. , Unger J.B. , Sussman S. , Cho J. .
Source: JAMA internal medicine, 2021-03-01; 181(3), p. 399-403.
PMID: 33315091
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Eating to Cope With the COVID-19 Pandemic and Body Weight Change in Young Adults.
Authors: Mason T.B. , Barrington-Trimis J. , Leventhal A.M. .
Source: The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2021 02; 68(2), p. 277-283.
EPub date: 2020-12-05.
PMID: 33288456
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Assessment of Nicotine and Cannabis Vaping and Respiratory Symptoms in Young Adults.
Authors: Braymiller J.L. , Barrington-Trimis J.L. , Leventhal A.M. , Islam T. , Kechter A. , Krueger E.A. , Cho J. , Lanza I. , Unger J.B. , McConnell R. .
Source: JAMA network open, 2020-12-01; 3(12), p. e2030189.
EPub date: 2020-12-01.
PMID: 33351085
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Sexual minority tobacco use disparities across adolescence and the transition to young adulthood.
Authors: Krueger E.A. , Braymiller J.L. , Barrington-Trimis J.L. , Cho J. , McConnell R.S. , Leventhal A.M. .
Source: Drug and alcohol dependence, 2020-12-01; 217, p. 108298.
EPub date: 2020-09-16.
PMID: 33070056
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E-cigarette flavour enhancers: Flavoured pod attachments compatible with JUUL and other pod-based devices.
Authors: Cwalina S.N. , Leventhal A.M. , Barrington-Trimis J.L. .
Source: Tobacco control, 2020 12; 29(e1), p. e127-e128.
EPub date: 2020-04-09.
PMID: 32273434
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Young adult e-cigarette use: A latent class analysis of device and flavor use, 2018-2019.
Authors: Lanza H.I. , Leventhal A.M. , Cho J. , Braymiller J.L. , Krueger E.A. , McConnell R. , Barrington-Trimis J.L. .
Source: Drug and alcohol dependence, 2020-11-01; 216, p. 108258.
EPub date: 2020-08-28.
PMID: 32906038
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Trajectories of Nicotine and Cannabis Vaping and Polyuse From Adolescence to Young Adulthood.
Authors: Lanza H.I. , Barrington-Trimis J.L. , McConnell R. , Cho J. , Braymiller J.L. , Krueger E.A. , Leventhal A.M. .
Source: JAMA network open, 2020-10-01; 3(10), p. e2019181.
EPub date: 2020-10-01.
PMID: 33021651
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Trends in the Age of Cigarette Smoking Initiation Among Young Adults in the US From 2002 to 2018.
Authors: Barrington-Trimis J.L. , Braymiller J.L. , Unger J.B. , McConnell R. , Stokes A. , Leventhal A.M. , Sargent J.D. , Samet J.M. , Goodwin R.D. .
Source: JAMA network open, 2020-10-01; 3(10), p. e2019022.
EPub date: 2020-10-01.
PMID: 33021650
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Blunt and Non-Blunt Cannabis Use and Risk of Subsequent Combustible Tobacco Product Use Among Adolescents.
Authors: Mayer M.E. , Kong G. , Barrington-Trimis J.L. , McConnell R. , Leventhal A.M. , Krishnan-Sarin S. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2020-07-16; 22(8), p. 1409-1413.
PMID: 31811296
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Psychiatric comorbidity in adolescent use and poly-use of combustible, vaporized, and edible cannabis products.
Authors: Leventhal A.M. , Bae D. , Kechter A. , Barrington-Trimis J.L. .
Source: Journal of psychiatric research, 2020 05; 124, p. 91-98.
EPub date: 2020-02-25.
PMID: 32135391
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Past 30-day co-use of tobacco and marijuana products among adolescents and young adults in California.
Authors: Nguyen N. , Barrington-Trimis J.L. , Urman R. , Cho J. , McConnell R. , Leventhal A.M. , Halpern-Felsher B. .
Source: Addictive behaviors, 2019 11; 98, p. 106053.
EPub date: 2019-07-15.
PMID: 31357072
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