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Grant Details

Grant Number: 5P50CA244688-02 Interpret this number
Primary Investigator: Glasgow, Russell
Organization: University Of Colorado Denver
Project Title: Pragmatic Implementation Science Approaches to Assess and Enhance Value of Cancer Prevention and Control in Rural Primary Care
Fiscal Year: 2020


Project Summary/Abstract – Overall The theme of our proposed Implementation Science Center is “Pragmatic implementation science approaches to assess and enhance the value of cancer prevention and control in rural primary care.” We will apply and advance frameworks, pragmatic methods, and measures related to cost, benefits, and value that are rigorous, but also generalizable across rural primary care settings that are often struggling with low resources, and a high need population. These models and methods will be used to guide selection and implementation of evidence-based programs for cancer prevention and control (CPC). We will initially focus on lung cancer screening in rural primary care settings, first in Colorado and then nationally through collaboration with a well- established primary care network (i.e., National Research Network). Our overarching framework will be our enhanced RE-AIM/PRISM model, which is an extension of the broadly used Reach, Effectiveness, Adoption, Implementation, and Maintenance framework with the addition of contextual factors (e.g., Intervention characteristics, implementation and sustainability infrastructure). It will serve as the basis to develop and test innovative assessments of costs, benefits, and value from the perspective of different stakeholders to understand and guide implementation. We will meaningfully engage with and include the perspectives of patients, providers, and staff stakeholders in all our studies. Our pilot Implementation Study will adapt, implement, and evaluate strategies using stakeholder-engaged approaches to value to guide the implementation of shared decision-making and smoking cessation related to lung cancer screening. Our Methods Unit will refine and evaluate our pragmatic cost assessment methods to determine implementation/replication costs from the perspective(s) of patients, providers, and delivery staff and then develop and pilot test brief survey measures of preferences regarding the relative benefit of different RE-AIM outcomes. We will then assess relationships among RE-AIM outcomes preferences and selection of different CPC programs. Finally, our Outreach and Network Unit will engage in a) outreach activities targeted at junior and mid-career investigators and practitioners including online professional development (e.g., graduate certificate program, micro-certification) and tailored mentoring and technical assistance approaches; b) dissemination activities to support the packaging and communication of research findings; and c) collaboration activities to facilitate partnerships on CPC and implementation science using multiple channels and including development of shared pragmatic D&I measures and data.


Dissemination and Implementation Science Approaches for Occupational Safety and Health Research: Implications for Advancing Total Worker Health.
Authors: Guerin R.J. , Harden S.M. , Rabin B.A. , Rohlman D.S. , Cunningham T.R. , TePoel M.R. , Parish M. , Glasgow R.E. .
Source: International journal of environmental research and public health, 2021-10-21; 18(21), .
EPub date: 2021-10-21.
PMID: 34769573
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Implementation science issues in understanding, collecting, and using cost estimates: a multi-stakeholder perspective.
Authors: Eisman A.B. , Quanbeck A. , Bounthavong M. , Panattoni L. , Glasgow R.E. .
Source: Implementation science : IS, 2021-08-03; 16(1), p. 75.
EPub date: 2021-08-03.
PMID: 34344411
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Shared Decision-Making for Left Ventricular Assist Devices: Rationale and Design of a Nationwide Dissemination and Implementation Project.
Authors: Thompson J.S. , Fitzgerald M.D. , Allen L.A. , McIlvennan C.K. , Glasgow R.E. , Wynia M. , Morris M.A. , Beilenson J. , Gherst C. , Matlock D.D. .
Source: Circulation. Cardiovascular quality and outcomes, 2021 02; 14(2), p. e007256.
EPub date: 2021-02-03.
PMID: 33530698
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A Scoping Review and General User's Guide for Facilitating the Successful Use of eHealth Programs for Diabetes in Clinical Care.
Authors: Fisher L. , Glasgow R.E. , Huebschmann A. .
Source: Diabetes technology & therapeutics, 2021 02; 23(2), p. 133-145.
EPub date: 2020-08-31.
PMID: 32865431
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Roles dissemination and implementation scientists can play in supporting research teams.
Authors: Tabak R.G. , Bauman A.A. , Holtrop J.S. .
Source: Implementation science communications, 2021-01-15; 2(1), p. 9.
EPub date: 2021-01-15.
PMID: 33451364
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The Importance of Mental Models in Implementation Science.
Authors: Holtrop J.S. , Scherer L.D. , Matlock D.D. , Glasgow R.E. , Green L.A. .
Source: Frontiers in public health, 2021; 9, p. 680316.
EPub date: 2021-07-06.
PMID: 34295871
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Editorial: Use of the RE-AIM Framework: Translating Research to Practice With Novel Applications and Emerging Directions.
Authors: Estabrooks P.A. , Gaglio B. , Glasgow R.E. , Harden S.M. , Ory M.G. , Rabin B.A. , Smith M.L. .
Source: Frontiers in public health, 2021; 9, p. 691526.
EPub date: 2021-06-11.
PMID: 34178933
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Motivational Interviewing for Maternal Immunisation (MI4MI) study: a protocol for an implementation study of a clinician vaccine communication intervention for prenatal care settings.
Authors: Brewer S.E. , Cataldi J.R. , Fisher M. , Glasgow R.E. , Garrett K. , O'Leary S.T. .
Source: BMJ open, 2020-11-17; 10(11), p. e040226.
EPub date: 2020-11-17.
PMID: 33203635
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What Can Implementation Science Do for You? Key Success Stories from the Field.
Authors: Kilbourne A.M. , Glasgow R.E. , Chambers D.A. .
Source: Journal of general internal medicine, 2020 11; 35(Suppl 2), p. 783-787.
PMID: 33107001
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Integrating the Practical Robust Implementation and Sustainability Model With Best Practices in Clinical Decision Support Design: Implementation Science Approach.
Authors: Trinkley K.E. , Kahn M.G. , Bennett T.D. , Glasgow R.E. , Haugen H. , Kao D.P. , Kroehl M.E. , Lin C.T. , Malone D.C. , Matlock D.D. .
Source: Journal of medical Internet research, 2020-10-29; 22(10), p. e19676.
EPub date: 2020-10-29.
PMID: 33118943
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Characterizing evolving frameworks: issues from Esmail et al. (2020) review.
Authors: Glasgow R.E. , Estabrooks P.A. , Ory M.G. .
Source: Implementation science : IS, 2020-07-02; 15(1), p. 53.
EPub date: 2020-07-02.
PMID: 32611414
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Enhancing Success of Medicare's Shared Decision Making Mandates Using Implementation Science: Examples Applying the Pragmatic Robust Implementation and Sustainability Model (PRISM).
Authors: Matlock D.D. , Fukunaga M.I. , Tan A. , Knoepke C. , McNeal D.M. , Mazor K.M. , Glasgow R.E. .
Source: MDM policy & practice, 2020 Jul-Dec; 5(2), p. 2381468320963070.
EPub date: 2020-10-15.
PMID: 33117890
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Making Implementation Science More Rapid: Use of the RE-AIM Framework for Mid-Course Adaptations Across Five Health Services Research Projects in the Veterans Health Administration.
Authors: Glasgow R.E. , Battaglia C. , McCreight M. , Ayele R.A. , Rabin B.A. .
Source: Frontiers in public health, 2020; 8, p. 194.
EPub date: 2020-05-27.
PMID: 32528921
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An Extension of RE-AIM to Enhance Sustainability: Addressing Dynamic Context and Promoting Health Equity Over Time.
Authors: Shelton R.C. , Chambers D.A. , Glasgow R.E. .
Source: Frontiers in public health, 2020; 8, p. 134.
EPub date: 2020-05-12.
PMID: 32478025
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RE-AIM in the Real World: Use of the RE-AIM Framework for Program Planning and Evaluation in Clinical and Community Settings.
Authors: Kwan B.M. , McGinnes H.L. , Ory M.G. , Estabrooks P.A. , Waxmonsky J.A. , Glasgow R.E. .
Source: Frontiers in public health, 2019; 7, p. 345.
EPub date: 2019-11-22.
PMID: 31824911
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