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Grant Details

Grant Number: 5U01CA173642-07 Interpret this number
Primary Investigator: Anderson, Garnet
Organization: Fred Hutchinson Cancer Research Center
Project Title: Life and Longevity After Cancer (LILAC): the Women's Health Initiative Cancer Survivor Cohort
Fiscal Year: 2020


Abstract

SUMMARY/ABSTRACT There are 16 million cancer survivors in the United States, and approximately 60% are age 65 years and over. By 2040, it is estimated that the number of cancer survivors will grow to 26 million with 73% age 65 and older and almost 50% age 75 and older. Despite this so-called silver tsunami of older cancer survivors, there are significant knowledge gaps regarding how cancer and cancer treatment impacts the aging process. There is also a growing consensus regarding the need for studies of cancer in older adults because of the prevalence of comorbidities, functional losses, cognitive impairment, and frailty, and particularly for those age ≥ 75 for whom there are virtually no data. Studies are needed to better understand how cancer and its treatment interact with underlying vulnerabilities, which in turn impacts the feasibility, safety, and efficacy of interventions in this population. The Life and Longevity After Cancer (LILAC) project is a cancer survivor cohort embedded within the Women’s Health Initiative to support studies of cancer survivorship in an aging population. During the initial funding period, we developed the LILAC cohort of 13,453 WHI cancer survivors who were diagnosed with one of eight LILAC designated cancers: invasive breast, colorectal, endometrial, melanoma, leukemia, lung, lymphoma, melanoma, or ovarian. We collected information on first course of treatment, clinical and patient reported outcomes, as well as archival tissue from 4351 solid tumors. With a minimum of 20 years of data on these women and a current age-range of 70 to101 years, the LILAC population is poised to provide key information on cancer and aging to advance our cancer and aging research agenda. To accomplish this we propose to enhance the LILAC resource through several mechanisms designed to support analyses of emerging questions. Specifically, we propose: 1) To fill critical gaps in knowledge regarding the self-reported physical, mental and social health of older female cancer survivors by continuing to enroll newly diagnosed survivors (N=2685) and follow the LILAC cohort; 2) To develop the analytic framework to assess trajectories of aging, including an accelerated aging phenotype in the WHI/LILAC database; 3) To establish cohorts of age- matched WHI participants with similar data who have remained cancer free, to help us understand the diagnosis of cancer and its treatment on the trajectories of aging, the accelerated aging phenotype and age- related comorbidities; 4) To obtain performance-based measures of physical function and new post-treatment blood samples to assess potential biomarkers of accelerated aging; and 5) To maximize the use and impact of this resource. Given the aging of the US population, the increase in the number of cancer survivors and the association between cancer and aging, these strategic and timely investments in the LILAC infrastructure will help to fill many of these critical research gaps.



Publications

Association of Prediagnostic Frailty, Change in Frailty Status, and Mortality After Cancer Diagnosis in the Women's Health Initiative.
Authors: Cespedes Feliciano E.M. , Hohensee C. , Rosko A.E. , Anderson G.L. , Paskett E.D. , Zaslavsky O. , Wallace R.B. , Caan B.J. .
Source: JAMA network open, 2020-09-01; 3(9), p. e2016747.
EPub date: 2020-09-01.
PMID: 32926116
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Guideline-concordant endometrial cancer treatment and survival in the Women's Health Initiative Life and Longevity After Cancer study.
Authors: Felix A.S. , McLaughlin E.M. , Caan B.J. , Cohn D.E. , Anderson G.L. , Paskett E.D. .
Source: International journal of cancer, 2020-07-15; 147(2), p. 404-412.
EPub date: 2019-10-31.
PMID: 31618444
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Prediagnosis social support, social integration, living status, and colorectal cancer mortality in postmenopausal women from the women's health initiative.
Authors: Kroenke C.H. , Paskett E.D. , Cené C.W. , Caan B.J. , Luo J. , Shadyab A.H. , Robinson J.R.M. , Nassir R. , Lane D.S. , Anderson G.L. .
Source: Cancer, 2020-04-15; 126(8), p. 1766-1775.
EPub date: 2020-01-23.
PMID: 31972054
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The association of delay in curative intent treatment with survival among breast cancer patients: findings from the Women's Health Initiative.
Authors: Yung R. , Ray R.M. , Roth J. , Johnson L. , Warnick G. , Anderson G.L. , Kroenke C.H. , Chlebowski R.T. , Simon M.S. , Fung C. , et al. .
Source: Breast cancer research and treatment, 2020 Apr; 180(3), p. 747-757.
EPub date: 2020-02-15.
PMID: 32062784
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An Environmental Scan of Biopsychosocial and Clinical Variables in Cohort Studies of Cancer Survivors.
Authors: Krok-Schoen J.L. , Bernardo B.M. , Elena J.W. , Green P.A. , Hoover E. , Peng J. , Anderson G.L. , Caan B. , Johnson L.G. , Paskett E.D. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2019 10; 28(10), p. 1621-1641.
EPub date: 2019-07-17.
PMID: 31315912
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Financial burden among older, long-term cancer survivors: Results from the LILAC study.
Authors: Hastert T.A. , Young G.S. , Pennell M.L. , Padamsee T. , Zafar S.Y. , DeGraffinreid C. , Naughton M. , Simon M. , Paskett E.D. .
Source: Cancer medicine, 2018 09; 7(9), p. 4261-4272.
EPub date: 2018-07-17.
PMID: 30019387
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Fear of recurrence among older breast, ovarian, endometrial, and colorectal cancer survivors: Findings from the WHI LILAC study.
Authors: Krok-Schoen J.L. , Naughton M.J. , Bernardo B.M. , Young G.S. , Paskett E.D. .
Source: Psycho-oncology, 2018 07; 27(7), p. 1810-1815.
EPub date: 2018-05-16.
PMID: 29644766
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Predictors of vasomotor symptoms among breast cancer survivors.
Authors: Reeves K.W. , Pennell M. , Foraker R.E. , Crandall C.J. , Stefanick M. , Paskett E.D. .
Source: Journal of cancer survivorship : research and practice, 2018 06; 12(3), p. 379-387.
EPub date: 2018-02-09.
PMID: 29427202
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Cardiometabolic risk factors and survival after breast cancer in the Women's Health Initiative.
Authors: Simon M.S. , Beebe-Dimmer J.L. , Hastert T.A. , Manson J.E. , Cespedes Feliciano E.M. , Neuhouser M.L. , Ho G.Y.F. , Freudenheim J.L. , Strickler H. , Ruterbusch J. , et al. .
Source: Cancer, 2018-04-15; 124(8), p. 1798-1807.
EPub date: 2018-01-16.
PMID: 29338086
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The Women's Health Initiative (WHI) Life and Longevity After Cancer (LILAC) Study: Description and Baseline Characteristics of Participants.
Authors: Paskett E.D. , Caan B.J. , Johnson L. , Bernardo B.M. , Young G.S. , Pennell M.L. , Ray R.M. , Kroenke C.H. , Porter P.L. , Anderson G.L. .
Source: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 2018 02; 27(2), p. 125-137.
EPub date: 2018-01-29.
PMID: 29378785
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Change in longitudinal trends in sleep quality and duration following breast cancer diagnosis: results from the Women's Health Initiative.
Authors: Beverly C.M. , Naughton M.J. , Pennell M.L. , Foraker R.E. , Young G. , Hale L. , Feliciano E.M.C. , Pan K. , Crane T.E. , Danhauer S.C. , et al. .
Source: NPJ breast cancer, 2018; 4, p. 15.
EPub date: 2018-06-29.
PMID: 29978034
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Addressing Bias in Electronic Health Record-Based Surveillance of Cardiovascular Disease Risk: Finding the Signal Through the Noise.
Authors: Bower J.K. , Patel S. , Rudy J.E. , Felix A.S. .
Source: Current epidemiology reports, 2017 Dec; 4(4), p. 346-352.
EPub date: 2017-11-02.
PMID: 31223556
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Methodological considerations for disentangling a risk factor's influence on disease incidence versus postdiagnosis survival: The example of obesity and breast and colorectal cancer mortality in the Women's Health Initiative.
Authors: Cespedes Feliciano E.M. , Prentice R.L. , Aragaki A.K. , Neuhouser M.L. , Banack H.R. , Kroenke C.H. , Ho G.Y.F. , Zaslavsky O. , Strickler H.D. , Cheng T.D. , et al. .
Source: International journal of cancer, 2017-12-01; 141(11), p. 2281-2290.
EPub date: 2017-08-31.
PMID: 28833074
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Low-Fat Dietary Pattern and Breast Cancer Mortality in the Women's Health Initiative Randomized Controlled Trial.
Authors: Chlebowski R.T. , Aragaki A.K. , Anderson G.L. , Thomson C.A. , Manson J.E. , Simon M.S. , Howard B.V. , Rohan T.E. , Snetselar L. , Lane D. , et al. .
Source: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 2017-09-01; 35(25), p. 2919-2926.
EPub date: 2017-06-27.
PMID: 28654363
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Effect of depression before breast cancer diagnosis on mortality among postmenopausal women.
Authors: Liang X. , Margolis K.L. , Hendryx M. , Reeves K. , Wassertheil-Smoller S. , Weitlauf J. , Danhauer S.C. , Chlebowski R.T. , Caan B. , Qi L. , et al. .
Source: Cancer, 2017-08-15; 123(16), p. 3107-3115.
EPub date: 2017-04-07.
PMID: 28387934
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Medication use trajectories of postmenopausal breast cancer survivors and matched cancer-free controls.
Authors: Pan K. , Chlebowski R.T. , Simon M.S. , Ray R.M. , Livaudais-Toman J. , Sullivan S.D. , Stefanick M.L. , Wallace R.B. , LeBoff M. , Bluhm E.C. , et al. .
Source: Breast cancer research and treatment, 2016 Apr; 156(3), p. 567-576.
EPub date: 2016-04-13.
PMID: 27075917
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Enhancing Breast Cancer Recurrence Algorithms Through Selective Use of Medical Record Data.
Authors: Kroenke C.H. , Chubak J. , Johnson L. , Castillo A. , Weltzien E. , Caan B.J. .
Source: Journal of the National Cancer Institute, 2016 Mar; 108(3), .
EPub date: 2015-11-18.
PMID: 26582243
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Survivorship: screening for cancer and treatment effects, version 2.2014.
Authors: Denlinger C.S. , Ligibel J.A. , Are M. , Baker K.S. , Demark-Wahnefried W. , Dizon D. , Friedman D.L. , Goldman M. , Jones L. , King A. , et al. .
Source: Journal of the National Comprehensive Cancer Network : JNCCN, 2014 Nov; 12(11), p. 1526-31.
PMID: 25361799
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Survivorship: nutrition and weight management, Version 2.2014. Clinical practice guidelines in oncology.
Authors: Denlinger C.S. , Ligibel J.A. , Are M. , Baker K.S. , Demark-Wahnefried W. , Dizon D. , Friedman D.L. , Goldman M. , Jones L. , King A. , et al. .
Source: Journal of the National Comprehensive Cancer Network : JNCCN, 2014 Oct; 12(10), p. 1396-406.
PMID: 25313179
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Survivorship: healthy lifestyles, version 2.2014.
Authors: Denlinger C.S. , Ligibel J.A. , Are M. , Baker K.S. , Demark-Wahnefried W. , Dizon D. , Friedman D.L. , Goldman M. , Jones L. , King A. , et al. .
Source: Journal of the National Comprehensive Cancer Network : JNCCN, 2014 Sep; 12(9), p. 1222-37.
PMID: 25190692
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Survivorship: immunizations and prevention of infections, version 2.2014.
Authors: Denlinger C.S. , Ligibel J.A. , Are M. , Baker K.S. , Demark-Wahnefried W. , Dizon D. , Friedman D.L. , Goldman M. , Jones L. , King A. , et al. .
Source: Journal of the National Comprehensive Cancer Network : JNCCN, 2014 Aug; 12(8), p. 1098-111.
PMID: 25099442
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Survivorship: cognitive function, version 1.2014.
Authors: Denlinger C.S. , Ligibel J.A. , Are M. , Baker K.S. , Demark-Wahnefried W. , Friedman D.L. , Goldman M. , Jones L. , King A. , Ku G.H. , et al. .
Source: Journal of the National Comprehensive Cancer Network : JNCCN, 2014 Jul; 12(7), p. 976-86.
PMID: 24994918
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Survivorship: fatigue, version 1.2014.
Authors: Denlinger C.S. , Ligibel J.A. , Are M. , Baker K.S. , Demark-Wahnefried W. , Friedman D.L. , Goldman M. , Jones L. , King A. , Ku G.H. , et al. .
Source: Journal of the National Comprehensive Cancer Network : JNCCN, 2014 Jun; 12(6), p. 876-87.
PMID: 24925198
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Survivorship: sleep disorders, version 1.2014.
Authors: Denlinger C.S. , Ligibel J.A. , Are M. , Baker K.S. , Demark-Wahnefried W. , Friedman D.L. , Goldman M. , Jones L. , King A. , Ku G.H. , et al. .
Source: Journal of the National Comprehensive Cancer Network : JNCCN, 2014 May; 12(5), p. 630-42.
PMID: 24812132
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Survivorship: pain version 1.2014.
Authors: Denlinger C.S. , Ligibel J.A. , Are M. , Baker K.S. , Demark-Wahnefried W. , Friedman D.L. , Goldman M. , Jones L. , King A. , Ku G.H. , et al. .
Source: Journal of the National Comprehensive Cancer Network : JNCCN, 2014 Apr; 12(4), p. 488-500.
PMID: 24717568
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Survivorship: sexual dysfunction (male), version 1.2013.
Authors: Denlinger C.S. , Carlson R.W. , Are M. , Baker K.S. , Davis E. , Edge S.B. , Friedman D.L. , Goldman M. , Jones L. , King A. , et al. .
Source: Journal of the National Comprehensive Cancer Network : JNCCN, 2014-03-01; 12(3), p. 356-63.
PMID: 24616541
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Survivorship: sexual dysfunction (female), version 1.2013.
Authors: Denlinger C.S. , Carlson R.W. , Are M. , Baker K.S. , Davis E. , Edge S.B. , Friedman D.L. , Goldman M. , Jones L. , King A. , et al. .
Source: Journal of the National Comprehensive Cancer Network : JNCCN, 2014 Feb; 12(2), p. 184-92.
PMID: 24586080
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Survivorship: introduction and definition. Clinical practice guidelines in oncology.
Authors: Denlinger C.S. , Carlson R.W. , Are M. , Baker K.S. , Davis E. , Edge S.B. , Friedman D.L. , Goldman M. , Jones L. , King A. , et al. .
Source: Journal of the National Comprehensive Cancer Network : JNCCN, 2014 Jan; 12(1), p. 34-45.
PMID: 24453291
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