||5U01CA164973-09 Interpret this number
||Le Marchand, Loic
||University Of Hawaii At Manoa
||Understanding Ethnic Differences in Cancer: the Multiethnic Cohort Study
This renewal application seeks support for the infrastructure of the Multiethnic Cohort (MEC) Study, which was
established in Hawaii and southern California in 1993-1996 to study risk factors for cancer and other chronic
diseases. The study was designed to take advantage of the ethnic and cultural diversity of the two geographic
areas, as well as the expertise of the investigators in nutrition, ethnic/racial studies, and genetics. It is the most
ethnically diverse cancer cohort in existence. It achieves high cost-efficiency by supplementing active follow-up
information with computerized linkages to SEER, vital statistics, hospital-discharge diagnoses, medical claim
data, electronic medical records and geospatial information. At baseline, the cohort included information on
215,000 men and women, comprised almost entirely of five ethnic/racial populations: Caucasians, Japanese
Americans, Native Hawaiians, African Americans, and Latinos. The resource was later expanded to include a
prospective biorepository of blood and urine specimens from ~70,000 of the participants. Leadership of the
MEC entails a highly interactive, team approach; and the investigators have amply demonstrated their
willingness to share data/samples, and to participate actively in consortia. This application describes our aims
over the next 5 years for maintaining and enhancing the infrastructure of the MEC, as well as plans for
methodological research. Research accomplishments include significant contributions to understanding both
genetic and environmental risk factors for cancer. Over 280 papers describing our findings have been
published during the current grant cycle. In addition, over the last 20 years, 98 research grants have been built
around the MEC, and more than 75 students and postdoctoral fellows have been trained on the study. This
grant renewal will make possible the continuation of a well-integrated program of research aimed at evaluating
environmental and genetic risk factors for cancer and other common chronic diseases, taking advantage of
new approaches, such as genomics, microbiomics, adductomics and metabolomics. The MEC will allow the
testing of innovative research hypotheses aimed at ensuring that progress in prevention applies to major US
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