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Grant Details

Grant Number: 5R01CA207158-05 Interpret this number
Primary Investigator: Foley, Kristie
Organization: Wake Forest University Health Sciences
Project Title: Implementation of Smoking Cessation Services Within NCI Ncorp Community Sites with Organized Lung Cancer Screening Programs
Fiscal Year: 2020


PROJECT SUMMARY Implementing effective tobacco cessation programs within LDCT lung cancer screening is needed as quitting smoking increases life expectancy, decreases risk of competing causes of death, improves length of survival among lung cancer patients, and maximizes the cost-effectiveness of lung cancer screening. Our research team, including experts in smoking cessation, lung cancer screening, and implementation science, will: (1) evaluate a multi-faceted training program to improve short-term smoking cessation rates and sustained abstinence among 1,114 patients who present for LDCT lung cancer screening in 22 community-based practices using a cluster, randomized control trial design; (2) characterize the adoption and adaptation of evidence-based tobacco cessation strategies within community-based LDCT lung cancer screening programs using extensive qualitative data, including analysis of strategic planning documents, a team blog and performance coaching notes, key informant interviews, and observational data; and (3) develop and evaluate an implementation toolkit that explains how to integrate evidence-based tobacco cessation strategies in community-based LDCT lung cancer screening programs in absence of the research team. The majority of lung cancer screening will occur in non-academic, community-based settings with diverse patient populations who are at high risk for lung cancer and other smoking-related illnesses. This effectiveness-implementation hybrid design is intended to promote the rapid translation of the evidence-based tobacco cessation strategies into community-based practices offering LDCT lung cancer screening to reduce smoking-related morbidity and mortality.


The Optimizing Lung Screening Trial (WF-20817CD): Multicenter Randomized Effectiveness Implementation Trial to Increase Tobacco Use Cessation for Individuals Undergoing Lung Screening.
Authors: Foley K.L. , Dressler E.V. , Weaver K.E. , Sutfin E.L. , Miller D.P. , Bellinger C. , Kittel C. , Stone R.J. , Petty W.J. , Land S.R. , et al. .
Source: Chest, 2023 Aug; 164(2), p. 531-543.
EPub date: 2023-03-15.
PMID: 36931460
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Accelerating integration of tobacco use treatment in the context of lung cancer screening: Relevance and application of implementation science to achieving policy and practice.
Authors: Shelley D. , Wang V.H. , Taylor K. , Williams R. , Toll B. , Rojewski A. , Foley K.L. , Rigotti N. , Ostroff J.S. .
Source: Translational behavioral medicine, 2022-11-21; 12(11), p. 1076-1083.
PMID: 36227937
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Organizational Characteristics and Smoking Cessation Support in Community-Based Lung Cancer Screening Programs.
Authors: Bellinger C. , Foley K.L. , Dressler E.V. , Kittel C. , Miller D.P. , Weaver K.E. , Sutfin E.L. , Petty W.J. , Spangler J. , Stone R. , et al. .
Source: Journal of the American College of Radiology : JACR, 2022 Apr; 19(4), p. 529-533.
EPub date: 2022-03-02.
PMID: 35247325
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Predictors of Enrollment of Older Smokers in Six Smoking Cessation Trials in the Lung Cancer Screening Setting: The Smoking Cessation at Lung Examination (SCALE) Collaboration.
Authors: Eyestone E. , Williams R.M. , Luta G. , Kim E. , Toll B.A. , Rojewski A. , Neil J. , Cinciripini P.M. , Cordon M. , Foley K. , et al. .
Source: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco, 2021-11-05; 23(12), p. 2037-2046.
PMID: 34077535
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Impact of the COVID-19 pandemic on telehealth research in cancer prevention and care: A call to sustain telehealth advances.
Authors: Park E.R. , Chiles C. , Cinciripini P.M. , Foley K.L. , Fucito L.M. , Haas J.S. , Joseph A.M. , Ostroff J.S. , Rigotti N.A. , Shelley D.R. , et al. .
Source: Cancer, 2021-02-01; 127(3), p. 334-338.
EPub date: 2020-10-13.
PMID: 33048350
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The OaSiS trial: A hybrid type II, national cluster randomized trial to implement smoking cessation during CT screening for lung cancer.
Authors: Foley K.L. , Miller D.P. , Weaver K. , Sutfin E.L. , Petty W.J. , Bellinger C. , Spangler J. , Stone R.J. , Lawler D. , Davis W. , et al. .
Source: Contemporary clinical trials, 2020 Apr; 91, p. 105963.
EPub date: 2020-02-20.
PMID: 32087340
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Lung Cancer Screening and Smoking Cessation Clinical Trials. SCALE (Smoking Cessation within the Context of Lung Cancer Screening) Collaboration.
Authors: Joseph A.M. , Rothman A.J. , Almirall D. , Begnaud A. , Chiles C. , Cinciripini P.M. , Fu S.S. , Graham A.L. , Lindgren B.R. , Melzer A.C. , et al. .
Source: American journal of respiratory and critical care medicine, 2018-01-15; 197(2), p. 172-182.
PMID: 28977754
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