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Grant Details

Grant Number: 3R01CA124402-05S1 Interpret this number
Primary Investigator: Weiner, Bryan
Organization: Univ Of North Carolina Chapel Hill
Project Title: Implementing Systemic Interventions to Close the Discovery-Delivery Gap
Fiscal Year: 2012
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Abstract

DESCRIPTION (provided by applicant): The NIH and other federal agencies see provider-based research networks (PBRNs) as a promising model for disseminating and implementing evidence-based clinical services in community-based practice settings. PBRNs are collaborative partnerships between community-based providers and academic institutions to conduct clinical research on an ongoing basis. As an indicator of its commitment to PBRNs, the NIH is investigating the feasibility of training 50,000 community-based health-care practitioners to participate in clinical research and integrate new research findings into routine health care delivery. Yet, reports indicate that PBRNs are challenging to implement and sustain. Further, the extent to which PBRNs actually promote the use of evidence-based clinical services in community-based practice settings remains largely unknown. This project will examine the implementation, impact, sustainability, and business case of the NCI's Community Clinical Oncology Program (CCOP), a federally funded national PBRN that the NIH sees as a model for PBRNs in other disease areas. Specifically, the project will (1) investigate the implementation of the CCOP in community-based practice settings through in-depth case studies of three newly funded CCOP organizations and a survey of all 50 CCOP organizations; (2) examine the impact of the CCOP on clinical practice through longitudinal analysis of adoption rates of evidence-based cancer therapies by CCOP- affiliated and non-CCOP-affiliated providers using SEER-Medicare data; (3) assess the factors affecting sustainability of the CCOP in community-based practice settings through a longitudinal analysis of all CCOP organizations active from 1991 through 2003; and (4) investigate the business case for CCOP participation by providers through analysis of financial and statistical data and in-depth case studies. The project will provide the NIH with much-needed information about what it takes to implement and sustain PBRNs and what it can expect from PBRNs as a model for disseminating and implementing evidence-based clinical services in community-based practice settings.

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Publications

Provider-based research networks may improve early access to innovative colon cancer treatment for African Americans treated in the community.
Authors: Penn DC, Chang Y, Meyer AM, DeFilippo Mack C, Sanoff HK, Stitzenberg KB, Carpenter WR
Source: Cancer, 2014 Sep 10;null, p. null.
EPub date: 2014 Sep 10.
PMID: 25209056
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Organizational and physician factors associated with patient enrollment in cancer clinical trials.
Authors: Jacobs SR, Weiner BJ, Reeve BB, Weinberger M, Minasian LM, Good MJ
Source: Clin Trials, 2014 Oct;11(5), p. 565-75.
EPub date: 2014 Jun 5.
PMID: 24902923
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Context matters: measuring implementation climate among individuals and groups.
Authors: Jacobs SR, Weiner BJ, Bunger AC
Source: Implement Sci, 2014 Apr 17;9, p. 46.
EPub date: 2014 Apr 17.
PMID: 24742308
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Differential receipt of sentinel lymph node biopsy within practice-based research networks.
Authors: Meyer AM, Reeder-Hayes KE, Liu H, Wheeler SB, Penn D, Weiner BJ, Carpenter WR
Source: Med Care, 2013 Sep;51(9), p. 812-8.
PMID: 23942221
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Challenges and facilitators of community clinical oncology program participation: a qualitative study.
Authors: McAlearney AS, Reiter KL, Weiner BJ, Minasian L, Song PH
Source: J Healthc Manag, 2013 Jan-Feb;58(1), p. 29-44; discussion 45-6.
PMID: 23424817
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Calendar time-specific propensity scores and comparative effectiveness research for stage III colon cancer chemotherapy.
Authors: Mack CD, Glynn RJ, Brookhart MA, Carpenter WR, Meyer AM, Sandler RS, Stürmer T
Source: Pharmacoepidemiol Drug Saf, 2013 Aug;22(8), p. 810-8.
EPub date: 2013 Jan 7.
PMID: 23296544
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Achieving high cancer control trial enrollment in the community setting: an analysis of the Community Clinical Oncology Program.
Authors: Jacobs SR, Weiner BJ, Minasian LM, Good MJ
Source: Contemp Clin Trials, 2013 Mar;34(2), p. 320-5.
EPub date: 2013 Jan 5.
PMID: 23295315
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The business case for provider participation in clinical trials research: an application to the National Cancer Institute's community clinical oncology program.
Authors: Song PH, Reiter KL, Weiner BJ, Minasian L, McAlearney AS
Source: Health Care Manage Rev, 2013 Oct-Dec;38(4), p. 284-94.
PMID: 23044836
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Why providers participate in clinical trials: considering the National Cancer Institute's Community Clinical Oncology Program.
Authors: McAlearney AS, Song PH, Reiter KL
Source: Contemp Clin Trials, 2012 Nov;33(6), p. 1143-9.
EPub date: 2012 Aug 19.
PMID: 22925970
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Effect of state-mandated insurance coverage on accrual to community cancer clinical trials.
Authors: Ellis SD, Carpenter WR, Minasian LM, Weiner BJ
Source: Contemp Clin Trials, 2012 Sep;33(5), p. 933-41.
EPub date: 2012 Jun 8.
PMID: 22683991
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Implementing community-based provider participation in research: an empirical study.
Authors: Teal R, Bergmire DM, Johnston M, Weiner BJ
Source: Implement Sci, 2012 May 8;7, p. 41.
EPub date: 2012 May 8.
PMID: 22568935
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Translating research into practice: the role of provider-based research networks in the diffusion of an evidence-based colon cancer treatment innovation.
Authors: Carpenter WR, Meyer AM, Wu Y, Qaqish B, Sanoff HK, Goldberg RM, Weiner BJ
Source: Med Care, 2012 Aug;50(8), p. 737-48.
PMID: 22437624
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A method for analyzing the business case for provider participation in the National Cancer Institute's Community Clinical Oncology Program and similar federally funded, provider-based research networks.
Authors: Reiter KL, Song PH, Minasian L, Good M, Weiner BJ, McAlearney AS
Source: Cancer, 2012 Sep 1;118(17), p. 4253-61.
EPub date: 2011 Dec 27.
PMID: 22213241
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Racial disparities in receipt and comparative effectiveness of oxaliplatin for stage III colon cancer in older adults.
Authors: Mack CD, Carpenter W, Meyer AM, Sanoff H, Stürmer T
Source: Cancer, 2012 Jun 1;118(11), p. 2925-34.
EPub date: 2011 Nov 9.
PMID: 22072441
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Sustainability and performance of the National Cancer Institute's Community Clinical Oncology Program.
Authors: Carpenter WR, Fortune-Greeley AK, Zullig LL, Lee SY, Weiner BJ
Source: Contemp Clin Trials, 2012 Jan;33(1), p. 46-54.
EPub date: 2011 Oct 2.
PMID: 21986391
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The meaning and measurement of implementation climate.
Authors: Weiner BJ, Belden CM, Bergmire DM, Johnston M
Source: Implement Sci, 2011 Jul 22;6, p. 78.
EPub date: 2011 Jul 22.
PMID: 21781328
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Systems antecedents for dissemination and implementation: a review and analysis of measures.
Authors: Emmons KM, Weiner B, Fernandez ME, Tu SP
Source: Health Educ Behav, 2012 Feb;39(1), p. 87-105.
EPub date: 2011 Jul 1.
PMID: 21724933
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Breast MRI utilization in older patients with newly diagnosed breast cancer.
Authors: Sommer CA, Stitzenberg KB, Tolleson-Rinehart S, Carpenter WR, Carey TS
Source: J Surg Res, 2011 Sep;170(1), p. 77-83.
EPub date: 2011 May 17.
PMID: 21658724
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Race and age disparities in receipt of sentinel lymph node biopsy for early-stage breast cancer.
Authors: Reeder-Hayes KE, Bainbridge J, Meyer AM, Amos KD, Weiner BJ, Godley PA, Carpenter WR
Source: Breast Cancer Res Treat, 2011 Aug;128(3), p. 863-71.
EPub date: 2011 Feb 22.
PMID: 21340480
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The role of organizational affiliations and research networks in the diffusion of breast cancer treatment innovation.
Authors: Carpenter WR, Reeder-Hayes K, Bainbridge J, Meyer AM, Amos KD, Weiner BJ, Godley PA
Source: Med Care, 2011 Feb;49(2), p. 172-9.
PMID: 21206296
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Racial differences in PSA screening interval and stage at diagnosis.
Authors: Carpenter WR, Howard DL, Taylor YJ, Ross LE, Wobker SE, Godley PA
Source: Cancer Causes Control, 2010 Jul;21(7), p. 1071-80.
EPub date: 2010 Mar 24.
PMID: 20333462
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A theory of organizational readiness for change.
Authors: Weiner BJ
Source: Implement Sci, 2009 Oct 19;4, p. 67.
EPub date: 2009 Oct 19.
PMID: 19840381
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