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Grant Details

Grant Number: 3R01CA124402-05S1 Interpret this number
Primary Investigator: Weiner, Bryan
Organization: Univ Of North Carolina Chapel Hill
Project Title: Implementing Systemic Interventions to Close the Discovery-Delivery Gap
Fiscal Year: 2012
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Abstract

DESCRIPTION (provided by applicant): The NIH and other federal agencies see provider-based research networks (PBRNs) as a promising model for disseminating and implementing evidence-based clinical services in community-based practice settings. PBRNs are collaborative partnerships between community-based providers and academic institutions to conduct clinical research on an ongoing basis. As an indicator of its commitment to PBRNs, the NIH is investigating the feasibility of training 50,000 community-based health-care practitioners to participate in clinical research and integrate new research findings into routine health care delivery. Yet, reports indicate that PBRNs are challenging to implement and sustain. Further, the extent to which PBRNs actually promote the use of evidence-based clinical services in community-based practice settings remains largely unknown. This project will examine the implementation, impact, sustainability, and business case of the NCI's Community Clinical Oncology Program (CCOP), a federally funded national PBRN that the NIH sees as a model for PBRNs in other disease areas. Specifically, the project will (1) investigate the implementation of the CCOP in community-based practice settings through in-depth case studies of three newly funded CCOP organizations and a survey of all 50 CCOP organizations; (2) examine the impact of the CCOP on clinical practice through longitudinal analysis of adoption rates of evidence-based cancer therapies by CCOP- affiliated and non-CCOP-affiliated providers using SEER-Medicare data; (3) assess the factors affecting sustainability of the CCOP in community-based practice settings through a longitudinal analysis of all CCOP organizations active from 1991 through 2003; and (4) investigate the business case for CCOP participation by providers through analysis of financial and statistical data and in-depth case studies. The project will provide the NIH with much-needed information about what it takes to implement and sustain PBRNs and what it can expect from PBRNs as a model for disseminating and implementing evidence-based clinical services in community-based practice settings.

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Publications

Challenges and facilitators of community clinical oncology program participation: a qualitative study.
Authors: McAlearney AS, Reiter KL, Weiner BJ, Minasian L, Song PH
Source: J Healthc Manag, 2013 Jan-Feb;58(1), p. 29-44; discussion 45-6.
PMID: 23424817
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Grant Numbers:
NCI NIH HHS - R01CA124402

MeSH Terms:
United States Qualitative Research Attitude of Health Personnel
National Cancer Institute (U.S.) Humans Hospital Administrators
Medical Staff, Hospital Government Programs Medical Oncology
Community Health Services Organizational Case Studies Health Services Accessibility

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Calendar time-specific propensity scores and comparative effectiveness research for stage III colon cancer chemotherapy.
Authors: Mack CD, Glynn RJ, Brookhart MA, Carpenter WR, Meyer AM, Sandler RS, Stürmer T
Source: Pharmacoepidemiol Drug Saf, 2013 Jan 7;null, p. null.
EPub date: 2013 Jan 7.
PMID: 23296544
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Grant Numbers:
NIDDK NIH HHS - T32 DK007634 NIA NIH HHS - R01 AG023178 NCI NIH HHS - U54 CA153602
NCI NIH HHS - R01 CA124402 NCI NIH HHS - HHSN261200800726P

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Achieving high cancer control trial enrollment in the community setting: an analysis of the Community Clinical Oncology Program.
Authors: Jacobs SR, Weiner BJ, Minasian LM, Good MJ
Source: Contemp Clin Trials, 2013 Mar;34(2), p. 320-5.
EPub date: 2013 Jan 5.
PMID: 23295315
Related Citations

Grant Numbers:
NCI NIH HHS - R25CA116339 NCI NIH HHS - R01 CA124402 NCI NIH HHS - R01CA124402

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The business case for provider participation in clinical trials research: An application to the National Cancer Institute's community clinical oncology program.
Authors: Song PH, Reiter KL, Weiner BJ, Minasian L, McAlearney AS
Source: Health Care Manage Rev, 2012 Oct 5;null, p. null.
EPub date: 2012 Oct 5.
PMID: 23044836
Related Citations

Grant Numbers:
NCI NIH HHS - R01 CA124402

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Why providers participate in clinical trials: considering the National Cancer Institute's Community Clinical Oncology Program.
Authors: McAlearney AS, Song PH, Reiter KL
Source: Contemp Clin Trials, 2012 Nov;33(6), p. 1143-9.
EPub date: 2012 Aug 19.
PMID: 22925970
Related Citations

Grant Numbers:
NCI NIH HHS - R01 CA124402 NCI NIH HHS - R01CA124402

MeSH Terms:
United States Attitude of Health Personnel Motivation
National Cancer Institute (U.S.) Humans Clinical Trials as Topic
Physicians Medical Oncology Decision Making
Research Design Community-Based Participatory Research Translational Medical Research

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Effect of state-mandated insurance coverage on accrual to community cancer clinical trials.
Authors: Ellis SD, Carpenter WR, Minasian LM, Weiner BJ
Source: Contemp Clin Trials, 2012 Sep;33(5), p. 933-41.
EPub date: 2012 Jun 8.
PMID: 22683991
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Grant Numbers:
NCI NIH HHS - R25CA116339 NCI NIH HHS - R01 CA124402 NCI NIH HHS - R01CA124402

MeSH Terms:
United States Neoplasms State Government
Humans Insurance, Health Clinical Trials as Topic
Patient Selection Longitudinal Studies Community-Based Participatory Research
Insurance Coverage

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Implementing community-based provider participation in research: an empirical study.
Authors: Teal R, Bergmire DM, Johnston M, Weiner BJ
Source: Implement Sci, 2012 May 8;7, p. 41.
EPub date: 2012 May 8.
PMID: 22568935
Related Citations

Grant Numbers:
NCI NIH HHS - 1 R01 CA124402 NCI NIH HHS - R01 CA124402

MeSH Terms:
United States Models, Organizational Organizational Innovation
Humans Medical Oncology Patients
Longitudinal Studies Research Design Community-Based Participatory Research
Neoplasms National Cancer Institute (U.S.) Program Evaluation
Data Collection Physicians Community Health Services
Health Care Rationing

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Translating research into practice: the role of provider-based research networks in the diffusion of an evidence-based colon cancer treatment innovation.
Authors: Carpenter WR, Meyer AM, Wu Y, Qaqish B, Sanoff HK, Goldberg RM, Weiner BJ
Source: Med Care, 2012 Aug;50(8), p. 737-48.
PMID: 22437624
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Grant Numbers:
NCI NIH HHS - N01-PC-35139 PHS HHS - U55/CCR921930-02 NCI NIH HHS - 5R01CA124402
PHS HHS - HHSN261200800726P NCI NIH HHS - N01-PC-35136 NCI NIH HHS - R01 CA124402-01A1
NCI NIH HHS - N02-PC-15105

MeSH Terms:
United States Antineoplastic Agents Humans
Diffusion of Innovation Medicare Retrospective Studies
Pyridines Translational Medical Research Chemoradiotherapy, Adjuvant
Biomedical Research Fluorouracil Organoplatinum Compounds
Adenocarcinoma Colonic Neoplasms

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A method for analyzing the business case for provider participation in the National Cancer Institute's Community Clinical Oncology Program and similar federally funded, provider-based research networks.
Authors: Reiter KL, Song PH, Minasian L, Good M, Weiner BJ, McAlearney AS
Source: Cancer, 2012 Sep 1;118(17), p. 4253-61.
EPub date: 2011 Dec 27.
PMID: 22213241
Related Citations

Grant Numbers:
NCI NIH HHS - R01 CA124402-03S1 NCI NIH HHS - R01CA124402 NCI NIH HHS - R01 CA124402-05

MeSH Terms:
United States Financial Management, Hospital National Cancer Institute (U.S.)
Humans Cost-Benefit Analysis Government Programs
Clinical Trials as Topic Medical Oncology Community Health Services
Research Design Research Support as Topic

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Racial disparities in receipt and comparative effectiveness of oxaliplatin for stage III colon cancer in older adults.
Authors: Mack CD, Carpenter W, Meyer AM, Sanoff H, Stürmer T
Source: Cancer, 2012 Jun 1;118(11), p. 2925-34.
EPub date: 2011 Nov 9.
PMID: 22072441
Related Citations

Grant Numbers:
NCI NIH HHS - R01-CA124402 NIA NIH HHS - R01 AG023178 NCI NIH HHS - R01 CA124402-05

MeSH Terms:
United States Antineoplastic Agents Humans
SEER Program Retrospective Studies Medicare
African Americans Aged Survival Rate
European Continental Ancestry Group Fluorouracil Cohort Studies
Treatment Outcome Organoplatinum Compounds Colonic Neoplasms
Chemotherapy, Adjuvant Female Healthcare Disparities
Male

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Sustainability and performance of the National Cancer Institute's Community Clinical Oncology Program.
Authors: Carpenter WR, Fortune-Greeley AK, Zullig LL, Lee SY, Weiner BJ
Source: Contemp Clin Trials, 2012 Jan;33(1), p. 46-54.
EPub date: 2011 Oct 2.
PMID: 21986391
Related Citations

Grant Numbers:
NCI NIH HHS - 5R01CA124402 PHS HHS - HHSN-261200800726P NCI NIH HHS - HHSN261200800726P
NCI NIH HHS - R01 CA124402-05 NCI NIH HHS - 5R25CA116339

MeSH Terms:
United States Neoplasms National Cancer Institute (U.S.)
Humans Program Evaluation Medical Oncology
Organizational Affiliation Community Health Services Research Design
National Health Programs

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The meaning and measurement of implementation climate.
Authors: Weiner BJ, Belden CM, Bergmire DM, Johnston M
Source: Implement Sci, 2011 Jul 22;6, p. 78.
EPub date: 2011 Jul 22.
PMID: 21781328
Related Citations

Grant Numbers:
NCI NIH HHS - R01 CA124402). NCI NIH HHS - R01 CA124402

MeSH Terms:
Organizational Innovation Cooperative Behavior Biomedical Research
Humans Organizational Culture Diffusion of Innovation
Health Plan Implementation Medical Oncology Models, Theoretical

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Systems antecedents for dissemination and implementation: a review and analysis of measures.
Authors: Emmons KM, Weiner B, Fernandez ME, Tu SP
Source: Health Educ Behav, 2012 Feb;39(1), p. 87-105.
EPub date: 2011 Jul 1.
PMID: 21724933
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Grant Numbers:
NCCDPHP CDC HHS - U48-DP001946 NCCDPHP CDC HHS - U48-DP001911 NCCDPHP CDC HHS - U48-DP000057
NCCDPHP CDC HHS - U48/DP001944 NCI NIH HHS - R01 CA124397 NCI NIH HHS - R01 CA123228
NCI NIH HHS - R01 CA123228-05 NCI NIH HHS - R01 CA124402 NCI NIH HHS - 1K05 CA124415-01A1
NCI NIH HHS - K05 CA124415-05 NCI NIH HHS - R01 CA124397-05 NCCDPHP CDC HHS - U48/DP000059
NCI NIH HHS - R01 CA124402-05

MeSH Terms:
Humans Organizational Culture Information Dissemination
Leadership Health Promotion

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Breast MRI utilization in older patients with newly diagnosed breast cancer.
Authors: Sommer CA, Stitzenberg KB, Tolleson-Rinehart S, Carpenter WR, Carey TS
Source: J Surg Res, 2011 Sep;170(1), p. 77-83.
EPub date: 2011 May 17.
PMID: 21658724
Related Citations

Grant Numbers:
AHRQ HHS - 5-T-32 HS000032-21 NCI NIH HHS - N01-PC-35139 PHS HHS - U55/CCR921930-02
NCI NIH HHS - 5R01CA124402 NCI NIH HHS - N01-PC-35136 NCI NIH HHS - N02-PC-15105
NCI NIH HHS - R01 CA124402-05

MeSH Terms:
United States Magnetic Resonance Imaging Age Factors
Neoplasm Staging Humans SEER Program
Breast Medicare Breast Neoplasms
Aged Female

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Race and age disparities in receipt of sentinel lymph node biopsy for early-stage breast cancer.
Authors: Reeder-Hayes KE, Bainbridge J, Meyer AM, Amos KD, Weiner BJ, Godley PA, Carpenter WR
Source: Breast Cancer Res Treat, 2011 Aug;128(3), p. 863-71.
EPub date: 2011 Feb 22.
PMID: 21340480
Related Citations

Grant Numbers:
NCI NIH HHS - N01-PC-35139 PHS HHS - U55/CCR921930-02 NCI NIH HHS - 5R01CA124402
NCI NIH HHS - N01-PC-35136 NCI NIH HHS - N02-PC-15105 NCI NIH HHS - R01 CA124402-04
NCI NIH HHS - R01 CA124402-05

MeSH Terms:
United States Age Factors Neoplasm Staging
Aged, 80 and over Sentinel Lymph Node Biopsy Humans
European Continental Ancestry Group Breast Neoplasms Aged
African Americans Healthcare Disparities Female

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The role of organizational affiliations and research networks in the diffusion of breast cancer treatment innovation.
Authors: Carpenter WR, Reeder-Hayes K, Bainbridge J, Meyer AM, Amos KD, Weiner BJ, Godley PA
Source: Med Care, 2011 Feb;49(2), p. 172-9.
PMID: 21206296
Related Citations

Grant Numbers:
NCI NIH HHS - N01-PC-35139 PHS HHS - U55/CCR921930-02 NCI NIH HHS - 5R01CA124402
NCI NIH HHS - N01-PC-35136 NCI NIH HHS - N02-PC-15105 NCI NIH HHS - R01 CA124402-04
NCI NIH HHS - R01 CA124402-05

MeSH Terms:
United States Humans Interinstitutional Relations
SEER Program Diffusion of Innovation Health Services Research
Linear Models Medicare Aged
Breast Neoplasms Medical Oncology Translational Medical Research
Multivariate Analysis Aged, 80 and over Logistic Models
Sentinel Lymph Node Biopsy Insurance Claim Reporting Physician's Practice Patterns
Organizational Affiliation Societies, Medical Female

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Racial differences in PSA screening interval and stage at diagnosis.
Authors: Carpenter WR, Howard DL, Taylor YJ, Ross LE, Wobker SE, Godley PA
Source: Cancer Causes Control, 2010 Jul;21(7), p. 1071-80.
EPub date: 2010 Mar 24.
PMID: 20333462
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Grant Numbers:
NCI NIH HHS - PC040907 NCRR NIH HHS - #C06 RR020139 NIMHD NIH HHS - P60 MD000239-05
NCI NIH HHS - N02-PC-15105 NCRR NIH HHS - C06 RR020139-010004 NCI NIH HHS - PC060224
NCI NIH HHS - N01-PC-35139 NIMHD NIH HHS - P60 MD000239 NCI NIH HHS - U01 CA114629-05
NCI NIH HHS - N01-PC-35136 NCI NIH HHS - R01 CA124402-03 AHRQ HHS - R24 HS013353
PHS HHS - #U55/CCR921930-02

MeSH Terms:
United States Neoplasm Staging Humans
Prostate-Specific Antigen SEER Program Medicare
African Americans Aged Mass Screening
Aged, 80 and over Logistic Models European Continental Ancestry Group
Time Factors Prostatic Neoplasms Female
Male

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A theory of organizational readiness for change.
Authors: Weiner BJ
Source: Implement Sci, 2009 Oct 19;4, p. 67.
EPub date: 2009 Oct 19.
PMID: 19840381
Related Citations

Grant Numbers:
NCI NIH HHS - R01 CA124402-03 NCI NIH HHS - R01 CA124402-05

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Last Updated: August 24, 2012
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