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National Institutes of Health: National Cancer Institute: Division of Cancer Control and Population Sciences
Grant Details

Grant Number: 5R01CA161780-02 Interpret this number
Primary Investigator: Schiffman, Joshua
Organization: University Of Utah
Project Title: Genetic Risk Factors for Ewing's Sarcoma
Fiscal Year: 2013
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DESCRIPTION (provided by applicant): Ewing's sarcoma is the second most common bone tumor in children and adolescents. When presenting with metastases or relapse, it is an often fatal disease. Unfortunately, little is known about the epidemiology or genetic risks for this deadly cancer. Ewing's sarcoma almost always contains a specific translocation between EWS-FLI1, are another fusion partner with the EWS gene. Recent laboratory investigations have revealed that a minimum number of microsatellite repeats are necessary in the promoter regions of the genes affected by the EWS-FLI1 translocation protein. These microsatellite repeats are necessary for Ewing's sarcoma tumors to develop in vitro. Another commonly reported feature of Ewing's sarcoma includes a very strong Caucasian predominance (the disease rarely occurs in Asian or African-American patients and only occasionally occurs in Hispanic patients) and also the association of increased hernias in patients who develop Ewing's sarcoma. For this study, we will collect DNA from 550 cases of Ewing's sarcoma in North America, along with DNA from both parents when available. We will then investigate: 1) whether children who develop Ewing's sarcoma have inherited longer microsatellite regions from their parents, 2) if non-Caucasian cases of Ewing's sarcoma actually contain genetic Caucasian ancestral markers, and 3) if cases of Ewing's sarcoma have inherited genomic variants associated with Ewing's sarcoma translocation genes and hernia-development. This study will help to explain the genetic risks for Ewing's sarcoma, one of the most deadly cancers in children and young adults.

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Connecting Molecular Pathways To Hereditary Cancer Risk Syndromes
Authors: Testa J.R. , Malkin D. , Schiffman J.D. .
Source: American Society Of Clinical Oncology Educational Book / Asco. American Society Of Clinical Oncology. Meeting, 2013; , p. 81-90.
PMID: 23714463
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Clinical And Biochemical Function Of Polymorphic Nr0b1 Ggaa-microsatellites In Ewing Sarcoma: A Report From The Children's Oncology Group
Authors: Monument M.J. , Johnson K.M. , McIlvaine E. , Abegglen L. , Watkins W.S. , Jorde L.B. , Womer R.B. , Beeler N. , Monovich L. , Lawlor E.R. , et al. .
Source: Plos One, 2014; 9(8), p. e104378.
PMID: 25093581
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